2024
Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
Collaborators G, Brauer M, Roth G, Aravkin A, Zheng P, Abate K, Abate Y, Abbafati C, Abbasgholizadeh R, Abbasi M, Abbasian M, Abbasifard M, Abbasi-Kangevari M, ElHafeez S, Abd-Elsalam S, Abdi P, Abdollahi M, Abdoun M, Abdulah D, Abdullahi A, Abebe M, Abedi A, Abedi A, Abegaz T, Zuñiga R, Abiodun O, Abiso T, Aboagye R, Abolhassani H, Abouzid M, Aboye G, Abreu L, Abualruz H, Abubakar B, Abu-Gharbieh E, Abukhadijah H, Aburuz S, Abu-Zaid A, Adane M, Addo I, Addolorato G, Adedoyin R, Adekanmbi V, Aden B, Adetunji J, Adeyeoluwa T, Adha R, Adibi A, Adnani Q, Adzigbli L, Afolabi A, Afolabi R, Afshin A, Afyouni S, Afzal M, Afzal S, Agampodi S, Agbozo F, Aghamiri S, Agodi A, Agrawal A, Agyemang-Duah W, Ahinkorah B, Ahmad A, Ahmad D, Ahmad F, Ahmad N, Ahmad S, Ahmad T, Ahmed A, Ahmed A, Ahmed A, Ahmed L, Ahmed M, Ahmed S, Ahmed S, Ajami M, Akalu G, Akara E, Akbarialiabad H, Akhlaghi S, Akinosoglou K, Akinyemiju T, Akkaif M, Akkala S, Akombi-Inyang B, Al Awaidy S, Al Hasan S, Alahdab F, AL-Ahdal T, Alalalmeh S, Alalwan T, Al-Aly Z, Alam K, Alam N, Alanezi F, Alanzi T, Albakri A, AlBataineh M, Aldhaleei W, Aldridge R, Alemayohu M, Alemu Y, Al-Fatly B, Al-Gheethi A, Al-Habbal K, Alhabib K, Alhassan R, Ali A, Ali A, Ali B, Ali I, Ali L, Ali M, Ali R, Ali S, Ali W, Alicandro G, Alif M, Aljunid S, Alla F, Al-Marwani S, Al-Mekhlafi H, Almustanyir S, Alomari M, Alonso J, Alqahtani J, Alqutaibi A, Al-Raddadi R, Alrawashdeh A, Al-Rifai R, Alrousan S, Al-Sabah S, Alshahrani N, Altaany Z, Altaf A, Al-Tawfiq J, Altirkawi K, Aluh D, Alvis-Guzman N, Alvis-Zakzuk N, Alwafi H, Al-Wardat M, Al-Worafi Y, Aly H, Aly S, Alzoubi K, Al-Zyoud W, Amaechi U, Mohammadi M, Amani R, Amiri S, Amirzade-Iranaq M, Ammirati E, Amu H, Amugsi D, Amusa G, Ancuceanu R, Anderlini D, Anderson J, Andrade P, Andrei C, Andrei T, Anenberg S, Angappan D, Angus C, Anil A, Anil S, Anjum A, Anoushiravani A, Antonazzo I, Antony C, Antriyandarti E, Anuoluwa B, Anvari D, Anvari S, Anwar S, Anwar S, Anwer R, Anyabolo E, Anyasodor A, Apostol G, Arabloo J, Bahri R, Arafat M, Areda D, Aregawi B, Aremu A, Armocida B, Arndt M, Ärnlöv J, Arooj M, Artamonov A, Artanti K, Aruleba I, Arumugam A, Asbeutah A, Asgary S, Asgedom A, Ashbaugh C, Ashemo M, Ashraf T, Askarinejad A, Assmus M, Astell-Burt T, Athar M, Athari S, Atorkey, Atreya A, Aujayeb A, Ausloos M, Avila-Burgos L, Awoke A, Quintanilla B, Ayatollahi H, Portugal C, Ayuso-Mateos J, Azadnajafabad S, Azevedo R, Azhar G, Azizi H, Azzam A, Backhaus I, Badar M, Badiye A, Bagga A, Baghdadi S, Bagheri N, Bagherieh S, Taghanaki P, Bai R, Baig A, Baker J, Bakkannavar S, Balasubramanian M, Baltatu O, Bam K, Bandyopadhyay S, Banik B, Banik P, Banke-Thomas A, Bansal H, Barchitta M, Bardhan M, Bardideh E, Barker-Collo S, Bärnighausen T, Barone-Adesi F, Barqawi H, Barrero L, Barrow A, Barteit S, Basharat Z, Basiru A, Basso J, Bastan M, Basu S, Batchu S, Batra K, Batra R, Baune B, Bayati M, Bayileyegn N, Beaney T, Behnoush A, Beiranvand M, Béjot Y, Bekele A, Belgaumi U, Bell A, Bell M, Bello M, Bello O, Belo L, Beloukas A, Bendak S, Bennett D, Bennitt F, Bensenor I, Benzian H, Beran A, Berezvai Z, Bernabe E, Bernstein R, Bettencourt P, Bhagavathula A, Bhala N, Bhandari D, Bhardwaj N, Bhardwaj P, Bhaskar S, Bhat A, Bhat V, Bhatti G, Bhatti J, Bhatti M, Bhatti R, Bhuiyan M, Bhutta Z, Bikbov B, Bishai J, Bisignano C, Biswas A, Biswas B, Biswas R, Bjørge T, Boachie M, Boakye H, Bockarie M, Bodolica V, Bodunrin A, Bogale E, Bolla S, Boloor A, Hashemi M, Boppana S, Basara B, Borhany H, Carvajal A, Bouaoud S, Boufous S, Bourne R, Boxe C, Braithwaite D, Brant L, Brar A, Breitborde N, Breitner S, Brenner H, Briko A, Britton G, Brown C, Browne A, Brunoni A, Bryazka D, Bulamu N, Bulto L, Buonsenso D, Burkart K, Burns R, Busse R, Bustanji Y, Butt N, Butt Z, dos Santos F, Cagney J, Cahuana-Hurtado L, Calina D, Cámera L, Campos L, Campos-Nonato I, Cao C, Cao F, Cao Y, Capodici A, Cárdenas R, Carr S, Carreras G, Carrero J, Carugno A, Carvalho F, Carvalho M, Castaldelli-Maia J, Castañeda-Orjuela C, Castelpietra G, Catalá-López F, Catapano A, Cattaruzza M, Caye A, Cederroth C, Cegolon L, Cenderadewi M, Cercy K, Cerin E, Chadwick J, Chakraborty C, Chakraborty P, Chakraborty S, Chan J, Chan R, Chandan J, Chandika R, Chaturvedi P, Chen A, Chen C, Chen H, Chen M, Chen M, Chen S, Cheng C, Cheng E, Cherbuin N, Chi G, Chichagi F, Chimed-Ochir O, Chimoriya R, Ching P, Chirinos-Caceres J, Chitheer A, Cho W, Chong B, Chopra H, Chowdhury R, Christopher D, Chu D, Chukwu I, Chung E, Chung S, Chutiyami M, Cioffi I, Cogen R, Cohen A, Columbus A, Conde J, Corlateanu A, Cortese S, Cortesi P, Costa V, Costanzo S, Criqui M, Cruz J, Cruz-Martins N, Culbreth G, da Silva A, Dadras O, Dai X, Dai Z, Daikwo P, Dalli L, Damiani G, D'Amico E, D'Anna L, Darwesh A, Das J, Das S, Dash N, Dashti M, Dávila-Cervantes C, Weaver N, Davitoiu D, De la Hoz F, de la Torre-Luque A, De Leo D, Debopadhaya S, Degenhardt L, Del Bo' C, Delgado-Enciso I, Delgado-Saborit J, Demoze C, Denova-Gutiérrez E, Dervenis N, Dervišević E, Desai H, Desai R, Devanbu V, Dewan S, Dhali A, Dhama K, Dhane A, Dhimal M, Dhimal M, Dhingra S, Dhulipala V, Dhungana R, da Silva D, Diaz D, Diaz L, Diaz M, Dima A, Ding D, Dinu M, Djalalinia S, Chi T, Phuong T, do Prado C, Dodangeh M, Dohare S, Dokova K, Dong W, Dongarwar D, D'Oria M, Dorostkar F, Dorsey E, Doshi R, Doshmangir L, Dowou R, Driscoll T, Dsouza A, Dsouza H, Dumith S, Duncan B, Duraes A, Duraisamy S, Dushpanova A, Dzianach P, Dziedzic A, Ebrahimi A, Echieh C, Ed-Dra A, Edinur H, Edvardsson D, Edvardsson K, Efendi F, Eftekharimehrabad A, Eini E, Ekholuenetale M, Ekundayo T, Arab R, Zaki M, El-Dahiyat F, Elemam N, Elgar F, ElGohary G, Elhabashy H, Elhadi M, Elmehrath A, Elmeligy O, Elshaer M, Elsohaby I, Emeto T, Esfandiari N, Eshrati B, Eslami M, Esmaeili S, Estep K, Etaee F, Fabin N, Fagbamigbe A, Fagbule O, Fahimi S, Falzone L, Fareed M, Farinha C, Faris M, Faris P, Faro A, Fasina F, Fatehizadeh A, Fauk N, Fazylov T, Feigin V, Feng X, Fereshtehnejad S, Feroze A, Ferrara P, Ferrari A, Ferreira N, Fetensa G, Feyisa B, Filip I, Fischer F, Fitriana I, Flavel J, Flohr C, Flood D, Flor L, Foigt N, Folayan M, Force L, Fortuna D, Foschi M, Franklin R, Freitas A, Friedman S, Fux B, Sridevi G, Gaal P, Gaihre S, Gajdács M, Galali Y, Gallus S, Gandhi A, Ganesan B, Ganiyani M, Garcia V, Gardner W, Garg R, Gautam R, Gebi T, Gebregergis M, Gebrehiwot M, Gebremariam T, Gebremeskel T, Gerema U, Getacher L, Getahun G, Getie M, Ghadirian F, Ghafarian S, Jolfayi A, Ghailan K, Ghajar A, Ghasemi M, Dabaghi G, Ghasemzadeh A, Ghassemi F, Ghazy R, Gholami A, Gholamrezanezhad A, Gholizadeh N, Ghorbani M, Gil A, Gil G, Gilbertson N, Gill P, Gill T, Gindaba E, Girmay A, Glasbey J, Gnedovskaya E, Göbölös L, Godinho M, Goel A, Golechha M, Goleij P, Golinelli D, Gomes N, Gopalani S, Gorini G, Goudarzi H, Goulart A, Gouravani, Goyal A, Graham S, Grivna M, Grosso G, Guan S, Guarducci G, Gubari M, Guha A, Guicciardi S, Gulati S, Gulisashvili D, Gunawardane D, Guo C, Gupta A, Gupta B, Gupta M, Gupta R, Gupta R, Gupta R, Gupta S, Gupta V, Gupta V, Gupta V, Habibzadeh F, Habibzadeh P, Hadaro T, Hadian Z, Haep N, Haghi-Aminjan H, Haghmorad D, Hagins H, Haile D, Hailu A, Ali A, Halboub E, Halimi A, Hall B, Haller S, Halwani R, Hamadeh R, Hamdy N, Hameed S, Hamidi S, Hammoud A, Hanif A, Hanifi N, Haq Z, Haque R, Harapan H, Hargono A, Haro J, Hasaballah A, Hasan I, Hasan M, Hasan S, Hasani H, Hasanian M, Hashmeh N, Hasnain S, Hassan A, Hassan I, Tabatabaei M, Hassani S, Hassanipour S, Hassankhani H, Haubold J, Havmoeller R, Hay S, Hebert J, Hegazi O, Hegena T, Heidari G, Heidari M, Helfer B, Hemmati M, Henson C, Herbert M, Herteliu C, Heuer A, Hezam K, Hinneh T, Hiraike Y, Hoan N, Holla R, Hon J, Hoque M, Horita N, Hossain S, Hosseini S, Hosseinzadeh H, Hosseinzadeh M, Hostiuc M, Hostiuc S, Hoven H, Hsairi M, Hsu J, Hu C, Huang J, Huda N, Hulland E, Hultström M, Hushmandi K, Hussain J, Hussein N, Huynh C, Huynh H, Ibitoye S, Idowu O, Ihler A, Ikeda N, Ikuta K, Ilesanmi O, Ilic I, Ilic M, Imam M, Immurana M, Inbaraj L, Irham L, Isa M, Islam R, Ismail F, Ismail N, Iso H, Isola G, Iwagami M, Iwu C, Iwu-Jaja C, Vinothini J, Jaafari J, Jacob L, Jacobsen K, Jadidi-Niaragh F, Jahankhani K, Jahanmehr N, Jahrami H, Jain A, Jain N, Jairoun A, Jaiswal A, Jakovljevic M, Yengejeh R, Jamora R, Jatau A, Javadov S, Javaheri T, Jayaram S, Jeganathan J, Jeswani B, Jiang H, Johnson C, Jokar M, Jomehzadeh N, Jonas J, Joo T, Joseph A, Joseph N, Joshi V, Joshua C, Jozwiak J, Jürisson M, Kaambwa B, Kabir A, Kabir Z, Kadashetti V, Kahn E, Kalani R, Kaliyadan F, Kalra S, Kamath R, Kanagasabai T, Kanchan T, Kandel H, Kanmiki E, Kanmodi K, Kansal S, Kapner D, Kapoor N, Karagiannidis E, Karajizadeh M, Karakasis P, Karanth S, Karaye I, Karch A, Karim A, Karimi H, Karmakar S, Kashoo F, Kasraei H, Kassahun W, Kassebaum N, Kassel M, Katikireddi S, Kauppila J, Kawakami N, Kaydi N, Kayode G, Kazemi F, Keiyoro P, Kemmer L, Kempen J, Kerr J, Kesse-Guyot E, Khader Y, Khafaie M, Khajuria H, Khalaji A, Khalil M, Khalilian A, Khamesipour F, Khan A, Khan M, Khan M, Khan M, Khan M, Khanmohammadi S, Khatab K, Khatatbeh H, Khatatbeh M, Khatib M, Khavandegar A, Kashani H, Khidri F, Khodadoust E, Khormali M, Khorrami Z, Khosla A, Khosrowjerdi M, Khreis H, Khusun H, Kifle Z, Kim K, Kim M, Kim Y, Kimokoti R, Kisa A, Kisa S, Knibbs L, Knudsen A, Koh D, Kolahi A, Kompani F, Kong J, Koren G, Korja M, Korshunov V, Korzh O, Kosen S, Kothari N, Koul P, Laxminarayana S, Krishan K, Krishnamoorthy V, Krishnamoorthy Y, Krishnan B, Krohn K, Defo B, Bicer B, Kuddus A, Kuddus M, Kugbey N, Kuitunen I, Kulimbet M, Kulkarni V, Kumar A, Kumar N, Kumar V, Kundu S, Kurmi O, Kusnali A, Kusuma D, Kutluk T, La Vecchia C, Ladan M, Laflamme L, Lahariya C, Lai D, Lal D, Lallukka T, Lám J, Lan Q, Lan T, Landires I, Lanfranchi F, Langguth B, Lansingh V, Laplante-Lévesque A, Larijani B, Larsson A, Lasrado S, Lauriola P, Le H, Le L, Le N, Le T, Leasher J, Ledda C, Lee M, Lee P, Lee S, Lee S, Lee Y, LeGrand K, Leigh J, Leong E, Lerango T, Lescinsky H, Leung J, Li M, Li W, Li W, Li Y, Li Z, Ligade V, Lim L, Lim S, Lin R, Lin S, Liu C, Liu G, Liu J, Liu J, Liu R, Liu S, Liu W, Liu X, Liu X, Livingstone K, Llanaj E, Lohiya A, López-Bueno R, Lopukhov P, Lorkowski S, Lotufo P, Lozano R, Lubinda J, Lucchetti G, Luo L, lv H, Amin H, Feei Z, Maass K, Mabrok M, Machairas N, Machoy M, Mafhoumi A, Razek M, Maghazachi A, Prasad D, Maharaj S, Mahmoud M, Mahmoudi E, Majeed A, Makram O, Makris K, Malasala S, Maled V, Malhotra K, Malik A, Malik I, Malinga L, Malta D, Mamun A, Manda A, Manla Y, Mansour A, Mansouri B, Mansouri P, Mansourian M, Mansournia M, Mantovani L, Manu E, Marateb H, Maravilla J, Marsh E, Martinez G, Martinez-Piedra R, Martini S, Martins-Melo F, Martorell M, Marx W, Maryam S, Mathangasinghe Y, Mathioudakis A, Matozinhos F, Mattumpuram J, Maugeri A, Maulik P, Mayeli M, Mazidi M, Mazzotti A, McGrath J, McKee M, McKowen A, McLaughlin S, McPhail M, McPhail S, Mechili E, Mehmood A, Mehmood K, Mehrabani-Zeinabad K, Nasab E, Meier T, Mejia-Rodriguez F, Meto T, Mekonnen B, Menezes R, Mengist B, Mensah G, Mensah L, Mentis A, Meo A, Meretoja A, Meretoja T, Mersha A, Mesfin B, Mestrovic T, Mettananda K, Mettananda S, Miazgowski T, Micha G, Michalek I, de Sá A, Miller T, Mirarefin M, Mirghafourvand M, Mirica A, Mirijello A, Mirrakhimov E, Mirshahi A, Mirzaei M, Mishra A, Mishra V, Mitchell P, Mithra P, Mittal C, Moazen B, Moberg M, Mocciaro G, Mohamadkhani A, Mohamed A, Mohamed A, Mohamed J, Mohamed M, Mohamed N, Mohammadi E, Mohammadi S, Mohammadian-Hafshejani A, Mohammadifard N, Mohammed H, Mohammed M, Mohammed S, Mohammed S, Mokdad A, Monasta L, Mondello S, Moni M, Ghalibaf A, Moore C, Moradi M, Moradi Y, Moraga P, Morawska L, Moreira R, Morovatdar N, Morrison S, Morze J, Heris R, Mossialos E, Motappa R, Mougin V, Mousavi P, Msherghi A, Mubarik S, Muccioli L, Mueller U, Mulita F, Mullany E, Munjal K, Murillo-Zamora E, Murlimanju B, Musina A, Mustafa G, Muthu S, Muthupandian S, Muthusamy R, Muzaffar M, Myung W, Nafei A, Nagarajan A, Nagaraju S, Nagel G, Naghavi M, Naghavi P, Naik G, Naik G, Nainu F, Nair T, Najdaghi S, Ansari N, Nanavaty D, Nangia V, Swamy S, Davani D, Nascimento B, Nascimento G, Nashwan A, Natto Z, Nauman J, Navaratna S, Naveed M, Nayak B, Nayak V, Ndejjo R, Nduaguba S, Negash H, Negoi I, Negoi R, Nejadghaderi S, Nejjari C, Nematollahi M, Nepal S, Neupane S, Ng M, Nguefack-Tsague G, Ngunjiri J, Nguyen D, Nguyen N, Nguyen P, Phuong The Nguyen, Nguyen V, Minh D, Niazi R, Nicholson S, Nie J, Nikoobar A, Nikpoor A, Ningrum D, Nnaji C, Noman E, Nomura S, Noroozi N, Norrving B, Noubiap J, Nri-Ezedi C, Ntaios G, Ntsekhe M, Nunemo M, Nurrika D, Nutor J, Oancea B, O'Connell E, Odetokun I, O'Donnell M, Oduro M, Ogunfowokan A, Ogunkoya A, Oh I, Okati-Aliabad H, Okeke S, Okekunle A, Okonji O, Olagunju A, Olasupo O, Olatubi M, Oliveira A, Oliveira G, Olorukooba A, Olufadewa I, Olusanya B, Olusanya J, Oluwafemi Y, Omar H, Bali A, Omer G, Ong K, Ong S, Onwujekwe O, Onyedibe K, Oppong A, Ordak M, Orish V, Ornello R, Orpana H, Ortiz A, Ortiz-Prado E, Osman W, Ostroff S, Osuagwu U, Otoiu A, Otstavnov N, Otstavnov S, Ouyahia A, Owolabi M, Oyeyemi I, Oyeyemi O, A M, Pacheco-Barrios K, Padron-Monedero A, Padubidri J, Pal P, Palicz T, Pan F, Pan H, Pana A, Panda S, Panda-Jonas S, Pandey A, Pandi-Perumal S, Pangaribuan H, Pantazopoulos I, Stoian A, Papadopoulou P, Parent M, Parija P, Parikh R, Park S, Park S, Parsons N, Pashaei A, Pasovic M, Passera R, Patil S, Patoulias D, Patthipati V, Paudel U, Pawar S, Toroudi H, Peden A, Pedersini P, Peng M, Pensato U, Pepito V, Peprah E, Peprah, Peres M, Perianayagam A, Perico N, Perna S, Pesudovs K, Petcu I, Petermann-Rocha F, Pham H, Philip A, Phillips M, Pickering B, Pierannunzio D, Pigeolet M, Pigott D, Piracha Z, Piradov M, Pisoni E, Piyasena M, Plass D, Plotnikov E, Poddighe D, Polkinghorne K, Poluru R, Pond C, Popovic D, Porru F, Postma M, Poudel G, Pour-Rashidi A, Pourshams A, Pourtaheri N, Prabhu D, Prada S, Pradhan J, Pradhan P, Prasad M, Prates E, Purnobasuki H, Purohit B, Puvvula J, Qasim N, Qattea I, Qazi A, Qian G, Qiu S, Rad M, Radfar A, Radhakrishnan R, Radhakrishnan V, Shahraki H, Rafferty Q, Rafiei A, Raggi A, Raghav P, Raheem N, Rahim F, Rahim J, Rahimifard M, Rahimi-Movaghar V, Rahman O, Rahman M, Rahmani A, Rahmani B, Rahmanian M, Rahmanian N, Rahmanian V, Rahmati M, Rahmawaty S, Raimondo D, Rajaa S, Rajendran V, Rajput P, Ramadan M, Ramasamy S, Ramasubramani P, Ramazanu S, Ramteke P, Rana J, Rana K, Ranabhat C, Rane A, Rani U, Ranta A, Rao C, Rao M, Rao P, Rao S, Rasella D, Rashedi S, Rashedi V, Rashidi M, Rashidi M, Rasouli-Saravani A, Ratan Z, Babu G, Rauniyar S, Rautalin I, Rawaf D, Rawaf S, Rawassizadeh R, Razo C, Reda Z, Reddy M, Redwan E, Reifels L, Reitsma M, Remuzzi G, Reshmi B, Resnikoff S, Restaino S, Reyes L, Rezaei M, Rezaei N, Rezaei N, Rezaeian M, Rhee T, Riaz M, Ribeiro A, Rickard J, Robinson-Oden H, Rodrigues C, Rodrigues M, Rodriguez J, Roever L, Romadlon D, Ronfani L, Rosauer J, Roshandel G, Rostamian M, Rotimi K, Rout H, Roy B, Roy N, Rubagotti E, de Andrade Ruela G, Rumisha S, Runghien T, Russo M, Ruzzante S, Chandan S, Saad A, Saber K, Saber-Ayad M, Sabour S, Sacco S, Sachdev P, Sachdeva R, Saddik B, Saddler A, Sadee B, Sadeghi E, Sadeghi M, Majd E, Saeb M, Saeed U, Safari M, Safi S, Safi S, Sagar R, Sagoe D, Sharif-Askari F, Sharif-Askari N, Sahebkar A, Sahoo S, Sahu M, Saif Z, Sajid M, Sakshaug J, Salam N, Salamati P, Salami A, Salaroli L, Salehi L, Salehi S, Salem M, Salem M, Salihu D, Salimi S, Salum G, Kafil H, Samadzadeh S, Samodra Y, Samuel V, Samy A, Sanabria J, Sanjeev R, Sanna F, Santomauro D, Santric-Milicevic M, Sarasmita M, Saraswathy S, Saravanan A, Saravi B, Sarikhani Y, Sarmiento-Suárez R, Sarode G, Sarode S, Sartorius B, Sarveazad A, Sathian B, Sattin D, Sawhney M, Saya G, Sayeed A, Abu Sayeed, Sayyah M, Schinckus C, Schmidt M, Schuermans 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Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet 2024, 403: 2162-2203. PMID: 38762324, PMCID: PMC11120204, DOI: 10.1016/s0140-6736(24)00933-4.Peer-Reviewed Original ResearchConceptsDisability-adjusted life yearsHigh body-mass indexTheoretical minimum risk exposure levelSocio-demographic indexBody-mass indexRisk-outcome pairsParticulate matter air pollutionChild growth failureBurden of diseaseGlobal disease burdenGlobal burdenHealth outcomesRisk factorsDisease burdenMetabolic riskAmbient particulate matter air pollutionSocio-demographic Index locationsGlobal Burden of Disease StudyBurden of Disease StudyGlobal Burden of DiseaseComparative risk assessment frameworkAge-standardised ratesExposure to risk factorsPopulation attributable fractionSpecific health outcomesGlobal burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
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Waqas M, Ward P, Wassie E, Watson S, Watson S, Weerakoon K, Wei M, Weintraub R, Weiss D, Westerman R, Whisnant J, Wiangkham T, Wickramasinghe D, Wickramasinghe N, Wilandika A, Wilkerson C, Willeit P, Wilson S, Wojewodzic M, Woldegebreal D, Wolf A, Wolfe C, Wondimagegene Y, Wong Y, Wongsin U, Wu A, Wu C, Wu F, Wu X, Wu Z, Xia J, Xiao H, Xie Y, Xu S, Xu W, Xu X, Xu Y, Yadollahpour A, Yamagishi K, Yang D, Yang L, Yano Y, Yao Y, Yaribeygi H, Ye P, Yehualashet S, Yesiltepe M, Yesuf S, Yezli S, Yi S, Yigezu A, Yiğit A, Yiğit V, Yip P, Yismaw M, Yismaw Y, Yon D, Yonemoto N, Yoon S, You Y, Younis M, Yousefi Z, Yu C, Yu Y, Yuh F, Zadey S, Zadnik V, Zafari N, Zakham F, Zaki N, Bin Zaman S, Zamora N, Zand R, Zangiabadian M, Zar H, Zare I, Zarrintan A, Zeariya M, Zeinali Z, Zhang H, Zhang J, Zhang J, Zhang L, Zhang Y, Zhang Z, Zhao H, Zhong C, Zhou J, Zhu B, Zhu L, Ziafati M, Zielińska M, Zitoun O, Zoladl M, Zou Z, Zuhlke L, Zumla A, Zweck E, Zyoud S, Wool E, Murray C. Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet 2024, 403: 2100-2132. PMID: 38582094, PMCID: PMC11126520, DOI: 10.1016/s0140-6736(24)00367-2.Peer-Reviewed Original ResearchConceptsAge-standardised death ratesChronic obstructive pulmonary diseaseGlobal burdenLife expectancyObstructive pulmonary diseaseGlobal life expectancyHighest age-standardised death ratesLower respiratory infectionsDeath rateCause-specific death ratesGlobal Burden of Disease StudyCause-of-death dataDecompose life expectancyLatin AmericaBurden of Disease StudyGlobal Burden of DiseaseHigh-income super-regionAge-standardised deathAge-standardised ratesSubnational locationsStudy periodOut-of-sample predictive validityCause-of-death estimatesCause-specific estimatesGBD super-regions
2023
Population health outcomes in South Korea 1990–2019, and projections up to 2040: a systematic analysis for the Global Burden of Disease Study 2019
Collaborators G, Park S, Kim M, Yon D, Lee S, Ward J, McLaughlin S, Mehlman M, Koyanagi A, Smith L, Jacob L, Agampodi S, Beiranvand M, Choi D, Hong S, Hosseinzadeh M, Kim C, Kim G, Kim J, Kim K, Kim S, Lee D, Lee H, Lee S, Lee Y, Mokdad A, Murray C, Okekunle A, Park E, Rabiee N, Shin Y, Hay S, Shin J. Population health outcomes in South Korea 1990–2019, and projections up to 2040: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet Public Health 2023, 8: e639-e650. PMID: 37516480, PMCID: PMC10400799, DOI: 10.1016/s2468-2667(23)00122-6.Peer-Reviewed Original ResearchConceptsNon-communicable diseasesDisease Study 2019Disease burdenPopulation health outcomesYears of lifeGlobal burdenHealth outcomesHigher systolic blood pressureAge-standardised DALYsSystolic blood pressureCause-specific mortalityAge-standardised ratesCause of deathUniversal health coverage systemSouth Korean populationHealth care policyRatio of maleBlood pressureRisk factorsTobacco useKorean populationMedical expendituresMelinda Gates FoundationMortalityHigher numberImpact of COVID-19 pandemic on health service utilisation and household economy of pregnant and postpartum women: a cross-sectional study from rural Sri Lanka
Gunarathna S, Wickramasinghe N, Agampodi T, Prasanna I, Agampodi S. Impact of COVID-19 pandemic on health service utilisation and household economy of pregnant and postpartum women: a cross-sectional study from rural Sri Lanka. BMJ Open 2023, 13: e070214. PMID: 37247958, PMCID: PMC10230333, DOI: 10.1136/bmjopen-2022-070214.Peer-Reviewed Original ResearchConceptsCurrent economic crisisHousehold economyFree public health servicesFinancial assistanceNon-parametric analysisEconomic crisisEconomic dataMonthly household incomeSri LankaHealth service utilisationHousehold incomeEconomic componentCOVID-19 pandemicEconomyPovertyIncomeService utilisationRural Sri LankaPostpartum womenCross-sectional studyPregnant womenAnuradhapura districtPublic health servicesLankaHealthcare utilisation‘We do not rush to the hospital for ordinary wounds (suḷu tuvāla)’: A qualitative study on the early clinical manifestations of cutaneous leishmaniasis and associated health behaviours in rural Sri Lanka
Gunasekara S, Wickramasinghe N, Agampodi S, Fernando M, Weerakoon K, Liyanage C, Dikomitis L, Agampodi T. ‘We do not rush to the hospital for ordinary wounds (suḷu tuvāla)’: A qualitative study on the early clinical manifestations of cutaneous leishmaniasis and associated health behaviours in rural Sri Lanka. PLOS Neglected Tropical Diseases 2023, 17: e0010939. PMID: 37172051, PMCID: PMC10208456, DOI: 10.1371/journal.pntd.0010939.Peer-Reviewed Original ResearchConceptsEarly clinical manifestationsClinical manifestationsCutaneous leishmaniasisHealth behaviorsRural Sri LankaAssociated health behaviorsHealthcare-seeking behaviorSelf-management actionsEarly skinTreatment periodFirst visitSkin lesionsQualitative studyHealth interventionsWorm infestationAnt bitesLeishmaniasisTropical diseasesNarrative thematic approachHealthcare facilitiesManifestationsRural settingsSymptomsAnuradhapura districtSubstantial delayEarly pregnancy metabolic syndrome and risk for adverse pregnancy outcomes: findings from Rajarata Pregnancy Cohort (RaPCo) in Sri Lanka
Jayasinghe I, Agampodi T, Dissanayake A, Agampodi S. Early pregnancy metabolic syndrome and risk for adverse pregnancy outcomes: findings from Rajarata Pregnancy Cohort (RaPCo) in Sri Lanka. BMC Pregnancy And Childbirth 2023, 23: 231. PMID: 37020187, PMCID: PMC10074348, DOI: 10.1186/s12884-023-05548-y.Peer-Reviewed Original ResearchConceptsGestational agePreterm birthPregnancy outcomesPregnant womenMetabolic syndromePregnancy cohortJoint Interim Statement criteriaFirst trimester pregnant womenMajor pregnancy outcomesSouth Asian pregnant womenAdverse pregnancy outcomesNeonatal birth weightGestational weight gainMedian gestational ageProspective cohort studyLive singleton birthsSignificant risk predictorAsian pregnant womenConclusionPregnant womenFPG thresholdMetS prevalenceCohort studyCumulative incidenceProspective cohortMetS definitions
2022
Quality of life among community-dwelling older adults: evidence from a large population-based study in rural Sri Lanka
Wickramasinghe ND, Ratnayake HE, Perera RA, Agampodi SB. Quality of life among community-dwelling older adults: evidence from a large population-based study in rural Sri Lanka. Quality Of Life Research 2022, 32: 93-103. PMID: 35964270, DOI: 10.1007/s11136-022-03230-y.Peer-Reviewed Original ResearchConceptsCommunity-dwelling older adultsQuality of lifeRural Sri LankaOlder adultsMultivariable binary logistic regression modelSignificant associationMethodsThis cross-sectional studyLarge population-based studyPopulation-based studyCross-sectional studyCommunity-based interventionsLevel of QoLLow educational levelSelf-reported healthLogistic regression modelsBinary logistic regression modelAged 70Mean ageBetter QOLChronic diseasesChronic illnessLower mean scoresQOL domainsQoLAdultsInvolvement of alcohol in injury cases in rural Sri Lanka: prevalence and associated factors among in-patients in three primary care hospitals
Schölin L, Weerasinghe M, Agampodi S, Chathurange U, Rajapaksha S, Holloway A, Norrie J, Mohamed F, Eddleston M, Pearson M. Involvement of alcohol in injury cases in rural Sri Lanka: prevalence and associated factors among in-patients in three primary care hospitals. BMC Public Health 2022, 22: 514. PMID: 35296275, PMCID: PMC8928674, DOI: 10.1186/s12889-022-12958-8.Peer-Reviewed Original ResearchConceptsAlcohol-related injuriesAlcohol Use Disorders Identification TestBlood alcohol concentrationRural Sri LankaAlcohol useInjury characteristicsPrimary care hospitalHospital-based sampleTransport-related injuriesCurrent alcohol usersDisorders Identification TestCurrent alcohol useBinary logistic regressionInvolvement of alcoholHigher AUDIT scoresAdult patientsCare hospitalGlobal morbidityResultsA totalIntentional injuriesAcute intoxicationProblematic alcohol usePatientsPossible alcohol dependenceInjury casesTemporal Variation and Factors Associated with Allergic Rhinitis in a Cohort of Rural Preschool Children from Sri Lanka
Rajapakse S, Amarasiri L, Yasaratne D, Warnasekara J, Agampodi S. Temporal Variation and Factors Associated with Allergic Rhinitis in a Cohort of Rural Preschool Children from Sri Lanka. Journal Of Tropical Pediatrics 2022, 68: fmac017. PMID: 35188209, DOI: 10.1093/tropej/fmac017.Peer-Reviewed Original ResearchConceptsAllergic rhinitisNasal symptomsSymptom exacerbationPopulation-based cross-sectional studyCommon chronic childhood diseaseChronic childhood diseaseCross-sectional studyLow diagnosis rateSignificant healthcare costsRural preschool childrenPreschool childrenSevere asthmaEye symptomsMean ageChildhood questionnaireRhinitisChildhood diseasesDaily livingHealthcare costsResponse rateRural Sri LankaDiagnosis rateExacerbationLow monthly temperatureSymptoms
2021
Clinical spectrum of endemic leptospirosis in relation to cytokine response
Dahanayaka NJ, Agampodi SB, Seneviratna I, Warnasekara J, Rajapakse R, Ranathunga K, Matthias M, Vinetz JM. Clinical spectrum of endemic leptospirosis in relation to cytokine response. PLOS ONE 2021, 16: e0261025. PMID: 34879100, PMCID: PMC8654203, DOI: 10.1371/journal.pone.0261025.Peer-Reviewed Original ResearchConceptsCytokine responsesLeptospirosis patientsClinical spectrumHigher IL-13 levelsHigher IL-5Acute kidney injuryHigher serum creatinineIL-13 levelsSerum cytokine levelsIL-6 levelsUniversity Teaching HospitalMultiplex cytokine kitKidney injuryLung involvementCytokine levelsSerum creatinineAcute phaseCytokine kitIL-1βAcute samplesConvalescence periodIL-8IL-5Prognostic informationEndemic settingsEpidemiology of wheeze among preschool children: a population-based cross-sectional study from rural Sri Lanka
Mudiyanselage S, Amarasiri WADL, Yasaratne BMGD, Warnasekara J, Agampodi S. Epidemiology of wheeze among preschool children: a population-based cross-sectional study from rural Sri Lanka. BMJ Open 2021, 11: e046688. PMID: 34233982, PMCID: PMC8264903, DOI: 10.1136/bmjopen-2020-046688.Peer-Reviewed Original ResearchConceptsIndependent risk factorCross-sectional studySevere wheezeAllergic rhinitisPassive smokingRisk factorsFrequent consumptionPopulation-based cross-sectional studyRural Sri LankaPreschool childrenPrevalence of wheezeWheezing attacksFrequent symptomsSevere wheezingMean ageYear old childrenChildhood questionnaireSevere episodesWheezeFemale childrenProtective factorsOlder childrenStudy sampleSize samplingAsthmaticsOptimizing the microscopic agglutination test (MAT) panel for the diagnosis of Leptospirosis in a low resource, hyper-endemic setting with varied microgeographic variation in reactivity
Jayasundara D, Gamage C, Senavirathna I, Warnasekara J, Matthias MA, Vinetz J, Agampodi S. Optimizing the microscopic agglutination test (MAT) panel for the diagnosis of Leptospirosis in a low resource, hyper-endemic setting with varied microgeographic variation in reactivity. PLOS Neglected Tropical Diseases 2021, 15: e0009565. PMID: 34197457, PMCID: PMC8279374, DOI: 10.1371/journal.pntd.0009565.Peer-Reviewed Original Research12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka
Jayasundara D, Senavirathna I, Warnasekara J, Gamage C, Siribaddana S, Kularatne SAM, Matthias M, Mariet JF, Picardeau M, Agampodi S, Vinetz J. 12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka. PLOS Neglected Tropical Diseases 2021, 15: e0009272. PMID: 33735202, PMCID: PMC8009393, DOI: 10.1371/journal.pntd.0009272.Peer-Reviewed Original ResearchConceptsClonal groupsAcute kidney injuryL. interrogansMajor clinical challengeGlobal disease threatsLeptospira speciesL. interrogans infectionKidney injuryLiver impairmentCardiovascular involvementL. borgpeterseniiClinical presentationProspective studyClinical severityClinical challengePathogenic Leptospira speciesAnnual epidemicsUbiquitous zoonotic diseaseNew serogroupEpidemiological contextZoonotic diseaseCulture isolationLeptospiral culturesL. weiliiLeptospira diversity
2020
Factors associated with purchasing pesticide from shops for intentional self‐poisoning in Sri Lanka
Weerasinghe M, Konradsen F, Eddleston M, Pearson M, Jayamanne S, Knipe D, Hawton K, Gunnell D, Agampodi S. Factors associated with purchasing pesticide from shops for intentional self‐poisoning in Sri Lanka. Tropical Medicine And International Health 2020, 25: 1198-1204. PMID: 33463883, DOI: 10.1111/tmi.13469.Peer-Reviewed Original ResearchIs leishmaniasis adequately notified in Sri Lanka? A survey among doctors from an endemic district, Sri Lanka
Hewawasam C, Weerakoon HS, Thilakan V, Lelwala T, Prasanka K, Rathnayaka AS, Gamage S, Agampodi S. Is leishmaniasis adequately notified in Sri Lanka? A survey among doctors from an endemic district, Sri Lanka. BMC Public Health 2020, 20: 913. PMID: 32532244, PMCID: PMC7290071, DOI: 10.1186/s12889-020-09066-w.Peer-Reviewed Original ResearchConceptsMedical officersMethodsA cross-sectional studyFirst clinical suspicionHigh disease burdenCross-sectional studyHigh case loadSelf-administered questionnaireHealth Care InstituteAnuradhapura districtCurrent notification systemClinical suspicionResultsOne hundredDisease burdenCare instituteCausative organismEarly diagnosisEndemic districtsCutaneous leishmaniasisParasitic infectionsLeishmaniasisNotifiable diseaseCase loadLeishmania donovaniDiseaseSupportive staffCytokine response in human leptospirosis with different clinical outcomes: a systematic review
Senavirathna I, Rathish D, Agampodi S. Cytokine response in human leptospirosis with different clinical outcomes: a systematic review. BMC Infectious Diseases 2020, 20: 268. PMID: 32264832, PMCID: PMC7137275, DOI: 10.1186/s12879-020-04986-9.Peer-Reviewed Original ResearchConceptsDifferent clinical outcomesCross-sectional studyCytokine responsesIL-10Clinical outcomesSystematic reviewDisease severityHealth Quality Assessment ToolComparative cross-sectional studyTNF-α levelsMethodsA systematic reviewMeasurement of cytokinesEnzyme-linked immunosorbent assayMicroscopic agglutination testPublic health professionalsQuality assessment toolMild leptospirosisCytokine stormElevated cytokinesObservational cohortLeptospirosis patientsProspective studyIL-1βIL-6IL-8Qualitative and quantitative dermatoglyphics of chronic kidney disease of unknown origin (CKDu) in Sri Lanka
Wijerathne BTB, Meier RJ, Salgado SS, Agampodi SB. Qualitative and quantitative dermatoglyphics of chronic kidney disease of unknown origin (CKDu) in Sri Lanka. Journal Of Physiological Anthropology 2020, 39: 1. PMID: 31952553, PMCID: PMC6967092, DOI: 10.1186/s40101-019-0207-0.Peer-Reviewed Original ResearchConceptsDevelopment of CKDuChronic kidney diseaseControl groupCKDu casesKidney diseaseCKDu patientsFetal developmentUnknown origin (PUO) patientsCase-control studyCertain medical conditionsCKDu endemic regionsNon-endemic regionsNon-invasive diagnostic toolHuman fetal developmentDiagnostic toolCKDu endemic areasRidge countTotal ridge countWeek 14Medical conditionsEndemic areasHealthy peopleEndemic regionsB ridge countControl study
2019
How context matters: Demonstrating microgeographical differences in social capital and its implications for mental wellbeing in pregnancy with a novel bubble diagram technique
Agampodi T, Agampodi S, Glozier N, Chithrani W, Warnasekara Y, Siribaddana S. How context matters: Demonstrating microgeographical differences in social capital and its implications for mental wellbeing in pregnancy with a novel bubble diagram technique. Health & Place 2019, 60: 102231. PMID: 31629193, DOI: 10.1016/j.healthplace.2019.102231.Peer-Reviewed Original ResearchConceptsSocial capitalSocial capital implicationsSocial capital constructsSri LankaMental wellbeingNeighborhood cohesionCapital implicationsMajor conflictsQualitative approachPolicy makersSpecific communitiesMaternal mental wellbeingQualitative studyContextual levelHealth inequalitiesMental health problemsNorth Central ProvinceDiverse communitiesDifferent communitiesDigestible wayMicrogeographical differencesPoor mental wellbeingMaternal deathsPregnant womenMaternal healthBody image perception and body dissatisfaction among rural Sri Lankan adolescents; do they have a better understanding about their weight?
Goonapienuwala BL, Agampodi SB, Kalupahana NS, Siribaddana S. Body image perception and body dissatisfaction among rural Sri Lankan adolescents; do they have a better understanding about their weight? Ceylon Medical Journal 2019, 64: 82-90. PMID: 32115403, DOI: 10.4038/cmj.v64i3.8950.Peer-Reviewed Original ResearchConceptsBody dissatisfactionBody image perceptionImage perceptionBody image distortionPubertal Development ScaleFigure Rating ScaleIdeal body sizeHalf of boysSri Lankan adolescentsDiscrepancy scoresCurrent body sizeRural adolescentsDevelopment ScaleAdolescentsDissatisfactionMore boysBoysGirlsPerceptionRating ScalePubertal developmentStudentsOverweight studentsImage distortionPhysical problemsStudy protocol: characterising the clinical, epidemiological and aetiological aspects of leptospirosis in Sri Lanka: a hospital based clinico-epidemiological study
Agampodi S, Warnasekara J, Jayasundara D, Senawirathna I, Gamage C, Kularatne S, Siribaddana S, Maththias M, Vinetz J. Study protocol: characterising the clinical, epidemiological and aetiological aspects of leptospirosis in Sri Lanka: a hospital based clinico-epidemiological study. BMJ Open 2019, 9: e027850. PMID: 31511281, PMCID: PMC6738675, DOI: 10.1136/bmjopen-2018-027850.Peer-Reviewed Original ResearchConceptsEthics Review CommitteeMultilocus sequence typingOutpatient departmentClinico-epidemiological studyMulticentre prospective studyDay of admissionMicroscopic agglutination testPresence of diseaseHospital stayFebrile patientsMedical wardsProspective studySri Lankan isolatesRisk factorsVenous bloodDisease progressionEthical clearanceHigh incidenceAetiological aspectsPatientsAgglutination testMolecular epidemiologyPatient contextBedside inoculationLeptospirosis