2024
Levels of Cytokines in Leptospirosis Patients with Different Serovars and rfb Locus
Senavirathna I, Jayasundara D, Warnasekara J, Kappagoda C, Agampodi S. Levels of Cytokines in Leptospirosis Patients with Different Serovars and rfb Locus. Journal Of Interferon & Cytokine Research 2024, 44: 80-93. PMID: 38377491, PMCID: PMC10880283, DOI: 10.1089/jir.2023.0091.Peer-Reviewed Original ResearchConceptsRfb locusGenome sequencePacBio RS II systemBacterial cell wallCulture-positive samplesLipopolysaccharide synthesisRapid AnnotationLeptospira borgpetersenii</i>,Genomic dataMicroscopic agglutination testSubsystem TechnologyLociCell wallSerovarsIsolated culturesSevere clinical manifestationsCytokine responsesLeptospira interrogans serovar autumnalisClinical manifestationsGenomeSamples of cultureSequenceRFBLevels of cytokinesSerum cytokine concentrations
2023
‘We do not rush to the hospital for ordinary wounds (suḷu tuvāla)’: A qualitative study on the early clinical manifestations of cutaneous leishmaniasis and associated health behaviours in rural Sri Lanka
Gunasekara S, Wickramasinghe N, Agampodi S, Fernando M, Weerakoon K, Liyanage C, Dikomitis L, Agampodi T. ‘We do not rush to the hospital for ordinary wounds (suḷu tuvāla)’: A qualitative study on the early clinical manifestations of cutaneous leishmaniasis and associated health behaviours in rural Sri Lanka. PLOS Neglected Tropical Diseases 2023, 17: e0010939. PMID: 37172051, PMCID: PMC10208456, DOI: 10.1371/journal.pntd.0010939.Peer-Reviewed Original ResearchConceptsEarly clinical manifestationsClinical manifestationsCutaneous leishmaniasisHealth behaviorsRural Sri LankaAssociated health behaviorsHealthcare-seeking behaviorSelf-management actionsEarly skinTreatment periodFirst visitSkin lesionsQualitative studyHealth interventionsWorm infestationAnt bitesLeishmaniasisTropical diseasesNarrative thematic approachHealthcare facilitiesManifestationsRural settingsSymptomsAnuradhapura districtSubstantial delay
2012
Utility of Quantitative Polymerase Chain Reaction in Leptospirosis Diagnosis: Association of Level of Leptospiremia and Clinical Manifestations in Sri Lanka
Agampodi SB, Matthias MA, Moreno AC, Vinetz JM. Utility of Quantitative Polymerase Chain Reaction in Leptospirosis Diagnosis: Association of Level of Leptospiremia and Clinical Manifestations in Sri Lanka. Clinical Infectious Diseases 2012, 54: 1249-1255. PMID: 22354922, PMCID: PMC3404689, DOI: 10.1093/cid/cis035.Peer-Reviewed Original ResearchConceptsQuantitative polymerase chain reactionClinical manifestationsPolymerase chain reactionBlood samplesChain reactionWhole bloodOnset of symptomsSensitivity of qPCRAssociation of levelsSerum/bloodMicroscopic agglutination test panelValid diagnostic testPatient blood samplesOptimal sample typeFailure patientsRenal failureWhole blood samplesPatient populationTimely diagnosisLeptospiral loadEndemic areasDay 2Day 15LeptospiremiaDiagnostic tests