High-throughput investigation of molecular and cellular biomarkers in NMOSD
Yandamuri SS, Jiang R, Sharma A, Cotzomi E, Zografou C, Ma AK, Alvey JS, Cook LJ, Smith TJ, Yeaman MR, O'Connor KC. High-throughput investigation of molecular and cellular biomarkers in NMOSD. Neurology Neuroimmunology & Neuroinflammation 2020, 7: e852. PMID: 32753407, PMCID: PMC7413712, DOI: 10.1212/nxi.0000000000000852.Peer-Reviewed Original ResearchConceptsNeuromyelitis optica spectrum disorderPeripheral blood mononuclear cellsHealthy controlsNK cellsCell subsetsT cellsUnstimulated peripheral blood mononuclear cellsB-cell activating factorDendritic cell subsetsOptica spectrum disorderRegulatory T cellsNatural killer cellsImmune cell subsetsMultivariable logistic regressionBlood mononuclear cellsSerum analyte levelsMultivariable linear regressionMultivariable regression modelsNovel biomarker candidatesCX3CL1 levelsNMOSD cohortSerum cytokinesDisease relapseKiller cellsSerum cohort