2020
High-throughput investigation of molecular and cellular biomarkers in NMOSD
Yandamuri SS, Jiang R, Sharma A, Cotzomi E, Zografou C, Ma AK, Alvey JS, Cook LJ, Smith TJ, Yeaman MR, O'Connor KC. High-throughput investigation of molecular and cellular biomarkers in NMOSD. Neurology Neuroimmunology & Neuroinflammation 2020, 7: e852. PMID: 32753407, PMCID: PMC7413712, DOI: 10.1212/nxi.0000000000000852.Peer-Reviewed Original ResearchConceptsNeuromyelitis optica spectrum disorderPeripheral blood mononuclear cellsHealthy controlsNK cellsCell subsetsT cellsUnstimulated peripheral blood mononuclear cellsB-cell activating factorDendritic cell subsetsOptica spectrum disorderRegulatory T cellsNatural killer cellsImmune cell subsetsMultivariable logistic regressionBlood mononuclear cellsSerum analyte levelsMultivariable linear regressionMultivariable regression modelsNovel biomarker candidatesCX3CL1 levelsNMOSD cohortSerum cytokinesDisease relapseKiller cellsSerum cohort
2019
Biomechanical analysis of motion following sacroiliac joint fusion using lateral sacroiliac screws with or without lumbosacral instrumented fusion
Dall BE, Eden SV, Cho W, Karkenny A, Brooks DM, Hayward GM, Moldavsky M, Yandamuri S, Bucklen BS. Biomechanical analysis of motion following sacroiliac joint fusion using lateral sacroiliac screws with or without lumbosacral instrumented fusion. Clinical Biomechanics 2019, 68: 182-189. PMID: 31234032, DOI: 10.1016/j.clinbiomech.2019.05.025.Peer-Reviewed Original ResearchConceptsSacroiliac joint screwLumbosacral instrumented fusionSacroiliac joint fusionRange of motionJoint rangeSacroiliac screwsInstrumented fusionSacroiliac jointJoint fusionLumbosacral fixationL5-S1 fixationLoad controlSacroiliac joint motionScrew configurationSacroiliac joint injuriesSource of painIntact motionSix-degreeJoint screwsMotion reductionIntact jointLigament injuryJoint hypermobilityJoint injuryFreedom machine
2018
Does pedicle screw fixation of the subaxial cervical spine provide adequate stabilization in a multilevel vertebral body fracture model? An in vitro biomechanical study
Duff J, Hussain MM, Klocke N, Harris JA, Yandamuri SS, Bobinski L, Daniel RT, Bucklen BS. Does pedicle screw fixation of the subaxial cervical spine provide adequate stabilization in a multilevel vertebral body fracture model? An in vitro biomechanical study. Clinical Biomechanics 2018, 53: 72-78. PMID: 29455101, DOI: 10.1016/j.clinbiomech.2018.02.009.Peer-Reviewed Original ResearchConceptsVertebral body fracturesCervical pedicle screwsPedicle screw reconstructionBody fracturesFlexion-extension testingCervical pedicleCervical vertebral body fracturesPedicle screwsBiomechanical studyAnterior-posterior approachSubaxial cervical spineRange of motionGreater initial stabilityLateral mass screwsLateral bendingAxial rotationCervical spineCircumferential fixationGroup 2Group 1Cadaveric specimensC2-T1PedicleAdequate stabilization
2009
In vivo evaluation of a neural stem cell-seeded prosthesis
Purcell E, Seymour J, Yandamuri S, Kipke D. In vivo evaluation of a neural stem cell-seeded prosthesis. Journal Of Neural Engineering 2009, 6: 026005. PMID: 19287078, PMCID: PMC2930820, DOI: 10.1088/1741-2560/6/2/026005.Peer-Reviewed Original ResearchConceptsNeuronal lossGlial encapsulationNeural stem cellsNeurotrophic factorSensory deficitsGraft cellsNeuronal activityChronic applicationBrain tissueHealing responseSubsequent cell deathDegenerative diseasesSynthetic prosthesesTime pointsProgenitor cellsInitial weeksVivo evaluationReactive tissue responseTissue responseCell deathStem cellsWeeksProsthesisImplantationCells