The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling
Brown DG, Soto R, Yandamuri S, Stone C, Dickey L, Gomes-Neto JC, Pastuzyn ED, Bell R, Petersen C, Buhrke K, Fujinami RS, O'Connell RM, Stephens WZ, Shepherd JD, Lane TE, Round JL. The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling. ELife 2019, 8: e47117. PMID: 31309928, PMCID: PMC6634972, DOI: 10.7554/elife.47117.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease Models, AnimalEncephalitis, ViralGastrointestinal MicrobiomeGerm-Free LifeMiceMicrogliaSignal TransductionSymbiosisToll-Like ReceptorsConceptsToll-like receptorsCentral nervous systemNeurologic damageMicroglia functionDisruption of TLR4Viral-specific immunityEntire central nervous systemCNS damageMicroglia depletionHomeostatic activationNeurotropic virusesOral administrationClinical diseaseViral infectionGermfree miceNervous systemHost defenseViral replicationMicrogliaTLR4InfectionMicrobiotaAnimalsDamageDemyelination