2019
The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling
Brown DG, Soto R, Yandamuri S, Stone C, Dickey L, Gomes-Neto JC, Pastuzyn ED, Bell R, Petersen C, Buhrke K, Fujinami RS, O'Connell RM, Stephens WZ, Shepherd JD, Lane TE, Round JL. The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling. ELife 2019, 8: e47117. PMID: 31309928, PMCID: PMC6634972, DOI: 10.7554/elife.47117.Peer-Reviewed Original ResearchConceptsToll-like receptorsCentral nervous systemNeurologic damageMicroglia functionDisruption of TLR4Viral-specific immunityEntire central nervous systemCNS damageMicroglia depletionHomeostatic activationNeurotropic virusesOral administrationClinical diseaseViral infectionGermfree miceNervous systemHost defenseViral replicationMicrogliaTLR4InfectionMicrobiotaAnimalsDamageDemyelination
2009
In vivo evaluation of a neural stem cell-seeded prosthesis
Purcell E, Seymour J, Yandamuri S, Kipke D. In vivo evaluation of a neural stem cell-seeded prosthesis. Journal Of Neural Engineering 2009, 6: 026005. PMID: 19287078, PMCID: PMC2930820, DOI: 10.1088/1741-2560/6/2/026005.Peer-Reviewed Original ResearchConceptsNeuronal lossGlial encapsulationNeural stem cellsNeurotrophic factorSensory deficitsGraft cellsNeuronal activityChronic applicationBrain tissueHealing responseSubsequent cell deathDegenerative diseasesSynthetic prosthesesTime pointsProgenitor cellsInitial weeksVivo evaluationReactive tissue responseTissue responseCell deathStem cellsWeeksProsthesisImplantationCells