2021
Lost in post-translational modification-Dengue virus writes its own sequel.
Yandamuri SS, O'Connor KC. Lost in post-translational modification-Dengue virus writes its own sequel. Science Immunology 2021, 6 PMID: 34215681, DOI: 10.1126/sciimmunol.abk1555.Peer-Reviewed Original Research
2019
The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling
Brown DG, Soto R, Yandamuri S, Stone C, Dickey L, Gomes-Neto JC, Pastuzyn ED, Bell R, Petersen C, Buhrke K, Fujinami RS, O'Connell RM, Stephens WZ, Shepherd JD, Lane TE, Round JL. The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling. ELife 2019, 8: e47117. PMID: 31309928, PMCID: PMC6634972, DOI: 10.7554/elife.47117.Peer-Reviewed Original ResearchConceptsToll-like receptorsCentral nervous systemNeurologic damageMicroglia functionDisruption of TLR4Viral-specific immunityEntire central nervous systemCNS damageMicroglia depletionHomeostatic activationNeurotropic virusesOral administrationClinical diseaseViral infectionGermfree miceNervous systemHost defenseViral replicationMicrogliaTLR4InfectionMicrobiotaAnimalsDamageDemyelination