2024
Classification of Suicide Attempt Risk Using Environmental and Lifestyle Factors in 3 Large Youth Cohorts
Visoki E, Moore T, Zhang X, Tran K, Ly C, Gataviņš M, DiDomenico G, Brogan L, Fein J, Warrier V, Guloksuz S, Barzilay R. Classification of Suicide Attempt Risk Using Environmental and Lifestyle Factors in 3 Large Youth Cohorts. JAMA Psychiatry 2024, 81: 1020-1029. PMID: 39018056, PMCID: PMC11255979, DOI: 10.1001/jamapsychiatry.2024.1887.Peer-Reviewed Original ResearchMillennium Cohort StudyExposome scoreLifestyle factorsAdolescent Brain Cognitive DevelopmentCohort studyExposome-wide association studyAssociated with suicide attemptsUK Millennium Cohort StudyNational longitudinal cohortSuicide attemptsProtective exposuresLogistic regression modelsFamily history of suicideRisk classificationAdolescent Brain Cognitive Development StudyUS hospitalsEnvironmental/lifestyle factorsEmergency departmentTest associationsHistory of suicidePopulation settingCause of deathUS adolescentsFamily historyLongitudinal cohortOn the proportion of patients who experience a prodrome prior to psychosis onset: A systematic review and meta-analysis
Benrimoh D, Dlugunovych V, Wright A, Phalen P, Funaro M, Ferrara M, Powers A, Woods S, Guloksuz S, Yung A, Srihari V, Shah J. On the proportion of patients who experience a prodrome prior to psychosis onset: A systematic review and meta-analysis. Molecular Psychiatry 2024, 29: 1361-1381. PMID: 38302562, DOI: 10.1038/s41380-024-02415-w.Peer-Reviewed Original ResearchSources of heterogeneitySystematic reviewProportion of patientsMeta-analysisSubgroup analysisCochrane Database of Systematic ReviewsDatabase of Systematic ReviewsMeta-analysis of studies of patientsPsychosis onsetProspective cohort studyCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsRegister of Controlled TrialsAPA PsycInfoNarrative synthesisMeta-analysis estimatesCochrane Central RegisterPrevention of psychosisAscertainment methodsWeb of Science Core CollectionRecall biasQualitative studyAssess heterogeneityCohort studyOvid MEDLINE
2023
Associations between genetic liabilities to smoking behavior and schizophrenia symptoms in patients with a psychotic disorder, their siblings and healthy controls
Lin B, Vermeulen J, Bolhuis K, Chang X, Schirmbeck F, van Eijk K, investigators G, Alizadeh B, Bartels-Velthuis A, van Amelsvoort T, Bruggeman R, Cahn W, de Haan L, Rutten B, Guloksuz S, Luykx J, van Os J, Simons C, van Winkel R, Guloksuz S, Blankers M, van den Brink W, de Haan L, Luykx J. Associations between genetic liabilities to smoking behavior and schizophrenia symptoms in patients with a psychotic disorder, their siblings and healthy controls. Psychiatry Research 2023, 323: 115143. PMID: 36948018, DOI: 10.1016/j.psychres.2023.115143.Peer-Reviewed Original ResearchConceptsHealthy controlsSmoking behaviorPsychotic symptomsSchizophrenia symptomsUnaffected siblingsProspective cohort studySix-year followMental health symptomsSymptom dimensionsCohort studyRisk factorsDepressive symptomsPsychotic disordersPatientsPositive symptomsHealth symptomsNegative symptomsSimilar effect sizesSymptomsLinear mixed-effects modelsMixed-effects modelsGenetic riskMean numberPolygenic scoresOverall sample
2022
Bidirectional relationships between cannabis use, anxiety and depressive symptoms in the mediation of the association with psychotic experience: further support for an affective pathway to psychosis
Radhakrishnan R, Pries LK, Erzin G, Have M, de Graaf R, van Dorsselaer S, Gunther N, Bak M, Rutten BPF, van Os J, Guloksuz S. Bidirectional relationships between cannabis use, anxiety and depressive symptoms in the mediation of the association with psychotic experience: further support for an affective pathway to psychosis. Psychological Medicine 2022, 53: 5551-5557. PMID: 36093677, PMCID: PMC10482707, DOI: 10.1017/s0033291722002756.Peer-Reviewed Original ResearchConceptsAnxiety/depressive symptomsDepressive symptomsCannabis usePE incidencePsychotic experiencesFirst longitudinal cohort studyNetherlands Mental Health SurveyLongitudinal cohort studyMental Health SurveyRole of cannabisBidirectional relationshipCohort studyHealth SurveyIncidence studyAffective symptomsSymptomsCannabisEducation statusLongitudinal studyPsychosisIncidenceAnxietyTemporal relationshipMediation analysisFurther support
2021
Longitudinal associations between alcohol use, smoking, genetic risk scoring and symptoms of depression in the general population: a prospective 6-year cohort study
de Boer N, Vermeulen J, Lin B, van Os J, Have M, de Graaf R, van Dorsselaer S, Bak M, Rutten B, Batalla A, Guloksuz S, Luykx J. Longitudinal associations between alcohol use, smoking, genetic risk scoring and symptoms of depression in the general population: a prospective 6-year cohort study. Psychological Medicine 2021, 53: 1409-1417. PMID: 35023464, PMCID: PMC10009403, DOI: 10.1017/s0033291721002968.Peer-Reviewed Original ResearchConceptsNumber of cigarettesDepressive symptomsAlcohol useLongitudinal associationsGeneral populationSmoking behaviorAlcohol consumptionGenetic risk scoringSymptoms of depressionGenetic risk score analysisGenetic risk scoreAlcohol cessationCohort studySmoking statusGlobal burdenMood disordersRisk scoreSmokingModerate drinkingRisk score analysisLess symptomsLinear mixed effects modelsSymptomsScore analysisRisk scoringClinical, Biochemical and Genetic Variables Associated With Metabolic Syndrome in Patients With Schizophrenia Spectrum Disorders Using Second-Generation Antipsychotics: A Systematic Review
Sneller M, de Boer N, Everaars S, Schuurmans M, Guloksuz S, Cahn W, Luykx J. Clinical, Biochemical and Genetic Variables Associated With Metabolic Syndrome in Patients With Schizophrenia Spectrum Disorders Using Second-Generation Antipsychotics: A Systematic Review. Frontiers In Psychiatry 2021, 12: 625935. PMID: 33868046, PMCID: PMC8044798, DOI: 10.3389/fpsyt.2021.625935.Peer-Reviewed Original ResearchSecond-generation antipsychoticsC-reactive proteinSchizophrenia spectrum disordersMetabolic syndromeCurrent BMIGenetic factorsHigher ageHigher white blood cell countSystematic reviewWhite blood cell countSevere mental illness experienceHigher baseline BMIRisk of MetS.Cardiovascular disease mortalityBlood cell countCross-sectional studyHigher current BMIMore studiesMental illness experienceSpectrum disorderSGA exposureBaseline BMICohort studyClinical factorsTobacco smoking
2020
Association of Recent Stressful Life Events With Mental and Physical Health in the Context of Genomic and Exposomic Liability for Schizophrenia
Pries L, van Os J, Have M, de Graaf R, van Dorsselaer S, Bak M, Lin B, van Eijk K, Kenis G, Richards A, O’Donovan M, Luykx J, Rutten B, Guloksuz S. Association of Recent Stressful Life Events With Mental and Physical Health in the Context of Genomic and Exposomic Liability for Schizophrenia. JAMA Psychiatry 2020, 77: 1296-1304. PMID: 32805017, PMCID: PMC7711318, DOI: 10.1001/jamapsychiatry.2020.2304.Peer-Reviewed Original ResearchConceptsRecent stressful life eventsStressful life eventsAssociations of SLEsPoor physical healthMental health outcomesHealth outcomesPhysical healthGeneral populationPopulation-based prospective cohort studyPRS-SCZNetherlands Mental Health SurveyES-SCZMental healthProspective cohort studyIncidence Study-2Modifiable environmental factorsAdulthood stressful life eventsMental Health SurveyDutch general populationPoor mental healthPopulation-based health outcomesLife eventsCohort studyMean ageHealth SurveyM126. THE MAIN AND INTERACTIVE EFFECTS OF ADULT STRESSFUL LIFE EVENTS WITH GENOMIC AND EXPOSOMIC LIABILITY FOR SCHIZOPHRENIA ON MENTAL AND PHYSICAL HEALTH: A PROSPECTIVE COHORT STUDY
Pries L, Have M, de Graaf R, van Dorsselaer S, Gunther N, Bak M, Li B, Luykx J, Rutten B, van Os J, Guloksuz S. M126. THE MAIN AND INTERACTIVE EFFECTS OF ADULT STRESSFUL LIFE EVENTS WITH GENOMIC AND EXPOSOMIC LIABILITY FOR SCHIZOPHRENIA ON MENTAL AND PHYSICAL HEALTH: A PROSPECTIVE COHORT STUDY. Schizophrenia Bulletin 2020, 46: s183-s183. PMCID: PMC7234581, DOI: 10.1093/schbul/sbaa030.438.Peer-Reviewed Original ResearchAdult stressful life eventsAssociations of SLEsStressful life eventsGeneral populationPhysical healthMental healthHealth SurveyHealth outcomesShort Form-36 Health SurveyNetherlands Mental Health SurveyImpact of SLEsRecent stressful life eventsProspective cohort studyPrevious health statusMental Health SurveyDutch general populationLife eventsCohort studyProspective surveyPolygenic risk scoresRisk scoreGene-environment interactionsGenetic predispositionHealth statusSchizophrenia
2019
Organization framework and preliminary findings from the Athens First‐Episode Psychosis Research Study
Xenaki L, Kollias C, Stefanatou P, Ralli I, Soldatos R, Dimitrakopoulos S, Hatzimanolis A, Triantafyllou T, Kosteletos I, Vlachos I, Selakovic M, Foteli S, Mantonakis L, Ermiliou V, Voulgaraki M, Psarra E, Gülöksüz S, van Os J, Stefanis N. Organization framework and preliminary findings from the Athens First‐Episode Psychosis Research Study. Early Intervention In Psychiatry 2019, 14: 343-355. PMID: 31402581, DOI: 10.1111/eip.12865.Peer-Reviewed Original ResearchConceptsRisk factorsMild functional improvementLongitudinal cohort studySymptom severity criteriaPoor cognitive performanceOutcome of psychosisPreliminary findingsPatients 16Cohort studyAntipsychotic treatmentClinical pictureFEP patientsClinical managementFunctional improvementFamily historyEmergency unitBaseline presentationSeverity criteriaPsychiatric hospitalPsychotic disordersClinical InterviewDrug usePotential associationGene-environment interaction studiesBiochemical parameters