High-Dimensional Gene–Environment Interaction Analysis
Wu M, Li Y, Ma S. High-Dimensional Gene–Environment Interaction Analysis. Annual Review Of Statistics And Its Application 2024 DOI: 10.1146/annurev-statistics-112723-034315.Peer-Reviewed Original ResearchFixed- and random-effects analysisG-E interaction analysisG-E interactionsVariable selectionFrequentist analysisGene-environmentRandom effects analysisGeneral frameworkStatistical propertiesProgression of complex diseasesDimension reductionHypothesis testingG-EComplex diseasesGenetic factorsInteraction analysisNonlinear effect analysisStatistical perspectiveDisease outcomeEnvironmental factorsPrediction-basedEstimation-basedA penalized integrative deep neural network for variable selection among multiple omics datasets
Li Y, Ren X, Yu H, Sun T, Ma S. A penalized integrative deep neural network for variable selection among multiple omics datasets. Quantitative Biology 2024, 12: 313-323. DOI: 10.1002/qub2.51.Peer-Reviewed Original ResearchOmics data analysisAvailability of omics dataMultiple omics datasetsGene expression datasetsAggregate multiple datasetsDeep neural networksOmics dataIntegrated deep neural networkOmics datasetsExpression datasetsMultiple datasetsDeep learningDiverse originsNeural networkOmicsAbstract Deep learningVariable selection resultsSample sizeVariable selectionIntegrated analysis frameworkCognitive statusOvarian cancer patientsModel interpretationExtensive simulation studyDataset