2022
Response to comment on: “Association of propofol induction dose and severe pre-incision hypotension among surgical patients over age 65”
Bardia A, Akhtar S, Schonberger RB. Response to comment on: “Association of propofol induction dose and severe pre-incision hypotension among surgical patients over age 65”. Journal Of Clinical Anesthesia 2022, 81: 110911. PMID: 35780644, PMCID: PMC11146281, DOI: 10.1016/j.jclinane.2022.110911.Peer-Reviewed Original ResearchRelationship Between Glucose Time in Range in Diabetic and Non-Diabetic Patients and Mortality in Critically Ill Patients
Ammar MA, Ammar AA, Wee T, Deshpande R, Band M, Akhtar S. Relationship Between Glucose Time in Range in Diabetic and Non-Diabetic Patients and Mortality in Critically Ill Patients. Journal Of Intensive Care Medicine 2022, 37: 1625-1633. PMID: 35491687, DOI: 10.1177/08850666221098383.Peer-Reviewed Original ResearchConceptsNon-diabetic patientsBlood glucose rangeDiabetic patientsIll patientsGlucose rangeTIR 70Hospital mortalityMortality rateHospital mortality rateNon-diabetic cohortLower mortality rateAdult patientsCohort studyMortality benefitSingle centerGlucose timePercentage of timeHigh incidencePatientsMortalityDlLtDiabeticsICUHyperglycemia
2021
Pressure-Regulated Ventilator Splitting for Disaster Relief: Design, Testing, and Clinical Experience
Raredon MSB, Fisher C, Heerdt PM, Schonberger RB, Nargi A, Nivison S, Fajardo E, Deshpande R, Akhtar S, Greaney AM, Belter J, Raredon T, Zinter J, McKee A, Michalski M, Baevova P, Niklason LE. Pressure-Regulated Ventilator Splitting for Disaster Relief: Design, Testing, and Clinical Experience. Anesthesia & Analgesia 2021, 134: 1094-1105. PMID: 34928890, DOI: 10.1213/ane.0000000000005825.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressureClinical experienceIndividualized positive end-expiratory pressureIntensive care unitEnd-expiratory pressureCoronavirus disease 2019 (COVID-19) pandemicHealth care teamDisease 2019 pandemicVentilatory supportIll patientsCare unitCare teamVentilator sharingFuture clinical applicationsPatientsIndependent careVentilator capacityClinical applicationCOVID-19 pandemicVentilatorClinical environmentOutline recommendationsMass traumaPandemicHospitalPreoperative evaluation of geriatric patients undergoing liver transplantation
Akhtar S. Preoperative evaluation of geriatric patients undergoing liver transplantation. Current Opinion In Anaesthesiology 2021, 35: 96-104. PMID: 34878418, DOI: 10.1097/aco.0000000000001084.Peer-Reviewed Original ResearchConceptsLiver transplantationNonalcoholic steatohepatitisGeriatric patientsElderly patientsPreoperative evaluationIncidence of NASHAge-related physiological changesPercent of patientsHepatitis C virusPortopulmonary hypertensionCirrhotic cardiomyopathyHepatopulmonary syndromeMultiple comorbiditiesPulmonary evaluationMetabolic syndromeFrailty evaluationPractice advisoryHepatocellular carcinomaPatientsTransplantationSyndromePhysiological changesHypertensionComorbiditiesSteatohepatitisNeurological Aging and Pharmacological Management of Geriatric Patients
Akhtar S. Neurological Aging and Pharmacological Management of Geriatric Patients. Current Anesthesiology Reports 2021, 11: 381-386. DOI: 10.1007/s40140-021-00497-8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPharmacological Adjuncts to Palliation in the Trauma Patient: Optimal Symptom Management
Ammar M, Ammar A, Cheung C, Akhtar S. Pharmacological Adjuncts to Palliation in the Trauma Patient: Optimal Symptom Management. Current Trauma Reports 2021, 7: 73-82. DOI: 10.1007/s40719-021-00215-z.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsTrauma patientsSymptom managementQuality of lifePalliative careOptimal symptom managementPatients' symptom managementAdequate palliative careMultidisciplinary team approachHealth care costsSummaryPalliative careEnd of lifePharmacological managementCommon symptomsEarly recognitionEffective pharmacotherapyVulnerable patientsPharmacological adjunctsLife carePatientsReviewThe purposeCare costsPatient careTeam approachCareSymptoms
2018
Perioperative Outcome in Geriatric Patients
Akhtar S. Perioperative Outcome in Geriatric Patients. Current Anesthesiology Reports 2018, 8: 232-237. DOI: 10.1007/s40140-018-0267-4.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsNon-cardiac surgeryPerioperative outcomesOlder patientsNon-home dispositionEmergency general surgeryRate of complicationsIntensive care unitPostoperative admissionPostoperative mortalityPerioperative morbidityCancer resectionPerioperative careCardiac operationsCare unitGeriatric patientsGeneral surgeryHigh riskInvasive proceduresElderly individualsPatientsSurgeryOctogenariansMortalityOverall rateOutcomes
2017
- Factor VIIIFactor replacementHemophilia AFactor XIFactor IXExogenous factor VIIIRecessive inheritance patternCoagulation workupElevated aPTTPlatelet countProthrombin concentrateSevere haemophiliaPlatelet functionCongenital deficiencyFactor VIIPatientsHemophiliaSpecific mutationsDisordersFIX concentrationInheritance patternLow levelsDeficiencyAntifibrinolyticsNSAIDs
2015
Geriatric Pharmacology
Akhtar S, Ramani R. Geriatric Pharmacology. Anesthesiology Clinics 2015, 33: 457-469. PMID: 26315631, DOI: 10.1016/j.anclin.2015.05.004.Peer-Reviewed Original ResearchConceptsElderly patientsLong-term outcomesEnd-organ sensitivityFurther pharmacologic studiesOlder patientsAnesthetic medicationsGeriatric pharmacologyPharmacologic studiesAnesthetic drugsPatientsDrug overdosingDecreased volumePhysiologic processesContinuous variablesTrue extentMedicationsAnesthetics
2014
Kidney Injury After Vascular Surgery
Akhtar S. Kidney Injury After Vascular Surgery. 2014, 125-134. DOI: 10.1007/978-1-4939-1273-5_10.ChaptersAcute kidney injuryKidney injuryVascular surgeryRisk factorsRisk of AKIContrast-induced kidney injurySurgery-related factorsPatient-related factorsLong-term outcomesAortic pathologyVascular proceduresEndovascular proceduresPatientsSurgeryInjuryManagement-related factorsFactorsKidneyIncidencePathology
2012
Vascular Surgery: Endovascular and Major Vascular Surgery
Akhtar S. Vascular Surgery: Endovascular and Major Vascular Surgery. 2012, 235-253. DOI: 10.1007/978-1-4614-3888-5_16.ChaptersElderly patientsVascular surgeryAdverse eventsPerioperative managementMajor vascular surgeryPerioperative adverse eventsComplex medical historyElderly patient presentingHigh-risk procedureNoncardiac surgerySignificant comorbiditiesCardiac eventsPreoperative evaluationPatient presentingMedical historyVascular proceduresSurgeryPatientsHealthy counterpartsSignificant proportionSame age cohortAge cohortsRiskComorbiditiesEndovascular
2011
Creating a Perioperative Glycemic Control Program
Alexanian SM, McDonnell ME, Akhtar S. Creating a Perioperative Glycemic Control Program. Anesthesiology Research And Practice 2011, 2011: 465974. PMID: 21912542, PMCID: PMC3168770, DOI: 10.1155/2011/465974.Peer-Reviewed Original ResearchGlycemic control programManagement of hyperglycemiaComprehensive multidisciplinary approachPostoperative complicationsSurgical populationPerioperative periodPreoperative clinicMetabolic abnormalitiesInsulin infusionRisk factorsGlucose levelsStandardized recommendationsHyperglycemiaOperating roomMultidisciplinary approachPatientsControl programsComplicationsHypoglycemiaSurgeryDiabetesHospitalInfusionClinicAbnormalities
2010
Pain Management in Elderly Patients
Akhtar S, Rappa R, Ghori M. Pain Management in Elderly Patients. 2010, 699-713. DOI: 10.1007/978-0-387-87579-8_32.ChaptersPhysiologic changesNormal physiologic changesExtremes of ageNormal physiological changesProgressive physiological changesPhysiological changesChronological ageElderly patientsPhysiologic reservePain managementMedical conditionsNormal physiologyAgeCognitive changesInjuryBiological ageDiseaseBirth datePhysiological degenerationSame individualPhysiological processesPatientsDegenerationIndividualsScientific Principles and Clinical Implications of Perioperative Glucose Regulation and Control
Akhtar S, Barash PG, Inzucchi SE. Scientific Principles and Clinical Implications of Perioperative Glucose Regulation and Control. Anesthesia & Analgesia 2010, 110: 478-497. PMID: 20081134, DOI: 10.1213/ane.0b013e3181c6be63.Peer-Reviewed Original ResearchConceptsIntensive glycemic controlGlycemic controlPerioperative periodPostsurgical patientsAcute insulin resistanceClose glucose monitoringPerioperative glycemic controlRecent prospective trialsDevelopment of hyperglycemiaRisk of hypoglycemiaIntraoperative glycemic controlNeuroendocrine stress responseGlycemic targetsProspective trialIll patientsIntraoperative managementPoor outcomeInsulin resistanceImproved outcomesTrue efficacyGlucose levelsGlucose regulationHyperglycemiaPatientsClinical implications
2007
Survey of anesthesiologists as to the value of prior ECG in a patient with nonspecific ST-T wave changes.
Tantawy H, Silverman TJ, Silverman DG, Akhtar S. Survey of anesthesiologists as to the value of prior ECG in a patient with nonspecific ST-T wave changes. Connecticut Medicine 2007, 71: 453-6. PMID: 17902381.Peer-Reviewed Original Research
2000
Room 302, 10/18/2000 9: 00 AM - 10: 30 AM (PD) Incidence of Perioperative Myocardial Injury Based on ACC/ AHA Guidelines in Vascular Surgery Patients
Akhtar S, Fleisher L, Jermyn R, Weiss J, Rosenbaum S. Room 302, 10/18/2000 9: 00 AM - 10: 30 AM (PD) Incidence of Perioperative Myocardial Injury Based on ACC/ AHA Guidelines in Vascular Surgery Patients. Anesthesiology 2000, 93: a-260. DOI: 10.1097/00000542-200009001-00260.Peer-Reviewed Original ResearchUse of active noise cancellation devices in caregivers in the intensive care unit
Akhtar S, Weigle C, Cheng E, Toohill R, Berens R. Use of active noise cancellation devices in caregivers in the intensive care unit. Critical Care Medicine 2000, 28: 1157-1160. PMID: 10809298, DOI: 10.1097/00003246-200004000-00040.Peer-Reviewed Original ResearchConceptsIntensive care unitVisual analog scaleMedical intensive care unitCare unitAdult medical intensive care unitPediatric intensive care unitIntensive care unit environmentCaregivers of patientsPediatric intensive careVAS pointsIll patientsAnalog scaleIntensive careHearing assessmentRespiratory therapistsTeaching hospitalSubjective assessmentNursing assistantsFurther evaluationUnit environmentCaregiversPatientsObjective measurementsHeadphone useSound level meterThe Effect of Heart Rate Control on Myocardial Ischemia Among High-Risk Patients After Vascular Surgery
RABY K, BRULL S, TIMIMI F, AKHTAR S, ROSENBAUM S, NAIMI C, WHITTEMORE A. The Effect of Heart Rate Control on Myocardial Ischemia Among High-Risk Patients After Vascular Surgery. Survey Of Anesthesiology 2000, 44: 10. DOI: 10.1097/00132586-200002000-00010.Peer-Reviewed Original Research