Featured Publications
Distinct neural networks predict cocaine versus cannabis treatment outcomes
Lichenstein S, Kohler R, Ye F, Potenza M, Kiluk B, Yip S. Distinct neural networks predict cocaine versus cannabis treatment outcomes. Molecular Psychiatry 2023, 28: 3365-3372. PMID: 37308679, PMCID: PMC10713861, DOI: 10.1038/s41380-023-02120-0.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingCognitive behavior therapyCognitive behavioral therapySubstance use disordersCannabis abstinenceNeural mechanismsBehavior therapyDistinct neural networksComputer-based trainingCannabis use disorderFMRI scanningNeural predictorsStudy 1Study 2Treatment outcomesContingency managementPrior workComparison subjectsNetwork strengthUse disordersNovel treatment targetsAbstinenceIndependent samplesCocaine abstinenceTreatment respondersEmerging Topics in Computational Psychiatric Research: Clarity Through Complexity?
Yip S, Konova A. Emerging Topics in Computational Psychiatric Research: Clarity Through Complexity? Biological Psychiatry 2023, 93: 652-654. PMID: 36948759, DOI: 10.1016/j.biopsych.2023.02.005.Peer-Reviewed Original Research
2024
Prediction of craving across studies: A commentary on conceptual and methodological considerations when using data-driven methods
Antons S, Yip S, Lacadie C, Dadashkarimi J, Scheinost D, Brand M, Potenza M. Prediction of craving across studies: A commentary on conceptual and methodological considerations when using data-driven methods. Journal Of Behavioral Addictions 2024, 13: 695-701. PMID: 39356557, PMCID: PMC11457034, DOI: 10.1556/2006.2024.00050.Peer-Reviewed Original ResearchConceptsAddictive behaviorsDisorders due to addictive behaviorsConnectome-based predictive modelingPrediction of cravingInvestigate neural mechanismsSubstance use disordersNeural mechanismsCravingSubstance useMethodological considerationsDisordersMethodological featuresBehaviorConceptualizationCommentaryStudyFindingsSubstancesA shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine D2/3 receptor densities
Ricard J, Labache L, Segal A, Dhamala E, Cocuzza C, Jones G, Yip S, Chopra S, Holmes A. A shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine D2/3 receptor densities. Communications Biology 2024, 7: 1178. PMID: 39300138, PMCID: PMC11413242, DOI: 10.1038/s42003-024-06836-9.Peer-Reviewed Original ResearchConceptsCocaine use disorderPatterns of functional connectivityUse disorderFunctional connectivityReceptor densityLarge-scale functional brain networksMaintenance of substance useDopamine D2/3 receptorsDopamine receptor densityCortico-striatal circuitsProfile of functional connectivitySubstance use disordersFunctional brain networksNeurotransmitter receptor densityD2/3 receptorsDopamine systemTransporter bindingSubcortical systemsBrain networksSubstance useCocaineSpatial topographyDisordersDopamineBiological mechanismsCOCAINE SELF-ADMINISTRATION BEHAVIOR IS ASSOCIATED WITH SUBCORTICAL AND CORTICAL GRAY MATTER IN INDIVIDUALS WITH COCAINE USE DISORDER
Kohler R, Zhornitsky S, Potenza M, Yip S, Worhunsky P, Angarita G. COCAINE SELF-ADMINISTRATION BEHAVIOR IS ASSOCIATED WITH SUBCORTICAL AND CORTICAL GRAY MATTER IN INDIVIDUALS WITH COCAINE USE DISORDER. Drug And Alcohol Dependence 2024, 260: 110081. DOI: 10.1016/j.drugalcdep.2023.110081.Peer-Reviewed Original ResearchW147 Neural and Behavioral Habituation to Sad Infant Stimuli in Mothers who Use Substances
McCurdy L, Yip S, Worhunsky P, Kim S, Strathearn L, Potenza M, Mayes L, Rutherford H. W147 Neural and Behavioral Habituation to Sad Infant Stimuli in Mothers who Use Substances. Drug And Alcohol Dependence 2024, 260: 110848. DOI: 10.1016/j.drugalcdep.2023.110848.Peer-Reviewed Original Research304. Multidimensional Components of Impulsivity in Youth: Insights From the Baseline Adolescent Brain and Cognitive Development Study Data
Riley S, Kohler R, Lichenstein S, Potenza M, Holmes A, Bzdok D, Yip S. 304. Multidimensional Components of Impulsivity in Youth: Insights From the Baseline Adolescent Brain and Cognitive Development Study Data. Biological Psychiatry 2024, 95: s224. DOI: 10.1016/j.biopsych.2024.02.803.Peer-Reviewed Original ResearchInvestigating Brain State Engagement Variability in Individuals With Opioid Use Disorder Using Naturalistic and Task-Based fMRI Data
Ye J, Mehta S, Peterson H, Ibrahim A, Saeed G, Linsky S, Kreinin I, Tsang S, Nwanaji-Enwerem U, Raso A, Yip S, Tokoglu F, Arora J, Constable R, Barry D, Redeker N, Yaggi H, Scheinost D. Investigating Brain State Engagement Variability in Individuals With Opioid Use Disorder Using Naturalistic and Task-Based fMRI Data. Biological Psychiatry 2024, 95: s6. DOI: 10.1016/j.biopsych.2024.02.022.Peer-Reviewed Original Research499. Identification of a Composite Latent Dimension of Reward and Impulsivity Across Clinical, Behavioral and Neurobiological Domains Among Youth
Kohler R, Lichenstein S, Cheng R, Holmes A, Bzdok D, Pearlson G, Yip S. 499. Identification of a Composite Latent Dimension of Reward and Impulsivity Across Clinical, Behavioral and Neurobiological Domains Among Youth. Biological Psychiatry 2024, 95: s303. DOI: 10.1016/j.biopsych.2024.02.998.Peer-Reviewed Original ResearchCocaine self-administration behavior is associated with subcortical and cortical morphometry measures in individuals with cocaine use disorder
Kohler R, Zhornitsky S, Potenza M, Yip S, Worhunsky P, Angarita G. Cocaine self-administration behavior is associated with subcortical and cortical morphometry measures in individuals with cocaine use disorder. The American Journal Of Drug And Alcohol Abuse 2024, 50: 345-356. PMID: 38551365, PMCID: PMC11305926, DOI: 10.1080/00952990.2024.2318585.Peer-Reviewed Original ResearchGray-matter volumeSelf-administer cocaineSelf-administration behaviorCocaine use disorderSelf-administrationGray-matterFrontal cortexUse disorderCocaine self-administration behaviorSelf-administered cocaine infusionsCocaine self-administrationSelf-administration paradigmInfusions self-administeredSelf-report assessmentsCortical brain regionsStructural MRI dataFR1 scheduleInsular thicknessCocaine infusionsPredisposing vulnerabilitiesCocaine consumptionCocaine useBrain regionsBilateral regionsLimbic systemNeural correlates of altered emotional responsivity to infant stimuli in mothers who use substances
McCurdy L, Yip S, Worhunsky P, Zhai Z, Kim S, Strathearn L, Potenza M, Mayes L, Rutherford H. Neural correlates of altered emotional responsivity to infant stimuli in mothers who use substances. Journal Of Psychiatric Research 2024, 171: 126-133. PMID: 38277872, PMCID: PMC10922955, DOI: 10.1016/j.jpsychires.2024.01.024.Peer-Reviewed Original ResearchConceptsResponses to infant stimuliInfant stimuliMaternal behaviorAffective processesBrain regionsPsychological processesEmotional responsesFunctional magnetic resonance imagingPotential neural targetsInfant emotional expressionsMaternal emotional responsivenessSubstance-use statusAssociated with difficultiesSocial-emotional developmentInfant social-emotional developmentMaternal substance useInfant facesCognitive processesImprove child outcomesEmotional expressionEmotional intensityNeural targetsSubstance useGroups of mothersChild outcomes
2023
Identification of a Composite Latent Dimension of Reward and Impulsivity Across Clinical, Behavioral, and Neurobiological Domains Among Youth
Kohler R, Lichenstein S, Cheng A, Holmes A, Bzdok D, Pearlson G, Yip S. Identification of a Composite Latent Dimension of Reward and Impulsivity Across Clinical, Behavioral, and Neurobiological Domains Among Youth. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 9: 407-416. PMID: 38052266, PMCID: PMC11149944, DOI: 10.1016/j.bpsc.2023.11.008.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderDisruptive behavior disordersAnterior cingulate responsesLatent dimensionsAnticipatory reward processingDeficit hyperactivity disorderSingle latent dimensionRisk-taking behaviorNegative urgencyExecutive functionIndividual differencesNeurobiological domainsReward anticipationCingulate responseReward processingAdolescent brainCognitive developmentNeural substratesHyperactivity disorderDevelopmental trajectoriesEarly adolescenceMultivariate patternsReward processesBehavioral variablesBehavior disorder399. The Neural Underpinnings of Cocaine Use Disorder
Ricard J, Labache L, Chopra S, Dhamala E, Jones G, Harnett N, Yip S, Holmes A. 399. The Neural Underpinnings of Cocaine Use Disorder. Biological Psychiatry 2023, 93: s255-s256. DOI: 10.1016/j.biopsych.2023.02.639.Peer-Reviewed Original Research
2022
Bayesian network mediation analysis with application to the brain functional connectome
Zhao Y, Chen T, Cai J, Lichenstein S, Potenza M, Yip S. Bayesian network mediation analysis with application to the brain functional connectome. Statistics In Medicine 2022, 41: 3991-4005. PMID: 35795965, PMCID: PMC10131252, DOI: 10.1002/sim.9488.Peer-Reviewed Original ResearchConceptsStochastic block modelBayesian paradigmBrain functional connectomeBlock modelConnectivity weightsFunctional connectomeNetwork measurementsEffect componentApproach applicationBlock allocationOpioid abstinenceAnalytic approachNetwork neurosciencePractical illustrationTherapeutic interventionsMediation analysisNeural circuitsNetwork structureBrain functioningMediatorsFunctional networksFeature selectionApplicationsModelNetworkTask-Based Co-Activation Patterns Reliably Predict Resting State Canonical Network Engagement During Development
Ye F, Kohler R, Serio B, Lichenstein S, Yip S. Task-Based Co-Activation Patterns Reliably Predict Resting State Canonical Network Engagement During Development. Biological Psychiatry 2022, 91: s83. DOI: 10.1016/j.biopsych.2022.02.225.Peer-Reviewed Original ResearchFrom Computation to Clinic
Yip S, Barch D, Chase H, Flagel S, Huys Q, Konova A, Montague R, Paulus M. From Computation to Clinic. Biological Psychiatry Global Open Science 2022, 3: 319-328. PMID: 37519475, PMCID: PMC10382698, DOI: 10.1016/j.bpsgos.2022.03.011.Peer-Reviewed Original ResearchMultivariate, Transgenerational Associations of the COVID-19 Pandemic Across Minoritized and Marginalized Communities
Yip SW, Jordan A, Kohler RJ, Holmes A, Bzdok D. Multivariate, Transgenerational Associations of the COVID-19 Pandemic Across Minoritized and Marginalized Communities. JAMA Psychiatry 2022, 79: 350-358. PMID: 35138333, PMCID: PMC8829750, DOI: 10.1001/jamapsychiatry.2021.4331.Peer-Reviewed Original ResearchConceptsOngoing prospective longitudinal studyParent-child discussionsCOVID-19 experienceNighttime sleep durationAdolescent developmentAdolescent brainABCD dataProspective longitudinal studyParent reportMeasures of dayExperienced consequencesExperiences of racismAge 9COVID-19 pandemicTransgenerational associationsLongitudinal studyIntervention strategiesPsychiatric conditionsSleep durationFinancial worriesLess difficultyResponse measuresParentsFamily indicatorsWorryHyperbolic discounting rates and risk for problematic alcohol use in youth enrolled in the Adolescent Brain and Cognitive Development study
Kohler RJ, Lichenstein SD, Yip SW. Hyperbolic discounting rates and risk for problematic alcohol use in youth enrolled in the Adolescent Brain and Cognitive Development study. Addiction Biology 2022, 27: e13160. PMID: 35229959, PMCID: PMC9289942, DOI: 10.1111/adb.13160.Peer-Reviewed Original ResearchConceptsCognitive Development StudyProblematic alcohol useAdolescent brainDelay discountingSubstance useIndividual difference factorsAlcohol useForms of psychopathologyEarly Substance Use InitiationPrenatal drug exposureProblematic substance useSubstance Use InitiationAlcohol risk statusDevelopment studiesDifference factorsABCD studyDevelopmental trajectoriesYoung adolescentsKey demographic variablesFamilial variablesSignificant psychopathologyDemographic variablesDrug problemsPsychopathologyDiscounting
2021
Systematic review of structural and functional neuroimaging studies of cannabis use in adolescence and emerging adulthood: evidence from 90 studies and 9441 participants
Lichenstein SD, Manco N, Cope LM, Egbo L, Garrison KA, Hardee J, Hillmer AT, Reeder K, Stern EF, Worhunsky P, Yip SW. Systematic review of structural and functional neuroimaging studies of cannabis use in adolescence and emerging adulthood: evidence from 90 studies and 9441 participants. Neuropsychopharmacology 2021, 47: 1000-1028. PMID: 34839363, PMCID: PMC8938408, DOI: 10.1038/s41386-021-01226-9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAdolescent cannabis usersCannabis-related harmsCannabis usersCannabis effectsAdolescent brain functionOngoing brain developmentFunctional neuroimaging studiesEffects of cannabisAdolescent brainNeuroimaging studiesNeural effectsPotential moderatorsNeural alterationsCannabis policy changesReduced perceptionSystematic reviewCannabis useCerebellar regionsAdolescenceBrain functionPreliminary evidenceFuture researchEarly interventionLong-term goalExtant literatureDensely sampled neuroimaging for maximizing clinical insight in psychiatric and addiction disorders
Yip SW, Konova AB. Densely sampled neuroimaging for maximizing clinical insight in psychiatric and addiction disorders. Neuropsychopharmacology 2021, 47: 395-396. PMID: 34354248, PMCID: PMC8617277, DOI: 10.1038/s41386-021-01124-0.Peer-Reviewed Original Research