2024
Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147)
Sheth S, Oh J, Bellone S, Siegel E, Greenman M, Mutlu L, McNamara B, Pathy S, Clark M, Azodi M, Altwerger G, Andikyan V, Huang G, Ratner E, Kim D, Iwasaki A, Levi A, Buza N, Hui P, Flaherty S, Schwartz P, Santin A. Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147). Clinical Cancer Research 2024, 30: of1-of10. PMID: 38592381, DOI: 10.1158/1078-0432.ccr-23-3639.Peer-Reviewed Original ResearchConceptsRandomized phase II trialCD4/CD8 T cellsT cellsHPV clearanceArm BNo significant differenceClinical surveillanceRate of HPV clearanceSecondary outcomesPre-neoplastic cervical lesionsCervical intraepithelial neoplasiaT cell infiltrationT cell responsesSignificant differenceCIN3 patientsIntraepithelial neoplasiaArm ACervical lesionsImiquimod groupSurveillance armVaginal suppositoriesProspective trialsArm CHPV vaccinationImiquimod
2023
Human Papillomavirus Vaccination Status and Correlates Among Mid-Adult Women: Connecticut, USA, 2016–2019
Sheth S, Johnson N, Sullivan E, Torres A, Oliveira C, Niccolai L. Human Papillomavirus Vaccination Status and Correlates Among Mid-Adult Women: Connecticut, USA, 2016–2019. Journal Of Women's Health 2023, 33: 28-32. PMID: 37943625, PMCID: PMC10794823, DOI: 10.1089/jwh.2022.0456.Peer-Reviewed Original ResearchConceptsMid-adult womenVaccination statusHPV vaccinationHPV vaccineHuman Papillomavirus Vaccination StatusHPV vaccination statusHuman papillomavirus vaccinationAge 26 yearsHealth care providersCross-sectional surveyPapillomavirus vaccinationUnvaccinated womenVaccinated womenVaccine informationCare providersVaccinationAdult womenVaccineWomenBehavioral correlatesCorrelatesStatusPotential benefitsYearsParticipantsExpedited Partner Therapy: A Multicomponent Initiative to Boost Provider Counseling
Markowitz M, Ackerman-Banks C, Oliveira C, Fashina O, Pathy S, Sheth S. Expedited Partner Therapy: A Multicomponent Initiative to Boost Provider Counseling. Sexually Transmitted Diseases 2023, 51: 15-21. PMID: 37921862, PMCID: PMC11413968, DOI: 10.1097/olq.0000000000001894.Peer-Reviewed Original ResearchConceptsPartner therapyProvider counselingMulticomponent initiativesQuasi-experimental interrupted time-series studyExpedited Partner TherapyInterrupted time series studyRecords of patientsFrequent reinfectionsInterrupted time series modelObstetric indicationsGynecology clinicTherapy prescriptionPatients' perceptionsPatient acceptanceChlamydia trachomatisPatient encountersNeisseria gonorrhoeaeTherapyRegistered NursesTime-series studyPublic insurancePatientsAcademic obstetricsCounselingSignificant increaseDisparities in adherence to retesting guidelines in women with Trichomonas vaginalis infection
Getaneh F, Oliveira C, Pathy S, Sheth S. Disparities in adherence to retesting guidelines in women with Trichomonas vaginalis infection. American Journal Of Obstetrics And Gynecology 2023, 229: 284.e1-284.e10. PMID: 37393012, PMCID: PMC10530237, DOI: 10.1016/j.ajog.2023.06.045.Peer-Reviewed Original ResearchConceptsHospital-based obstetricsNon-Hispanic black womenTrichomonas vaginalis infectionPregnant subgroupsClinic populationSubgroup analysisVaginalis infectionNon-Hispanic white womenGuideline-concordant testingRetrospective cohort studyTrichomonas vaginalisMultivariable logistic regressionSingle marital statusHigh prevalence ratesNon-Hispanic blacksCharacteristics of womenBlack womenHigh rateCohort studyGynecology clinicTobacco smokingGuideline recommendationsEntire cohortAssociated FactorsPrevalence ratesUptake of Cervical Cancer Screening Among Female Patients Using a Mobile Medical Clinic
Degife E, Oliveira C, Znamierowski E, Meyer J, Sheth S. Uptake of Cervical Cancer Screening Among Female Patients Using a Mobile Medical Clinic. American Journal Of Preventive Medicine 2023, 65: 835-843. PMID: 37220860, PMCID: PMC10592483, DOI: 10.1016/j.amepre.2023.05.013.Peer-Reviewed Original ResearchConceptsCervical cancer screeningMobile medical clinicHealth-related social needsCervical cancerCancer screeningMedical clinicsFemale patientsCervical cancer screening uptakeCancer screening uptakeHuman papillomavirus vaccinationHigh-risk populationMultivariate logistic regressionElectronic health recordsPapillomavirus vaccinationScreening uptakePap testingRetrospective cohortPatient cohortClinic modelLower oddsPatientsUnstable housingClinicLogistic regressionCancerAssociation between cancer stigma and cervical cancer screening uptake among women of Dhulikhel and Banepa, Nepal
Paneru B, Karmacharya A, Bharati A, Makaju S, Adhikari B, Kafle D, Shakya S, Spiegelman D, Seth S, Stangl A, Shrestha A, Shrestha A. Association between cancer stigma and cervical cancer screening uptake among women of Dhulikhel and Banepa, Nepal. PLOS ONE 2023, 18: e0285771. PMID: 37200234, PMCID: PMC10194964, DOI: 10.1371/journal.pone.0285771.Peer-Reviewed Original ResearchConceptsCervical cancer screening uptakeCancer screening uptakeScreening uptakeMultivariable logistic regressionCancer Stigma ScaleCancer stigmaCervical cancerAge of menarcheFirst sexual intercourseLogistic regressionNepalese womenSexual intercourseReproductive health variablesCervical cancer screeningEffective screening programsSemi-urban areasCross-sectional studyPercent of womenMean total scoreFamily planning usersScreening servicesCancer screeningCommon cancerDisease burdenScreening programValidation of the Cancer Stigma Scale in Nepalese Women
Shrestha A, Stangl A, Paneru B, Poudel L, Karmacharya A, Makaju S, Spiegelman D, Shakya S, Shrestha A, Sheth S. Validation of the Cancer Stigma Scale in Nepalese Women. Asian Pacific Journal Of Cancer Prevention 2023, 24: 204-214. PMID: 36708569, PMCID: PMC10152840, DOI: 10.31557/apjcp.2023.24.1.207.Peer-Reviewed Original ResearchConceptsCancer Stigma ScaleCancer stigmaCancer patientsStigma ScaleCronbach's alphaNepali womenInternal consistencyCross-cultural adaptationNepalese populationNepalese womenSufficient internal consistencyCancerWomenPatientsSatisfactory internal reliabilityVulnerable groupsAlphaInternal reliabilityStigmaOverall scaleModel fit indicesHigh levelsSix-factor structure
2022
Optimizing menstrual health and hygiene management in the U.S.: A mixed-methods study of the barriers and the role of healthcare professionals
Trant A, Espinal M, Kisanga E, Vash-Margita A, Lundsberg L, Sheth S, Fan L. Optimizing menstrual health and hygiene management in the U.S.: A mixed-methods study of the barriers and the role of healthcare professionals. Sexual & Reproductive Healthcare 2022, 35: 100808. PMID: 36563412, DOI: 10.1016/j.srhc.2022.100808.Peer-Reviewed Original ResearchConceptsResponse rateSurvey response rateThematic content analysisMH screeningPatient interviewsPatient surveyPatient understandingPatient's abilityPatientsHealthcare providersHealthcare professionalsHealth practicesMedical staffMenstrual productsStaff viewsDaily activitiesMixed-method studyMenstrual healthMenstruationDescriptive statisticsHealthHygiene managementScreeningAnnual incomeQualitative interviewsPilot Implementation of a Health Equity Checklist to Improve the Identification of Equity-Related Adverse Events
Fan LL, Sheth SS, Pettker CM. Pilot Implementation of a Health Equity Checklist to Improve the Identification of Equity-Related Adverse Events. Obstetrics And Gynecology 2022, 140: 667-673. PMID: 36075061, DOI: 10.1097/aog.0000000000004934.Peer-Reviewed Original ResearchHealth Disparities in Uterine Cancer
Whetstone S, Burke W, Sheth SS, Brooks R, Cavens A, Huber-Keener K, Scott DM, Worly B, Chelmow D. Health Disparities in Uterine Cancer. Obstetrics And Gynecology 2022, 139: 645-659. PMID: 35272301, PMCID: PMC8936152, DOI: 10.1097/aog.0000000000004710.Peer-Reviewed Original ResearchConceptsHealth care cliniciansUterine cancerWomen's health care cliniciansHealth disparitiesEvidence-based educational materialsCare cliniciansGynecologic cancerEvidence summariesGynecologic oncologyPractice guidelinesEarly diagnosisAmerican CollegeGeneral obstetricsEvidence reviewDisease controlCancerPanel of expertsSubstantive knowledge gapsEducational materialsCliniciansPreventionContent expertsLiterature reviewRelevant literatureReviewExecutive Summary of the Uterine Cancer Evidence Review Conference
Chelmow D, Brooks R, Cavens A, Huber-Keener K, Scott DM, Sheth SS, Whetstone S, Worly B, Burke W. Executive Summary of the Uterine Cancer Evidence Review Conference. Obstetrics And Gynecology 2022, 139: 626-643. PMID: 35272316, PMCID: PMC8936160, DOI: 10.1097/aog.0000000000004711.Peer-Reviewed Original ResearchConceptsHealth care cliniciansUterine cancerEarly diagnosisWomen's health care cliniciansEvidence-based educational materialsCare cliniciansGynecologic cancerEvidence summariesGynecologic oncologyPatient advocacy organizationsPractice guidelinesAmerican CollegeGeneral obstetricsPanel membersEvidence reviewDisease controlPanel of expertsSubstantive knowledge gapsCancerCliniciansRelevant literaturePreventionEducational materialsDiagnosisContent expertsState Laws Permitting Adolescent Consent to Human Papillomavirus Vaccination and Rates of Immunization
Torres AR, Johnson NP, Ellingson MK, Hansen CE, Oliveira CR, Niccolai LM, Sheth SS. State Laws Permitting Adolescent Consent to Human Papillomavirus Vaccination and Rates of Immunization. JAMA Pediatrics 2022, 176: 203-205. PMID: 34779839, PMCID: PMC8593826, DOI: 10.1001/jamapediatrics.2021.4591.Peer-Reviewed Original ResearchOverlapping needs for sexual and reproductive health and HIV prevention in women with substance use disorders
Gibson B, Hoff E, Haas A, Adams ZM, Price CR, Goddard-Eckrich D, Sheth SS, Dasgupta A, Meyer JP. Overlapping needs for sexual and reproductive health and HIV prevention in women with substance use disorders. Women's Health 2022, 18: 17455065211070543. PMID: 35023410, PMCID: PMC8771433, DOI: 10.1177/17455065211070543.Peer-Reviewed Original ResearchConceptsSubstance use disordersPre-exposure prophylaxisUse disordersHIV preventionReproductive healthReproductive health service utilizationHigh HIV risk behaviorHealth service utilizationUnique health issuesCross-sectional evaluationHIV risk behaviorsHigh unmet needReproductive health behaviorsReproductive health needsConcurrent clinical trialsForm of contraceptionTime of assessmentPregnancy intentionReproductive ageClinical trialsUnintended pregnancyService utilizationCriminal justice involvementDrug treatmentContraceptive useMenstrual Health and Hygiene among Adolescents in the United States
Trant AA, Vash-Margita A, Camenga D, Braverman P, Wagner D, Espinal M, Kisanga EP, Lundsberg L, Sheth SS, Fan L. Menstrual Health and Hygiene among Adolescents in the United States. Journal Of Pediatric And Adolescent Gynecology 2022, 35: 277-287. PMID: 34999229, DOI: 10.1016/j.jpag.2021.12.014.Peer-Reviewed Original ResearchConceptsMenstrual health educationHealth educationSurvey response rateHealth careResponse rateMenstrual healthTertiary academic centerAdolescent medicine clinicMedicine clinicPatient interviewsPatient surveyGynecology practiceProvider surveyAcademic centersPatientsThematic saturationProvider perspectivesThematic content analysisProvider rolesAnonymous surveyCarePediatric facultyDescriptive statisticsMenstrual productsHealth
2021
Unindicated cervical cancer screening in adolescent females within a large healthcare system in the United States
Hosier H, Sheth SS, Oliveira CR, Perley LE, Vash-Margita A. Unindicated cervical cancer screening in adolescent females within a large healthcare system in the United States. American Journal Of Obstetrics And Gynecology 2021, 225: 649.e1-649.e9. PMID: 34256029, PMCID: PMC8633062, DOI: 10.1016/j.ajog.2021.07.005.Peer-Reviewed Original ResearchConceptsCervical cancerLarge healthcare systemYears of ageIncidence rateScreening testAdolescent femalesHealthcare systemLarge multihospital health systemCervical cancer screening resultsNew cervical cancer casesCurrent consensus recommendationsHuman papillomavirus testingHuman papillomavirus vaccinationCervical cancer casesCervical cancer screeningMultihospital health systemCancer risk reductionScreening resultsPoisson regression analysisEvidence-based strategiesGuideline nonadherencePapillomavirus vaccinationCytology testingIntraepithelial lesionsProvider factorsPatterns of recommended vaccine receipt among women ages 24–45 years: a cross-sectional analysis
Ellingson MK, Oliveira CR, Sheth SS, Sullivan EL, Torres A, Shapiro ED, Niccolai LM. Patterns of recommended vaccine receipt among women ages 24–45 years: a cross-sectional analysis. BMC Public Health 2021, 21: 1283. PMID: 34193100, PMCID: PMC8247221, DOI: 10.1186/s12889-021-11340-4.Peer-Reviewed Original ResearchConceptsMid-adult womenVaccine receiptCross-sectional analysisHPV vaccineOngoing case-control studyReceipt of influenzaHealth care visitsCase-control studyWomen ages 24Quarter of adultsLogistic regression analysisCare visitsIndividual vaccinesHealthcare utilizationMultiple vaccinesVaccineAge 24White womenWomenDemographic characteristicsRegression analysisLower ratesInfluenzaReceiptPast yearEffectiveness of HPV vaccine by age at vaccination and number of doses: protocol for a population-based matched case–control study
Oliveira CR, Ortiz AM, Sheth SS, Shapiro ED, Niccolai LM. Effectiveness of HPV vaccine by age at vaccination and number of doses: protocol for a population-based matched case–control study. BMJ Open 2021, 11: e043093. PMID: 33875441, PMCID: PMC8057558, DOI: 10.1136/bmjopen-2020-043093.Peer-Reviewed Case Reports and Technical NotesConceptsHigh-grade cervical lesionsPre-licensure clinical trialsHPV vaccineCase-control studyNumber of dosesClinical trialsFirst human papillomavirus (HPV) vaccineMultivariate conditional logistic regressionNormal Pap test resultsReal-world clinical settingHuman papillomavirus vaccinePap test resultsHPV types 16Time of immunisationReal-world effectivenessConditional logistic regressionInstitutional review boardDate of testingPapillomavirus vaccineCervical lesionsPotential confoundersVaccine programMedical recordsPersistent infectionType 16Association of Inadvertent 9-Valent Human Papillomavirus Vaccine in Pregnancy With Spontaneous Abortion and Adverse Birth Outcomes
Kharbanda EO, Vazquez-Benitez G, DeSilva MB, Naleway AL, Klein NP, Hechter RC, Glanz JM, Donahue JG, Jackson LA, Sheth SS, Greenberg V, Panagiotakopoulos L, Mba-Jonas A, Lipkind HS. Association of Inadvertent 9-Valent Human Papillomavirus Vaccine in Pregnancy With Spontaneous Abortion and Adverse Birth Outcomes. JAMA Network Open 2021, 4: e214340. PMID: 33818618, PMCID: PMC8022219, DOI: 10.1001/jamanetworkopen.2021.4340.Peer-Reviewed Original ResearchConceptsVaccine exposureHuman papillomavirus vaccineAdverse birth outcomesBirth outcomesSGA birthLive birthsPapillomavirus vaccinePreterm birthSpontaneous abortionCox proportional hazards regression modelProportional hazards regression modelsVaccine Safety DatalinkMean maternal ageMedical record reviewAge 45 yearsTime of pregnancyHazards regression modelsBirth defectsMajor structural birth defectsAge 26 yearsElectronic health recordsCohort studySingleton pregnanciesFinal cohortRecord reviewInpatient Immunization With HPV Vaccine: A Qualitative Study With Postpartum Women
Avni-Singer L, Oliveira CR, Torres A, Shapiro ED, Niccolai LM, Sheth SS. Inpatient Immunization With HPV Vaccine: A Qualitative Study With Postpartum Women. Women's Health Issues 2021, 31: 384-391. PMID: 33715924, PMCID: PMC8260440, DOI: 10.1016/j.whi.2021.02.002.Peer-Reviewed Original ResearchConceptsHPV vaccinePostpartum womenPatient-centered approachHPV immunization programHuman papillomavirus vaccineRates of immunizationIterative thematic approachYoung adult femalesInpatient immunizationHospital dischargePapillomavirus vaccinePostpartum patientsMedian ageImmunization programsPatient's perspectiveProgram implementationVaccine hesitancyImmunizationVaccineWomenQualitative studyThematic approachPatientsHospitalAdult females
2020
Evaluation of an Inpatient Postpartum Human Papillomavirus Immunization Program.
Avni-Singer L, Oliveira CR, Torres A, Shapiro ED, Niccolai LM, Sheth SS. Evaluation of an Inpatient Postpartum Human Papillomavirus Immunization Program. Obstetrics And Gynecology 2020, 136: 1006-1015. PMID: 33030866, PMCID: PMC7584732, DOI: 10.1097/aog.0000000000004097.Peer-Reviewed Original ResearchConceptsHPV immunization programImmunization programsHPV vaccinePostpartum womenHuman papillomavirus immunization programmesLow-income patient populationCharacteristics of patientsRates of immunizationHospital-based obstetricsProportion of womenChi-squared testEligible visitsOutpatient doseOutpatient dosesHospital stayVaccine seriesCohort studyHospital dischargeGynecology clinicVaccine uptakePatient populationAdditional dosesSubsequent doseLogistic regressionDose