2024
P12.10.B HYPOKINETIC MOVEMENT DISORDERS FOLLOWING ADOPTIVE IMMUNOTHERAPY WITH BCMA-DIRECTED CAR T-CELLS: A CONSECUTIVE CASE SERIES
Gudera J, Baehring J, Fulbright R, Dietrich J, Karschnia P. P12.10.B HYPOKINETIC MOVEMENT DISORDERS FOLLOWING ADOPTIVE IMMUNOTHERAPY WITH BCMA-DIRECTED CAR T-CELLS: A CONSECUTIVE CASE SERIES. Neuro-Oncology 2024, 26: v68-v68. PMCID: PMC11485477, DOI: 10.1093/neuonc/noae144.223.Peer-Reviewed Original ResearchChimeric antigen receptorCAR-T cellsChimeric antigen receptor T cellsB-cell maturation antigenT cellsParkinsonism-like symptomsChimeric antigen receptor T-cell productsMovement disordersCirculating CAR T cellsHypokinetic movement disordersOn-target/off-tumor toxicityPatient died of sepsisCare of affected patientsRefractory multiple myelomaMedian follow-upConsecutive case seriesT cell productionDegree of suspicionBasal ganglia hypometabolismDiffusion-weighted sequencesMovement symptomsHead of the caudate nucleusAdoptive immunotherapyPatient diedSystemic immunosuppression
2020
Primary melanotic tumors of the nervous system: a consecutive case series
Grosshans H, Huttner A, Piepmeier J, Kaulen L, Fulbright R, Baehring J, Karschnia P. Primary melanotic tumors of the nervous system: a consecutive case series. European Journal Of Neurology 2020, 27: 2303-2307. PMID: 32654331, DOI: 10.1111/ene.14437.Peer-Reviewed Original ResearchConceptsPrimary melanotic tumorsNervous systemRelapsed diseaseClinical presentationMelanotic lesionsFavorable outcomeRadiation therapyPre-contrast T1-weighted imagingRelative incidenceMelanotic tumorsHomogenous contrast enhancementYale Cancer CenterAggressive surgical treatmentConsecutive case seriesPsammomatous melanotic schwannomaNervous system tumorsT1-weighted imagingT2-weighted imagingTumor mass effectMagnetic resonance imagingMelanin-containing cellsS100 positivitySurgical resectionSurgical treatmentTumor Registry