Featured Publications
Noonan syndrome and pregnancy outcomes
Chow CA, Campbell KH, Chou JC, Elder RW. Noonan syndrome and pregnancy outcomes. Cardiology In The Young 2022, 32: 1925-1929. PMID: 35034678, DOI: 10.1017/s104795112100514x.Peer-Reviewed Original ResearchConceptsNoonan syndromeCaesarean sectionHeart defectsLow-risk cardiac lesionsNeonatal intensive care unitIntra-uterine fetal demiseYale-New Haven HospitalMaternal cardiac diseaseMaternal cardiac dysfunctionSafety of pregnancyPulmonary valve stenosisLong-term morbidityRetrospective chart reviewTrial of laborIntensive care unitInterventricular septal thicknessPre-term birthTime of pregnancyAtrial septal defectStructural heart defectsMajority of mothersCongenital heart defectsWeeks of ageMaternal complicationsPregnancy details
2016
Hypercalcemia in Patients with Williams-Beuren Syndrome
Sindhar S, Lugo M, Levin MD, Danback JR, Brink BD, Yu E, Dietzen DJ, Clark AL, Purgert CA, Waxler JL, Elder RW, Pober BR, Kozel BA. Hypercalcemia in Patients with Williams-Beuren Syndrome. The Journal Of Pediatrics 2016, 178: 254-260.e4. PMID: 27574996, PMCID: PMC5085847, DOI: 10.1016/j.jpeds.2016.08.027.Peer-Reviewed Original ResearchConceptsAcute life-threatening eventsLife-threatening eventsPlasma calcium levelsWilliams-Beuren syndromeCalcium levelsHigh plasma calcium levelsOccurrence of hypercalcemiaMulticenter retrospective studyPediatric reference intervalsGastrointestinal complaintsRelevant comorbiditiesRetrospective studyRenal anomaliesSubgroup analysisCardiovascular diseaseQT intervalHypercalcemiaDisease processEvidence of dehydrationAvailable normative dataOlder individualsSmall childrenCalcium concentrationInverse correlationReference intervals
2015
The Changing Epidemiology of Pediatric Endocarditis
Elder RW, Baltimore RS. The Changing Epidemiology of Pediatric Endocarditis. Infectious Disease Clinics Of North America 2015, 29: 513-524. PMID: 26311357, DOI: 10.1016/j.idc.2015.05.004.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseInfective endocarditisHeart diseaseRheumatic heart diseaseManagement of childrenIntroduction of antibioticsPediatric EndocarditisSurgical interventionMicrobiologic changesCardiac interventionsViridans streptococciEarly detectionEndocarditisEarly predominanceEpidemiologyDiseaseInterventionVirtual disappearanceMortalityModern Incidence of Complete Heart Block in Patients with L‐looped Ventricles: Does Univentricular Status Matter?
Simmons MA, Rollinson N, Fishberger S, Qin L, Fahey J, Elder RW. Modern Incidence of Complete Heart Block in Patients with L‐looped Ventricles: Does Univentricular Status Matter? Congenital Heart Disease 2015, 10: e237-e242. PMID: 26077963, DOI: 10.1111/chd.12279.Peer-Reviewed Original ResearchConceptsComplete heart blockSpontaneous complete heart blockSingle ventricle anatomyHeart blockL-transpositionGreat arteriesVentricle anatomyYale-New Haven HospitalGroup III patientsTwo-ventricle anatomyRetrospective cohort studyMajor cardiac defectsAge of onsetSized ventriclesVentricle patientsCohort studyMedian ageModern cohortPerson yearsIII patientsIncidence rateSimilar riskPatientsArteryCardiac defectsImmunologic Aging in Adults with Congenital Heart Disease: Does Infant Sternotomy Matter?
Elder RW, George RP, McCabe NM, Rodriguez III FH, Book WM, Mahle WT, Kirk AD. Immunologic Aging in Adults with Congenital Heart Disease: Does Infant Sternotomy Matter? Pediatric Cardiology 2015, 36: 1411-1416. PMID: 25916315, PMCID: PMC5319831, DOI: 10.1007/s00246-015-1174-9.Peer-Reviewed Original ResearchConceptsAdult congenital heart diseaseCongenital heart diseaseACHD patientsHeart diseaseExact testMean percentageImmune phenotypic changesT lymphocyte compositionCD8 T cellsFisher's exact testPolychromatic flow cytometryT cell maturationMann-Whitney ULower mean percentageImmune exhaustionImmunologic exhaustionPrior sternotomyCD8 lymphocytesCD4 cellsCD8 cellsLymphocyte compositionMedian ageClinical impactT cellsT lymphocytes
2012
Outcomes of the infant Ross procedure for congenital aortic stenosis followed into adolescence
Elder RW, Quaegebeur JM, Bacha EA, Chen JM, Bourlon F, Williams IA. Outcomes of the infant Ross procedure for congenital aortic stenosis followed into adolescence. Journal Of Thoracic And Cardiovascular Surgery 2012, 145: 1504-1511. PMID: 23062969, PMCID: PMC3657341, DOI: 10.1016/j.jtcvs.2012.09.004.Peer-Reviewed Original ResearchConceptsCongenital aortic stenosisRoss procedureLong-term outcomesAortic stenosisRight ventricular outflow tract reinterventionVentricular outflow tract reinterventionRight ventricular outflow tractSignificant aortic stenosisVentricular outflow tractAortic valve diseaseNew York-PresbyterianAvoidance of anticoagulationCatheter-based interventionsMonths of ageAutograft annulusAutograft growthAutograft reinterventionAortic insufficiencyLatest followMedian ageRetrospective reviewRoss operationCardiothoracic centreRecent followModerate dilatation