2020
A window into portal hemodynamics in adult fontan patients?
Simmons MA, Revzin M, To U, Liapakis A, Fahey J, Elder RW. A window into portal hemodynamics in adult fontan patients? International Journal Of Cardiology 2020, 323: 61-64. PMID: 32979426, DOI: 10.1016/j.ijcard.2020.09.047.Peer-Reviewed Original ResearchMeSH KeywordsAdultElasticity Imaging TechniquesFontan ProcedureHemodynamicsHumansLiverLiver CirrhosisRetrospective StudiesConceptsAdult Fontan patientsFontan patientsSpleen stiffnessCongenital heart diseaseLiver stiffnessShear wave elastographyControl patientsPortal hemodynamicsLiver diseaseHeart diseaseFontan-associated liver diseaseLimited subgroup analysisPortal venous hemodynamicsAssociated liver diseasePassive hepatic congestionUltrasound shear wave elastographyFontan circulationStudy cohortHealthy patientsHepatic congestionVenous hemodynamicsSubgroup analysisLiver fibrosisHealthy controlsPatients
2019
Surveillance and screening practices of New England congenital cardiologists for patients after the Fontan operation
Davey B, Toro‐Salazar O, Gauthier N, Valente A, Elder R, Wu F, Berman N, Pollack P, Lee J, Rathod R. Surveillance and screening practices of New England congenital cardiologists for patients after the Fontan operation. Congenital Heart Disease 2019, 14: 1013-1023. PMID: 31642600, DOI: 10.1111/chd.12854.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCardiologistsChildChild, PreschoolFontan ProcedureHealth Care SurveysHealth Services AccessibilityHealthcare DisparitiesHeart Defects, CongenitalHeart Function TestsHumansNew EnglandPractice Patterns, Physicians'Predictive Value of TestsReferral and ConsultationRisk FactorsTreatment OutcomeYoung AdultConceptsHigh-risk Fontan patientsFontan patientsCongenital cardiologistsLow riskMagnetic resonance imaging availabilityQuality of life testHigh-risk populationEvidence-based guidelinesFontan operationFontan procedureCardiac catheterizationScreening low-riskAnticoagulation regimensPractice of screeningFontanAspirin monotherapyCardiology associationsPatientsCardiac physiciansComplex patientsScreening practicesOutcome measuresCardiologistsYears of practiceDesigning future research studies
2016
“Frontiers in Fontan failure: A summary of conference proceedings”
Hebson C, Book W, Elder RW, Ford R, Jokhadar M, Kanter K, Kogon B, Kovacs AH, Levit RD, Lloyd M, Maher K, Reshamwala P, Rodriguez F, Romero R, Tejada T, Valente A, Veldtman G, McConnell M. “Frontiers in Fontan failure: A summary of conference proceedings”. Congenital Heart Disease 2016, 12: 6-16. PMID: 27597140, DOI: 10.1111/chd.12407.Peer-Reviewed Original ResearchSuperior Mesenteric Arterial Flow Pattern is Associated with Major Adverse Events in Adults with Fontan Circulation
Mori M, Shioda K, Elder RW, Pernetz MA, Rodriguez FH, Rangosch A, Kogon BE, Book WM. Superior Mesenteric Arterial Flow Pattern is Associated with Major Adverse Events in Adults with Fontan Circulation. Pediatric Cardiology 2016, 37: 1013-1021. PMID: 27033246, DOI: 10.1007/s00246-016-1382-y.Peer-Reviewed Original ResearchConceptsVelocity time integralAdult Fontan patientsEnd-diastolic velocitySystolic/diastolic ratioMajor adverse eventsAdverse eventsMesenteric arterial flowFontan patientsFontan circulationResistive indexDiastolic ratioArterial flowSuperior mesenteric arterial flowDiastolic velocity-time integralAdult Fontan populationSystolic velocity time integralVenous outflow obstructionCox regression analysisPediatric Fontan patientsKaplan-Meyer analysisNon-event groupArterial flow patternsFontan populationAdult patientsOutflow obstructionClinical Approaches to the Patient with a Failing Fontan Procedure
Elder RW, Wu FM. Clinical Approaches to the Patient with a Failing Fontan Procedure. Current Cardiology Reports 2016, 18: 44. PMID: 27002620, DOI: 10.1007/s11886-016-0716-y.Peer-Reviewed Original ResearchConceptsClinical approachPotential therapeutic optionGeneral clinical approachLong-term healthFontan failureFontan populationFontan operationFontan procedureFontan survivorsFontan circulationUniventricular heartPatient presentingTherapeutic optionsOrgan systemsAltered physiologyVaried manifestationsVulnerable populationsMulti-institutional collaborationPatientsModern managementVast majorityExtracardiacPresentingPopulationCardiologistsCatheter‐measured Hemodynamics of Adult Fontan Circulation: Associations with Adverse Event and End‐organ Dysfunctions
Mori M, Hebson C, Shioda K, Elder RW, Kogon BE, Rodriguez FH, Jokhadar M, Book WM. Catheter‐measured Hemodynamics of Adult Fontan Circulation: Associations with Adverse Event and End‐organ Dysfunctions. Congenital Heart Disease 2016, 11: 589-597. PMID: 26932151, DOI: 10.1111/chd.12345.Peer-Reviewed Original ResearchMeSH KeywordsAdultCardiac CatheterizationChi-Square DistributionFemaleFontan ProcedureGeorgiaHeart Defects, CongenitalHeart FailureHeart TransplantationHemodynamicsHumansKidney DiseasesLinear ModelsLiver DiseasesMaleMultivariate AnalysisPredictive Value of TestsProportional Hazards ModelsRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeYoung AdultConceptsPulmonary capillary wedge pressureHigh central venous pressureCentral venous pressureEnd-organ dysfunctionSystemic vascular resistance indexCox proportional hazards analysisAdult Fontan patientsProportional hazards analysisCardiac indexFontan patientsAdverse eventsFontan circulationHemodynamic measurementsHigh systemic vascular resistance indexMultivariate Cox proportional hazards analysisRight heart catheterization dataSignificant associationLow cardiac indexVascular resistance indexCapillary wedge pressureChild-Pugh scoreSerious adverse eventsVenous outflow obstructionHigher cardiac indexPost-Fontan patients
2015
Half a Century’s Experience With the Superior Cavopulmonary (Classic Glenn) Shunt
Zahr RA, Kirshbom PM, Kopf GS, Sainathan S, Steele MM, Elder RW, Karimi M. Half a Century’s Experience With the Superior Cavopulmonary (Classic Glenn) Shunt. The Annals Of Thoracic Surgery 2015, 101: 177-182. PMID: 26603022, DOI: 10.1016/j.athoracsur.2015.08.018.Peer-Reviewed Original ResearchConceptsGlenn shuntPulmonary arteriovenous fistulaClassic Glenn shuntArteriovenous fistulaOriginal cohortSuperior cavopulmonary shuntMedian overall survivalEarly postoperative periodPermanent pacemaker placementSingle ventricle patientsSingle-ventricle palliationSinus node dysfunctionTwo-ventricle repairImportant outcome measureElectronic medical recordsCavopulmonary shuntLate deathsMedian survivalAtresia groupOverall survivalPostoperative periodBidirectional GlennPacemaker placementAtrial tachyarrhythmiasRetrospective study
2014
Adult Fontan failure — Distinct disease entity
Mori M, Elder RW, Book WM. Adult Fontan failure — Distinct disease entity. International Journal Of Cardiology 2014, 177: 650. PMID: 25449472, DOI: 10.1016/j.ijcard.2014.09.177.Peer-Reviewed Original ResearchRisk Factors for Major Adverse Events Late after Fontan Palliation
Elder RW, McCabe NM, Veledar E, Kogon BE, Jokhadar M, Rodriguez FH, McConnell ME, Book WM. Risk Factors for Major Adverse Events Late after Fontan Palliation. Congenital Heart Disease 2014, 10: 159-168. PMID: 25130602, PMCID: PMC4512755, DOI: 10.1111/chd.12212.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleFontan ProcedureHumansMalePalliative CarePostoperative ComplicationsRetrospective StudiesRisk FactorsTime FactorsConceptsMajor adverse eventsAdult Fontan patientsAdverse eventsRisk factorsFontan patientsFontan palliationOxygen desaturationPortal hypertensionVentricular functionAdverse outcomesTransplant-free survival rateLate-term outcomesSystemic oxygen desaturationSystolic ventricular functionAdverse event profileCongestive heart failureKaplan-Meier methodTertiary academic centerAdditional risk factorsImportant risk factorMode of deathFontan failureFontan typeSystemic ventricleThromboembolic eventsBeyond a Broken Heart: Circulatory Dysfunction in the Failing Fontan
Mori M, Aguirre AJ, Elder RW, Kashkouli A, Farris AB, Ford RM, Book WM. Beyond a Broken Heart: Circulatory Dysfunction in the Failing Fontan. Pediatric Cardiology 2014, 35: 569-579. PMID: 24531876, DOI: 10.1007/s00246-014-0881-y.Peer-Reviewed Original ResearchConceptsAdult Fontan patientsFontan patientsCirculatory dysfunctionPortal hypertensionPostsinusoidal portal hypertensionMultiple organ involvementPulmonary blood flowFailing FontanClinical deteriorationFontan palliationHeart transplantationHepatic dysfunctionLate morbidityVentricular dysfunctionOrgan involvementUniventricular heartVentricular functionLiver diseaseHepatic perfusionPulmonary vasculatureCardiac functionLiver histopathologyBlood flowCirrhotic diseaseClinicopathologic states
2013
Hemodynamic Phenotype of the Failing Fontan in an Adult Population
Hebson CL, McCabe NM, Elder RW, Mahle WT, McConnell M, Kogon BE, Veledar E, Jokhadar M, Vincent RN, Sahu A, Book WM. Hemodynamic Phenotype of the Failing Fontan in an Adult Population. The American Journal Of Cardiology 2013, 112: 1943-1947. PMID: 24075283, PMCID: PMC4505550, DOI: 10.1016/j.amjcard.2013.08.023.Peer-Reviewed Original ResearchConceptsFontan failureCardiac indexFontan patientsLiver diseaseSVR indexLower systemic vascular resistance indexNormal systolic ventricular functionSystemic vascular resistance indexAdult Fontan patientsSimilar cardiac indexSystolic ventricular functionVascular resistance indexSignificant liver diseasePediatric Fontan patientsCase-cohort analysisFailing FontanPF cohortsPortal hypertensionAdult patientsCatheterization findingsFontan circulationHeart failureVentricular functionCirculatory derangementsPediatric cohortMore on Hepatocellular Carcinoma after the Fontan Procedure
Elder RW, Parekh S, Book WM. More on Hepatocellular Carcinoma after the Fontan Procedure. New England Journal Of Medicine 2013, 369: 490. PMID: 23902510, DOI: 10.1056/nejmc1306854.Peer-Reviewed Original ResearchFeatures of portal hypertension are associated with major adverse events in Fontan patients: The VAST study
Elder RW, McCabe NM, Hebson C, Veledar E, Romero R, Ford RM, Mahle WT, Kogon BE, Sahu A, Jokhadar M, McConnell ME, Book WM. Features of portal hypertension are associated with major adverse events in Fontan patients: The VAST study. International Journal Of Cardiology 2013, 168: 3764-3769. PMID: 23849105, PMCID: PMC3805740, DOI: 10.1016/j.ijcard.2013.06.008.Peer-Reviewed Original ResearchConceptsMajor adverse eventsPortal hypertensionAdverse eventsPost-Fontan patientsFontan patientsVAST scoresSingle-ventricle palliationFuture prospective studiesCongestive hepatopathyEarly referralHeart transplantRetrospective reviewClinical manifestationsProspective studyHepatic fibrosisClinical significanceHypertensionLiver evaluationPatientsLogistic regressionTransplantScoresSignificant relationshipPalliationFontan