Featured Publications
T cell response to influenza vaccination remains intact in adults with congenital heart disease who underwent early thymectomy
Leone DM, Park HJ, Unlu S, Gurvitz M, Kang I, Elder RW. T cell response to influenza vaccination remains intact in adults with congenital heart disease who underwent early thymectomy. International Journal Of Cardiology Congenital Heart Disease 2022, 8: 100359. PMID: 35600131, PMCID: PMC9122016, DOI: 10.1016/j.ijcchd.2022.100359.Peer-Reviewed Original ResearchT cell responsesCongenital heart diseaseT cellsInfluenza vaccinationEarly thymectomyMemory CD4Heart diseaseAdequate T-cell responsesCell responsesT cell distributionT cell subsetsNaïve T cellsCongenital heart surgeryYears of ageHemagglutination inhibition assaysRoutine vaccinationVaccine immunityCell subsetsMean ageHeart surgeryNaïve CD4Healthy controlsThymectomyBlood samplesDiminished response
2019
T-Cell Receptor Excision Circles in Newborns with Congenital Heart Disease
Davey B, Elder R, Cloutier M, Bennett N, Lee J, Wang Z, Manning A, Doan T, Griffiths M, Perez M, Ahluwalia N, Toro-Salazar O. T-Cell Receptor Excision Circles in Newborns with Congenital Heart Disease. The Journal Of Pediatrics 2019, 213: 96-102.e2. PMID: 31277900, DOI: 10.1016/j.jpeds.2019.05.061.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseLower TREC levelsTREC levelsGeneral populationT-cell receptor excision circlesCongenital heart disease severityAssociated with clinical complicationsHeart diseaseCombination of prematurityRetrospective chart reviewNewborn screening programsPreterm childrenAssociated with hospitalizationExcision circlesT cellsChart reviewClinical complicationsNewbornsScreening programHigh riskChildren's hospitalInfectionOutcome measuresHospitalDisease
2015
Immunologic Aging in Adults with Congenital Heart Disease: Does Infant Sternotomy Matter?
Elder RW, George RP, McCabe NM, Rodriguez III FH, Book WM, Mahle WT, Kirk AD. Immunologic Aging in Adults with Congenital Heart Disease: Does Infant Sternotomy Matter? Pediatric Cardiology 2015, 36: 1411-1416. PMID: 25916315, PMCID: PMC5319831, DOI: 10.1007/s00246-015-1174-9.Peer-Reviewed Original ResearchConceptsAdult congenital heart diseaseCongenital heart diseaseACHD patientsHeart diseaseExact testMean percentageImmune phenotypic changesT lymphocyte compositionCD8 T cellsFisher's exact testPolychromatic flow cytometryT cell maturationMann-Whitney ULower mean percentageImmune exhaustionImmunologic exhaustionPrior sternotomyCD8 lymphocytesCD4 cellsCD8 cellsLymphocyte compositionMedian ageClinical impactT cellsT lymphocytes