Featured Publications
T cell response to influenza vaccination remains intact in adults with congenital heart disease who underwent early thymectomy
Leone DM, Park HJ, Unlu S, Gurvitz M, Kang I, Elder RW. T cell response to influenza vaccination remains intact in adults with congenital heart disease who underwent early thymectomy. International Journal Of Cardiology Congenital Heart Disease 2022, 8: 100359. PMID: 35600131, PMCID: PMC9122016, DOI: 10.1016/j.ijcchd.2022.100359.Peer-Reviewed Original ResearchT cell responsesCongenital heart diseaseT cellsInfluenza vaccinationEarly thymectomyMemory CD4Heart diseaseAdequate T-cell responsesCell responsesT cell distributionT cell subsetsNaïve T cellsCongenital heart surgeryYears of ageHemagglutination inhibition assaysRoutine vaccinationVaccine immunityCell subsetsMean ageHeart surgeryNaïve CD4Healthy controlsThymectomyBlood samplesDiminished responseHair and skin predict cardiomyopathies: Carvajal and erythrokeratodermia cardiomyopathy syndromes
Sun Q, Lee L, Hall EK, Choate KA, Elder RW. Hair and skin predict cardiomyopathies: Carvajal and erythrokeratodermia cardiomyopathy syndromes. Pediatric Dermatology 2020, 38: 31-38. PMID: 33275305, DOI: 10.1111/pde.14478.Peer-Reviewed Original ResearchConceptsCongestive heart failureCardiac evaluationHeart failureHeart diseaseSudden deathNail abnormalitiesCardiac pathologyNovel therapeuticsCardiomyopathy syndromeFatal consequencesYoung childrenPatientsWarning signsSyndromeFamily membersCardiocutaneous disorderSkinCharacteristic hairCardiomyopathyAbnormalitiesDiseasePathology
2023
Unique clinical challenges for the teenager with congenital heart disease
Pastor T, Elder R. Unique clinical challenges for the teenager with congenital heart disease. Current Opinion In Pediatrics 2023, 35: 553-560. PMID: 37700620, DOI: 10.1097/mop.0000000000001281.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseHeart diseaseHeart-healthy behaviorsUnderlying medical conditionsAdult-oriented careCareful history takingImportance of exerciseUnique clinical challengesImportant long-term benefitsMental health concernsOutpatient cardiologistCHD riskCHD patientsLong-term benefitsPotential complicationsWeight managementAppropriate screeningClinical challengeMedical conditionsHistory takingClinical practiceSexual healthCHD adolescentsHealth concernMotivational interviewing
2020
A window into portal hemodynamics in adult fontan patients?
Simmons MA, Revzin M, To U, Liapakis A, Fahey J, Elder RW. A window into portal hemodynamics in adult fontan patients? International Journal Of Cardiology 2020, 323: 61-64. PMID: 32979426, DOI: 10.1016/j.ijcard.2020.09.047.Peer-Reviewed Original ResearchConceptsAdult Fontan patientsFontan patientsSpleen stiffnessCongenital heart diseaseLiver stiffnessShear wave elastographyControl patientsPortal hemodynamicsLiver diseaseHeart diseaseFontan-associated liver diseaseLimited subgroup analysisPortal venous hemodynamicsAssociated liver diseasePassive hepatic congestionUltrasound shear wave elastographyFontan circulationStudy cohortHealthy patientsHepatic congestionVenous hemodynamicsSubgroup analysisLiver fibrosisHealthy controlsPatients
2019
T-Cell Receptor Excision Circles in Newborns with Congenital Heart Disease
Davey B, Elder R, Cloutier M, Bennett N, Lee J, Wang Z, Manning A, Doan T, Griffiths M, Perez M, Ahluwalia N, Toro-Salazar O. T-Cell Receptor Excision Circles in Newborns with Congenital Heart Disease. The Journal Of Pediatrics 2019, 213: 96-102.e2. PMID: 31277900, DOI: 10.1016/j.jpeds.2019.05.061.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseLower TREC levelsTREC levelsGeneral populationT-cell receptor excision circlesCongenital heart disease severityAssociated with clinical complicationsHeart diseaseCombination of prematurityRetrospective chart reviewNewborn screening programsPreterm childrenAssociated with hospitalizationExcision circlesT cellsChart reviewClinical complicationsNewbornsScreening programHigh riskChildren's hospitalInfectionOutcome measuresHospitalDiseaseModern Day Care of Patients With Single Ventricle Heart Disease: Late Complications of Fontan Palliation
Simmons M, Elder R. Modern Day Care of Patients With Single Ventricle Heart Disease: Late Complications of Fontan Palliation. Current Pediatrics Reports 2019, 7: 53-61. DOI: 10.1007/s40124-019-00192-7.Peer-Reviewed Original ResearchFontan palliationSingle ventricle heart diseaseLate hepatic complicationsHepatic complicationsPulmonary vasodilatorsReviewThe majorityFontan failureVascular complicationsFontan operationLate complicationsHeart failureHeart diseaseLymphatic complicationsNovel therapiesLiver cancerHigh riskComplicationsRecent FindingsRecentScoring systemPatientsDay carePalliationTherapyStructural complicationsSeparate entities
2018
T-CELL RECEPTOR EXCISION CIRCLES: A NOVEL APPROACH TO IDENTIFY IMMUNODEFICIENCY IN NEWBORNS WITH CONGENITAL HEART DISEASE
Davey B, Elder R, Salazar O, Manning A, Bennett N, Lee J, Cross N, Doan T, Griffiths M, Ahluwalia N, Perez M, Rodrigues R, Bernstein R, Rigos L, Cloutier M. T-CELL RECEPTOR EXCISION CIRCLES: A NOVEL APPROACH TO IDENTIFY IMMUNODEFICIENCY IN NEWBORNS WITH CONGENITAL HEART DISEASE. Journal Of The American College Of Cardiology 2018, 71: a575. DOI: 10.1016/s0735-1097(18)31116-1.Peer-Reviewed Original Research
2015
The Changing Epidemiology of Pediatric Endocarditis
Elder RW, Baltimore RS. The Changing Epidemiology of Pediatric Endocarditis. Infectious Disease Clinics Of North America 2015, 29: 513-524. PMID: 26311357, DOI: 10.1016/j.idc.2015.05.004.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseInfective endocarditisHeart diseaseRheumatic heart diseaseManagement of childrenIntroduction of antibioticsPediatric EndocarditisSurgical interventionMicrobiologic changesCardiac interventionsViridans streptococciEarly detectionEndocarditisEarly predominanceEpidemiologyDiseaseInterventionVirtual disappearanceMortalityImmunologic Aging in Adults with Congenital Heart Disease: Does Infant Sternotomy Matter?
Elder RW, George RP, McCabe NM, Rodriguez III FH, Book WM, Mahle WT, Kirk AD. Immunologic Aging in Adults with Congenital Heart Disease: Does Infant Sternotomy Matter? Pediatric Cardiology 2015, 36: 1411-1416. PMID: 25916315, PMCID: PMC5319831, DOI: 10.1007/s00246-015-1174-9.Peer-Reviewed Original ResearchConceptsAdult congenital heart diseaseCongenital heart diseaseACHD patientsHeart diseaseExact testMean percentageImmune phenotypic changesT lymphocyte compositionCD8 T cellsFisher's exact testPolychromatic flow cytometryT cell maturationMann-Whitney ULower mean percentageImmune exhaustionImmunologic exhaustionPrior sternotomyCD8 lymphocytesCD4 cellsCD8 cellsLymphocyte compositionMedian ageClinical impactT cellsT lymphocytes
2012
Cerebellar metastatic papillary thyroid carcinoma in a pediatric patient with complex congenital heart disease
Remy KE, Elder RW, Tsankova NM, Conroy RM. Cerebellar metastatic papillary thyroid carcinoma in a pediatric patient with complex congenital heart disease. Journal Of Pediatric Endocrinology And Metabolism 2012, 25: 1195-1199. PMID: 23329771, DOI: 10.1515/jpem-2012-0162.Peer-Reviewed Original ResearchConceptsPapillary thyroid carcinomaMetastatic papillary thyroid carcinomaComplex congenital heart diseaseCongenital heart diseaseHeart diseaseThyroid carcinomaFirst pediatric caseStrong risk factorDiagnostic radiation exposurePediatric patientsPresenting signPediatric casesRisk factorsCHARGE syndromeRadiation exposureCarcinomaDiseasePatientsSyndromeCancerCerebellumPulmonary Venous Obstruction in the Atrial Switch Operation: A Forgotten Complication
Elder RW, Hellenbrand WE. Pulmonary Venous Obstruction in the Atrial Switch Operation: A Forgotten Complication. Pediatric Cardiology 2012, 33: 1183-1186. PMID: 22354225, DOI: 10.1007/s00246-012-0241-8.Peer-Reviewed Original ResearchConceptsPulmonary venous obstructionVenous obstructionObstructive heart diseaseSymptoms of dyspneaAtrial switch operationChest X-rayContext of patientsForgotten ComplicationMustard surgeryRare complicationCardiac catheterizationSurgical managementGreat arteriesHeart diseaseBaffle obstructionSitus inversusComplicationsObstructionSwitch operationSymptomsCurrent literatureDyspneaCcTGACatheterizationPatients