2022
Short Bowel Syndrome and Intestinal Lengthening Procedures
Salvi P, Cowles R. Short Bowel Syndrome and Intestinal Lengthening Procedures. 2022, 345-356. DOI: 10.1007/978-3-030-96542-6_31.ChaptersIntestinal lengthening proceduresParenteral nutritionLengthening proceduresIntestinal transplantSurgical interventionMultidisciplinary intestinal rehabilitation programParenteral nutrition failureIntestinal rehabilitation programShort bowel syndromeSmall bowel resectionSignificant physiologic consequencesCompensatory-adaptive changesBowel functionBowel resectionBowel syndromeIntestinal transitIntestinal adaptationIntestinal lossSpecialized epithelial cellsMucosal growthRehabilitation programPhysiologic consequencesDistal ileumPatientsFat absorption
2019
Potentiation of serotonin signaling leads to increased carbohydrate and lipid absorption in the murine small intestine
Park CJ, Armenia SJ, Shaughnessy MP, Greig CJ, Cowles RA. Potentiation of serotonin signaling leads to increased carbohydrate and lipid absorption in the murine small intestine. Journal Of Pediatric Surgery 2019, 54: 1245-1249. PMID: 30879746, DOI: 10.1016/j.jpedsurg.2019.02.027.Peer-Reviewed Original ResearchConceptsPotentiation of serotoninSmall intestineMucosal growthLipid absorptionSmall intestinal mucosal growthMucosal growth factorsSerotonin reuptake transporterSERT knockout miceDistal small intestineIntestinal mucosal growthCrypt cell proliferationT-testMucosal surface areaMurine small intestineStudent's t-testEnteric serotoninIntestinal failureIntestinal adaptationReuptake transporterDeficient miceWT animalsIntestinal homeostasisFatty acid analogueCrypt depthVillus height
2018
Retracing our STEPs: Four decades of progress in intestinal lengthening procedures for short bowel syndrome
Greig CJ, Oh PS, Gross ER, Cowles RA. Retracing our STEPs: Four decades of progress in intestinal lengthening procedures for short bowel syndrome. The American Journal Of Surgery 2018, 217: 772-782. PMID: 30514435, DOI: 10.1016/j.amjsurg.2018.11.025.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsShort bowel syndromeBowel syndromeReversed intestinal segmentInnovative new treatmentsBowel dilationIntestinal rehabilitationIntestinal failureBowel lengthSurgical managementBacterial overgrowthIntestinal adaptationColonic transpositionPatient outcomesSurgical techniqueLengthening surgeryIntestinal segmentsArtificial valvesNew treatmentsSyndromeCare paradigmPoor motilityBirthOutcomesTransit timeLong term