2022
Jejunoileal mucosal growth in mice with a limited microbiome
Shaughnessy MP, Park CJ, Salvi PS, Cowles RA. Jejunoileal mucosal growth in mice with a limited microbiome. PLOS ONE 2022, 17: e0266251. PMID: 35349599, PMCID: PMC8963542, DOI: 10.1371/journal.pone.0266251.Peer-Reviewed Original ResearchConceptsIntestinal mucosal growthMucosal surface areaSmall intestinal mucosal growthCrypt proliferation indexCONV miceGF miceMucosal growthVillus heightEnteral antibioticsCrypt depthCell proportionSmall intestinal villus heightGerm-free miceBroad-spectrum antibioticsConventional floraIntestinal villus heightGerm-free conditionsEnteral administrationMucosal homeostasisGnotobiotic miceProliferation indexEnterocyte proliferationMiceTaller villiGF conditions
2018
Mucosal homeostasis is altered in the ileum of gnotobiotic mice
Greig CJ, Alper A, Goodman AL, Cowles RA. Mucosal homeostasis is altered in the ileum of gnotobiotic mice. Journal Of Surgical Research 2018, 231: 331-337. PMID: 30278949, DOI: 10.1016/j.jss.2018.05.055.Peer-Reviewed Original ResearchConceptsGnotobiotic miceMucosal homeostasisGastrointestinal tractCrypt depthVillus heightDistal ileal segmentConventional floraFuture therapeutic strategiesGnotobiotic mouse modelMarkers of proliferationIleal segmentMucosal restorationAkkermansia muciniphilaMouse modelTherapeutic strategiesAdult miceCF miceDisease pathogenesisHistologic sectionsMiceEscherichia coli MG1655IleumNormal physiologyGnotobiotic groupFurther studies