Featured Publications
Quantification of Amphetamine-Induced Changes in [11C] Raclopride Binding with Continuous Infusion
Carson R, Breier* A, de Bartolomeis* A, Saunders† R, Su* T, Schmall B, Der M, Pickar* D, Eckelman W. Quantification of Amphetamine-Induced Changes in [11C] Raclopride Binding with Continuous Infusion. Cerebrovascular And Brain Metabolism Reviews 1997, 17: 437-447. PMID: 9143226, DOI: 10.1097/00004647-199704000-00009.Peer-Reviewed Original Research
2020
Separating dopamine D2 and D3 receptor sources of [11C]-(+)-PHNO binding potential: Independent component analysis of competitive binding
Smart K, Gallezot JD, Nabulsi N, Labaree D, Zheng MQ, Huang Y, Carson RE, Hillmer AT, Worhunsky PD. Separating dopamine D2 and D3 receptor sources of [11C]-(+)-PHNO binding potential: Independent component analysis of competitive binding. NeuroImage 2020, 214: 116762. PMID: 32201327, PMCID: PMC7263955, DOI: 10.1016/j.neuroimage.2020.116762.Peer-Reviewed Original Research
2000
Measurement of dopamine release with continuous infusion of [11C]raclopride: optimization and signal-to-noise considerations.
Watabe H, Endres CJ, Breier A, Schmall B, Eckelman WC, Carson RE. Measurement of dopamine release with continuous infusion of [11C]raclopride: optimization and signal-to-noise considerations. Journal Of Nuclear Medicine 2000, 41: 522-30. PMID: 10716328.Peer-Reviewed Original ResearchConceptsOptimal timingAdministration of amphetamineReceptor imaging studiesHuman dataContinuous infusionDopamine releaseOptimal scan timeHealthy volunteersHuman studiesSynaptic dopamineImaging studiesPET studiesDopamine responsePercentage changeCareful assessmentStatistical significanceDeltaBPInfusionMeasurement of changesIndirect measureActivity curvesPrePatients
1998
Assessment of Dynamic Neurotransmitter Changes With Bolus or Infusion Delivery of Neuroreceptor Ligands
Endres C, Carson R. Assessment of Dynamic Neurotransmitter Changes With Bolus or Infusion Delivery of Neuroreceptor Ligands. Cerebrovascular And Brain Metabolism Reviews 1998, 18: 1196-1210. PMID: 9809509, DOI: 10.1097/00004647-199811000-00006.Peer-Reviewed Original ResearchBrainCarbon RadioisotopesComputer SimulationDopamineDopamine AntagonistsFlumazenilHumansInfusions, ParenteralInjectionsKineticsMicrodialysisModels, NeurologicalNaltrexoneNarcotic AntagonistsRacloprideRadioligand AssayReceptors, DopamineSalicylamidesSensitivity and SpecificityTomography, Emission-Computed