Featured Publications
EM reconstruction algorithms for emission and transmission tomography.
Lange K, Carson R. EM reconstruction algorithms for emission and transmission tomography. Journal Of Computer Assisted Tomography 1984, 8: 306-16. PMID: 6608535.Peer-Reviewed Original ResearchMeSH KeywordsFourier AnalysisHumansModels, TheoreticalProbabilityTomography, Emission-ComputedTomography, X-Ray ComputedConceptsEM algorithmGood physical modelTransmission image reconstructionTransmission tomographyMaximum likelihood estimatesAlgebraic schemeRelevant physical featuresNon-negativity constraintsGlobal convergenceIterative techniquePoisson natureLikelihood estimatesParameter estimatesCounting noiseMaximum likelihoodDetector geometryPhysical modelAccurate incorporationEM reconstruction algorithmPhysical featuresSpecific algorithmsImage reconstructionAlgorithmReconstruction algorithmActual reconstruction
2017
Quantification of Tumor Hypoxic Fractions Using Positron Emission Tomography with [18F]Fluoromisonidazole ([18F]FMISO) Kinetic Analysis and Invasive Oxygen Measurements
Kelada OJ, Rockwell S, Zheng MQ, Huang Y, Liu Y, Booth CJ, Decker RH, Oelfke U, Carson RE, Carlson DJ. Quantification of Tumor Hypoxic Fractions Using Positron Emission Tomography with [18F]Fluoromisonidazole ([18F]FMISO) Kinetic Analysis and Invasive Oxygen Measurements. Molecular Imaging And Biology 2017, 19: 893-902. PMID: 28409339, PMCID: PMC5640490, DOI: 10.1007/s11307-017-1083-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell HypoxiaCell Line, TumorHumansKineticsMaleMice, Inbred BALB CMisonidazoleMusclesNeoplasmsOxygenPositron-Emission TomographyTomography, X-Ray ComputedTumor BurdenConceptsPositron emission tomographyTumor hypoxic fractionHypoxic fractionEmission tomographyLung cancer radiotherapy patientsPO2 measurementsAbsolute tumor volumeC miceDirect pO2 measurementsBlood ratioClinical impactTumor volumeHypoxia quantificationSubcutaneous tumorsPurposeThe purposeTracer kinetic modelingRadiotherapy patientsPET imagingPatientsPO2 valuesScansPatlak modelTomographyTwo-compartmentTBR