Toxic epidermal necrolysis‐like acute graft‐versus‐host disease in pediatric bone marrow transplant patients: Case series and review of the literature
Song J, Huang JT, del Carmen Fraile Alonso M, Antaya RJ, Price HN, Funk T, Francois RA, Shah SD. Toxic epidermal necrolysis‐like acute graft‐versus‐host disease in pediatric bone marrow transplant patients: Case series and review of the literature. Pediatric Dermatology 2022, 39: 889-895. PMID: 35730149, DOI: 10.1111/pde.15069.Peer-Reviewed Original ResearchConceptsToxic epidermal necrolysisHematopoietic stem cell transplantCase seriesAcute graftHost diseaseTransplant patientsSkin symptomsPediatric bone marrow transplant patientsBone marrow transplant patientsMulti-institutional case seriesMarrow transplant patientsStem cell transplantBone marrow transplantationGVHD involvementGVHD prophylaxisEpidermal necrolysisPain medicationConcurrent medicationsCulprit medicationGeneralized erythrodermaBSA involvementInfection prophylaxisMedian ageMultidisciplinary carePediatric patientsMolecular and Clinical Outcomes After Intravenous Gentamicin Treatment for Patients With Junctional Epidermolysis Bullosa Caused by Nonsense Variants
Mosallaei D, Hao M, Antaya RJ, Levian B, Kwong A, Cogan J, Hamilton C, Schwieger-Briel A, Tan C, Tang X, Woodley DT, Chen M. Molecular and Clinical Outcomes After Intravenous Gentamicin Treatment for Patients With Junctional Epidermolysis Bullosa Caused by Nonsense Variants. JAMA Dermatology 2022, 158: 366-374. PMID: 35234826, PMCID: PMC8892363, DOI: 10.1001/jamadermatol.2021.5992.Peer-Reviewed Original ResearchConceptsNonrandomized clinical trialIntravenous gentamicinJunctional epidermolysis bullosaNonsense variantDermal-epidermal junctionGentamicin treatmentClinical trialsEpidermolysis bullosaPopulation of patientsLaminin-332Low-dose gentamicinTotal activity scoreHome infusion servicesLong-term safetyDisease activityGentamicin therapySecondary outcomesLaminin-332 expressionPediatric patientsPrimary outcomeActivity scoreClinical outcomesAvailable therapiesNephrotoxic effectsOtotoxic effects