2023
Sodium currents in naïve mouse dorsal root ganglion neurons: No major differences between sexes
Ghovanloo M, Tyagi S, Zhao P, Effraim P, Dib-Hajj S, Waxman S. Sodium currents in naïve mouse dorsal root ganglion neurons: No major differences between sexes. Channels 2023, 18: 2289256. PMID: 38055732, PMCID: PMC10761158, DOI: 10.1080/19336950.2023.2289256.Peer-Reviewed Original ResearchConceptsSexual dimorphismRodent dorsal root ganglion neuronsBiophysical propertiesDorsal root ganglion neuronsExpression patternsSex-dependent regulationVoltage-gated sodiumFunctional analysisGanglion neuronsRodent sensory neuronsMouse dorsal root ganglion neuronsNaïve WT miceNumber of cellsMixed populationDimorphismUniform experimental conditionsSex-dependent differencesSensory neuronsNative DRG neuronsPain pathwaysDRG neuronsWT miceClinical studiesNav currentsAdult males
2020
Cannabidiol protects against high glucose‐induced oxidative stress and cytotoxicity in cardiac voltage‐gated sodium channels
Fouda MA, Ghovanloo M, Ruben PC. Cannabidiol protects against high glucose‐induced oxidative stress and cytotoxicity in cardiac voltage‐gated sodium channels. British Journal Of Pharmacology 2020, 177: 2932-2946. PMID: 32077098, PMCID: PMC7279989, DOI: 10.1111/bph.15020.Peer-Reviewed Original ResearchConceptsHigh glucoseOxidative stressHigh glucose-induced oxidative stressCardiac voltage-gated sodium channelGlucose-induced oxidative stressReactive oxygen speciesCardiac sodium channel isoformChannel inhibitory effectVoltage-gated sodium channelsSteady-state fast inactivationHigh glucose conditionsSodium channel isoformsAction potential modellingDeleterious effectsCardiovascular complicationsDiabetic patientsAction potentialsCell viability assaysArrhythmiasMajor causeInhibitory effectChannel isoformsCannabidiolGlucose conditionsSodium channelsSay Cheese: Structure of the Cardiac Electrical Engine Is Captured
Ghovanloo MR, Ruben PC. Say Cheese: Structure of the Cardiac Electrical Engine Is Captured. Trends In Biochemical Sciences 2020, 45: 369-371. PMID: 32311330, DOI: 10.1016/j.tibs.2020.02.003.Peer-Reviewed Original Research
2018
A Mixed Periodic Paralysis & Myotonia Mutant, P1158S, Imparts pH-Sensitivity in Skeletal Muscle Voltage-gated Sodium Channels
Ghovanloo MR, Abdelsayed M, Peters CH, Ruben PC. A Mixed Periodic Paralysis & Myotonia Mutant, P1158S, Imparts pH-Sensitivity in Skeletal Muscle Voltage-gated Sodium Channels. Scientific Reports 2018, 8: 6304. PMID: 29674667, PMCID: PMC5908869, DOI: 10.1038/s41598-018-24719-y.Peer-Reviewed Original ResearchConceptsPeriodic paralysisSkeletal muscle voltageSkeletal muscle channelopathiesHypokalemic periodic paralysisSteady-state fast inactivationLow potassium levelsAutosomal dominant mutationsEpisodic attacksIntense exercisePhysical activityMuscle channelopathiesBlood acidosisCommon triggerPotassium levelsAction potential modelingParalysisSodium channelsMuscular contractionSkeletal muscleMyotoniaPhenotype correlationLate currentPatientsExtracellular pHFast inactivationpH Modulation of Voltage-Gated Sodium Channels
Peters CH, Ghovanloo MR, Gershome C, Ruben PC. pH Modulation of Voltage-Gated Sodium Channels. Handbook Of Experimental Pharmacology 2018, 246: 147-160. PMID: 29460150, DOI: 10.1007/164_2018_99.Peer-Reviewed Original ResearchConceptsElectrical diseaseSodium channelsChannel gatingDisease-causing mutantsSodium channel poreTransient sodium currentModulation of VoltageIschemic strokeNon-inactivating channelsSkeletal muscle sodium channelsAcute symptomsCocaine ingestionCardiac ischemiaSodium channel mutationsMuscle sodium channelsSodium currentIsoform specificitySodium channel gatingTissue-level effectsPathophysiological conditionsChannel mutationsSkeletal muscleDiseaseCardiac tissueChannel poreEffects of acidosis on neuronal voltage-gated sodium channels: Nav1.1 and Nav1.3
Ghovanloo MR, Peters CH, Ruben PC. Effects of acidosis on neuronal voltage-gated sodium channels: Nav1.1 and Nav1.3. Channels 2018, 12: 367-377. PMID: 30362397, PMCID: PMC6284583, DOI: 10.1080/19336950.2018.1539611.Peer-Reviewed Original ResearchConceptsSodium channel subtypesVoltage-gated sodium channelsChannel subtypesNeuronal voltage-gated sodium channelsSodium channelsEffect of acidosisSteady-state fast inactivationPH-sensitive channelsNeonatal neuronsFast inactivationAdult neuronsInhibitory neuronsPathophysiological manifestationsNav1.3Nav1.1Membrane excitabilityExtracellular acidosisNeuronsSubtypesAcidosisModerate reductionExtracellular pHTissue-specific mannerKey contributorExcitability
2016
Chapter Fifteen Physiology and Pathophysiology of Sodium Channel Inactivation
Ghovanloo MR, Aimar K, Ghadiry-Tavi R, Yu A, Ruben PC. Chapter Fifteen Physiology and Pathophysiology of Sodium Channel Inactivation. Current Topics In Membranes 2016, 78: 479-509. PMID: 27586293, DOI: 10.1016/bs.ctm.2016.04.001.Peer-Reviewed Original Research