α2A-adrenergic heteroreceptors are required for stress-induced reinstatement of cocaine conditioned place preference
Perez RE, Basu A, Nabit BP, Harris NA, Folkes OM, Patel S, Gilsbach R, Hein L, Winder DG. α2A-adrenergic heteroreceptors are required for stress-induced reinstatement of cocaine conditioned place preference. Neuropsychopharmacology 2020, 45: 1473-1481. PMID: 32074627, PMCID: PMC7360592, DOI: 10.1038/s41386-020-0641-z.Peer-Reviewed Original ResearchConceptsStress-induced reinstatementStress-induced relapseBNST activityPlace preferenceDesigner drug (DREADD) approachEfficacy of guanfacineImpact of doseStress-induced cravingSubstance use disordersKey brain regionsRelapse rateBeneficial efficacyCPP procedureAgonist guanfacineDesigner receptorsGenetic deletion strategiesStria terminalisBed nucleusHeteroreceptorsUse disordersGuanfacineHuman studiesAnimal modelsCocaine CPPPotential treatment