Dorsal BNST α2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors
Harris NA, Isaac AT, Günther A, Merkel K, Melchior J, Xu M, Eguakun E, Perez R, Nabit BP, Flavin S, Gilsbach R, Shonesy B, Hein L, Abel T, Baumann A, Matthews R, Centanni SW, Winder DG. Dorsal BNST α2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors. Journal Of Neuroscience 2018, 38: 8922-8942. PMID: 30150361, PMCID: PMC6191524, DOI: 10.1523/jneurosci.0963-18.2018.Peer-Reviewed Original ResearchConceptsExcitatory actionAnxiety-like behaviorBed nucleusNeuronal activityAdrenergic receptorsCation channelsEffective treatment modalityDorsal bed nucleusHyperpolarization-activated cyclicCell-specific actionsSubstance use disordersReward-related behaviorsDrug-seeking behaviorDrugs of abuseTreatment of addictionAntidepressant actionBNST neuronsAnxiolytic actionDorsal BNSTTreatment modalitiesReceptor agonistAgonist guanfacineAnxiogenic behaviorStria terminalisClinical utility