Investigating the dose-dependency of the midgut escape barrier using a mechanistic model of within-mosquito dengue virus population dynamics
Johnson R, Stopard I, Byrne H, Armstrong P, Brackney D, Lambert B. Investigating the dose-dependency of the midgut escape barrier using a mechanistic model of within-mosquito dengue virus population dynamics. PLOS Pathogens 2024, 20: e1011975. PMID: 38557892, PMCID: PMC11008821, DOI: 10.1371/journal.ppat.1011975.Peer-Reviewed Original ResearchConceptsBasal lamina layersInfection dynamicsYellow fever virusEpidemics of severe diseaseMidgut escape barrierDengue virusVirus population dynamicsAmount of virusEstablishment of infectionDose-dependentlyMosquito feeding behaviorDEN virusesExtrinsic incubation periodFever virusMidgut epitheliumBlood feedingFeeding eventsMidgutViral infection dynamicsZika virusAedes aegyptiCourse of infectionEscape barrierAedes albopictusIncubation periodField Isolation and Laboratory Vector-Host Studies of Brazoran Virus (Peribunyaviridae: Orthobunyavirus) from Florida.
Armstrong P, Anderson J, Sharma R, Misencik M, Bransfield A, Vossbrinck C, Brackney D. Field Isolation and Laboratory Vector-Host Studies of Brazoran Virus (Peribunyaviridae: Orthobunyavirus) from Florida. American Journal Of Tropical Medicine And Hygiene 2024, 110: 968-970. PMID: 38531101, PMCID: PMC11066360, DOI: 10.4269/ajtmh.23-0799.Peer-Reviewed Original ResearchConceptsCulex quinquefasciatusMultiple mouse tissuesVector competenceDisseminated infectionNucleotide identityTexas isolatesL segmentField isolatesS segmentFlorida strainBlood mealMidgut infectionDisease signsMouse tissuesLaboratory trialsCulex erraticusIntradermal inoculationAedes aegyptiQuinquefasciatusCulex mosquitoesCulexIsolatesSouthern FloridaSuckling miceVirus transmission