2024
In vivo neuropil density from anatomical MRI and machine learning
Akif A, Staib L, Herman P, Rothman D, Yu Y, Hyder F. In vivo neuropil density from anatomical MRI and machine learning. Cerebral Cortex 2024, 34: bhae200. PMID: 38771239, PMCID: PMC11107380, DOI: 10.1093/cercor/bhae200.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSynaptic densityNeuropil densityCellular densityArtificial neural networkNeural networkPositron emission tomographyAnatomical magnetic resonance imagingHealthy subjectsSynaptic activityMRI scansMachine learning algorithmsBrain's energy budgetEmission tomographyIn vivo MRI scansResonance imagingTissue cellularityLearning algorithmsDiffusion magnetic resonance imagingMachine learningMicroscopic interpretationInterpretation of functional neuroimaging dataIndividual predictionsSubjectsMultimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization
Vafaii H, Mandino F, Desrosiers-Grégoire G, O’Connor D, Markicevic M, Shen X, Ge X, Herman P, Hyder F, Papademetris X, Chakravarty M, Crair M, Constable R, Lake E, Pessoa L. Multimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization. Nature Communications 2024, 15: 229. PMID: 38172111, PMCID: PMC10764905, DOI: 10.1038/s41467-023-44363-z.Peer-Reviewed Original Research
2022
A 3D atlas of functional human brain energetic connectome based on neuropil distribution
Yu Y, Akif A, Herman P, Cao M, Rothman D, Carson R, Agarwal D, Evans A, Hyder F. A 3D atlas of functional human brain energetic connectome based on neuropil distribution. Cerebral Cortex 2022, 33: 3996-4012. PMID: 36104858, PMCID: PMC10068297, DOI: 10.1093/cercor/bhac322.Peer-Reviewed Original ResearchConceptsSynaptic densityCortical regionsHigher synapse densityHuman cortical circuitsFunctional imaging studiesCortical activity mapsVivo PET imagingNeuropil distributionGlucose oxidationSynapse densityCortical circuitsMetabolic rateSynaptic connectionsCortical energeticsImaging studiesHuman cortexPET imagingHistological stainingRecent evidenceCortexHuman brainBrainVoxel levelActivity ratesAtlas
2010
Hypersensitivity to Thromboxane Receptor Mediated Cerebral Vasomotion and CBF Oscillations during Acute NO-Deficiency in Rats
Horváth B, Lenzsér G, Benyó B, Németh T, Benkő R, Iring A, Hermán P, Komjáti K, Lacza Z, Sándor P, Benyó Z. Hypersensitivity to Thromboxane Receptor Mediated Cerebral Vasomotion and CBF Oscillations during Acute NO-Deficiency in Rats. PLOS ONE 2010, 5: e14477. PMID: 21217826, PMCID: PMC3013104, DOI: 10.1371/journal.pone.0014477.Peer-Reviewed Original ResearchMeSH Keywords15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidAnimalsBrainCerebrovascular CirculationEnzyme InhibitorsHypersensitivityLaser-Doppler FlowmetryMaleMiddle Cerebral ArteryMotionNG-Nitroarginine Methyl EsterNitric OxideRatsRats, WistarReceptors, ThromboxaneRho-Associated KinasesSignal TransductionThromboxane A2ConceptsCerebral blood flowCBF oscillationsNitric oxideCerebral vasomotionThromboxane receptorNitro-L-arginine methyl esterDecreased cerebral blood flowMean arterial blood pressureEndothelium-derived nitric oxideTP receptor agonist UAbsence of NOCerebral circulatory parametersLow-frequency spontaneous fluctuationsArterial blood pressureTP receptor activationCerebrovascular toneEndothelial dysfunctionBlood pressureL-NAMEVascular effectsAgonist UNO deficiencyCirculatory parametersPharmacological modulationBlood flow
2008
Frequency‐dependent tactile responses in rat brain measured by functional MRI
Sanganahalli BG, Herman P, Hyder F. Frequency‐dependent tactile responses in rat brain measured by functional MRI. NMR In Biomedicine 2008, 21: 410-416. PMID: 18435491, PMCID: PMC2774500, DOI: 10.1002/nbm.1259.Peer-Reviewed Original Research