2022
Major Depressive Disorder in an International Multisite Wilson Disease Registry
Camarata M, Ala A, Coskun A, Deng Y, Embel V, Gonzalez-Peralta R, Maciejewski K, Patel A, Rubman S, To U, Tomlin R, Schilsky M, Zimbrean P. Major Depressive Disorder in an International Multisite Wilson Disease Registry. Journal Of The Academy Of Consultation-Liaison Psychiatry 2022, 64: 106-117. PMID: 36521682, DOI: 10.1016/j.jaclp.2022.12.001.Peer-Reviewed Original ResearchMeSH KeywordsCopperCross-Sectional StudiesDepressive Disorder, MajorHepatolenticular DegenerationHumansQuality of LifeConceptsMajor depressive disorderWilson's diseaseDepressive disorderLifetime major depressive disorderMental health QOLPhysical health QoLMajor depressive episodeMental health qualityStructured psychiatric evaluationSignificant differencesCross-sectional reportsLiver testsLiver diseaseNeurological assessmentLife scoresClinical correlatesDepressive episodePsychiatric symptomsPsychiatric evaluationDisease RegistrySevere anxietyLaboratory testsLifetime historySignificant associationPatientsA multidisciplinary approach to the diagnosis and management of Wilson disease: Executive summary of the 2022 Practice Guidance on Wilson disease from the American Association for the Study of Liver Diseases
Schilsky ML, Roberts EA, Bronstein JM, Dhawan A, Hamilton JP, Rivard AM, Washington MK, Weiss KH, Zimbrean PC. A multidisciplinary approach to the diagnosis and management of Wilson disease: Executive summary of the 2022 Practice Guidance on Wilson disease from the American Association for the Study of Liver Diseases. Hepatology 2022, 77: 1428-1455. PMID: 36152019, DOI: 10.1002/hep.32805.Peer-Reviewed Original Research
2021
The Effect of Mental Health, Neurological Disease, and Liver Disease on Quality of Life in Patients With Wilson Disease
Camarata MA, Ala A, Coskun AK, Deng Y, Gonzalez-Peralta R, Maciejewski KR, Patel A, Rubman S, To U, Tomlin R, Schilsky ML, Zimbrean PC. The Effect of Mental Health, Neurological Disease, and Liver Disease on Quality of Life in Patients With Wilson Disease. Journal Of The Academy Of Consultation-Liaison Psychiatry 2021, 62: 528-537. PMID: 34044196, PMCID: PMC11165927, DOI: 10.1016/j.jaclp.2021.04.004.Peer-Reviewed Original ResearchMeSH KeywordsDepressive Disorder, MajorEnd Stage Liver DiseaseHepatolenticular DegenerationHumansMental HealthQuality of LifeSeverity of Illness IndexConceptsRating Scale scoresP-QOL scoresP-QOLNeurological diseasesWilson's diseaseMental healthOverall QoLUnified Wilson's Disease Rating Scale scoreScale scoreEnd-stage liver disease (MELD) scoreDisease severityStage liver disease scoreDegree of liverNeurological disease severityLiver Disease scoreLiver disease severityMajor depressive disorderQuality of lifeMental health issuesChild-PughCirrhosis severityLiver diseaseNeurological assessmentPatients' qualityChronic disorders
2017
Psychiatric comorbidity in Wilson’s disease
Mura G, Zimbrean PC, Demelia L, Carta MG. Psychiatric comorbidity in Wilson’s disease. International Review Of Psychiatry 2017, 29: 445-462. PMID: 28681670, DOI: 10.1080/09540261.2017.1311845.Peer-Reviewed Original ResearchMeSH KeywordsBrainComorbidityCopperHepatolenticular DegenerationHumansMental DisordersQuality of LifeConceptsWilson's diseasePsychiatric disordersCase-control studyAutosomal recessive inherited disorderPubMed/MEDLINERare autosomal recessive inherited disorderBetter life expectancyRecessive inherited disorderPsychiatric comorbidityCase reportSpecific therapyAvailable treatmentsPsychiatric disturbancesHigh prevalenceMood disordersPsychiatric symptomsPsychiatric outcomesClinical monitoringTherapeutic issuesPsychosocial outcomesInherited disorderRelevant articlesDiseaseGoogle ScholarCareful evaluationChapter 11 Cognitive and psychiatric symptoms in Wilson disease
Zimbrean P, Seniów J. Chapter 11 Cognitive and psychiatric symptoms in Wilson disease. Handbook Of Clinical Neurology 2017, 142: 121-140. PMID: 28433097, DOI: 10.1016/b978-0-444-63625-6.00011-2.Peer-Reviewed Original ResearchMeSH KeywordsCognitionCognition DisordersHepatolenticular DegenerationHumansMood DisordersNeuropsychological TestsPsychotic DisordersConceptsWilson's diseaseClinical experienceAuthors' clinical experienceNonpharmacologic treatmentsGreat masqueraderIndividual patientsPsychiatric symptomsMood disturbanceCognitive symptomsPsychiatric pathologyCognitive deficitsDiseaseSymptomsExecutive functionImpairmentPatientsPrevalencePsychosisPathology
2015
The Spectrum of Psychiatric Symptoms in Wilson’s Disease: Treatment and Prognostic Considerations
Zimbrean PC, Schilsky ML. The Spectrum of Psychiatric Symptoms in Wilson’s Disease: Treatment and Prognostic Considerations. American Journal Of Psychiatry 2015, 172: 1068-1072. PMID: 26575449, DOI: 10.1176/appi.ajp.2015.15030371.Peer-Reviewed Original ResearchDelay in Diagnosis of Wilson Disease in Children With Insidious Psychiatric Symptoms: A Case Report and Review of the Literature
Millard H, Zimbrean P, Martin A. Delay in Diagnosis of Wilson Disease in Children With Insidious Psychiatric Symptoms: A Case Report and Review of the Literature. Journal Of The Academy Of Consultation-Liaison Psychiatry 2015, 56: 700-705. PMID: 26481962, DOI: 10.1016/j.psym.2015.07.008.Peer-Reviewed Educational MaterialsMeSH KeywordsAdolescentDelayed DiagnosisDiagnosis, DifferentialHepatolenticular DegenerationHumansMaleMental Disorders
2013
Psychiatric aspects of Wilson disease: a review
Zimbrean PC, Schilsky ML. Psychiatric aspects of Wilson disease: a review. General Hospital Psychiatry 2013, 36: 53-62. PMID: 24120023, DOI: 10.1016/j.genhosppsych.2013.08.007.Peer-Reviewed Original ResearchMeSH KeywordsDepressive Disorder, MajorHepatolenticular DegenerationHumansMental DisordersPersonality DisordersPsychotic DisordersSchizophreniaSchizophrenic PsychologyConceptsPsychiatric symptomsPsychiatric manifestationsWilson's diseasePsychiatric disordersPercent of patientsTime of diagnosisDiagnosis of WDCertain gene mutationsHepatic involvementNeurologic involvementClinical presentationPsychiatric presentationsCurrent evidencePsychiatric aspectsPubMed databaseWD patientsSymptomsDiseaseDiagnosisWD diagnosisGene mutationsAverage timePatientsManifestationsDisorders