2022
Major Depressive Disorder in an International Multisite Wilson Disease Registry
Camarata M, Ala A, Coskun A, Deng Y, Embel V, Gonzalez-Peralta R, Maciejewski K, Patel A, Rubman S, To U, Tomlin R, Schilsky M, Zimbrean P. Major Depressive Disorder in an International Multisite Wilson Disease Registry. Journal Of The Academy Of Consultation-Liaison Psychiatry 2022, 64: 106-117. PMID: 36521682, DOI: 10.1016/j.jaclp.2022.12.001.Peer-Reviewed Original ResearchConceptsMajor depressive disorderWilson's diseaseDepressive disorderLifetime major depressive disorderMental health QOLPhysical health QoLMajor depressive episodeMental health qualityStructured psychiatric evaluationSignificant differencesCross-sectional reportsLiver testsLiver diseaseNeurological assessmentLife scoresClinical correlatesDepressive episodePsychiatric symptomsPsychiatric evaluationDisease RegistrySevere anxietyLaboratory testsLifetime historySignificant associationPatientsA multidisciplinary approach to the diagnosis and management of Wilson disease: 2022 practice guidance on Wilson disease from the American Association for the Study of Liver Diseases
Schilsky ML, Roberts EA, Bronstein JM, Dhawan A, Hamilton JP, Rivard AM, Washington MK, Weiss KH, Zimbrean PC. A multidisciplinary approach to the diagnosis and management of Wilson disease: 2022 practice guidance on Wilson disease from the American Association for the Study of Liver Diseases. Hepatology 2022 PMID: 36151586, DOI: 10.1002/hep.32801.Peer-Reviewed Original ResearchA multidisciplinary approach to the diagnosis and management of Wilson disease: Executive summary of the 2022 Practice Guidance on Wilson disease from the American Association for the Study of Liver Diseases
Schilsky ML, Roberts EA, Bronstein JM, Dhawan A, Hamilton JP, Rivard AM, Washington MK, Weiss KH, Zimbrean PC. A multidisciplinary approach to the diagnosis and management of Wilson disease: Executive summary of the 2022 Practice Guidance on Wilson disease from the American Association for the Study of Liver Diseases. Hepatology 2022, 77: 1428-1455. PMID: 36152019, DOI: 10.1002/hep.32805.Peer-Reviewed Original Research
2021
The Effect of Mental Health, Neurological Disease, and Liver Disease on Quality of Life in Patients With Wilson Disease
Camarata MA, Ala A, Coskun AK, Deng Y, Gonzalez-Peralta R, Maciejewski KR, Patel A, Rubman S, To U, Tomlin R, Schilsky ML, Zimbrean PC. The Effect of Mental Health, Neurological Disease, and Liver Disease on Quality of Life in Patients With Wilson Disease. Journal Of The Academy Of Consultation-Liaison Psychiatry 2021, 62: 528-537. PMID: 34044196, PMCID: PMC11165927, DOI: 10.1016/j.jaclp.2021.04.004.Peer-Reviewed Original ResearchConceptsRating Scale scoresP-QOL scoresP-QOLNeurological diseasesWilson's diseaseMental healthOverall QoLUnified Wilson's Disease Rating Scale scoreScale scoreEnd-stage liver disease (MELD) scoreDisease severityStage liver disease scoreDegree of liverNeurological disease severityLiver Disease scoreLiver disease severityMajor depressive disorderQuality of lifeMental health issuesChild-PughCirrhosis severityLiver diseaseNeurological assessmentPatients' qualityChronic disorders
2020
P12 Effect of liver disease, neurological disease and mental health issues on quality of life in patients with wilson disease
Camarata M, Ala A, Maciejewski K, To U, Zimbrean P, Rubman S, Coskun A, Patel A, Wadhwa A, Apdik T, Tomlin R, Deng Y, Gonzalez-Peralta R, Schilsky M. P12 Effect of liver disease, neurological disease and mental health issues on quality of life in patients with wilson disease. Gut 2020, 69: a13-a13. DOI: 10.1136/gutjnl-2020-basl.23.Peer-Reviewed Original ResearchMental health issuesWilson's diseaseHealth issuesSeverity of liverMental health QOLPhysical health QoLReview of imagingP-QOL scoresQuality of lifeFIB4 scoreAdult patientsRegistry studyNeurological assessmentPhysical health issuesChronic diseasesOutcome measuresPatientsNeurological diseasesWD patientsQoLAssess qualityDiseaseCirrhosisSignificant differencesScoresP13 Major depressive disorder in patients with wilson’s disease: relationship with liver disease, neurological disease and quality of life
Camarata M, Ala A, Maciejewski K, To U, Zimbrean P, Rubman S, Patel A, Wadhwa A, Coskun A, Apdik T, Tomlin R, Deng Y, Schilsky M. P13 Major depressive disorder in patients with wilson’s disease: relationship with liver disease, neurological disease and quality of life. Gut 2020, 69: a13-a13. DOI: 10.1136/gutjnl-2020-basl.24.Peer-Reviewed Original ResearchMajor depressive disorderQuality of lifeMental health QOLWilson's diseaseNeurological diseasesLiver diseaseDepressive disorderFirst presentationExact testDepression symptomologySeverity of liverLifetime major depressive disorderLiver disease severityFisher's exact testPhysical health QOLSignificant differencesWilcoxon rank sum testMental health problemsRank sum testFIB4 scoreClinical featuresNeurological assessmentPHQ-9PatientsCurrent depressionFRI303 Major depressive disorder in patients with Wilson’s disease: relationship with liver disease, neurological disease and quality of life
Camarata M, Ala A, To U, Zimbrean P, Rubman S, Patel A, Wadhwa A, Maciejewski K, Song X, Deng Y, Tomlin R, Apdik T, Coskun A, Schilsky M. FRI303 Major depressive disorder in patients with Wilson’s disease: relationship with liver disease, neurological disease and quality of life. Journal Of Hepatology 2020, 73: s550-s551. DOI: 10.1016/s0168-8278(20)31573-7.Peer-Reviewed Original Research
2019
Chapter 19 Wilson Disease Psychiatric Aspects
Zimbrean P. Chapter 19 Wilson Disease Psychiatric Aspects. 2019, 215-225. DOI: 10.1016/b978-0-12-810532-0.00019-7.Peer-Reviewed Original ResearchQuality of lifeWilson's diseasePsychiatric presentationsGoals of careNewer psychotropic medicationsIrreversible cognitive declineCommon presentationNeurological findingsSymptomatic treatmentPsychotropic medicationsCurrent treatmentGeneral populationPsychiatric aspectsCognitive declineFunctional psychosesWD patientsCognitive deficitsMood instabilitySymptomsTreatmentPresentationSecondary effectsRemissionMedicationsPatientsChapter 14 Psychiatric Symptoms in WD
Zimbrean P. Chapter 14 Psychiatric Symptoms in WD. 2019, 159-170. DOI: 10.1016/b978-0-12-811077-5.00014-1.Peer-Reviewed Original ResearchWilson's diseasePsychiatric presentationsGoals of careNewer psychotropic medicationsSevere side effectsQuality of lifeIrreversible cognitive declineNeurological findingsPatients' qualitySymptomatic treatmentPsychotropic medicationsCurrent treatmentPsychiatric symptomsMood symptomsGeneral populationSide effectsFunctional psychosesCognitive declineWD patientsCognitive deficitsMood instabilitySymptomsTreatmentPresentationRemission
2018
Psychiatric Aspects of Wilson Disease
Munjal S, Zimbrean P. Psychiatric Aspects of Wilson Disease. Clinical Gastroenterology 2018, 121-142. DOI: 10.1007/978-3-319-91527-2_7.Peer-Reviewed Original Research
2017
Psychiatric comorbidity in Wilson’s disease
Mura G, Zimbrean PC, Demelia L, Carta MG. Psychiatric comorbidity in Wilson’s disease. International Review Of Psychiatry 2017, 29: 445-462. PMID: 28681670, DOI: 10.1080/09540261.2017.1311845.Peer-Reviewed Original ResearchConceptsWilson's diseasePsychiatric disordersCase-control studyAutosomal recessive inherited disorderPubMed/MEDLINERare autosomal recessive inherited disorderBetter life expectancyRecessive inherited disorderPsychiatric comorbidityCase reportSpecific therapyAvailable treatmentsPsychiatric disturbancesHigh prevalenceMood disordersPsychiatric symptomsPsychiatric outcomesClinical monitoringTherapeutic issuesPsychosocial outcomesInherited disorderRelevant articlesDiseaseGoogle ScholarCareful evaluationChapter 11 Cognitive and psychiatric symptoms in Wilson disease
Zimbrean P, Seniów J. Chapter 11 Cognitive and psychiatric symptoms in Wilson disease. Handbook Of Clinical Neurology 2017, 142: 121-140. PMID: 28433097, DOI: 10.1016/b978-0-444-63625-6.00011-2.Peer-Reviewed Original ResearchConceptsWilson's diseaseClinical experienceAuthors' clinical experienceNonpharmacologic treatmentsGreat masqueraderIndividual patientsPsychiatric symptomsMood disturbanceCognitive symptomsPsychiatric pathologyCognitive deficitsDiseaseSymptomsExecutive functionImpairmentPatientsPrevalencePsychosisPathology
2015
Delay in Diagnosis of Wilson Disease in Children With Insidious Psychiatric Symptoms: A Case Report and Review of the Literature
Millard H, Zimbrean P, Martin A. Delay in Diagnosis of Wilson Disease in Children With Insidious Psychiatric Symptoms: A Case Report and Review of the Literature. Journal Of The Academy Of Consultation-Liaison Psychiatry 2015, 56: 700-705. PMID: 26481962, DOI: 10.1016/j.psym.2015.07.008.Peer-Reviewed Educational Materials
2013
Psychiatric aspects of Wilson disease: a review
Zimbrean PC, Schilsky ML. Psychiatric aspects of Wilson disease: a review. General Hospital Psychiatry 2013, 36: 53-62. PMID: 24120023, DOI: 10.1016/j.genhosppsych.2013.08.007.Peer-Reviewed Original ResearchConceptsPsychiatric symptomsPsychiatric manifestationsWilson's diseasePsychiatric disordersPercent of patientsTime of diagnosisDiagnosis of WDCertain gene mutationsHepatic involvementNeurologic involvementClinical presentationPsychiatric presentationsCurrent evidencePsychiatric aspectsPubMed databaseWD patientsSymptomsDiseaseDiagnosisWD diagnosisGene mutationsAverage timePatientsManifestationsDisorders