2022
Major Depressive Disorder in an International Multisite Wilson Disease Registry
Camarata M, Ala A, Coskun A, Deng Y, Embel V, Gonzalez-Peralta R, Maciejewski K, Patel A, Rubman S, To U, Tomlin R, Schilsky M, Zimbrean P. Major Depressive Disorder in an International Multisite Wilson Disease Registry. Journal Of The Academy Of Consultation-Liaison Psychiatry 2022, 64: 106-117. PMID: 36521682, DOI: 10.1016/j.jaclp.2022.12.001.Peer-Reviewed Original ResearchConceptsMajor depressive disorderWilson's diseaseDepressive disorderLifetime major depressive disorderMental health QOLPhysical health QoLMajor depressive episodeMental health qualityStructured psychiatric evaluationSignificant differencesCross-sectional reportsLiver testsLiver diseaseNeurological assessmentLife scoresClinical correlatesDepressive episodePsychiatric symptomsPsychiatric evaluationDisease RegistrySevere anxietyLaboratory testsLifetime historySignificant associationPatients
2019
Chapter 14 Psychiatric Symptoms in WD
Zimbrean P. Chapter 14 Psychiatric Symptoms in WD. 2019, 159-170. DOI: 10.1016/b978-0-12-811077-5.00014-1.Peer-Reviewed Original ResearchWilson's diseasePsychiatric presentationsGoals of careNewer psychotropic medicationsSevere side effectsQuality of lifeIrreversible cognitive declineNeurological findingsPatients' qualitySymptomatic treatmentPsychotropic medicationsCurrent treatmentPsychiatric symptomsMood symptomsGeneral populationSide effectsFunctional psychosesCognitive declineWD patientsCognitive deficitsMood instabilitySymptomsTreatmentPresentationRemission
2018
Perioperative Psychiatric Aspects in Neurosurgery
Munjal S, Zimbrean P. Perioperative Psychiatric Aspects in Neurosurgery. 2018, 145-171. DOI: 10.1007/978-3-319-99774-2_10.Peer-Reviewed Original ResearchComorbid neurological conditionsPerioperative psychiatric symptomsTraumatic brain injuryCommon neurosurgical procedurePsychotropic medicationsNeurosurgical treatmentPsychiatric presentationsBrain injuryNeurosurgical interventionPerioperative settingNeurological conditionsPsychiatric symptomsNeurosurgical conditionsPsychiatric assessmentBrain tumorsPsychiatric aspectsPsychiatric conditionsNeurosurgical proceduresPsychoactive effectsMedicationsSymptomsPatientsEpilepsyInjuryTumorsPsychiatric Aspects of Wilson Disease
Munjal S, Zimbrean P. Psychiatric Aspects of Wilson Disease. Clinical Gastroenterology 2018, 121-142. DOI: 10.1007/978-3-319-91527-2_7.Peer-Reviewed Original Research
2017
Psychiatric comorbidity in Wilson’s disease
Mura G, Zimbrean PC, Demelia L, Carta MG. Psychiatric comorbidity in Wilson’s disease. International Review Of Psychiatry 2017, 29: 445-462. PMID: 28681670, DOI: 10.1080/09540261.2017.1311845.Peer-Reviewed Original ResearchConceptsWilson's diseasePsychiatric disordersCase-control studyAutosomal recessive inherited disorderPubMed/MEDLINERare autosomal recessive inherited disorderBetter life expectancyRecessive inherited disorderPsychiatric comorbidityCase reportSpecific therapyAvailable treatmentsPsychiatric disturbancesHigh prevalenceMood disordersPsychiatric symptomsPsychiatric outcomesClinical monitoringTherapeutic issuesPsychosocial outcomesInherited disorderRelevant articlesDiseaseGoogle ScholarCareful evaluationChapter 11 Cognitive and psychiatric symptoms in Wilson disease
Zimbrean P, Seniów J. Chapter 11 Cognitive and psychiatric symptoms in Wilson disease. Handbook Of Clinical Neurology 2017, 142: 121-140. PMID: 28433097, DOI: 10.1016/b978-0-444-63625-6.00011-2.Peer-Reviewed Original ResearchConceptsWilson's diseaseClinical experienceAuthors' clinical experienceNonpharmacologic treatmentsGreat masqueraderIndividual patientsPsychiatric symptomsMood disturbanceCognitive symptomsPsychiatric pathologyCognitive deficitsDiseaseSymptomsExecutive functionImpairmentPatientsPrevalencePsychosisPathology
2015
Delay in Diagnosis of Wilson Disease in Children With Insidious Psychiatric Symptoms: A Case Report and Review of the Literature
Millard H, Zimbrean P, Martin A. Delay in Diagnosis of Wilson Disease in Children With Insidious Psychiatric Symptoms: A Case Report and Review of the Literature. Journal Of The Academy Of Consultation-Liaison Psychiatry 2015, 56: 700-705. PMID: 26481962, DOI: 10.1016/j.psym.2015.07.008.Peer-Reviewed Educational Materials
2013
Psychiatric aspects of Wilson disease: a review
Zimbrean PC, Schilsky ML. Psychiatric aspects of Wilson disease: a review. General Hospital Psychiatry 2013, 36: 53-62. PMID: 24120023, DOI: 10.1016/j.genhosppsych.2013.08.007.Peer-Reviewed Original ResearchConceptsPsychiatric symptomsPsychiatric manifestationsWilson's diseasePsychiatric disordersPercent of patientsTime of diagnosisDiagnosis of WDCertain gene mutationsHepatic involvementNeurologic involvementClinical presentationPsychiatric presentationsCurrent evidencePsychiatric aspectsPubMed databaseWD patientsSymptomsDiseaseDiagnosisWD diagnosisGene mutationsAverage timePatientsManifestationsDisorders