2024
Physical space of thirty pediatric intensive care units in the United States of America: a national survey
Karam O, Ahmed A, Bizzarro M, Bogue C, Giuliano J, Collaborative P, Al-Subu A, Bateman S, Berning E, Brown K, Bulut Y, Cheifetz I, Chegondi M, Cholette J, Cowl A, Ceneviva G, Gehlbach J, Hobson M, Kudchadkar S, Labarinas S, Louis C, Miller M, Marinello M, Malone M, Nair A, Nishisaki A, Lowrie L, Rehder K, Rozenfeld R, Schneider J, Sequeira J, Shein S, Stalets E, Taylor J, Yager P. Physical space of thirty pediatric intensive care units in the United States of America: a national survey. Frontiers In Pediatrics 2024, 12: 1473805. PMID: 39359742, PMCID: PMC11445063, DOI: 10.3389/fped.2024.1473805.Peer-Reviewed Original ResearchRoom sizePediatric intensive care unitPhysical spaceConstruction of hospitalsIntensive care unitBuilding yearDesign practiceCare unitBuildings dateRoom designPrivate bathroomsOccupancy rateDouble roomRenovationBathroomCompliant unitsRoom characteristicsAmenitiesDesignConstructionIntermediate care unitCardiac ICUClinical outcomesInterquartile rangeUnit typesClinical outcomes in critically ill children on extracorporeal membrane oxygenation with severe thrombocytopenia.
Labarinas S, Norbisrath K, Johnson D, Meliones J, Greenleaf C, Salazar J, Karam O. Clinical outcomes in critically ill children on extracorporeal membrane oxygenation with severe thrombocytopenia. Perfusion 2024, 2676591241247981. PMID: 38626382, DOI: 10.1177/02676591241247981.Peer-Reviewed Original ResearchExtracorporeal membrane oxygenationExtracorporeal membrane oxygenation daysCritically ill childrenSevere thrombocytopeniaPlatelet countPlatelet transfusionsMembrane oxygenationIll childrenMortality rateDuration of extracorporeal membrane oxygenationAssociated with in-hospital mortality ratesExtracorporeal membrane oxygenation durationSingle-center retrospective studyPlatelet transfusion strategyFrequent platelet transfusionsIn-hospital mortality rateAssociated with bleedingTransfusion strategyAssociated with higher proportionsMedian weightMulticenter studyRetrospective studyClinical outcomesOn-ECMOThrombocytopenia
2023
105: Clinical Outcomes in Critically Ill Children on Extracorporeal Membrane Oxygenation with Severe Thrombocytopenia.
Labarinas S, Singh K, Meliones J, Johnson D, Greenleaf C, Salazar J, Karam O. 105: Clinical Outcomes in Critically Ill Children on Extracorporeal Membrane Oxygenation with Severe Thrombocytopenia. ASAIO Journal 2023, 69: 57-57. DOI: 10.1097/01.mat.0000990932.67126.dc.Peer-Reviewed Original Research
2021
Epidemiology of Bleeding in Critically Ill Children
Sequeira J, Nellis ME, Karam O. Epidemiology of Bleeding in Critically Ill Children. Frontiers In Pediatrics 2021, 9: 699991. PMID: 34422724, PMCID: PMC8371326, DOI: 10.3389/fped.2021.699991.Peer-Reviewed Original ResearchPediatric critical care unitRisk of mortalityCritical care unitsIll childrenCare unitClinical outcomesProspective observational cohort studyEpidemiology of BleedingPICU-free daysPercent of patientsVentilator-free daysDuration of surgeryObservational cohort studyCritically Ill ChildrenWorse clinical outcomesType of surgeryFurther multicenter studiesHigher severityCohort studyCritical illnessPediatric IndexSevere complicationsConsecutive patientsIll patientsMedian ageBleeding in Critically Ill Children—Review of Literature, Knowledge Gaps, and Suggestions for Future Investigation
Aran AA, Karam O, Nellis ME. Bleeding in Critically Ill Children—Review of Literature, Knowledge Gaps, and Suggestions for Future Investigation. Frontiers In Pediatrics 2021, 9: 611680. PMID: 33585373, PMCID: PMC7873638, DOI: 10.3389/fped.2021.611680.Peer-Reviewed Original Research
2020
Effect of platelet storage duration on clinical outcomes and incremental platelet change in critically ill children
Nellis ME, Spinella PC, Tucci M, Stanworth SJ, Steiner ME, Cushing MM, Davis PJ, Karam O, The Pediatric Acute Lung Injury and Sepsis Investigators network P. Effect of platelet storage duration on clinical outcomes and incremental platelet change in critically ill children. Transfusion 2020, 60: 2849-2858. PMID: 32959409, PMCID: PMC8396066, DOI: 10.1111/trf.16094.Peer-Reviewed Original ResearchConceptsClinical outcomesIll childrenPLT transfusionsObservational point prevalence studyPediatric intensive care unitStorage ageSafety of plateletsFurther prospective evaluationPoint prevalence studyIntensive care unitImmune system dysfunctionFebrile transfusion reactionsDays of ageScreening weekCare unitProspective evaluationSystem dysfunctionTransfusion reactionsPlatelet changesTransfusionPLT countTransfusion efficacyAge groupsSecondary analysisSignificant associationAssociation Between Lactates, Blood Glucose, and Systemic Oxygen Delivery in Children After Cardiopulmonary Bypass
Klee P, Rimensberger PC, Karam O. Association Between Lactates, Blood Glucose, and Systemic Oxygen Delivery in Children After Cardiopulmonary Bypass. Frontiers In Pediatrics 2020, 8: 332. PMID: 32656170, PMCID: PMC7325592, DOI: 10.3389/fped.2020.00332.Peer-Reviewed Original ResearchPediatric critical care unitPICU admissionSystemic oxygen deliveryCardiopulmonary bypassCritical care unitsOxygen extractionBlood glucoseOxygen deliveryCardiac surgeryCare unitLow systemic oxygen deliveryObservational cohort studyDuration of bypassWorse clinical outcomesHigher oxygen extractionLogistic regression modelsCohort studyCardiac lesionsClinical outcomesSurrogate markerPyruvate ratioAdmissionHyperlactatemiaSame timepointsBypass
2019
Quantifiable Bleeding in Children Supported by Extracorporeal Membrane Oxygenation and Outcome.
Nellis ME, Dalton H, Karam O. Quantifiable Bleeding in Children Supported by Extracorporeal Membrane Oxygenation and Outcome. Critical Care Medicine 2019, 47: e886-e892. PMID: 31449061, PMCID: PMC8608374, DOI: 10.1097/ccm.0000000000003968.Peer-Reviewed Original ResearchConceptsChest tube bleedingExtracorporeal membrane oxygenationCollaborative Pediatric Critical Care Research NetworkMembrane oxygenationChest tubeClinical outcomesPlatelet countML/Large observational cohort studyEunice Kennedy Shriver National InstituteCritical Care Research NetworkPICU-free daysPercent of patientsObservational cohort studyWorse clinical outcomesHuman Development Collaborative Pediatric Critical Care Research NetworkMembrane oxygenation specialistsHospital mortalityTransfusion volumeCohort studyHeparin doseConsecutive patientsThrombotic eventsPediatric institutionHemostatic testsBleeding Scales Applicable to Critically Ill Children: A Systematic Review.
Nellis ME, Levasseur J, Stribling J, Faustino EVS, Zantek ND, Sheth S, Karam O. Bleeding Scales Applicable to Critically Ill Children: A Systematic Review. Pediatric Critical Care Medicine 2019, 20: 603-607. PMID: 30925573, DOI: 10.1097/pcc.0000000000001943.Peer-Reviewed Original ResearchConceptsIll childrenIdiopathic thrombocytopenic purpuraFull-text articlesBleeding scoreBleeding scaleClinical outcomesIll patientsThrombocytopenic purpuraOvid EmbaseCochrane LibraryDatabase inceptionOvid MEDLINEElectronic searchUnique citationsSystematic reviewFinal reviewClinical measurementsOutpatientsInpatientsChildrenAdultsOutcomesBleedingPurpuraHemorrhageEffects of Blindfold on Leadership in Pediatric Resuscitation Simulation: A Randomized Trial
Buyck M, Manzano S, Haddad K, Moncousin AC, Galetto-Lacour A, Blondon K, Karam O. Effects of Blindfold on Leadership in Pediatric Resuscitation Simulation: A Randomized Trial. Frontiers In Pediatrics 2019, 7: 10. PMID: 30838188, PMCID: PMC6383074, DOI: 10.3389/fped.2019.00010.Peer-Reviewed Original ResearchPediatric resuscitationControl groupPediatric emergency nursesSimulation-based trainingSelf-reported changesClinical outcomesEmergency nursesSurvival rateResuscitationPediatric residentsNon-clinical skillsResuscitation scenariosResuscitation simulationVideo-recorded scenariosFuture studiesRare eventGroupNursesTrials
2018
Prognostic Evaluation of Mortality after Pediatric Resuscitation Assisted by Extracorporeal Life Support
De Mul A, Nguyen DA, Doell C, Perez MH, Cannizzaro V, Karam O. Prognostic Evaluation of Mortality after Pediatric Resuscitation Assisted by Extracorporeal Life Support. Journal Of Pediatric Intensive Care 2018, 08: 057-063. PMID: 31093456, PMCID: PMC6517051, DOI: 10.1055/s-0038-1667012.Peer-Reviewed Original ResearchExtracorporeal life supportECLS initiationCPR durationClinical outcomesCardiopulmonary resuscitationPediatric intensive care unitLife supportReceiver-operating characteristic curveIntensive care unitPositive predictive valueActive resuscitationMedian agePrognostic factorsCare unitCardiac patientsPrognostic evaluationRetrospective analysisMortality ratePredictive valueSurvival ratePatientsStudy settingMortalityECPRCharacteristic curve
2016
Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions
Karam O, Demaret P, Duhamel A, Shefler A, Spinella PC, Stanworth SJ, Tucci M, Leteurtre S, for the PlasmaTV investigators. Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions. Annals Of Intensive Care 2016, 6: 98. PMID: 27714707, PMCID: PMC5053948, DOI: 10.1186/s13613-016-0197-6.Peer-Reviewed Original ResearchPELOD-2 scorePlasma transfusionIll childrenDay 1General pediatric intensive care unit populationPediatric Logistic Organ Dysfunction-2 scorePediatric intensive care unit populationIntensive care unit populationSpecific subpopulationsOrgan dysfunction scoreProspective observational studyHosmer-Lemeshow testObserved mortality ratePELOD-2Dysfunction scoreClinical outcomesOrgan failureResultsFour hundredClinical trialsScore scoresSerial evaluationAncillary studiesObservational studyTransfusionUnit populationIdentifying Prognostic Criteria for Survival after Resuscitation Assisted by Extracorporeal Membrane Oxygenation
Brunner A, Dubois N, Rimensberger PC, Karam O. Identifying Prognostic Criteria for Survival after Resuscitation Assisted by Extracorporeal Membrane Oxygenation. Critical Care Research And Practice 2016, 2016: 9521091. PMID: 27006826, PMCID: PMC4781941, DOI: 10.1155/2016/9521091.Peer-Reviewed Original ResearchECMO-cardiopulmonary resuscitationExtracorporeal membrane oxygenationMembrane oxygenationNormal cognitive statusECMO initiationHospital staySpastic quadriplegiaPrognostic factorsSuccessful weaningClinical outcomesPoor outcomeAppropriate indicationsPrognostic criteriaCardiopulmonary resuscitationSurvival ratePatientsCognitive statusLower lactateOverall rateResuscitationSurvivalChildrenSurvivorsOxygenationShorter length
2015
Clinical Outcomes Associated With RBC Transfusions in Critically Ill Children
Demaret P, Tucci M, Karam O, Trottier H, Ducruet T, Lacroix J. Clinical Outcomes Associated With RBC Transfusions in Critically Ill Children. Pediatric Critical Care Medicine 2015, 16: 505-514. PMID: 25905491, DOI: 10.1097/pcc.0000000000000423.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesChildChild, PreschoolCritical CareCritical IllnessErythrocyte TransfusionFemaleHumansInfantInfant, NewbornIntensive Care Units, PediatricLength of StayMaleMultiple Organ FailureOxygenPartial PressureProspective StudiesRenal Replacement TherapyRespiration, ArtificialTime FactorsTreatment OutcomeConceptsProgressive multiple organ dysfunction syndromeMultiple organ dysfunction syndromeFirst RBC transfusionOrgan dysfunction syndromeRBC transfusionIll childrenDysfunction syndromeRenal replacement therapyTertiary children's hospitalCritically Ill ChildrenProspective observational studyArterial partial pressurePICU lengthProlonged PICUPICU patientsMedical chartsClinical outcomesMechanical ventilationMultivariable analysisChildren's HospitalPotential confoundersReplacement therapyConsecutive admissionsPotential complicationsOdds ratio
2013
Plasma transfusion strategies for critically ill patients
Karam O, Tucci M, Combescure C, Lacroix J, Rimensberger PC. Plasma transfusion strategies for critically ill patients. Cochrane Database Of Systematic Reviews 2013, cd010654. PMID: 24374651, DOI: 10.1002/14651858.cd010654.pub2.Peer-Reviewed Original ResearchConceptsIll patientsPlasma transfusionTransfusion strategyCoagulation testsCochrane Injuries Group's Specialised RegisterInjuries Group Specialised RegisterGroup Specialised RegisterMild coagulation abnormalitiesAbnormal coagulation testsCochrane Central RegisterRisk of bleedingWorse clinical outcomesNon-Indexed CitationsSpecialised RegisterLack of evidenceTransfusion thresholdTrial qualityCentral RegisterCoagulation abnormalitiesCochrane HandbookControlled TrialsReview authorsTrials RegistryClinical effectsClinical outcomesAssociation between plasma transfusions and clinical outcome in critically ill children: a prospective observational study
Karam O, Lacroix J, Robitaille N, Rimensberger PC, Tucci M. Association between plasma transfusions and clinical outcome in critically ill children: a prospective observational study. Vox Sanguinis 2013, 104: 342-349. PMID: 23294337, DOI: 10.1111/vox.12009.Peer-Reviewed Original ResearchConceptsProgressive multiple organ dysfunction syndromeMultiple organ dysfunction syndromeOrgan dysfunction syndromeIntensive care unit lengthPlasma transfusionDysfunction syndromeClinical outcomesIll childrenNosocomial infectionsCare unitOdds ratioOutcome measuresPediatric intensive care unitPediatric critical care unitProspective pediatric studiesAdult trauma patientsProspective observational studySingle-center studySecondary outcome measuresWorse clinical outcomesExtracorporeal life supportPrimary outcome measureSeverity of illnessIntensive care unitCritical care units
2010
Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational study
Karam O, Tucci M, Bateman ST, Ducruet T, Spinella PC, Randolph AG, Lacroix J. Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational study. Critical Care 2010, 14: r57. PMID: 20377853, PMCID: PMC2887178, DOI: 10.1186/cc8953.Peer-Reviewed Original ResearchConceptsPediatric intensive care unitMultiple organ dysfunction syndromeRed blood cell unitsOrgan dysfunction syndromeDysfunction syndromeIll childrenPICU lengthClinical outcomesOdds ratioObservational studyMultiple logistic regression modelProspective observational studyWorse clinical outcomesPrimary outcome measureIntensive care unitNorth American centersCell unitsLogistic regression modelsSecondary outcomesConsecutive patientsOrgan dysfunctionCare unitMedian lengthProspective studyClinical impact