2023
The Biological Basis of Sex Differences in Athletic Performance: Consensus Statement for the American College of Sports Medicine
HUNTER S, ANGADI S, BHARGAVA A, HARPER J, HIRSCHBERG A, LEVINE B, MOREAU K, NOKOFF N, STACHENFELD N, BERMON S. The Biological Basis of Sex Differences in Athletic Performance: Consensus Statement for the American College of Sports Medicine. Medicine & Science In Sports & Exercise 2023, 55: 2328-2360. PMID: 37772882, DOI: 10.1249/mss.0000000000003300.Peer-Reviewed Original ResearchConceptsSex steroid hormonesConsensus statementAthletic performanceEndogenous sex steroid hormonesSex differencesSteroid hormonesOnset of pubertyExercise trainingMuscle strengthAcute boutFundamental sex differencesSex hormonesAmerican CollegeParticular testosteroneAdult menSports medicineTraining statusHigh-impact studiesHormoneSimilar ageNonphysiological factorsPrimary determinantMalesBiological basisWomen
2020
A recent history of preeclampsia is associated with elevated central pulse wave velocity and muscle sympathetic outflow
Usselman CW, Adler TE, Coovadia Y, Leone C, Paidas MJ, Stachenfeld NS. A recent history of preeclampsia is associated with elevated central pulse wave velocity and muscle sympathetic outflow. AJP Heart And Circulatory Physiology 2020, 318: h581-h589. PMID: 32004082, DOI: 10.1152/ajpheart.00578.2019.Peer-Reviewed Original ResearchConceptsMuscle sympathetic nerve activitySympathetic nerve activityArterial stiffnessBaroreflex sensitivityPreeclamptic womenUncomplicated pregnanciesNerve activityBlood pressureCardiovascular diseaseCentral pulse wave velocityCardiovagal baroreflex sensitivityElevated arterial stiffnessMuscle sympathetic outflowElevated cardiovascular riskHistory of preeclampsiaNormal blood pressurePeripheral arterial stiffnessSympathetic baroreflex sensitivitySympathetic nervous systemPulse wave velocityHigher MSNACardiovascular dysregulationSympathetic outflowCardiovascular riskNormal pregnancy
2019
Compromised endothelial function in transgender men taking testosterone
Gulanski BI, Flannery CA, Peter PR, Leone CA, Stachenfeld NS. Compromised endothelial function in transgender men taking testosterone. Clinical Endocrinology 2019, 92: 138-144. PMID: 31765022, PMCID: PMC6957681, DOI: 10.1111/cen.14132.Peer-Reviewed Original ResearchConceptsEndothelial functionTransgender menEndothelial dysfunctionCisgender femalesClinical cardiovascular riskCardiovascular risk factorsImpaired endothelial functionEarly follicular phaseAndrogen excessCardiovascular riskVasodilatory responseCoronary arteryHormonal milieuFollicular phaseTestosterone treatmentMenstrual cycleRisk factorsFemale genderAtherosclerotic plaquesEarly signsTestosteroneTotal TSImportant markerDysfunctionMenAndrogens drive microvascular endothelial dysfunction in women with polycystic ovary syndrome: role of the endothelin B receptor
Usselman CW, Yarovinsky T, Steele FE, Leone CA, Taylor HS, Bender JR, Stachenfeld NS. Androgens drive microvascular endothelial dysfunction in women with polycystic ovary syndrome: role of the endothelin B receptor. The Journal Of Physiology 2019, 597: 2853-2865. PMID: 30847930, DOI: 10.1113/jp277756.Peer-Reviewed Original ResearchMeSH KeywordsAdultAndrogensCardiovascular DiseasesDihydrotestosteroneEndothelin-1Endothelium, VascularEstrogensEthinyl EstradiolFemaleGlucose Tolerance TestHumansMicrovesselsNitric OxideObesityPolycystic Ovary SyndromeReceptor, Endothelin BSkinVascular Endothelial Growth Factor AVasodilationYoung AdultConceptsPolycystic ovary syndromeCardiovascular dysfunctionEndothelial dysfunctionOvary syndromeEndothelin-1Endothelial functionNO productionAndrogen receptor-dependent mannerEndothelin-B receptor subtypeCardiovascular risk factorsMicrovascular endothelial dysfunctionMicrovascular endothelial functionCutaneous vascular conductanceB receptor subtypesEndothelin B receptorLaser Doppler flowmetryNitric oxide inhibitionReceptor-dependent mannerEndothelial cell NO productionDose-response curveVasodilating responsePCOS subjectsLean womenObese womenVascular conductanceEffects of bazedoxifene/conjugated estrogens on reproductive endocrinology and reproductive tract ultrasonographic appearance in premenopausal women: a preliminary study
Flores VA, Leone C, Taylor HS, Stachenfeld NS. Effects of bazedoxifene/conjugated estrogens on reproductive endocrinology and reproductive tract ultrasonographic appearance in premenopausal women: a preliminary study. Gynecological Endocrinology 2019, 35: 390-394. PMID: 30668182, DOI: 10.1080/09513590.2018.1559288.Peer-Reviewed Original ResearchConceptsBZA/CEPremenopausal womenConjugated estrogensReproductive hormonesUltrasonographic appearanceBazedoxifene/conjugated estrogensAbnormal ovarian folliculogenesisReproductive hormone changesCase series studyUnited States FoodEstrogen-receptor complexEndometrial alterationsDaily administrationSerum assessmentLH surgeMenopausal womenMenopausal symptomsMenstrual cycleClinical trialsEndocrinologic functionsOvarian morphologyHormone levelsPosttreatment valuesMurine modelOvarian folliculogenesis
2018
Bazedoxifene–Conjugated Estrogens for Treating Endometriosis
Flores VA, Stachenfeld NS, Taylor HS. Bazedoxifene–Conjugated Estrogens for Treating Endometriosis. Obstetrics And Gynecology 2018, 132: 475-477. PMID: 29995747, DOI: 10.1097/aog.0000000000002739.Peer-Reviewed Original ResearchConceptsConjugated estrogensPelvic painTreatment optionsStage III endometriosisCyclic pelvic painFirst-line therapyReproductive-aged womenPotential treatment optionManagement of dysmenorrheaUnfavorable side effectsEndometriotic lesionsGynecologic disordersHormonal agentsMenopausal symptomsOvarian parametersSide effectsAnimal studiesEndometriosisEstrogenBazedoxifenePainEffective alternativeFailure rateAbnormal effectsDysmenorrheaBlood pressure predicts endothelial function and the effects of ethinyl estradiol exposure in young women
Adler TE, Usselman CW, Takamata A, Stachenfeld NS. Blood pressure predicts endothelial function and the effects of ethinyl estradiol exposure in young women. AJP Heart And Circulatory Physiology 2018, 315: h925-h933. PMID: 29906227, DOI: 10.1152/ajpheart.00188.2018.Peer-Reviewed Original ResearchMeSH KeywordsAdiposityAdministration, OralAdolescentAdultAntihypertensive AgentsArterial PressureBrachial ArteryDrug Administration ScheduleEndothelium, VascularEthinyl EstradiolExercise TestFemaleHand StrengthHumansHypertensionIschemiaObesityTime FactorsTreatment OutcomeVasodilator AgentsYoung AdultConceptsEthinyl estradiol administrationEndothelial functionBlood pressureEstradiol administrationEthinyl estradiol exposureEndothelial dysfunctionShear stress stimulusEndothelial impairmentEstradiol exposureHBP groupExercise responseNBP groupFlow-mediated dilation responseHigh blood pressure groupYoung womenIschemic handgrip exerciseOral ethinyl estradiolOvert cardiovascular dysfunctionBlood pressure groupFlow-mediated dilationNormal blood pressureHigh blood pressureMild hypertensionFMD responseHandgrip exercise
2017
Water intake reverses dehydration associated impaired executive function in healthy young women
Stachenfeld NS, Leone CA, Mitchell E, Freese E, Harkness L. Water intake reverses dehydration associated impaired executive function in healthy young women. Physiology & Behavior 2017, 185: 103-111. PMID: 29277553, DOI: 10.1016/j.physbeh.2017.12.028.Peer-Reviewed Original ResearchConceptsExecutive functionDaily levelsCognitive tasksVisual-Analogue TestImpairs memoryMemory errorsCognitive functionHealthy young womenSensory perceptionSession 1MemoryBalanced orderSessionsControl sessionAnalog testDeficitsAdult womenEmotionsCognitionYoung womenDaily activitiesPerceptionTaskPhysical activityLearningMild exercise in female subjects impairs complex learning independent of hydration status and emotion
Turner JM, Marsteller DA, Luxkaranayagam AT, Fletcher JM, Stachenfeld NS. Mild exercise in female subjects impairs complex learning independent of hydration status and emotion. Physiology & Behavior 2017, 180: 113-119. PMID: 28842190, DOI: 10.1016/j.physbeh.2017.08.013.Peer-Reviewed Original ResearchConceptsCognitive functionComplex learningMeasures of emotionTests of acquisitionMemory taskCognitive tasksFunction tasksEmotionsMaze learningMild aerobic exerciseTaskLearningImpact of exerciseMemoryAerobic exerciseDetrimental effectsNew knowledgeRecumbent bicycleExecutivesAcquisitionMeasuresMild hypohydrationExerciseA translational approach for NMDA receptor profiling as a vulnerability biomarker for depression and schizophrenia
Gunduz‐Bruce H, Kenney J, Changlani S, Peixoto A, Gueorguieva R, Leone C, Stachenfeld N. A translational approach for NMDA receptor profiling as a vulnerability biomarker for depression and schizophrenia. Quarterly Journal Of Experimental Physiology And Cognate Medical Sciences 2017, 102: 587-597. PMID: 28294453, DOI: 10.1113/ep086212.Peer-Reviewed Original ResearchConceptsSubgroup of patientsHealthy control subjectsNMDA receptorsControl subjectsDepressed patientsAVP releaseAnimal studiesSchizophrenic subjectsTranslational approachVivo evidenceRecent clinical trialsNMDA receptor functionPlasma arginine vasopressin concentrationNMDA receptor activityHypertonic saline infusionNMDA antagonist ketamineArginine vasopressin concentrationHypertonic salineInverse associationClinical trialsHealthy controlsSaline infusionGlutamate signalingSchizophrenic patientsVasopressin concentration
2015
Peripheral Microvascular Vasodilatory Response to Estradiol and Genistein in Women with Insulin Resistance
Wenner MM, Taylor HS, Stachenfeld NS. Peripheral Microvascular Vasodilatory Response to Estradiol and Genistein in Women with Insulin Resistance. Microcirculation 2015, 22: 391-399. PMID: 25996650, PMCID: PMC4506724, DOI: 10.1111/micc.12208.Peer-Reviewed Original ResearchConceptsL-NMMAMicrovascular vasodilationHealthy womenVasodilatory responsivenessLocal cutaneous heatingMicrovascular vasodilatory functionMicrovascular vasodilatory responsesBeat blood pressureHealthy young womenLaser Doppler flowmetryHeat-induced vasodilationMicrovascular responsivenessVascular effectsVasodilatory responseBlood pressureMicrovascular functionVasodilatory functionCutaneous heatingInsulin resistanceCutaneous circulationDoppler flowmetryGEN exposureInteraction of E2VasodilationMicrodialysis perfusion
2013
Androgens influence microvascular dilation in PCOS through ET-A and ET-B receptors
Wenner MM, Taylor HS, Stachenfeld NS. Androgens influence microvascular dilation in PCOS through ET-A and ET-B receptors. AJP Endocrinology And Metabolism 2013, 305: e818-e825. PMID: 23921139, PMCID: PMC3798701, DOI: 10.1152/ajpendo.00343.2013.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeET-B receptorsMicrovascular dilationHeat-induced vasodilationReceptor inhibitionET-B receptor antagonistGonadotropin-releasing hormone antagonistLaser Doppler flowmetryAndrogen suppressionOvary syndromeVascular dysfunctionHealthy womenT administrationEnhanced vasodilationHormone antagonistReceptor antagonistCutaneous microdialysisDoppler flowmetryTestosterone effectsSubtype receptorsVasodilationDay 8WomenDilationGnRHantMechanisms contributing to low orthostatic tolerance in women: the influence of oestradiol
Wenner MM, Haddadin A, Taylor HS, Stachenfeld NS. Mechanisms contributing to low orthostatic tolerance in women: the influence of oestradiol. The Journal Of Physiology 2013, 591: 2345-2355. PMID: 23401618, PMCID: PMC3650699, DOI: 10.1113/jphysiol.2012.247882.Peer-Reviewed Original ResearchConceptsLow orthostatic toleranceE2 administrationOrthostatic toleranceVascular resistanceBlood pressureStroke volumeHeart rateGonadotrophin-releasing hormone antagonistLevels of LBNPLower central volumeReproductive hormone productionAdministration of E2Peripheral vascular resistanceBeat blood pressureAutonomic cardiovascular regulationLower stroke volumeLower body negative pressure testHeart rate responseInfluence of oestradiolBaroreflex controlTolerant womenHormone antagonistCardiovascular regulationPeripheral vasoconstrictionAutonomic control
2012
The Effects of Undergarment Composition Worn Beneath Hockey Protective Equipment on High-Intensity Intermittent Exercise
Noonan B, Stachenfeld N. The Effects of Undergarment Composition Worn Beneath Hockey Protective Equipment on High-Intensity Intermittent Exercise. The Journal Of Strength And Conditioning Research 2012, 26: 2309-2316. PMID: 22706578, DOI: 10.1519/jsc.0b013e3182606e1e.Peer-Reviewed Original Research
2010
Tissue Doppler of Early Mitral Filling Correlates With Simulated Volume Loss in Healthy Subjects
Moore CL, Tham ET, Samuels KJ, McNamara RL, Galante NJ, Stachenfeld N, Shelley K, Dziura J, Silverman DG. Tissue Doppler of Early Mitral Filling Correlates With Simulated Volume Loss in Healthy Subjects. Academic Emergency Medicine 2010, 17: 1162-1168. PMID: 21175513, DOI: 10.1111/j.1553-2712.2010.00906.x.Peer-Reviewed Original ResearchConceptsInferior vena cavaLBNP levelsTissue DopplerHealthy subjectsVital signsPulsed-wave tissue DopplerLower body negative pressureLateral mitral annulusEmergency department patientsTissue Doppler assessmentTissue Doppler velocitiesEarly diastolic fillingAccurate noninvasive assessmentPulsed-wave spectral DopplerLate transmitralNegative pressure levelBlood pressureDepartment patientsDoppler assessmentVena cavaDiastolic fillingVolume lossCardiovascular diseaseMitral annulusFilling waveGreater Exercise Sweating in Obese Women with Polycystic Ovary Syndrome Compared with Obese Controls
STACHENFELD NS, YECKEL CW, TAYLOR HS. Greater Exercise Sweating in Obese Women with Polycystic Ovary Syndrome Compared with Obese Controls. Medicine & Science In Sports & Exercise 2010, 42: 1660-1668. PMID: 20195177, PMCID: PMC3109293, DOI: 10.1249/mss.0b013e3181d8cf68.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromePCOS groupOvary syndromeControl groupGonadotropin-releasing hormone antagonistObese controlsObese womenAge-predicted HRmaxCore temperature thresholdHormone antagonistTestosterone effectsDay 4GnRHantSweat volumeDay 13Total sweat lossHormone conditionsWomenSweatingE2Sweat lossSyndromeEstradiolTestosteroneThermoregulatory responses
2008
An Experimental Model of Heat Storage in Working Firefighters
Van Gelder CM, Pranger LA, Wiesmann WP, Stachenfeld N, Bogucki S. An Experimental Model of Heat Storage in Working Firefighters. Prehospital Emergency Care 2008, 12: 225-235. PMID: 18379922, DOI: 10.1080/10903120801907430.Peer-Reviewed Original Research
2007
The Effects of Hockey Protective Equipment on High-Intensity Intermittent Exercise
NOONAN B, MACK G, STACHENFELD N. The Effects of Hockey Protective Equipment on High-Intensity Intermittent Exercise. Medicine & Science In Sports & Exercise 2007, 39: 1327-1335. PMID: 17762366, DOI: 10.1249/mss.0b013e3180619644.Peer-Reviewed Original ResearchConceptsProtective equipmentExercise protocolSprint power outputHigh-intensity intermittent exerciseIntermittent exercise protocolCore temperaturePlasma lactate concentrationRecovery heart rateElevated body temperatureCotton undergarmentsExercise performanceIntermittent exerciseHeart rateBlood lactateCycle ergometerMean power outputFluid homeostasisLactate concentrationExogenous oestradiol and progesterone administration does not cause oedema in healthy young women
Stachenfeld NS, Taylor HS. Exogenous oestradiol and progesterone administration does not cause oedema in healthy young women. Clinical Endocrinology 2007, 66: 410-418. PMID: 17302877, DOI: 10.1111/j.1365-2265.2007.02748.x.Peer-Reviewed Original ResearchConceptsExtracellular fluid volumeTranscapillary albumin escape rateGonadotropin-releasing hormone antagonistPmol/Plasma renin activitySerum aldosterone concentrationHealthy young womenAlbumin escape rateRenin activityAldosterone concentrationGnRH antagonistHealthy womenProgesterone administrationExogenous oestradiolIntravascular volumeHormone antagonistProgesterone increaseDay 2Day 5Hormone treatmentOestradiolDay 13Extravascular componentOncotic pressureYoung women
2006
THE FEMALE ATHLETE TRIAD MYTH
DiPietro L, Stachenfeld NS. THE FEMALE ATHLETE TRIAD MYTH. Medicine & Science In Sports & Exercise 2006, 38: 795. PMID: 16679999, DOI: 10.1249/01.mss.0000210148.04162.23.Commentaries, Editorials and Letters