2024
The effect of acute estrogen suppression on cutaneous endothelium-dependent vasodilation in women with endometriosis
Colburn A, Leone C, Alexander L, Stachenfeld N. The effect of acute estrogen suppression on cutaneous endothelium-dependent vasodilation in women with endometriosis. Physiology 2024, 39: 421. DOI: 10.1152/physiol.2024.39.s1.421.Peer-Reviewed Original ResearchEndothelium-dependent vasodilationEstrogen suppressionHealthy controlsLDF/mean arterial pressureSodium nitroprusside perfusionDose-response curveLaser Doppler flowmetryCardiovascular disease riskCutaneous vascular conductanceACh doseEndometriosis patientsPerfusion of acetylcholineMenstrual cycleIntradermal microdialysisSuppress estrogenEndothelial functionArterial pressureEndometriosisVasodilatory functionDoppler flowmetryVascular conductanceVasodilationMaximal vasodilationGraded perfusionEstrogen
2019
Androgens drive microvascular endothelial dysfunction in women with polycystic ovary syndrome: role of the endothelin B receptor
Usselman CW, Yarovinsky T, Steele FE, Leone CA, Taylor HS, Bender JR, Stachenfeld NS. Androgens drive microvascular endothelial dysfunction in women with polycystic ovary syndrome: role of the endothelin B receptor. The Journal Of Physiology 2019, 597: 2853-2865. PMID: 30847930, DOI: 10.1113/jp277756.Peer-Reviewed Original ResearchMeSH KeywordsAdultAndrogensCardiovascular DiseasesDihydrotestosteroneEndothelin-1Endothelium, VascularEstrogensEthinyl EstradiolFemaleGlucose Tolerance TestHumansMicrovesselsNitric OxideObesityPolycystic Ovary SyndromeReceptor, Endothelin BSkinVascular Endothelial Growth Factor AVasodilationYoung AdultConceptsPolycystic ovary syndromeCardiovascular dysfunctionEndothelial dysfunctionOvary syndromeEndothelin-1Endothelial functionNO productionAndrogen receptor-dependent mannerEndothelin-B receptor subtypeCardiovascular risk factorsMicrovascular endothelial dysfunctionMicrovascular endothelial functionCutaneous vascular conductanceB receptor subtypesEndothelin B receptorLaser Doppler flowmetryNitric oxide inhibitionReceptor-dependent mannerEndothelial cell NO productionDose-response curveVasodilating responsePCOS subjectsLean womenObese womenVascular conductance
2017
Microvascular endothelial function in lean versus obese women with polycystic ovary syndrome: role of the endothelin B receptor
Usselman C, Taylor H, Stachenfeld N. Microvascular endothelial function in lean versus obese women with polycystic ovary syndrome: role of the endothelin B receptor. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.691.5.Peer-Reviewed Original ResearchPolycystic ovary syndromeLean polycystic ovary syndromeObese PCOS womenCutaneous vascular conductanceNitric oxide inhibitionObese womenET-1PCOS womenOvary syndromeVasodilatory responseEndothelial functionOxide inhibitionEndothelin receptor subtype BObese polycystic ovary syndromeIntradermal microdialysis perfusionCardiovascular risk factorsMicrovascular endothelial functionPlasma endothelin-1Adverse cardiovascular outcomesAmerican Heart AssociationEndothelin B receptorLaser Doppler flowmetryDose-response curveCardiovascular outcomesIndependent vasodilation
2015
Peripheral Microvascular Vasodilatory Response to Estradiol and Genistein in Women with Insulin Resistance
Wenner MM, Taylor HS, Stachenfeld NS. Peripheral Microvascular Vasodilatory Response to Estradiol and Genistein in Women with Insulin Resistance. Microcirculation 2015, 22: 391-399. PMID: 25996650, PMCID: PMC4506724, DOI: 10.1111/micc.12208.Peer-Reviewed Original ResearchConceptsL-NMMAMicrovascular vasodilationHealthy womenVasodilatory responsivenessLocal cutaneous heatingMicrovascular vasodilatory functionMicrovascular vasodilatory responsesBeat blood pressureHealthy young womenLaser Doppler flowmetryHeat-induced vasodilationMicrovascular responsivenessVascular effectsVasodilatory responseBlood pressureMicrovascular functionVasodilatory functionCutaneous heatingInsulin resistanceCutaneous circulationDoppler flowmetryGEN exposureInteraction of E2VasodilationMicrodialysis perfusion
2014
Dichotomous estradiol and genistein effects on cutaneous endothelium‐dependent vasodilation in women with and without insulin resistance (678.6)
Wenner M, Taylor H, Stachenfeld N. Dichotomous estradiol and genistein effects on cutaneous endothelium‐dependent vasodilation in women with and without insulin resistance (678.6). The FASEB Journal 2014, 28 DOI: 10.1096/fasebj.28.1_supplement.678.6.Peer-Reviewed Original ResearchEndothelial-dependent dilationInsulin-resistant womenCutaneous vascular conductanceL-NMMAHealthy womenGenistein effectsEndothelium-dependent vasodilationLaser Doppler flowmetryResistant womenVascular conductanceE2 effectsInsulin resistanceMicrodialysis infusionDependent dilationDoppler flowmetryGEN effectsWomenE2National InstituteGrant funding sourcesC heatingCVCmaxVasodilationCardioprotectionFlowmetry
2013
Androgens influence microvascular dilation in PCOS through ET-A and ET-B receptors
Wenner MM, Taylor HS, Stachenfeld NS. Androgens influence microvascular dilation in PCOS through ET-A and ET-B receptors. AJP Endocrinology And Metabolism 2013, 305: e818-e825. PMID: 23921139, PMCID: PMC3798701, DOI: 10.1152/ajpendo.00343.2013.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeET-B receptorsMicrovascular dilationHeat-induced vasodilationReceptor inhibitionET-B receptor antagonistGonadotropin-releasing hormone antagonistLaser Doppler flowmetryAndrogen suppressionOvary syndromeVascular dysfunctionHealthy womenT administrationEnhanced vasodilationHormone antagonistReceptor antagonistCutaneous microdialysisDoppler flowmetryTestosterone effectsSubtype receptorsVasodilationDay 8WomenDilationGnRHantETA subtype receptor sensitivity to testosterone contributes to microvascular dysfunction in PCOS
Stachenfeld N, Wenner M, Taylor H. ETA subtype receptor sensitivity to testosterone contributes to microvascular dysfunction in PCOS. The FASEB Journal 2013, 27: 1133.10-1133.10. DOI: 10.1096/fasebj.27.1_supplement.1133.10.Peer-Reviewed Original ResearchPolycystic ovary syndromeCutaneous vascular conductanceHeat-induced vasodilationEndothelium-mediated vasodilationETB receptor antagonistLaser Doppler flowmetryETA blockadeTestosterone contributesEndothelial dysfunctionOvary syndromeVascular conductanceVasoconstrictor toneETA receptorsHormone antagonistReceptor antagonistMicrodialysis infusionSex hormonesDoppler flowmetryReceptor mechanismsReceptor sensitivityDay 8Day 4VasodilationDysfunctionAntagonist
2011
Sex differences in endothelial function in the microvasculature: effects of PCOS
Stachenfeld N, Wenner M, Taylor H. Sex differences in endothelial function in the microvasculature: effects of PCOS. The FASEB Journal 2011, 25: 837.2-837.2. DOI: 10.1096/fasebj.25.1_supplement.837.2.Peer-Reviewed Original ResearchPolycystic ovary syndromeETB receptorsEffects of PCOSHeart disease riskLaser Doppler flowmetrySkin blood flowNormal reproductive functionDose-response curveEndothelial dysfunctionOvary syndromeVasoconstrictive responseVasodilatory responseEndothelial functionCutaneous microvasculatureETA receptorsHealthy womenAntagonist infusionDoppler flowmetrySmooth muscleBlood flowReceptor AReproductive functionDisease riskWomenReceptorsTestosterone lowers microvascular ET‐B receptor responsiveness in women with PCOS
Wenner M, Taylor H, Stachenfeld N. Testosterone lowers microvascular ET‐B receptor responsiveness in women with PCOS. The FASEB Journal 2011, 25: lb559-lb559. DOI: 10.1096/fasebj.25.1_supplement.lb559.Peer-Reviewed Original ResearchPolycystic ovary syndromeHeat-induced vasodilationT administrationCutaneous vascular conductance responsesET-1 plasma concentrationsET-B receptor antagonistImpaired microvascular functionET-B receptorsVascular conductance responsesEndogenous sex hormonesLaser Doppler flowmetryPCOS showOvary syndromeGnRH antagonistMicrovascular functionVascular dysfunctionReceptor antagonistReceptor responsivenessMicrodialysis infusionSex hormonesPlasma concentrationsDoppler flowmetryReceptor sensitivityT exposureTestosterone exposure
2009
FEMALE REPRODUCTIVE HORMONE EFFECTS ON SKIN VESSEL ADRENERGIC RESPONSIVENESS IN WOMEN WITH LOW AND HIGH ORTHOSTATIC TOLERANCE.
Stachenfeld N, Hinds K, Taylor H. FEMALE REPRODUCTIVE HORMONE EFFECTS ON SKIN VESSEL ADRENERGIC RESPONSIVENESS IN WOMEN WITH LOW AND HIGH ORTHOSTATIC TOLERANCE. The FASEB Journal 2009, 23: 968.2-968.2. DOI: 10.1096/fasebj.23.1_supplement.968.2.Peer-Reviewed Original ResearchHigh orthostatic toleranceCumulative stress indexL-NMMAAdrenergic responsivenessOrthostatic toleranceLower body negative pressureReproductive hormone effectsNitric oxide mechanismBody negative pressureLaser Doppler flowmetrySkin blood flowStimulus-response curvesNorepinephrine infusionHormone antagonistDoppler flowmetryBlood flowDay 4Hormone effectsDay 13GnRHProgesteroneOxide mechanismWomenEstradiolResponsiveness