2024
Associations between fasting glucose rate-of-change and the missense variant, rs373863828, in an adult Samoan cohort
Rivara A, Russell E, Carlson J, Pomer A, Naseri T, Reupena M, Manna S, Viali S, Minster R, Weeks D, DeLany J, Kershaw E, McGarvey S, Hawley N. Associations between fasting glucose rate-of-change and the missense variant, rs373863828, in an adult Samoan cohort. PLOS ONE 2024, 19: e0302643. PMID: 38829901, PMCID: PMC11146712, DOI: 10.1371/journal.pone.0302643.Peer-Reviewed Original ResearchConceptsType 2 diabetesAllele of rs373863828Body mass indexFasting glucoseAdult SamoansDevelopment of type 2 diabetesOdds of type 2 diabetesReduction of modifiable risk factorsRs373863828 genotypeAssociated with higher body mass indexType 2 diabetes developmentGlucose rate of changeMass indexHousehold asset scoreUrbanization of residenceHigher body mass indexRisk factorsModifiable risk factorsRate of changeBaseline variablesMultivariate linear regressionPhysical activityDiabetes preventionType 2 diabetes mellitusSmoking status
2023
Identifying patient preferences for diabetes care: A protocol for implementing a discrete choice experiment in Samoa
Rivara A, Galárraga O, Selu M, Arorae M, Wang R, Faasalele-Savusa K, Rosen R, Hawley N, Viali S. Identifying patient preferences for diabetes care: A protocol for implementing a discrete choice experiment in Samoa. PLOS ONE 2023, 18: e0295845. PMID: 38134044, PMCID: PMC10745180, DOI: 10.1371/journal.pone.0295845.Peer-Reviewed Original ResearchProtocol: Implementation and evaluation of an adolescent-mediated intervention to improve glycemic control and diabetes self-management among Samoan adults
Hawley N, Rivara A, Naseri J, Faumuina K, Potoa’e-Solaita N, Iopu F, Faiai M, Naveno E, Tasele S, Lefale T, Lantini R, Carlson J, Rabin T, Semaia P, Mugadza P, Rosen R. Protocol: Implementation and evaluation of an adolescent-mediated intervention to improve glycemic control and diabetes self-management among Samoan adults. PLOS ONE 2023, 18: e0279084. PMID: 36795707, PMCID: PMC9934313, DOI: 10.1371/journal.pone.0279084.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultDiabetes Mellitus, Type 2EthnicityGlycemic ControlHealth BehaviorHumansMinority GroupsRandomized Controlled Trials as TopicSelf-ManagementConceptsGlycemic controlPrimary efficacy outcomeCardiovascular risk factorsChronic disease riskType 2 diabetesSelf-care strategiesSelf-care practicesHealth behavior changeBehavior changeEfficacy outcomesUsual careDiabetes InterventionsAdult family membersRisk factorsDiabetes knowledgeSamoan adultsIntervention acceptabilityFamily-centered culturePositive behavior changeDisease riskHealth disparitiesActive interventionDisproportionate riskInterventionEthnic minority groups
2022
The protective effect of rs373863828 on type 2 diabetes does not operate through a body composition pathway in adult Samoans
Hawley NL, Duckham RL, Carlson JC, Naseri T, Reupena MS, Lameko V, Pomer A, Wetzel A, Selu M, Lupematisila V, Unasa F, Vesi L, Fatu T, Unasa S, Faasalele‐Savusa K, Rivara AC, Russell E, Delany JP, Viali S, Kershaw EE, Minster RL, Weeks DE, McGarvey ST. The protective effect of rs373863828 on type 2 diabetes does not operate through a body composition pathway in adult Samoans. Obesity 2022, 30: 2468-2476. PMID: 36284436, PMCID: PMC10111239, DOI: 10.1002/oby.23559.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptiometry, PhotonAdultBody CompositionBody Mass IndexDiabetes Mellitus, Type 2FemaleGlucoseHumansMaleNative Hawaiian or Other Pacific IslanderObesityConceptsFat-free massType 2 diabetesFat distributionProtective effectBody compositionFavorable body fat distributionDual-energy X-ray absorptiometry-derived body compositionBody fat distributionGreater fat-free massPercent body fatBody size/compositionAssociation of genotypesRs373863828 genotypeVisceral adiposityHigher BMIAdult SamoansRole of fatGreater BMILean massBody fatLower oddsParadoxical associationTissue-specific mechanismsA alleleDiabetesCREBRF missense variant rs373863828 has both direct and indirect effects on type 2 diabetes and fasting glucose in Polynesian peoples living in Samoa and Aotearoa New Zealand
Russell EM, Carlson JC, Krishnan M, Hawley NL, Sun G, Cheng H, Naseri T, Reupena M, Viali S, Tuitele J, Major TJ, Miljkovic I, Merriman TR, Deka R, Weeks DE, McGarvey ST, Minster RL. CREBRF missense variant rs373863828 has both direct and indirect effects on type 2 diabetes and fasting glucose in Polynesian peoples living in Samoa and Aotearoa New Zealand. BMJ Open Diabetes Research & Care 2022, 10: e002275. PMID: 35144939, PMCID: PMC8845200, DOI: 10.1136/bmjdrc-2021-002275.Peer-Reviewed Original ResearchMeSH KeywordsAdultCross-Sectional StudiesDiabetes Mellitus, Type 2FastingGlucoseHumansNew ZealandSamoaTumor Suppressor ProteinsConceptsBody mass indexType 2 diabetesAssociation of BMIHigher body mass indexMinor alleleType 2 diabetes riskCross-sectional associationsPacific Island populationsRs373863828 genotypeMass indexDiabetes riskHigher oddsLower oddsDiabetesObesityEvidence of differencesMissense variantsRs373863828Regression analysisGlucoseAssociationOddsIndirect effectsPolynesian individuals