2024
A group prenatal care intervention reduces gestational weight gain and gestational diabetes in American Samoan women
Hawley N, Faasalele‐Savusa K, Faiai M, Suiaunoa‐Scanlan L, Loia M, Ickovics J, Kocher E, Piel C, Mahoney M, Suss R, Trocha M, Rosen R, Muasau‐Howard B. A group prenatal care intervention reduces gestational weight gain and gestational diabetes in American Samoan women. Obesity 2024, 32: 1833-1843. PMID: 39256170, DOI: 10.1002/oby.24102.Peer-Reviewed Original ResearchConceptsGestational weight gainPostpartum weight changeGestational diabetes screeningClinically important between-group differenceDiabetes screeningGestational diabetesUsual care participantsPrenatal care interventionsMode of birthLow-risk pregnant womenPre-pregnancy obesityAmerican Samoan womenIncidence of gestational diabetesProportion of womenGestational diabetes incidenceInfant birth weightWeight gainBetween-group differencesCare interventionsCare participantsPreliminary effectivenessWeight changeRandom group assignmentDiabetes incidenceHigh-risk settingsAssociations between fasting glucose rate-of-change and the missense variant, rs373863828, in an adult Samoan cohort
Rivara A, Russell E, Carlson J, Pomer A, Naseri T, Reupena M, Manna S, Viali S, Minster R, Weeks D, DeLany J, Kershaw E, McGarvey S, Hawley N. Associations between fasting glucose rate-of-change and the missense variant, rs373863828, in an adult Samoan cohort. PLOS ONE 2024, 19: e0302643. PMID: 38829901, PMCID: PMC11146712, DOI: 10.1371/journal.pone.0302643.Peer-Reviewed Original ResearchConceptsType 2 diabetesAllele of rs373863828Body mass indexFasting glucoseAdult SamoansDevelopment of type 2 diabetesOdds of type 2 diabetesReduction of modifiable risk factorsRs373863828 genotypeAssociated with higher body mass indexType 2 diabetes developmentGlucose rate of changeMass indexHousehold asset scoreUrbanization of residenceHigher body mass indexRisk factorsModifiable risk factorsRate of changeBaseline variablesMultivariate linear regressionPhysical activityDiabetes preventionType 2 diabetes mellitusSmoking status
2023
Association between age at menarche and cardiometabolic risk among Samoan adults
Oyama S, Duckham R, Pomer A, Rivara A, Kershaw E, Wood A, Fidow U, Naseri T, Reupena M, Viali S, McGarvey S, Hawley N. Association between age at menarche and cardiometabolic risk among Samoan adults. American Journal Of Human Biology 2023, 36: e23982. PMID: 37668413, PMCID: PMC10845161, DOI: 10.1002/ajhb.23982.Peer-Reviewed Original ResearchConceptsCardiometabolic riskOne-year increaseSubsequent cardiometabolic riskOdds of hypertensionHigher total cholesterolOdds of diabetesOdds of obesityEarly life exposureFat-free massCardiometabolic morbiditySerum lipidsBlood pressureMedian ageMetabolic syndromeTotal cholesterolProspective studyChildhood adiposityInsulin resistanceObesity prevalenceLife exposureSamoan adultsLean massEarly menarcheLogistic regressionMenarcheAssociation of rs9939609 in FTO with BMI among Polynesian peoples living in Aotearoa New Zealand and other Pacific nations
Krishnan M, Phipps-Green A, Russell E, Major T, Cadzow M, Stamp L, Dalbeth N, Hindmarsh J, Qasim M, Watson H, Liu S, Carlson J, Minster R, Hawley N, Naseri T, Reupena M, Deka R, McGarvey S, Merriman T, Murphy R, Weeks D. Association of rs9939609 in FTO with BMI among Polynesian peoples living in Aotearoa New Zealand and other Pacific nations. Journal Of Human Genetics 2023, 68: 463-468. PMID: 36864286, PMCID: PMC10313811, DOI: 10.1038/s10038-023-01141-5.Peer-Reviewed Original ResearchConceptsBody mass indexMean body mass indexHigher body mass indexPrevious smaller studiesAssociation of rs9939609New Zealand PolynesiansMass indexFat massSmall studySignificant associationPolynesian ancestryFTO variantsRs9939609Effect size estimatesAssociationSimilar effectsMean effect size estimatePrediction of fat mass from anthropometry at ages 7 to 9 years in Samoans: a cross-sectional study in the Ola Tuputupua’e cohort
Choy C, Johnson W, Duckham R, Naseri T, Soti-Ulberg C, Reupena M, Braun J, McGarvey S, Hawley N. Prediction of fat mass from anthropometry at ages 7 to 9 years in Samoans: a cross-sectional study in the Ola Tuputupua’e cohort. European Journal Of Clinical Nutrition 2023, 77: 495-502. PMID: 36624192, PMCID: PMC7614464, DOI: 10.1038/s41430-022-01256-6.Peer-Reviewed Original ResearchConceptsFat massSex-specific prediction modelsCross-sectional studyAge 7 yearsHigh-risk settingsFuture obesity preventionModel development sampleSamoan childrenObesity prevalenceObesity preventionBody fatHigh riskSex-specific modelsBland-Altman limitsSubscapularSubstantial concordanceAge 7Pacific IslandersChildrenDXADevelopment samplePreventionConcordanceYearsValidation sample
2022
Validity of anthropometric equation‐based estimators of fat mass in Samoan adults
Heinsberg L, Hawley N, Duckham R, Pomer A, Rivara A, Naseri T, Reupena M, Weeks D, McGarvey S, Minster R. Validity of anthropometric equation‐based estimators of fat mass in Samoan adults. American Journal Of Human Biology 2022, 35: e23838. PMID: 36428275, PMCID: PMC10023273, DOI: 10.1002/ajhb.23838.Peer-Reviewed Original ResearchMultivariate analysis of a missense variant in CREBRF reveals associations with measures of adiposity in people of Polynesian ancestries
Zhang J, Heinsberg L, Krishnan M, Hawley N, Major T, Carlson J, Hindmarsh J, Watson H, Qasim M, Stamp L, Dalbeth N, Murphy R, Sun G, Cheng H, Naseri T, Reupena M, Kershaw E, Deka R, McGarvey S, Minster R, Merriman T, Weeks D. Multivariate analysis of a missense variant in CREBRF reveals associations with measures of adiposity in people of Polynesian ancestries. Genetic Epidemiology 2022, 47: 105-118. PMID: 36352773, PMCID: PMC9892232, DOI: 10.1002/gepi.22508.Peer-Reviewed Original ResearchThe protective effect of rs373863828 on type 2 diabetes does not operate through a body composition pathway in adult Samoans
Hawley NL, Duckham RL, Carlson JC, Naseri T, Reupena MS, Lameko V, Pomer A, Wetzel A, Selu M, Lupematisila V, Unasa F, Vesi L, Fatu T, Unasa S, Faasalele‐Savusa K, Rivara AC, Russell E, Delany JP, Viali S, Kershaw EE, Minster RL, Weeks DE, McGarvey ST. The protective effect of rs373863828 on type 2 diabetes does not operate through a body composition pathway in adult Samoans. Obesity 2022, 30: 2468-2476. PMID: 36284436, PMCID: PMC10111239, DOI: 10.1002/oby.23559.Peer-Reviewed Original ResearchConceptsFat-free massType 2 diabetesFat distributionProtective effectBody compositionFavorable body fat distributionDual-energy X-ray absorptiometry-derived body compositionBody fat distributionGreater fat-free massPercent body fatBody size/compositionAssociation of genotypesRs373863828 genotypeVisceral adiposityHigher BMIAdult SamoansRole of fatGreater BMILean massBody fatLower oddsParadoxical associationTissue-specific mechanismsA alleleDiabetesMaternal responsiveness and toddler body mass index z-score: Prospective analysis of maternal and child mealtime interactions
Hart C, Phelan S, Coffman D, Jelalian E, Ventura A, Hodges E, Hawley N, Fisher J, Wing R. Maternal responsiveness and toddler body mass index z-score: Prospective analysis of maternal and child mealtime interactions. Appetite 2022, 180: 106348. PMID: 36272545, DOI: 10.1016/j.appet.2022.106348.Peer-Reviewed Original ResearchConceptsBody mass index z-scoreOverweight/overweightIndex z-scoreChild weight statusSatiation cuesWeight statusMaternal promptsToddler growthZ-scoreMaternal responsivenessOverweight/obesityHealthy weight statusHigher childHigher child weight statusLifestyle interventionMealtime interactionsHealthy weightResponsive feedingProspective analysisProspective associationsOverweightMonthsChild hungerSubset of familiesRiskThe missense variant, rs373863828, in CREBRF plays a role in longitudinal changes in body mass index in Samoans
Fu H, Hawley NL, Carlson JC, Russell EM, Pomer A, Cheng H, Naseri T, Reupena M, Deka R, Choy CC, McGarvey ST, Minster RL, Weeks DE. The missense variant, rs373863828, in CREBRF plays a role in longitudinal changes in body mass index in Samoans. Obesity Research & Clinical Practice 2022, 16: 220-227. PMID: 35606300, PMCID: PMC9373717, DOI: 10.1016/j.orcp.2022.04.004.Peer-Reviewed Original ResearchConceptsBMI rateHousehold asset scoreAA genotypeBody mass indexMissense variantsBMI of femalesSex-stratified modelsHigh rateAG participantsBaseline BMIMean BMICohort studyMass indexSamoan adultsPhysical activityGG genotypeBMIAge groupsA alleleLongitudinal changesAsset scoreRs373863828Older participantsFemalesCREBRFIs overweight or obesity associated with anemia in children? Follow-up of Samoans in the Ola Tuputupua’e “Growing Up” study
Choy CC, Howe CJ, Soti-Ulberg C, Naseri T, Reupena MS, Duckham RL, Hawley NL. Is overweight or obesity associated with anemia in children? Follow-up of Samoans in the Ola Tuputupua’e “Growing Up” study. Obesity Research & Clinical Practice 2022, 16: 144-150. PMID: 35256305, PMCID: PMC9636893, DOI: 10.1016/j.orcp.2022.02.008.Peer-Reviewed Original ResearchConceptsOverweight/obesityObesity-related inflammationPrevalence ratiosIron deficiencyDouble burdenPrevalence of anemiaBody mass indexAge z-scorePoisson regression modelsCohort studyMass indexSamoan childrenHigh prevalenceObesityAnemiaZ-scoreCovariate adjustmentConfidence intervalsMicronutrient deficienciesInflammationChildrenPrevalenceFurther investigationRegression modelsDeficiency
2021
Randomized controlled trial to enhance children’s sleep, eating, and weight
Hart CN, Hawley NL, Coffman DL, Raynor HA, Carskadon MA, Jelalian E, Owens JA, Spaeth A, Wing RR. Randomized controlled trial to enhance children’s sleep, eating, and weight. Pediatric Research 2021, 92: 1075-1081. PMID: 34930967, PMCID: PMC9413537, DOI: 10.1038/s41390-021-01870-3.Peer-Reviewed Original ResearchConceptsBrief behavioral interventionChildren's sleepBehavioral interventionsBMI/BMI z-scoreSleep periodDomains of functioningNocturnal sleepMin/nightTreatment controlGood night's sleepSleep interventionsBrief interventionCaloric intakeLower BMIPercent caloriesNight sleepWeight regulationChildren 8Body mass index (BMI) changeSleepBMI z-scoreBackgroundThe present studyInterventionWeight statusPrimary outcomeA murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress
Kanshana JS, Mattila PE, Ewing MC, Wood AN, Schoiswohl G, Meyer AC, Kowalski A, Rosenthal SL, Gingras S, Kaufman BA, Lu R, Weeks DE, McGarvey ST, Minster RL, Hawley NL, Kershaw EE. A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress. PLOS ONE 2021, 16: e0251895. PMID: 34520472, PMCID: PMC8439463, DOI: 10.1371/journal.pone.0251895.Peer-Reviewed Original ResearchConceptsMurine modelGlucose homeostasisEnergy/glucose homeostasisOdds of diabetesOdds of obesityObesity risk variantsAlternative preclinical modelsPromotes obesityPreclinical modelsKnockin miceObesityDiabetesStrong heritable componentExtensive phenotypic analysisMissense variantsOrthologous variantDiseaseMiceOddsAdaptive transcriptional responseExtreme nutritional stressNutritional stressHomeostasisGenetic contributionRegulatory factorsC‐reactive protein in adult Samoans: Population variation and physiological correlates
Rivara AC, Corley M, Choy CC, Duckham RL, Pomer A, Reupena MS, Viali S, Naseri T, Kershaw EE, Crouter SE, McGarvey ST, Bribiescas RG, Valeggia C, Hawley NL. C‐reactive protein in adult Samoans: Population variation and physiological correlates. American Journal Of Human Biology 2021, 34: e23646. PMID: 34260111, PMCID: PMC8758804, DOI: 10.1002/ajhb.23646.Peer-Reviewed Original ResearchMeSH KeywordsAdiposityAdultBody Mass IndexC-Reactive ProteinFemaleHumansInsulin ResistanceMaleMiddle AgedObesityConceptsC-reactive proteinBody mass indexCardiometabolic disease riskMeasures of adiposityAdult SamoansCRP correlateDisease riskSerum C-reactive proteinMeasures of BMICardiometabolic risk markersPercent body fatSex-dependent associationsCardiometabolic markersCardiometabolic riskCRP quartileMass indexUnadjusted analysesRisk markersBody fatKruskal-Wallis testAdiposityPacific Islander populationsSpearman rank correlationFirst examinationRank correlationFactorial validation analysis of the Baby and Children's Eating Behavior Questionnaires in Samoa
Oyama S, Arslanian KJ, Fidow UT, Naseri T, Soti-Ulberg C, Hawley NL. Factorial validation analysis of the Baby and Children's Eating Behavior Questionnaires in Samoa. Eating Behaviors 2021, 42: 101530. PMID: 34051664, PMCID: PMC8380697, DOI: 10.1016/j.eatbeh.2021.101530.Peer-Reviewed Original ResearchConceptsBaby Eating Behaviour QuestionnaireEating Behavior QuestionnaireMonths postpartumChildren's Eating Behaviour QuestionnaireInfant feeding behaviorsMother-infant dyadsBehavior QuestionnaireCEBQ scoresPediatric obesityElimination of factorsPostpartumTime pointsFurther qualitative researchCEBQEarly childhoodPacific IslandersLongitudinal analysisNine-itemMonthsFactor structureLow internal reliabilityInternal reliabilityThree-factor structureExploratory factor analysisQuestionnaire's factor structure
2020
Assessing the impact of high blood pressure referrals on hypertension awareness and management, BMI, and blood pressure values in adult Samoans 2010–2019
Rivara AC, Pomer A, Naseri T, Reupena MS, Viali S, Choy CC, McGarvey ST, Hawley NL. Assessing the impact of high blood pressure referrals on hypertension awareness and management, BMI, and blood pressure values in adult Samoans 2010–2019. Annals Of Human Biology 2020, 47: 597-601. PMID: 32924611, PMCID: PMC8180238, DOI: 10.1080/03014460.2020.1822914.Peer-Reviewed Original ResearchConceptsElevated blood pressureBody mass indexBlood pressureNon-communicable diseasesMedication usePhysician diagnosisRisk factorsLong-term health improvementsHypertension medication useBlood pressure valuesNCD risk factorsHypertension controlCardiometabolic healthHypertension awarenessMass indexAdult SamoansHealth referralsDisease burdenReduced oddsBP valuesSamoan adultsReferralLogistic regressionHealth sector actorsMcNemar testLongitudinal Assessment of Childhood Dietary Patterns: Associations with Body Mass Index z-Score among Children in the Samoan Ola Tuputupua'e (Growing Up) Cohort
Choy CC, Wang D, Naseri T, Soti-Ulberg C, Reupena MS, Duckham RL, Baylin A, Hawley NL. Longitudinal Assessment of Childhood Dietary Patterns: Associations with Body Mass Index z-Score among Children in the Samoan Ola Tuputupua'e (Growing Up) Cohort. Childhood Obesity 2020, 16: 534-543. PMID: 32907355, PMCID: PMC7575349, DOI: 10.1089/chi.2020.0058.Peer-Reviewed Original ResearchConceptsDietary patternsHigh adherenceBody mass index zChildhood obesity prevention strategiesObesity prevention strategiesBody mass indexFood frequency dataChildhood dietary patternsBiological mother-child dyadsCohort studyMass indexPattern adherencePotential confoundersChildhood obesityPrevention strategiesMother-child dyadsLongitudinal assessmentTime pointsConvenience sampleAdherenceBMIzIntervention strategiesChildrenScoresAssociation
2016
A thrifty variant in CREBRF strongly influences body mass index in Samoans
Minster RL, Hawley NL, Su CT, Sun G, Kershaw EE, Cheng H, Buhule OD, Lin J, Reupena MS, Viali S, Tuitele J, Naseri T, Urban Z, Deka R, Weeks DE, McGarvey ST. A thrifty variant in CREBRF strongly influences body mass index in Samoans. Nature Genetics 2016, 48: 1049-1054. PMID: 27455349, PMCID: PMC5069069, DOI: 10.1038/ng.3620.Peer-Reviewed Original Research
2014
Epigenetic patterns in successful weight loss maintainers: a pilot study
Huang Y, Maccani J, Hawley N, Wing R, Kelsey K, McCaffery J. Epigenetic patterns in successful weight loss maintainers: a pilot study. International Journal Of Obesity 2014, 39: 865-868. PMID: 25520250, PMCID: PMC4422763, DOI: 10.1038/ijo.2014.213.Peer-Reviewed Original ResearchConceptsOB individualsSuccessful weight loss maintainersBrain-derived neurotrophic factorBehavioral weight loss interventionWeight loss maintainersWeight loss interventionMyelin protein zeroLoss interventionNormal weightNeurotrophic factorObese individualsRyanodine receptor 1Weight statusAnimal modelsCalorie restrictionReceptor 1NW individualsPilot studyWeight lossProtein zeroMethylation patternsEpigenome-wide analysisHuman subjectsEpigenetic patternsDNA methylation changes