2023
Randomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors
Puklin L, Harrigan M, Cartmel B, Sanft T, Gottlieb L, Zhou B, Ferrucci L, Li F, Spiegelman D, Sharifi M, Irwin M. Randomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors. Cancers 2023, 15: 4719. PMID: 37835412, PMCID: PMC10571774, DOI: 10.3390/cancers15194719.Peer-Reviewed Original ResearchBreast cancer survivorsCancer survivorsLifestyle interventionPhysical activityQuality of lifeBody weightWaitlist groupDiet qualitySelf-reported body weightWeight lossFavorable weight changeHealthy weight lossBody mass indexHealthy body weightGreater weight lossEvidence-based materialsDiverse healthcare settingsIntervention armMass indexClinical practicePositive behavior changeHealthcare settingsSurvivorsWeight changeInterventionDiet and physical activity interventions in Black and Latina women with breast cancer: A scoping review
Pichardo M, Sanft T, Ferrucci L, Romero-Ramos Y, Cartmel B, Harrigan M, Velazquez A, Fayanju O, Winer E, Irwin M. Diet and physical activity interventions in Black and Latina women with breast cancer: A scoping review. Frontiers In Oncology 2023, 13: 1079293. PMID: 36994212, PMCID: PMC10040823, DOI: 10.3389/fonc.2023.1079293.Peer-Reviewed Original ResearchBreast cancer survivorsPhysical activity interventionsLifestyle interventionCancer survivorsActivity interventionsLatina womenEfficacy trialsBreast cancerLatina breast cancer survivorsTrial of dietOne-year followFavorable behavioral changesBreast cancer diagnosisPrimary outcomeAvailable peer-reviewed literatureFuture trialsInformal care giversPilot trialSustained behavior changeEfficacy studiesHealthful lifestyleCare giversTrialsWeight lossCancer diagnosis
2022
Impact of a randomized weight loss trial on breast tissue markers in breast cancer survivors
Dieli-Conwright CM, Harrigan M, Cartmel B, Chagpar A, Bai Y, Li FY, Rimm DL, Pusztai L, Lu L, Sanft T, Irwin ML. Impact of a randomized weight loss trial on breast tissue markers in breast cancer survivors. Npj Breast Cancer 2022, 8: 29. PMID: 35256599, PMCID: PMC8901848, DOI: 10.1038/s41523-022-00396-z.Peer-Reviewed Original ResearchBreast cancer survivorsWeight loss interventionBreast tissue biopsiesUsual careLoss interventionCancer survivorsWeight lossBreast cancerTissue markersTissue biopsiesLifestyle behavioural interventionUsual care groupSerum insulin levelsWeight loss trialWeight loss groupBreast cancer treatmentBreast tissue markersInsulin receptor levelsInflammatory markersAdiponectin levelsSerum leptinCare groupInsulin levelsSerum biomarkersBlood draw
2021
Dietary Supplement Use and Interactions with Tamoxifen and Aromatase Inhibitors in Breast Cancer Survivors Enrolled in Lifestyle Interventions
Harrigan M, McGowan C, Hood A, Ferrucci LM, Nguyen T, Cartmel B, Li FY, Irwin ML, Sanft T. Dietary Supplement Use and Interactions with Tamoxifen and Aromatase Inhibitors in Breast Cancer Survivors Enrolled in Lifestyle Interventions. Nutrients 2021, 13: 3730. PMID: 34835986, PMCID: PMC8621720, DOI: 10.3390/nu13113730.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsDietary supplement useCancer survivorsAromatase inhibitorsSupplement useDietary supplementsEndocrine therapyLifestyle interventionWorld Cancer Research Fund/American InstituteSelf-reported dietary supplement useNatural Medicines databaseAdjuvant endocrine therapyBreast cancer treatmentAdverse interactionsPotential adverse interactionsPharmacodynamic interactionsClinical efficacyCancer preventionHigh prevalenceGeneral populationPotential interactionsMedicine DatabaseTamoxifenCancer treatmentSurvivorsEffect of the Lifestyle, Exercise, and Nutrition (LEAN) Study on Long-Term Weight Loss Maintenance in Women with Breast Cancer
Lisevick A, Cartmel B, Harrigan M, Li F, Sanft T, Fogarasi M, Irwin ML, Ferrucci LM. Effect of the Lifestyle, Exercise, and Nutrition (LEAN) Study on Long-Term Weight Loss Maintenance in Women with Breast Cancer. Nutrients 2021, 13: 3265. PMID: 34579142, PMCID: PMC8469752, DOI: 10.3390/nu13093265.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsLong-term weight loss maintenanceUsual care groupWeight loss maintenanceCancer survivorsStudy completionCare groupLoss maintenanceWeight lossBody weightLong-term weight maintenanceShort-term weight lossLong-term weight gainModest weight lossOverweight/obesityElectronic health recordsLifestyle interventionWeight maintenanceBreast cancerWeight trajectoriesWeight gainCurve analysisNutrition studiesWeight changeHealth recordsImpact of a randomized weight loss trial on breast tissue markers in breast cancer survivors.
Dieli-Conwright C, Harrigan M, Cartmel B, Chagpar A, Bai Y, Rimm D, Pusztai L, Lu L, Sanft T, Irwin M. Impact of a randomized weight loss trial on breast tissue markers in breast cancer survivors. Journal Of Clinical Oncology 2021, 39: e12501-e12501. DOI: 10.1200/jco.2021.39.15_suppl.e12501.Peer-Reviewed Original ResearchBreast cancer survivorsWeight loss interventionSerum insulin levelsCancer survivorsLoss interventionPercent body fatSerum levelsSerum biomarkersTissue biomarkersBody compositionMonth 6Insulin levelsBreast tissueBreast cancerInsulin receptorBody fatStage I breast cancerBreast tissue levelsI breast cancerWeight loss trialBreast tissue markersLevels of CD163Breast tissue biopsiesUsual careLifestyle interventionRandomized trial of weight loss on circulating ghrelin levels among breast cancer survivors
Puklin L, Cartmel B, Harrigan M, Lu L, Li FY, Sanft T, Irwin ML. Randomized trial of weight loss on circulating ghrelin levels among breast cancer survivors. Npj Breast Cancer 2021, 7: 49. PMID: 33976224, PMCID: PMC8113314, DOI: 10.1038/s41523-021-00260-6.Peer-Reviewed Original ResearchBreast cancer survivorsBody mass indexCancer survivorsGhrelin levelsLifestyle interventionUsual careWeight lossPg/Higher ghrelin levelsWeight loss interventionLean body massSix-month changesGreater weight lossWeight regainLoss interventionStudy armsMass indexWeight maintenanceBlood biomarkersHormone ghrelinBlood samplesGhrelinBody compositionBody weightBaseline associationsExamining the effect of obesity-associated gene variants on breast cancer survivors in a randomized weight loss intervention
Nguyen T, Irwin ML, Dewan AT, Cartmel B, Harrigan M, Ferrucci LM, Sanft T, Li F, Lu L, Salinas YD. Examining the effect of obesity-associated gene variants on breast cancer survivors in a randomized weight loss intervention. Breast Cancer Research And Treatment 2021, 187: 487-497. PMID: 33677781, DOI: 10.1007/s10549-021-06151-5.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsUsual care groupWeight loss interventionCancer survivorsLoss interventionCare groupFTO rs9939609Percent body fat changesWeight lossMeaningful weight lossBody fat changesBody mass indexObesity-associated gene FTOObesity-associated gene variantsPercent body fatGreater weight lossLifestyle interventionMass indexTreatment armsIntervention groupBreast cancerBody fatFat changesPurposeOur studyHealthy eating
2020
Skin carotenoids are inversely associated with adiposity in breast cancer survivors
Cartmel B, Anderson C, Irwin ML, Harrigan M, Sanft T, Li F, Gellermann W, Ermakov IV, Ferrucci LM. Skin carotenoids are inversely associated with adiposity in breast cancer survivors. Nutrition Research 2020, 79: 77-86. PMID: 32650223, PMCID: PMC7409553, DOI: 10.1016/j.nutres.2020.05.012.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsSkin carotenoid scoreUsual care groupCancer survivorsSkin carotenoidsBody fatCare groupSerum biomarkersAdiposity measuresLog C-reactive protein levelsBaseline percent body fatObese breast cancer survivorsC-reactive protein levelsDual-energy X-ray absorptiometryStrong associationBreast cancer patientsWeight loss trialStudy of overweightTotal body fatPercent body fatX-ray absorptiometryLog leptinPoor outcomeCancer patientsHip circumference
2019
Randomized phase II trial of exercise, metformin, or both on metabolic biomarkers in colorectal and breast cancer survivors
Meyerhardt JA, Irwin ML, Jones LW, Zhang S, Campbell N, Brown JC, Pollak M, Sorrentino A, Cartmel B, Harrigan M, Tolaney SM, Winer E, Ng K, Abrams T, Fuchs CS, Sanft T, Douglas PS, Hu F, Ligibel JA. Randomized phase II trial of exercise, metformin, or both on metabolic biomarkers in colorectal and breast cancer survivors. JNCI Cancer Spectrum 2019, 4: pkz096. PMID: 32090192, PMCID: PMC7025659, DOI: 10.1093/jncics/pkz096.Peer-Reviewed Original ResearchBreast cancer survivorsPhase II trialCancer survivorsControl armII trialInsulin levelsRandomized phase II trialInsulin-like growth factor-1Insulin-like growth factorHomeostatic model assessmentCombination of exerciseSignificant weight lossGrowth factor-1Combination armMetformin useSecondary outcomesStandard therapyPrimary outcomeIntervention armInsulin resistanceDisease outcomeModality interventionsAnthropometric measurementsMetabolic markersMetabolic biomarkersEndocrine‐related quality of life in a randomized trial of exercise on aromatase inhibitor–induced arthralgias in breast cancer survivors
Baglia ML, Lin I, Cartmel B, Sanft T, Ligibel J, Hershman DL, Harrigan M, Ferrucci LM, Li F, Irwin ML. Endocrine‐related quality of life in a randomized trial of exercise on aromatase inhibitor–induced arthralgias in breast cancer survivors. Cancer 2019, 125: 2262-2271. PMID: 30840336, PMCID: PMC6731173, DOI: 10.1002/cncr.32051.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsUsual care groupCancer survivorsAdverse side effectsCare groupOverall QoLSide effectsAromatase inhibitor-induced arthralgiaCancer Therapy questionnaireExercise intervention groupTrial of exerciseShort Form SurveyPhysical exercise studiesBreast cancer treatmentOverall QOL measuresRepeated-measures analysisMild arthralgiaTreatment discontinuationExercise groupExercise interventionNonpharmacologic interventionsResistance exerciseExercise studiesAromatase inhibitorsIntervention group
2018
Randomized controlled trial of weight loss versus usual care on telomere length in women with breast cancer: the lifestyle, exercise, and nutrition (LEAN) study
Sanft T, Usiskin I, Harrigan M, Cartmel B, Lu L, Li FY, Zhou Y, Chagpar A, Ferrucci LM, Pusztai L, Irwin ML. Randomized controlled trial of weight loss versus usual care on telomere length in women with breast cancer: the lifestyle, exercise, and nutrition (LEAN) study. Breast Cancer Research And Treatment 2018, 172: 105-112. PMID: 30062572, DOI: 10.1007/s10549-018-4895-7.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsWeight loss interventionUsual care groupBody mass indexBreast cancer riskCancer survivorsUsual careLoss interventionBreast cancerStage 0Quantitative polymerase chain reactionCare groupTelomere lengthCancer riskStage II/III breast cancerObese breast cancer survivorsWeight lossI breast cancerNon-Hispanic whitesPurposeSome studiesMass indexIntervention groupPhysical activityBlood samplesConclusionOur findingsExercise and weight loss interventions and miRNA expression in women with breast cancer
Adams BD, Arem H, Hubal MJ, Cartmel B, Li F, Harrigan M, Sanft T, Cheng CJ, Pusztai L, Irwin ML. Exercise and weight loss interventions and miRNA expression in women with breast cancer. Breast Cancer Research And Treatment 2018, 170: 55-67. PMID: 29511965, PMCID: PMC6444907, DOI: 10.1007/s10549-018-4738-6.Peer-Reviewed Original ResearchConceptsBaseline body mass indexBC survivorsTumor recurrenceWeight gainWeight lossBreast cancer survivorsSerum miRNA expressionWeight loss interventionBody mass indexWeight loss trialCancer-related deathIndependent clinical trialsMiRNA expressionSix-month interventionCanonical pathwaysTop canonical pathwaysPhysical exercise trialsIngenuity Pathway AnalysisIngenuity Pathway Analysis softwareSporadic BCDevelopment of cancerLoss interventionMass indexCancer survivorsExercise trials
2016
The effect of exercise on body composition and bone mineral density in breast cancer survivors taking aromatase inhibitors
Thomas GA, Cartmel B, Harrigan M, Fiellin M, Capozza S, Zhou Y, Ercolano E, Gross CP, Hershman D, Ligibel J, Schmitz K, Li F, Sanft T, Irwin ML. The effect of exercise on body composition and bone mineral density in breast cancer survivors taking aromatase inhibitors. Obesity 2016, 25: 346-351. PMID: 28026901, PMCID: PMC5450163, DOI: 10.1002/oby.21729.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsBone mineral densityUsual care groupBody mass indexCancer survivorsAromatase inhibitorsLean body massPercent body fatMineral densityBody compositionExercise interventionCare groupMass indexBody fatDual-energy X-ray absorptiometry scanPostmenopausal breast cancer survivorsX-ray absorptiometry scansAerobic exercise interventionResistance exercise trainingEffects of exerciseMin/wkPhysical exercise studiesUsual careBody massExercise groupChanges in diet quality in a randomized weight loss trial in breast cancer survivors: the lifestyle, exercise, and nutrition (LEAN) study
Anderson C, Harrigan M, George SM, Ferrucci LM, Sanft T, Irwin ML, Cartmel B. Changes in diet quality in a randomized weight loss trial in breast cancer survivors: the lifestyle, exercise, and nutrition (LEAN) study. Npj Breast Cancer 2016, 2: 16026. PMID: 28721384, PMCID: PMC5515327, DOI: 10.1038/npjbcancer.2016.26.Peer-Reviewed Original ResearchBreast cancer survivorsWeight loss interventionOverall diet qualityIntervention group participantsCancer survivorsDiet qualityLoss interventionHEI scoresObese breast cancer survivorsNutrition studiesUsual care groupFood frequency questionnaireWeight loss outcomesWeight loss trialHealthy Eating IndexBreast cancer recurrenceGroup participantsGreater weight lossGreater increaseFrequency questionnaireLifestyle interventionCare groupDietary intakeCancer recurrenceLoss outcomesRandomized Trial Of Exercise On Body Composition In Breast Cancer Survivors Taking Aromatase Inhibitors
Thomas G, Cartmel B, Harrigan M, Fiellin M, Capozza S, Zhou Y, Ercolano E, Gross C, Hershman D, Ligibel J, Schmitz K, Li F, Sanft T, Irwin M. Randomized Trial Of Exercise On Body Composition In Breast Cancer Survivors Taking Aromatase Inhibitors. Medicine & Science In Sports & Exercise 2016, 48: 334. DOI: 10.1249/01.mss.0000486010.57056.60.Peer-Reviewed Original ResearchTrial of exerciseBreast cancer survivorsCancer survivorsAromatase inhibitorsBody compositionSurvivorsTrialsExercise adherence in a randomized trial of exercise on aromatase inhibitor arthralgias in breast cancer survivors: the Hormones and Physical Exercise (HOPE) study
Arem H, Sorkin M, Cartmel B, Fiellin M, Capozza S, Harrigan M, Ercolano E, Zhou Y, Sanft T, Gross C, Schmitz K, Neogi T, Hershman D, Ligibel J, Irwin ML. Exercise adherence in a randomized trial of exercise on aromatase inhibitor arthralgias in breast cancer survivors: the Hormones and Physical Exercise (HOPE) study. Journal Of Cancer Survivorship 2016, 10: 654-662. PMID: 26782031, PMCID: PMC5418660, DOI: 10.1007/s11764-015-0511-6.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsCancer survivorsExercise adherenceAerobic exerciseCancer SurvivorsBreast cancer survivorsPostmenopausal breast cancer survivorsModerate-intensity aerobic exerciseAerobic exercise levelBetter exercise adherenceConclusionsBreast cancer survivorsLong exercise programSupervised exercise sessionsTrial of exerciseExercise training sessionsMin/weekPhysical exercise studiesPredictors of adherenceMaximal oxygen consumptionMonths postrandomizationJoint painExercise programExercise studiesCardiorespiratory fitnessExercise sessionsArthralgia
2015
Randomized Trial Comparing Telephone Versus In-Person Weight Loss Counseling on Body Composition and Circulating Biomarkers in Women Treated for Breast Cancer: The Lifestyle, Exercise, and Nutrition (LEAN) Study
Harrigan M, Cartmel B, Loftfield E, Sanft T, Chagpar AB, Zhou Y, Playdon M, Li F, Irwin ML. Randomized Trial Comparing Telephone Versus In-Person Weight Loss Counseling on Body Composition and Circulating Biomarkers in Women Treated for Breast Cancer: The Lifestyle, Exercise, and Nutrition (LEAN) Study. Journal Of Clinical Oncology 2015, 34: 669-676. PMID: 26598750, PMCID: PMC4872022, DOI: 10.1200/jco.2015.61.6375.Peer-Reviewed Original ResearchConceptsWeight loss counselingC-reactive protein levelsUsual careTelephone counselingPhysical activityBody compositionSerum biomarkersBreast cancerPerson counselingWeight loss intervention groupStage I breast cancerEffective weight loss strategyWeight lossI breast cancerBreast cancer survivorsBody mass indexBreast cancer mortalityWeight loss strategiesProtein levelsBreast cancer treatmentMean BMIUC groupMass indexCancer survivorsCancer mortality
2014
Randomized Exercise Trial of Aromatase Inhibitor–Induced Arthralgia in Breast Cancer Survivors
Irwin ML, Cartmel B, Gross CP, Ercolano E, Li F, Yao X, Fiellin M, Capozza S, Rothbard M, Zhou Y, Harrigan M, Sanft T, Schmitz K, Neogi T, Hershman D, Ligibel J. Randomized Exercise Trial of Aromatase Inhibitor–Induced Arthralgia in Breast Cancer Survivors. Journal Of Clinical Oncology 2014, 33: 1104-1111. PMID: 25452437, PMCID: PMC4372849, DOI: 10.1200/jco.2014.57.1547.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsBrief Pain InventoryUsual careAromatase inhibitorsCancer survivorsPain scoresAromatase Inhibitor-Induced ArthralgiaInactive breast cancer survivorsMcMaster Universities Osteoarthritis IndexJoint pain scoresRandomized exercise trialWorst joint painPrimary end pointWOMAC pain scoreImpact of exerciseResistance training sessionAI adherenceOsteoarthritis IndexHand questionnaireJoint painPain severityPain InventoryExercise trialsAerobic exerciseWestern Ontario
2013
Weight Loss Intervention for Breast Cancer Survivors: A Systematic Review
Playdon M, Thomas G, Sanft T, Harrigan M, Ligibel J, Irwin M. Weight Loss Intervention for Breast Cancer Survivors: A Systematic Review. Current Breast Cancer Reports 2013, 5: 222-246. PMID: 26605003, PMCID: PMC4655116, DOI: 10.1007/s12609-013-0113-0.Peer-Reviewed Original ResearchWeight loss interventionBreast cancer survivorsMeaningful weight lossLoss interventionCancer survivorsWeight lossWeight loss intervention trialLong-term weight maintenanceCardiovascular risk factorsSuccessful weight lossBreast cancer recurrenceSmall study sample sizesBreast cancer prognosisSignificant weight lossBreast cancer diagnosisWeight regainPrimary outcomeWeight maintenanceIntervention trialsInterventional studyRisk factorsCancer recurrenceBreast cancerStudy sample sizePhysical activity