2024
MyThisYourThat for interpretable identification of systematic bias in federated learning for biomedical images
Naumova K, Devos A, Karimireddy S, Jaggi M, Hartley M. MyThisYourThat for interpretable identification of systematic bias in federated learning for biomedical images. Npj Digital Medicine 2024, 7: 238. PMID: 39242810, PMCID: PMC11379706, DOI: 10.1038/s41746-024-01226-1.Peer-Reviewed Original ResearchX-ray datasetFederated learningData ownersBiomedical imagingCompromising privacyLearning networkClient dataGlobal prototypesBalanced accuracyData biasOriginal dataCollaborative learningClientsDataModel performanceLearningDiagnostic classifierImagesJoint modelPrediction modelClassifierPrivacyGlobal modelPerformanceDatasetWeb-based objective and structured assessment of point-of-care lung ultrasound skills in resource-limited settings
Suttels V, Chichignoud I, Wachinou P, Du Toit J, Mans P, Blanco J, Agodokpessi G, Brahier T, Hartley M, Garcia E, Boillat-Blanco N. Web-based objective and structured assessment of point-of-care lung ultrasound skills in resource-limited settings. BMC Medical Education 2024, 24: 939. PMID: 39198828, PMCID: PMC11360711, DOI: 10.1186/s12909-024-05925-x.Peer-Reviewed Original ResearchConceptsPoint-of-care ultrasoundPOCUS trainingContinuing educationAssessment toolWeb-based assessment toolMiddle-income countriesLung point-of-care ultrasoundPractical skills testResource-limited settingsPOCUS skillsSuccess rateUltrasound skillsFischer's exact testStructural assessmentSkills TestLung ultrasound scoreWeb-basedLMICsEvaluate traineesExact testTrainingUltrasound scoreTraineesWeb-based toolSkillsAutomated Interpretation of Lung Sounds by Deep Learning in Children With Asthma: Scoping Review and Strengths, Weaknesses, Opportunities, and Threats Analysis
Ruchonnet-Métrailler I, Siebert J, Hartley M, Lacroix L. Automated Interpretation of Lung Sounds by Deep Learning in Children With Asthma: Scoping Review and Strengths, Weaknesses, Opportunities, and Threats Analysis. Journal Of Medical Internet Research 2024, 26: e53662. PMID: 39178033, PMCID: PMC11380063, DOI: 10.2196/53662.Peer-Reviewed Original ResearchConceptsGrey literature searchArtificial intelligenceScoping reviewPediatric asthmaLiterature searchManagement of pediatric asthmaField of medical AILung auscultationDeep learningMedical AIPersonalized management strategiesData collectionThreat analysisRemote monitoring capabilitiesInterpretation of lung soundsLung soundsAccuracy of AIData setsStandardized assessmentAutomated interpretationPulmonary auscultationAbsence of external validationEarly diagnosisIdentified strengthsLung sound analysisPLUS-IS-LESS project: Procalcitonin and Lung UltraSonography-based antibiotherapy in patients with Lower rESpiratory tract infection in Swiss Emergency Departments: study protocol for a pragmatic stepped-wedge cluster-randomized trial
Bessat C, Bingisser R, Schwendinger M, Bulaty T, Fournier Y, Della Santa V, Pfeil M, Schwab D, Leuppi J, Geigy N, Steuer S, Roos F, Christ M, Sirova A, Espejo T, Riedel H, Atzl A, Napieralski F, Marti J, Cisco G, Foley R, Schindler M, Hartley M, Fayet A, Garcia E, Locatelli I, Albrich W, Hugli O, Boillat-Blanco N. PLUS-IS-LESS project: Procalcitonin and Lung UltraSonography-based antibiotherapy in patients with Lower rESpiratory tract infection in Swiss Emergency Departments: study protocol for a pragmatic stepped-wedge cluster-randomized trial. Trials 2024, 25: 86. PMID: 38273319, PMCID: PMC10809691, DOI: 10.1186/s13063-023-07795-y.Peer-Reviewed Original ResearchConceptsPrescription of antibioticsRespiratory tract infectionsLung ultrasoundSwiss emergency departmentEmergency departmentTract infectionsAntibiotic prescriptionsProportion of patients prescribed antibioticsBackgroundLower respiratory tract infectionsCluster-randomizedSide effectsAntibiotic-related side effectsLower respiratory tract infectionsLength of hospital stayPatients prescribed antibioticsClinical severity scoreClinical prediction scoreProportion of patientsReducing antibiotic prescriptionsCo-primary endpointsChest X-rayDecrease side effectsPreserving patient safetyPattern of pneumoniaProportion of antibiotics
2023
Safety and immunogenicity of a synthetic nanoparticle-based, T cell priming peptide vaccine against dengue in healthy adults in Switzerland: a double-blind, randomized, vehicle-controlled, phase 1 study
Miauton A, Audran R, Besson J, Hajjami H, Karlen M, Warpelin-Decrausaz L, Sene L, Schaufelberger S, Faivre V, Faouzi M, Hartley M, Spertini F, Genton B. Safety and immunogenicity of a synthetic nanoparticle-based, T cell priming peptide vaccine against dengue in healthy adults in Switzerland: a double-blind, randomized, vehicle-controlled, phase 1 study. EBioMedicine 2023, 99: 104922. PMID: 38128414, PMCID: PMC10776924, DOI: 10.1016/j.ebiom.2023.104922.Peer-Reviewed Original ResearchConceptsCD8+ T cellsT cellsDouble-blindIntention-to-treatVehicle-controlledAdverse eventsVirus-specific CD8+ T cellsPeptide vaccinesCD8+ T cell immunityInjection site erythemaInjection site painT cell immunityPhase 1 studyPhase 1 trialDengue vaccine candidateAnti-DENV antibodiesAntibody-dependent enhancementSite painSevere dengueGlobal health threatCentral memoryPrimary outcomeCD8Microneedle injectionInduced antibodiesModular Clinical Decision Support Networks (MoDN)—Updatable, interpretable, and portable predictions for evolving clinical environments
Trottet C, Vogels T, Keitel K, Kulinkina A, Tan R, Cobuccio L, Jaggi M, Hartley M. Modular Clinical Decision Support Networks (MoDN)—Updatable, interpretable, and portable predictions for evolving clinical environments. PLOS Digital Health 2023, 2: e0000108. PMID: 37459285, PMCID: PMC10351690, DOI: 10.1371/journal.pdig.0000108.Peer-Reviewed Original ResearchClinical decision support systemPrivacy-preserving learningSize of dataNeural network moduleDecision support systemRule-based logicNovel decision treeData-driven modelsMultilayer perceptronDecision treeMacro-F1Support systemNetwork modulesTraining updatesNew datasetBaseline modelDatasetCollaborative learningModular designClinical environmentPredictive feedbackDiagnostic predictionIdeal scenarioContinuous feedbackNetworkBarriers and facilitators to implementation of point-of-care lung ultrasonography in a tertiary centre in Benin: a qualitative study among general physicians and pneumologists
Suttels V, Da Costa S, Garcia E, Brahier T, Hartley M, Agodokpessi G, Wachinou P, Fasseur F, Boillat-Blanco N. Barriers and facilitators to implementation of point-of-care lung ultrasonography in a tertiary centre in Benin: a qualitative study among general physicians and pneumologists. BMJ Open 2023, 13: e070765. PMID: 37369423, PMCID: PMC10357755, DOI: 10.1136/bmjopen-2022-070765.Peer-Reviewed Original ResearchConceptsLower respiratory tract infectionsTertiary centerGeneral physiciansDiagnostic performanceProspective cohort studyRespiratory tract infectionsCare lung ultrasoundCare lung ultrasonographyProgram 6 monthsExcellent diagnostic performanceCohort studyImplementation of pointRespiratory symptomsTract infectionsMiddle-income countriesSpecialist careLung ultrasonographyLung ultrasoundPhysicians' perceptionsHospital settingPatient experienceQualitative studyDiagnostic approachClinical routineHealth equityDeepBreath—automated detection of respiratory pathology from lung auscultation in 572 pediatric outpatients across 5 countries
Heitmann J, Glangetas A, Doenz J, Dervaux J, Shama D, Garcia D, Benissa M, Cantais A, Perez A, Müller D, Chavdarova T, Ruchonnet-Metrailler I, Siebert J, Lacroix L, Jaggi M, Gervaix A, Hartley M. DeepBreath—automated detection of respiratory pathology from lung auscultation in 572 pediatric outpatients across 5 countries. Npj Digital Medicine 2023, 6: 104. PMID: 37268730, PMCID: PMC10238513, DOI: 10.1038/s41746-023-00838-3.Peer-Reviewed Original ResearchAcute respiratory illnessPediatric outpatientsRespiratory illnessRespiratory pathologyLung auscultationReceiver operator characteristicHealthy controlsRespiratory rateThoracic sitesRespiratory cycleBronchiolitisPneumoniaOutpatientsPatientsPathological breathingIllnessPathologyAuscultationDisordersSignificant improvementObjective estimatesBreathingAUROCePOCT+ and the medAL-suite: Development of an electronic clinical decision support algorithm and digital platform for pediatric outpatients in low- and middle-income countries
Tan R, Cobuccio L, Beynon F, Levine G, Vaezipour N, Luwanda L, Mangu C, Vonlanthen A, De Santis O, Salim N, Manji K, Naburi H, Chirande L, Matata L, Bulongeleje M, Moshiro R, Miheso A, Arimi P, Ndiaye O, Faye M, Thiongane A, Awasthi S, Sharma K, Kumar G, Van De Maat J, Kulinkina A, Rwandarwacu V, Dusengumuremyi T, Nkuranga J, Rusingiza E, Tuyisenge L, Hartley M, Faivre V, Thabard J, Keitel K, D’Acremont V. ePOCT+ and the medAL-suite: Development of an electronic clinical decision support algorithm and digital platform for pediatric outpatients in low- and middle-income countries. PLOS Digital Health 2023, 2: e0000170. PMID: 36812607, PMCID: PMC9931356, DOI: 10.1371/journal.pdig.0000170.Peer-Reviewed Original ResearchClinical decision support algorithmsDecision support algorithmQuality of careMiddle-income settingsMiddle-income countriesReliability of clinical signsCountry of implementationMobile healthSupport algorithmImprove uptakeClinical contentPediatric outpatientsHealth authoritiesChildhood mortalityClinical expertsIntegrated development processProgramming skillsPerformance of predictorsAntibiotic prescriptionsClinical algorithmCliniciansCareClinical validation studiesEnd-usersAlgorithm suite
2022
What If…? Pandemic policy-decision-support to guide a cost-benefit-optimised, country-specific response
Mannarini G, Posa F, Bossy T, Massemin L, Fernandez-Castanon J, Chavdarova T, Cañas P, Gupta P, Jaggi M, Hartley M. What If…? Pandemic policy-decision-support to guide a cost-benefit-optimised, country-specific response. PLOS Global Public Health 2022, 2: e0000721. PMID: 36962770, PMCID: PMC10022143, DOI: 10.1371/journal.pgph.0000721.Peer-Reviewed Original ResearchUnemployment rateHigh-income countriesPolicy mixCOVID-19 mitigation policiesEconomic informationPolicy efficacyPolicy impactCountry-specific responsesIndividual countriesOptimal policyMitigation policiesIncome countriesPolicyPandemic policiesDamage estimatesCountriesTerms of costEconomic damageYears of dataHealth policyCostCOVID-19 pandemicPandemic scenarioPublic health policyEconomic lossesGenomic Diversity of Torque Teno Virus in Blood Samples from Febrile Paediatric Outpatients in Tanzania: A Descriptive Cohort Study
Laubscher F, Hartley M, Kaiser L, Cordey S. Genomic Diversity of Torque Teno Virus in Blood Samples from Febrile Paediatric Outpatients in Tanzania: A Descriptive Cohort Study. Viruses 2022, 14: 1612. PMID: 35893678, PMCID: PMC9330782, DOI: 10.3390/v14081612.Peer-Reviewed Original ResearchConceptsTorque teno virusBlood samplesPediatric outpatientsMetagenomic next-generation sequencingFebrile pediatric outpatientsDescriptive cohort studyHuman blood viromeCohort studyIndividual blood samplesPatient ageTanzanian childrenBlood viromeSignificant associationMixed genotypesMonths/yearsTTV speciesNext-generation sequencingPositive samplesAgeOutpatientsFirst months/yearsMedianSubjectsVirusGenotypesPoint-of-care ultrasound for tuberculosis management in Sub-Saharan Africa—a balanced SWOT analysis
Suttels V, Du Toit J, Fiogbé A, Wachinou A, Guendehou B, Alovokpinhou F, Toukoui P, Hada A, Sefou F, Vinasse P, Makpemikpa G, Capo-Chichi D, Garcia E, Brahier T, Keitel K, Ouattara K, Cissoko Y, Beye S, Mans P, Agodokpessi G, Boillat-Blanco N, Hartley M. Point-of-care ultrasound for tuberculosis management in Sub-Saharan Africa—a balanced SWOT analysis. International Journal Of Infectious Diseases 2022, 123: 46-51. PMID: 35811083, DOI: 10.1016/j.ijid.2022.07.009.Peer-Reviewed Original ResearchConceptsTB managementCare ultrasoundLimitations of POCUSAdvent of ultrasoundLack of visualizationSub-Saharan AfricaTB contactTB sequelaePleural effusionLung pathologySubpleural nodulesHealthcare workersPericardial punctureTriage toolTuberculosis managementTB detectionMobile health devicesPoor specificityPOCUSUltrasoundTuberculosisObjective assessmentSmall consolidationsOperator dependencyRelevant literaturePoint-of-care lung ultrasonography for early identification of mild COVID-19: a prospective cohort of outpatients in a Swiss screening center
Schaad S, Brahier T, Hartley M, Cordonnier J, Bosso L, Espejo T, Pantet O, Hugli O, Carron P, Meuwly J, Boillat-Blanco N. Point-of-care lung ultrasonography for early identification of mild COVID-19: a prospective cohort of outpatients in a Swiss screening center. BMJ Open 2022, 12: e060181. PMID: 35750462, PMCID: PMC9234434, DOI: 10.1136/bmjopen-2021-060181.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionLung ultrasoundClinical findingsCOVID-19Early identificationCOVID-19 positive patientsAbnormal LUS findingsBlinded independent expertsProspective observational cohortMild COVID-19Healthy healthcare workersCare lung ultrasonographyLausanne University HospitalAppropriate screening toolSARS-CoV-2COVID-19 screeningLUS featuresLUS findingsObservational cohortProspective cohortSymptom onsetAbnormal findingsClinical featuresLung ultrasonographyLung zonesUltrasound for point-of-care sputum-free tuberculosis detection: Building collaborative standardized image-banks
Suttels V, Wachinou P, Du Toit J, Boillat-Blanco N, Hartley M. Ultrasound for point-of-care sputum-free tuberculosis detection: Building collaborative standardized image-banks. EBioMedicine 2022, 81: 104078. PMID: 35649304, PMCID: PMC9160315, DOI: 10.1016/j.ebiom.2022.104078.Peer-Reviewed Original Research
2021
Blood virosphere in febrile Tanzanian children
Cordey S, Laubscher F, Hartley M, Junier T, Keitel K, Docquier M, Guex N, Iseli C, Vieille G, Le Mercier P, Gleizes A, Samaka J, Mlaganile T, Kagoro F, Masimba J, Said Z, Temba H, Elbanna G, Tapparel C, Zanella M, Xenarios I, Fellay J, D’Acremont V, Kaiser L. Blood virosphere in febrile Tanzanian children. Emerging Microbes & Infections 2021, 10: 982-993. PMID: 33929935, PMCID: PMC8171259, DOI: 10.1080/22221751.2021.1925161.Peer-Reviewed Original ResearchConceptsInfection/diseaseBlood viromeMetagenomic next-generation sequencingAcute febrile illnessLow-resource clinical settingsAvailable diagnostic toolsFebrile childrenFebrile illnessPediatric populationOutpatient departmentRoutine screeningTanzanian childrenViral infectionPotential viral originViral variantsClinical settingOne-yearDetected virusNext-generation sequencingDar es SalaamDiagnostic toolCausal virusVirusViral originDisease
2020
Weight Erosion: An Update Aggregation Scheme for Personalized Collaborative Machine Learning
Grimberg F, Hartley M, Jaggi M, Karimireddy S. Weight Erosion: An Update Aggregation Scheme for Personalized Collaborative Machine Learning. Lecture Notes In Computer Science 2020, 12444: 160-169. DOI: 10.1007/978-3-030-60548-3_16.Peer-Reviewed Original ResearchAggregation schemeClassification taskBetter privacy guaranteesFederated learning techniquesSharing of dataMachine learning modelsBinary classification taskData setsCollaborative machinePrivacy guaranteesLearning techniquesLearning modelModel personalizationSharingSchemeTaskSuch copyingCopyingPersonalizationSetMachineGuaranteesSGDDataModelClinical relevance of low-density Plasmodium falciparum parasitemia in untreated febrile children: A cohort study
Hartley M, Hofmann N, Keitel K, Kagoro F, Moniz C, Mlaganile T, Samaka J, Masimba J, Said Z, Temba H, Gonzalez I, Felger I, Genton B, D’Acremont V. Clinical relevance of low-density Plasmodium falciparum parasitemia in untreated febrile children: A cohort study. PLOS Medicine 2020, 17: e1003318. PMID: 32956354, PMCID: PMC7505590, DOI: 10.1371/journal.pmed.1003318.Peer-Reviewed Original ResearchConceptsFebrile childrenLD patientsSecondary hospitalizationCohort studyLD infectionLow-density Plasmodium infectionsMalaria rapid diagnostic testsFebrile pediatric outpatientsPlasmodium falciparum parasitemiaPrimary care levelClinical decision support algorithmPrimary care facilitiesRapid diagnostic testsHigh-density infectionsViral originPediatric outpatientsUndifferentiated feverClinical featuresClinical presentationHD patientsSevere malnutritionClinical benefitIncidental findingPlasmodium infectionPolymerase chain reactionLung Ultrasonography for Risk Stratification in Patients with Coronavirus Disease 2019 (COVID-19): A Prospective Observational Cohort Study
Brahier T, Meuwly J, Pantet O, Vez M, Donnet H, Hartley M, Hugli O, Boillat-Blanco N. Lung Ultrasonography for Risk Stratification in Patients with Coronavirus Disease 2019 (COVID-19): A Prospective Observational Cohort Study. Clinical Infectious Diseases 2020, 73: e4189-e4196. PMID: 32940646, PMCID: PMC7543331, DOI: 10.1093/cid/ciaa1408.Peer-Reviewed Original ResearchConceptsLung ultrasonographyCoronavirus disease 2019Emergency departmentLUS scoreRisk stratificationDisease 2019Lower respiratory tract infectionsProspective observational cohort studyPleural line irregularitiesEarly risk stratificationObservational cohort studyProspective observational studyRespiratory tract infectionsRisk stratification toolConfluent B-linesDifferent clinical outcomesLausanne University HospitalCOVID-19B-linesLUS characteristicsLUS findingsCohort studyTract infectionsClinical outcomesPatient groupPrecision global health: a roadmap for augmented action
Sheath D, de Castañeda R, Bempong N, Raviglione M, Machalaba C, Pepper M, Vayena E, Ray N, Wernli D, Escher G, Grey F, Elger B, Helbing D, Kleineberg K, Beran D, Miranda J, Huffman M, Hersch F, Andayi F, Thumbi S, D’Acremont V, Hartley M, Zinsstag J, Larus J, Martínez M, Guerin P, Merson L, Ngyuen V, Rühli F, Geissbuhler A, Salathé M, Bolon I, Boehme C, Berkley S, Valleron A, Keiser O, Kaiser L, Eckerle I, Utzinger J, Flahault A. Precision global health: a roadmap for augmented action. Journal Of Public Health And Emergency 2020, 4: 5-5. DOI: 10.21037/jphe.2020.01.01.Peer-Reviewed Original Research
2019
Nearly Complete Genome Sequence of a Novel Phlebovirus-Like Virus Detected in a Human Plasma Sample by High-Throughput Sequencing
Laubscher F, Cordey S, Hartley M, Vieille G, Boillat-Blanco N, Samaka J, Mlaganile T, d’Acremont V, Kaiser L. Nearly Complete Genome Sequence of a Novel Phlebovirus-Like Virus Detected in a Human Plasma Sample by High-Throughput Sequencing. Microbiology Resource Announcements 2019, 8: 10.1128/mra.00764-19. PMID: 31467101, PMCID: PMC6715871, DOI: 10.1128/mra.00764-19.Peer-Reviewed Original Research