2024
A tale of two constructs: combined assessment of demoralization and subjective incompetence
Murri M, Folesani F, Azzolina D, Muscettola A, Bobevski I, Triolo F, Farkas G, Braccia F, Gavesi M, Toffanin T, Ferrara M, Zerbinati L, Khan M, Gregori D, De Figueredo J, Kissane D, Caruso R, Grassi L, Nanni M. A tale of two constructs: combined assessment of demoralization and subjective incompetence. Psychology Health & Medicine 2024, 29: 1635-1651. PMID: 39302008, DOI: 10.1080/13548506.2024.2405749.Peer-Reviewed Original ResearchConceptsSubjective incompetenceClinical dimensionsItem response theory analysisLatent trait scoresItem psychometric propertiesShort assessment instrumentDimension of demoralizationItem response theory modelsTrait scoresItem structurePsychometric propertiesDemoralization ScaleAssessment instrumentsDemoralizationIRT modelsTwenty itemsLong versionItemsDiscriminative propertiesClinical assessmentGeneral populationTheory analysisMultiple dimensionsHopelessnessEarly signsTimelinePTC: Development of a unified interface for pathways to care collection, visualization, and collaboration in first episode psychosis
Mathis W, Ferrara M, Cahill J, Karmani S, Tayfur S, Srihari V. TimelinePTC: Development of a unified interface for pathways to care collection, visualization, and collaboration in first episode psychosis. PLOS ONE 2024, 19: e0302116. PMID: 39028697, PMCID: PMC11259254, DOI: 10.1371/journal.pone.0302116.Peer-Reviewed Original ResearchConceptsPathways to CareDuration of untreated psychosisManual transcription errorsDevelopment of targeted interventionsReduce duration of untreated psychosisHealthcare accessibility researchReal-time data entryImprove patient outcomesEpisode psychosisCare pathwaysPatient journeyHealthcare contextPatient outcomesPaper-basedConversion of collected dataFEP treatmentData collection processNew HavenData collection methodsData entryTranscription errorsUntreated psychosisOpen-source codebaseData collectionWeb-based toolThe impact of early detection (ED) campaigns on care presentations: Beyond DUP reduction
Hazan H, Ferrara M, Riley S, Li F, Zhou B, Kline E, Gibbs-Dean T, Karmani S, Tayfur S, Tek C, Keshavan M, Srihari V. The impact of early detection (ED) campaigns on care presentations: Beyond DUP reduction. Schizophrenia Research 2024, 264: 457-461. PMID: 38266513, PMCID: PMC10923115, DOI: 10.1016/j.schres.2024.01.022.Peer-Reviewed Original ResearchConceptsCoordinated specialty careDuration of untreated psychosisImpact of early detectionEarly detectionEarly detection campaignsSpecialty careAdjustment scoresCampaign yearDetection campaignsMediation analysisEffects of EDRegression modelsCareUntreated psychosisPositive symptomsGAFPatientsSalutary effects
2023
Sampling from different populations: Sociodemographic, clinical, and functional differences between samples of first episode psychosis individuals and clinical high-risk individuals who progressed to psychosis
Hagler M, Ferrara M, Yoviene Sykes L, Li F, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Perkins D, Mathalon D, Seidman L, Tsuang M, Walker E, Powers A, Allen A, Srihari V, Woods S. Sampling from different populations: Sociodemographic, clinical, and functional differences between samples of first episode psychosis individuals and clinical high-risk individuals who progressed to psychosis. Schizophrenia Research 2023, 255: 239-245. PMID: 37028205, PMCID: PMC10207144, DOI: 10.1016/j.schres.2023.03.047.Peer-Reviewed Original ResearchConceptsFirst-episode psychosis servicesClinical high riskClinical high-risk individualsEarly detectionFirst-episode psychosis individualsRecent psychiatric hospitalizationCourse of illnessHigh-risk individualsAttenuated positive symptomsCHR researchGeographic catchmentSyndromal psychosisPsychosis individualsPsychiatric hospitalizationEarly intervention effortsHigh riskPsychosis servicesPositive symptomsGlobal functioningClinical resourcesProtective factorsDifferent populationsFE participantsGeneralizability of findingsFES program
2022
Machine Learning and Non-Affective Psychosis: Identification, Differential Diagnosis, and Treatment
Ferrara M, Franchini G, Funaro M, Cutroni M, Valier B, Toffanin T, Palagini L, Zerbinati L, Folesani F, Murri M, Caruso R, Grassi L. Machine Learning and Non-Affective Psychosis: Identification, Differential Diagnosis, and Treatment. Current Psychiatry Reports 2022, 24: 925-936. PMID: 36399236, PMCID: PMC9780131, DOI: 10.1007/s11920-022-01399-0.Peer-Reviewed Original ResearchConceptsMachine learning techniquesBinary classification caseSetting of hyperparametersSupport vector machineArtificial intelligenceLearning techniquesMachine learningML applicationsElectronic health recordsDigital contentML toolsSupervised approachClassification casesVector machineRandom forestGradient boostingML approachHealth recordsIllness detectionOverall performancePromising resultsSources of dataIdentification toolToolPreprocessing
2020
Analysis of Early Intervention Services on Adult Judicial Outcomes
Pollard JM, Ferrara M, Lin IH, Kucukgoncu S, Wasser T, Li F, Srihari VH. Analysis of Early Intervention Services on Adult Judicial Outcomes. JAMA Psychiatry 2020, 77: 871-872. PMID: 32320010, PMCID: PMC7177643, DOI: 10.1001/jamapsychiatry.2020.0448.Peer-Reviewed Original ResearchCOVID-19 disease emergency operational instructions for Mental Health Departments issued by the Italian Society of Epidemiological Psychiatry
Starace F, Ferrara M. COVID-19 disease emergency operational instructions for Mental Health Departments issued by the Italian Society of Epidemiological Psychiatry. Epidemiology And Psychiatric Sciences 2020, 29: e116. PMID: 32228737, PMCID: PMC7163186, DOI: 10.1017/s2045796020000372.Commentaries, Editorials and LettersMeSH KeywordsAmbulatory CareBetacoronavirusCommunity Mental Health ServicesCoronavirus InfectionsCOVID-19Emergency Service, HospitalHealth Services ResearchHumansItalyMental DisordersPandemicsPneumonia, ViralPractice Guidelines as TopicPsychiatryPublic HealthQuality of Health CareSARS-CoV-2Societies, MedicalConceptsMental health departmentHealth departmentsEpidemiological psychiatryItalian Mental Health DepartmentsSafety of proceduresItalian SocietyCOVID-19 diseaseCommunity psychiatry servicesMental health providersPublic health responsibilitiesCurrent COVID-19 pandemicPsychiatry servicesBetter health careInpatient servicesHealth responsibilityHealth providersPublic health necessityHealth emergencyDisease emergenciesHealth careCOVID-19 pandemicOriginal Italian versionCurrent pandemicItalian versionHealth necessity
2019
Predictive validity of conversion from the clinical high risk syndrome to frank psychosis
Yoviene Sykes LA, Ferrara M, Addington J, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, Perkins DO, Mathalon DH, Seidman LJ, Tsuang MT, Walker EF, McGlashan TH, Woodberry KA, Powers AR, Ponce AN, Cahill JD, Pollard JM, Srihari VH, Woods SW. Predictive validity of conversion from the clinical high risk syndrome to frank psychosis. Schizophrenia Research 2019, 216: 184-191. PMID: 31864837, PMCID: PMC7239715, DOI: 10.1016/j.schres.2019.12.002.Peer-Reviewed Original ResearchConceptsFrank psychosisFirst-episode psychosis patientsOne-yearNorth American Prodromal Longitudinal StudySeverity of illnessClinical high-risk syndromeCurrent antipsychotic medicationsHigh-risk syndromePsychosis risk syndromeClinical high riskPredictive validityFEP casesPrescription ratesAntipsychotic medicationPsychosis patientsRisk syndromePsychosis onsetHigh riskLittle investigative attentionDiagnostic stabilityCHR individualsPsychosis paradigmPsychosisLongitudinal studySyndromeParsing the impact of early detection on duration of untreated psychosis (DUP): Applying quantile regression to data from the Scandinavian TIPS study
Ferrara M, Guloksuz S, Li F, Burke S, Tek C, Friis S, Ten Velden Hegelstad W, Joa I, Johannessen JO, Melle I, Simonsen E, Srihari VH. Parsing the impact of early detection on duration of untreated psychosis (DUP): Applying quantile regression to data from the Scandinavian TIPS study. Schizophrenia Research 2019, 210: 128-134. PMID: 31204063, DOI: 10.1016/j.schres.2019.05.035.Peer-Reviewed Original ResearchEarly intervention service for first episode psychosis in Modena, Northern Italy: The first hundred cases
Ferrara M, Tedeschini E, Baccari F, Musella V, Vacca F, Mazzi F, Ferri M, Srihari V, Starace F, Group F. Early intervention service for first episode psychosis in Modena, Northern Italy: The first hundred cases. Early Intervention In Psychiatry 2019, 13: 1011-1017. PMID: 30672134, DOI: 10.1111/eip.12788.Peer-Reviewed Original ResearchConceptsEarly intervention servicesClinical improvementMedian ageIntervention servicesCommunity mental health centerCommunity outpatient servicesPsychiatric hospital unitMeaningful clinical improvementFirst-episode psychosisModel of careNon-affective psychosisNation Outcome ScalesMental health centersHigher median ageEarly detection effortsRefinement of treatmentMain referralsPharmacological consultationYounger patientsUntreated psychosisOutcome ScaleGeneral practitionersEpisode psychosisHealth centersOutpatient services
2017
Assessment of cardiovascular risk in an Italian psychiatric outpatient sample: A chart review of patients treated with second‐generation antipsychotics
Severi E, Ferrara M, Tedeschini E, Vacca F, Mungai F, Amendolara R, Baccari F, Starace F. Assessment of cardiovascular risk in an Italian psychiatric outpatient sample: A chart review of patients treated with second‐generation antipsychotics. International Journal Of Mental Health Nursing 2017, 27: 1002-1008. PMID: 29197134, DOI: 10.1111/inm.12407.Peer-Reviewed Original ResearchConceptsCardiovascular risk assessmentSecond-generation antipsychoticsChart reviewMental illnessCommunity mental health servicesCommunity mental health centerPhysical healthCardiovascular risk monitoringOutpatient sampleSignificant cardiovascular burdenPrevalence of MetSClinical chart reviewMore psychotropic medicationsMental health centersSubsample of patientsLow-density lipoproteinMental health servicesMental health professionalsΓ-glutamyl transpeptidaseCardiovascular riskBlood pressureCardiovascular burdenMetabolic syndromeTotal cholesterolWaist circumferenceSt John’s wort (Hypericum perforatum)-induced psychosis: a case report
Ferrara M, Mungai F, Starace F. St John’s wort (Hypericum perforatum)-induced psychosis: a case report. Journal Of Medical Case Reports 2017, 11: 137. PMID: 28502251, PMCID: PMC5430601, DOI: 10.1186/s13256-017-1302-7.Peer-Reviewed Case Reports and Technical NotesConceptsDrug-induced psychosisJohn's wortPositive family historySevere mental health problemsFlorid psychotic symptomsAttention of cliniciansMental health problemsCase presentationThe caseSt John's wortPatient presentingPsychotic depressionCounter medicationsCase reportBody of evidenceClinical managementPsychotic featuresFamily historyPsychotic relapsePsychiatric servicesPsychotic symptomsHealth problemsHealth professionalsPsychotic diathesisUnsupervised administrationWhite menLower Frailty Is Associated with Successful Cognitive Aging Among Older Adults with HIV
Wallace LM, Ferrara M, Brothers TD, Garlassi S, Kirkland SA, Theou O, Zona S, Mussini C, Moore D, Rockwood K, Guaraldi G. Lower Frailty Is Associated with Successful Cognitive Aging Among Older Adults with HIV. AIDS Research And Human Retroviruses 2017, 33: 157-163. PMID: 27869500, PMCID: PMC5335777, DOI: 10.1089/aid.2016.0189.Peer-Reviewed Original ResearchConceptsSuccessful cognitive agingFrailty indexModena HIV Metabolic ClinicPlasma HIV viral loadOlder adultsCombination antiretroviral therapyHIV viral loadLower frailty indexHIV-Associated NonAverage chronologic ageCross-sectional analysisCognitive agingHANA conditionsAntiretroviral therapyViral loadAIDS conditionsMetabolic clinicLower frailtyFunctional impairmentClinical dataNeurocognitive disordersNumber of deficitsSCA participantsChronologic ageHIV
2014
The Syndemic Illness of HIV and Trauma: Implications for a Trauma-Informed Model of Care
Brezing C, Ferrara M, Freudenreich O. The Syndemic Illness of HIV and Trauma: Implications for a Trauma-Informed Model of Care. Journal Of The Academy Of Consultation-Liaison Psychiatry 2014, 56: 107-118. PMID: 25597836, DOI: 10.1016/j.psym.2014.10.006.Peer-Reviewed Original ResearchConceptsHIV infectionTrauma-informed careHigh-risk HIV behaviorTrauma-Informed ModelCochrane Review databasesHIV risk behaviorsPrimary clinical researchIntimate partner violenceTreatment of peopleRates of traumaNegative health consequencesPosttraumatic stress disorderPoor HIVPoor adherencePractice guidelinesHIV behaviorsHIVHealth outcomesPosttraumatic sequelaeReviews databasesInfectionPoor healthClinical researchHealth consequencesStress disorderThe concomitant use of second-generation antipsychotics and long-term antiretroviral therapy may be associated with increased cardiovascular risk
Ferrara M, Umlauf A, Sanders C, Meyer JM, McCutchan J, Duarte N, Atkinson J, Grant I, Ellis RJ, Group T. The concomitant use of second-generation antipsychotics and long-term antiretroviral therapy may be associated with increased cardiovascular risk. Psychiatry Research 2014, 218: 201-208. PMID: 24794030, PMCID: PMC4082695, DOI: 10.1016/j.psychres.2014.04.015.Peer-Reviewed Original ResearchConceptsSecond-generation antipsychoticsBody mass indexAntiretroviral therapyCardiovascular riskMultivariable modelExact testUse of SGAsHIV Neurobehavioral Research ProgramLong-term antiretroviral therapyHigher body mass indexHigher mean triglyceridesMetabolic syndrome componentsHuman immunodeficiency virusDiabetes mellitus incidenceLogistic multivariable modelFisher's exact testMean triglyceridesMetabolic complicationsHIV diseaseSerum lipidsSyndrome componentsArterial pressureMedication combinationsMass indexImmunodeficiency virus
2011
Physical Restraints in an Italian Psychiatric Ward: Clinical Reasons and Staff Organization Problems
Di Lorenzo R, Baraldi S, Ferrara M, Mimmi S, Rigatelli M. Physical Restraints in an Italian Psychiatric Ward: Clinical Reasons and Staff Organization Problems. Perspectives In Psychiatric Care 2011, 48: 95-107. PMID: 22458723, DOI: 10.1111/j.1744-6163.2011.00308.x.Peer-Reviewed Original ResearchConceptsPsychiatric wardsHr of hospitalizationItalian psychiatric wardPhysical restraint rateAcute psychiatric wardsPhysical restraint useNursing chartsClinical reasonsRestraint usePsychotic disordersRestraint ratesVoluntary admissionPhysical restraintMechanical restraintPatientsAggressive behaviorWardsHospitalizationAltered statesAdmissionSchizophrenia
2008
What Is the Biopsychosocial Role of Human Immunodeficiency Virus Positivity in Patients With End-Stage Liver Disease Who Undergo Orthotopic Liver Transplantation?
Silva V, Ferrara M, Mazzi F, Pingani L, Cocchi S, Romano A, Masetti M, Gerunda GE, Guaraldi G, Rigatelli M. What Is the Biopsychosocial Role of Human Immunodeficiency Virus Positivity in Patients With End-Stage Liver Disease Who Undergo Orthotopic Liver Transplantation? Transplantation Proceedings 2008, 40: 1910-1912. PMID: 18675086, DOI: 10.1016/j.transproceed.2008.05.060.Peer-Reviewed Original ResearchConceptsTransplant Evaluation Rating ScaleMontgomery-Asberg Depression Rating ScaleHuman immunodeficiency virusHIV groupHIV patientsPsychiatric comorbidityEnd-stage liver disease patientsHuman immunodeficiency virus (HIV) positivityEnd-stage liver diseaseAsberg Depression Rating ScaleConsultation-liaison psychiatry serviceRating ScaleBaseline psychiatric comorbidityLiver transplantation centerNon-HIV patientsOLT waiting listOrthotopic liver transplantationLiver disease patientsObservational prospective studySolid organ transplantationLiaison psychiatry serviceDepression Rating ScaleLiver transplantationTransplantation centersVirus positivity