2024
Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia
Bonomi R, Hillmer A, Woodcock E, Bhatt S, Rusowicz A, Angarita G, Carson R, Davis M, Esterlis I, Nabulsi N, Huang Y, Krystal J, Pietrzak R, Cosgrove K. Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406005121. PMID: 39172786, PMCID: PMC11363315, DOI: 10.1073/pnas.2406005121.Peer-Reviewed Original ResearchConceptsPTSD groupPrefrontal-limbic circuitsNeuroimmune responseAssociated with anhedoniaPosttraumatic stress disorderPositron emission tomography brain imagingTranslocator protein availabilityBrain immune functionAnhedonic symptomsStress disorderPeripheral immune dysfunctionPTSDGroup differencesSeverity of symptomsPsychiatric diseasesTranslocator proteinBrain imagingAdministration of lipopolysaccharideSymptomsMicroglial markersLPS-induced increaseCompared to controlsImmune functionSickness symptomsAnhedoniaDifferences in Diagnostic Rules Used to Determine Borderline Personality Disorder Impact Prevalence and Associations with Clinically Relevant Variables: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions-III
Loya J, Wagner A, Pittman B, Davis M. Differences in Diagnostic Rules Used to Determine Borderline Personality Disorder Impact Prevalence and Associations with Clinically Relevant Variables: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions-III. Personality Disorders Theory Research And Treatment 2024, 15: 60-73. PMID: 38206863, PMCID: PMC10786338, DOI: 10.1037/per0000643.Peer-Reviewed Original ResearchConceptsBorderline personality disorderBorderline personality disorder diagnosisPrevalence of borderline personality disorderBorderline personality disorder statusClinically relevant variablesNational Epidemiologic SurveyRelated Conditions-IIIMental health conditionsGeneralizability of findingsPersonality disorderClinical interviewClinical variablesProblem behaviorsDisorder prevalenceConditions-IIIRelevant variablesMethodological differencesEpidemiological surveyDisordersBorderlineDiagnostic rulesPrevalence ratesU.S. adultsHealth consequencesHealth conditions
2020
PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies
Bhatt S, Hillmer AT, Girgenti MJ, Rusowicz A, Kapinos M, Nabulsi N, Huang Y, Matuskey D, Angarita GA, Esterlis I, Davis MT, Southwick SM, Friedman MJ, Duman R, Carson R, Krystal J, Pietrzak R, Cosgrove K. PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies. Nature Communications 2020, 11: 2360. PMID: 32398677, PMCID: PMC7217830, DOI: 10.1038/s41467-020-15930-5.Peer-Reviewed Original ResearchMeSH KeywordsAcetamidesAdaptor Proteins, Signal TransducingAdultBrainCase-Control StudiesFemaleGene Expression ProfilingHealthy VolunteersHumansMaleMicrogliaMiddle AgedPositron-Emission TomographyPyridinesRadiopharmaceuticalsReceptors, GABAReceptors, Tumor Necrosis Factor, Member 14Sex FactorsStress Disorders, Post-TraumaticYoung AdultConceptsPosttraumatic stress disorderPeripheral immune activationImmune activationHigher C-reactive protein levelsC-reactive protein levelsTSPO availabilityTranslocator proteinBrain microglial activationTomography brain imagingStress-related pathophysiologyPositron emission tomography (PET) brain imagingNeuroimmune activationMicroglial activationPTSD symptom severityImmunologic regulationPostmortem studiesPTSD subgroupHealthy individualsSymptom severityTrauma exposurePTSD groupStress disorderLower relative expressionBrain imagingPET imaging
2019
Measuring the effects of ketamine on mGluR5 using [18F]FPEB and PET
Holmes SE, Gallezot JD, Davis MT, DellaGioia N, Matuskey D, Nabulsi N, Krystal JH, Javitch JA, DeLorenzo C, Carson RE, Esterlis I. Measuring the effects of ketamine on mGluR5 using [18F]FPEB and PET. Cerebrovascular And Brain Metabolism Reviews 2019, 40: 2254-2264. PMID: 31744389, PMCID: PMC7585925, DOI: 10.1177/0271678x19886316.Peer-Reviewed Original ResearchConceptsEffects of ketamineKetamine infusionGlutamate transmissionMetabotropic glutamate receptor 5Ketamine-induced effectsKetamine-induced changesGlutamate receptor 5Promising treatment targetDrug challenge studiesTwo-tissue compartment modelMGluR5 radioligandBlood pressureMGluR5 availabilityBaseline scanOutcome measuresHealthy subjectsHeart ratePsychiatric disordersReceptor 5Modulatory effectsMGluR5Treatment targetsChallenge studiesArterial input functionChallenge paradigmIn vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation
Davis MT, Hillmer A, Holmes SE, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Angarita G, Carson RE, Krystal JH, Esterlis I. In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 11490-11495. PMID: 31085640, PMCID: PMC6561298, DOI: 10.1073/pnas.1818871116.Peer-Reviewed Original ResearchConceptsMGluR5 availabilitySuicidal ideationHC individualsPathophysiology of PTSDLimbic brain regionsVolume of distributionHealthy comparison controlsSuicide risk managementPositron emission tomographyReceptor 5Venous input functionsBrain regionsPTSD individualsEmission tomographyMDD individualsVivo evidenceRecent evidencePotential roleMGluR5PTSDComparison controlsDysregulationMDDIdeationIndividualsLower synaptic density is associated with depression severity and network alterations
Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Lower synaptic density is associated with depression severity and network alterations. Nature Communications 2019, 10: 1529. PMID: 30948709, PMCID: PMC6449365, DOI: 10.1038/s41467-019-09562-7.Peer-Reviewed Original ResearchConceptsMajor depressive disorderPost-traumatic stress disorderLower synaptic densitySynaptic densityPositron emission tomographyFunctional connectivityNetwork alterationsSynaptic vesicle glycoprotein 2ASymptoms of depressionSynaptic lossDepressive disorderHealthy controlsNerve terminalsDepressive symptomsDepression severityUnmedicated individualsSynaptic connectionsEmission tomographyStress disorderVivo evidenceSymptomsDepressionSeverityDisordersAlterationsA factor analytic evaluation of the World Health Organization Disability Assessment Schedule 2.0 among veterans presenting to a generalist mental health clinic
Sexton MB, Davis MT, Lusk RK, Lyubkin M, Chermack ST. A factor analytic evaluation of the World Health Organization Disability Assessment Schedule 2.0 among veterans presenting to a generalist mental health clinic. Psychiatry Research 2019, 272: 638-642. PMID: 30616134, DOI: 10.1016/j.psychres.2019.01.008.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmbulatory Care FacilitiesDiagnostic and Statistical Manual of Mental DisordersDisability EvaluationDisabled PersonsFactor Analysis, StatisticalFemaleHumansMaleMental HealthMental Health ServicesMiddle AgedSurveys and QuestionnairesUnited StatesVeteransWorld Health OrganizationYoung AdultConceptsWorld Health Organization Disability Assessment Schedule 2.0Disability Assessment Schedule 2.0WHODAS 2.0Veterans AffairsMental health clinicsU.S. veteran populationClinical decision makingVeterans Benefits AdministrationHealth clinicsVeteran populationMental disordersMental healthcareGlobal assessmentStatistical ManualFactor analytic evaluationVeteran sampleDSM-5Multiaxial systemVeteransFactor structureNon-clinical sampleFifth editionExploratory analysisGood model fitDiscontinuation
2018
Relation Between Sexual and Gender Minority Status and Suicide Attempts Among Veterans Seeking Treatment for Military Sexual Trauma
Sexton MB, Davis MT, Anderson RE, Bennett DC, Sparapani E, Porter KE. Relation Between Sexual and Gender Minority Status and Suicide Attempts Among Veterans Seeking Treatment for Military Sexual Trauma. Psychological Services 2018, 15: 357-362. PMID: 30080095, DOI: 10.1037/ser0000207.Peer-Reviewed Original ResearchConceptsMilitary sexual traumaSuicide attemptsAdditional risk factorsSimilar clinical profilesSemistructured clinical interviewTrauma-focused interventionsMilitary service membersClinical profileMorbidity outcomesClinical managementRisk factorsPsychiatric sequelaeDiagnostic evaluationClinical InterviewConsultation appointmentSuicidal behaviorDemographic characteristicsMinority veteransService membersVeteransSexual traumaCompetent deliveryResearch disparitiesSGM populationsSequelae
2017
A psychometric evaluation of the Posttraumatic Cognitions Inventory with Veterans seeking treatment following military trauma exposure
Sexton MB, Davis MT, Bennett DC, Morris DH, Rauch SAM. A psychometric evaluation of the Posttraumatic Cognitions Inventory with Veterans seeking treatment following military trauma exposure. Journal Of Affective Disorders 2017, 226: 232-238. PMID: 29017066, DOI: 10.1016/j.jad.2017.09.048.Peer-Reviewed Original ResearchConceptsPosttraumatic Cognitions InventoryMilitary sexual traumaPosttraumatic stress disorderTrauma-related beliefsMilitary trauma exposureTrauma-focused treatmentTrauma exposureFactor modelTrauma typesStress disorderSexual traumaCritical constructsSalient relationshipsMilitary traumaStress exposurePsychometric evaluationFactor scoresSubscale scoresReliability validityConfirmatory analysisStandard assessmentVeteransInventoryValidityTraumaMother–Child Interactions at Six Months Postpartum Are Not Predicted by Maternal Histories of Abuse and Neglect or Maltreatment Type
Sexton MB, Davis MT, Menke R, Raggio GA, Muzik M. Mother–Child Interactions at Six Months Postpartum Are Not Predicted by Maternal Histories of Abuse and Neglect or Maltreatment Type. Psychological Trauma Theory Research Practice And Policy 2017, 9: 622-626. PMID: 28481563, PMCID: PMC5589486, DOI: 10.1037/tra0000272.Peer-Reviewed Original ResearchConceptsPostpartum womenPostpartum mothersChildhood maltreatmentMaternal psychiatric symptomsHistory of CMCM historyPostpartum visitAdverse outcomesPsychiatric symptomsUnivariate general linear modelClinical implicationsTypes of CMCM severityGeneral linear modelPositive parentingWomenMother-child interactionMothersSignificant differencesPostpartumNonclinical groupPotential influenceTypes of abuseMaltreatment historyAltered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence
Holmes SE, Girgenti MJ, Davis MT, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Duman RS, Carson RE, Krystal JH, Esterlis I, Friedman M, Kowall N, Brady C, McKee A, Stein T, Huber B, Kaloupek D, Alvarez V, Benedek D, Ursano R, Williamson D, Cruz D, Young K, Duman R, Krystal J, Mash D, Hardegree M, Serlin G. Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 8390-8395. PMID: 28716937, PMCID: PMC5547601, DOI: 10.1073/pnas.1701749114.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderMGluR5 availabilityPositron emission tomographyGlutamate systemMetabotropic glutamate receptor 5Treatment of PTSDHuman posttraumatic stress disorderGlutamate receptor 5Mechanism-based treatmentsExpression of FKBP5Promising treatment targetHuman postmortem tissueTargeted pharmacological treatmentStress psychopathologyPharmacological treatmentExpression of proteinsReceptor 5MGluR5Treatment targetsPostmortem tissueEmission tomographyStress disorderPostmortem samplesPromising targetDisordersPreliminary evidence concerning the pattern and magnitude of cognitive dysfunction in major depressive disorder using cogstate measures
Davis MT, DellaGioia N, Matuskey D, Harel B, Maruff P, Pietrzak RH, Esterlis I. Preliminary evidence concerning the pattern and magnitude of cognitive dysfunction in major depressive disorder using cogstate measures. Journal Of Affective Disorders 2017, 218: 82-85. PMID: 28460315, PMCID: PMC6457447, DOI: 10.1016/j.jad.2017.04.064.Peer-Reviewed Original ResearchConceptsCogState measuresVerbal learningComputerized cognitive test batteryLower full-scale IQ scoresFull Scale IQ scoresCognitive test batteryCognitive test performanceMajor depressive disorderMagnitude of deficitsVisual attentionVisual memoryCognitive measuresExecutive functionCognitive functioningPsychomotor speedVisuospatial problemIntellectual functioningIQ scoresTest batteryCognitive deficitsTest performanceCognitive dysfunctionMemoryAssessment measuresDepressive disorderPosttraumatic Stress Disorder Symptom Clusters and Acquired Capability for Suicide: A Reexamination Using DSM‐5 Criteria
Spitzer EG, Zuromski KL, Davis MT, Witte TK, Weathers F. Posttraumatic Stress Disorder Symptom Clusters and Acquired Capability for Suicide: A Reexamination Using DSM‐5 Criteria. Suicide And Life-Threatening Behavior 2017, 48: 105-115. PMID: 28261858, DOI: 10.1111/sltb.12341.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorder (PTSD) symptom clustersPTSD symptom clustersSymptom clustersSpecific PTSD symptom clustersSix-factor Anhedonia modelTrauma-exposed undergraduatesInterpersonal-psychological theoryDSM-5 criteriaAcquired CapabilitySuppressor variableCommonality analysisAnhedonia modelBivariate correlationsSuicideComplex relationshipAnhedoniaFacetsUndergraduatesRelationshipStructure coefficientsFindingsTheory
2016
Family Social Support Modifies the Relationships Between Childhood Maltreatment Severity, Economic Adversity and Postpartum Depressive Symptoms
Muzik M, Umarji R, Sexton MB, Davis MT. Family Social Support Modifies the Relationships Between Childhood Maltreatment Severity, Economic Adversity and Postpartum Depressive Symptoms. Maternal And Child Health Journal 2016, 21: 1018-1025. PMID: 28028663, PMCID: PMC5392156, DOI: 10.1007/s10995-016-2197-4.Peer-Reviewed Original ResearchConceptsPostpartum depressive symptomsCM severityDepressive symptomsSocial Support ModifiesSocial supportChildhood maltreatmentDepressive symptom severityChildhood maltreatment severityPostpartum mothersMaternal characteristicsProtective effectRisk mothersLarge effect sizesLinear regression analysisSymptom severityPostpartum psychopathologyConclusionsThis studySeverityPDS scoresLongitudinal studyChildhood abuseHierarchical linear regression analysesFamily social supportMothersRegression analysisDevelopment and Initial Psychometric Evaluation of the Semi-Structured Emotion Regulation Interview
Lee DJ, Weathers FW, Sloan DM, Davis MT, Domino JL. Development and Initial Psychometric Evaluation of the Semi-Structured Emotion Regulation Interview. Journal Of Personality Assessment 2016, 99: 56-66. PMID: 27564399, DOI: 10.1080/00223891.2016.1215992.Peer-Reviewed Original ResearchConceptsSelf-report measuresEmotion Regulation InterviewInitial psychometric evaluationER strategiesEmotion typeStrategy useEmotion regulation strategy useER strategy useRegulation strategy usePsychometric evaluationClinician-administered measuresForms of psychopathologyConstruct validation frameworkTransdiagnostic predictorContent validity processExcellent discriminant validityDiscriminant validityValidity processFuture researchSevere anxietySubsequent interviewsMeasuresInterviewsAngerPsychopathologyDemonstration and validation of a new pressure-based MRI-safe pain tolerance device
Davis MT, Daniel TA, Witte TK, Beyers RJ, Willis JZ, Wang Y, Denney TS, Katz JS, Salibi N, Deshpande G. Demonstration and validation of a new pressure-based MRI-safe pain tolerance device. Journal Of Neuroscience Methods 2016, 271: 160-168. PMID: 27378028, DOI: 10.1016/j.jneumeth.2016.07.001.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingPain toleranceAnterior cingulate gyrusPressure-related painMagnetic resonance imagingElicit painPain applicationCingulate gyrusPainT MRI scannerMRI environmentResonance imagingAlgometerAvailable algometerBOLD activationBrain activationValid instrumentMRI scannerPresent studyActivationIdentical procedureLongitudinal suicidal ideation across 18-months postpartum in mothers with childhood maltreatment histories
Muzik M, Brier Z, Menke RA, Davis MT, Sexton MB. Longitudinal suicidal ideation across 18-months postpartum in mothers with childhood maltreatment histories. Journal Of Affective Disorders 2016, 204: 138-145. PMID: 27344623, PMCID: PMC5012909, DOI: 10.1016/j.jad.2016.06.037.Peer-Reviewed Original ResearchConceptsPostpartum suicidal ideationSuicidal ideationChildhood maltreatmentProtective factorsCM historyMaternal suicidal ideationSeverity of SIHistory of CMSample of womenChildhood maltreatment historyPostpartumFactor associationsPercentage countsMarital statusSeverityMothersRiskIdeationFamily supportHigh rateSelf-report measuresMaltreatment historyNon-clinical sampleWomenAssociationA Factor Analytic Evaluation of the Difficulties in Emotion Regulation Scale
Lee DJ, Witte TK, Bardeen JR, Davis MT, Weathers FW. A Factor Analytic Evaluation of the Difficulties in Emotion Regulation Scale. Journal Of Clinical Psychology 2016, 72: 933-946. PMID: 27018649, DOI: 10.1002/jclp.22297.Peer-Reviewed Original ResearchCollege Students' Responses to Suicidal Content on Social Networking Sites: An Examination Using a Simulated Facebook Newsfeed
Corbitt‐Hall D, Gauthier JM, Davis MT, Witte TK. College Students' Responses to Suicidal Content on Social Networking Sites: An Examination Using a Simulated Facebook Newsfeed. Suicide And Life-Threatening Behavior 2016, 46: 609-624. PMID: 26999294, DOI: 10.1111/sltb.12241.Peer-Reviewed Original Research“Do you expect me to receive PTSD care in a setting where most of the other patients remind me of the perpetrator?”: Home-based telemedicine to address barriers to care unique to military sexual trauma and veterans affairs hospitals
Gilmore AK, Davis MT, Grubaugh A, Resnick H, Birks A, Denier C, Muzzy W, Tuerk P, Acierno R. “Do you expect me to receive PTSD care in a setting where most of the other patients remind me of the perpetrator?”: Home-based telemedicine to address barriers to care unique to military sexual trauma and veterans affairs hospitals. Contemporary Clinical Trials 2016, 48: 59-64. PMID: 26992740, PMCID: PMC4926870, DOI: 10.1016/j.cct.2016.03.004.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderHome-based telemedicineMilitary sexual traumaFemale veteransProlonged exposureMajority of patientsEvidence-based treatment deliveryVeterans Affairs hospitalEvidence-based therapiesVA Medical CenterSexual traumaTreat analysisPTSD careHBT groupMedical CenterSession attendanceTreatment centersProvider availabilityLife IndexStress disorderLife outcomesTraumaTreatment deliveryLow attritionPatients