2023
Pathological response in mucinous carcinoma of breast after neoadjuvant therapy - a multi-institutional study
Zhan H, Fineberg S, Podany P, Zeng J, Wang Y, Harigopal M, Singh K. Pathological response in mucinous carcinoma of breast after neoadjuvant therapy - a multi-institutional study. Human Pathology 2023, 142: 15-19. PMID: 37972873, DOI: 10.1016/j.humpath.2023.10.002.Peer-Reviewed Original ResearchConceptsNeoadjuvant endocrine therapyResidual tumour cellularityNeoadjuvant chemotherapyNeoadjuvant therapyMucinous carcinomaPathologic responseEndocrine therapyPathological responseMucin poolsBreast cancerEstrogen receptorTumor cellularityAcellular mucin poolsFavorable histologic subtypePreoperative adjuvant therapyRetrospective cohort studyComplete pathologic responseInvasive breast cancerNET groupMulti-institutional studyNeoadjuvant HER2Adjuvant therapyMC patientsCohort studyPathologic review
2022
Cytomorphologic features of SMARCA4‐deficient non–small cell lung carcinoma and correlation with immunohistochemical and molecular features
Sun T, Gilani SM, Podany P, Harigopal M, Zhong M, Wang H. Cytomorphologic features of SMARCA4‐deficient non–small cell lung carcinoma and correlation with immunohistochemical and molecular features. Cancer Cytopathology 2022, 130: 620-629. PMID: 35468657, DOI: 10.1002/cncy.22581.Peer-Reviewed Original ResearchConceptsNon-small cell lung carcinomaCell lung carcinomaCytomorphologic featuresLung carcinomaExtensive antibody panelHigh-grade featuresCommon cytologic featuresDifferent anatomic sitesVariable expressionMajority of casesSquamoid featuresCo-mutated genesUndifferentiated carcinomaImmunohistochemical profileGlandular featuresPapillary architectureAnatomic sitesCytologic featuresAggressive carcinomasClinical informationAntibody panelEpithelial markersScant cytoplasmCarcinomaNuclear enlargement
2021
EZH2 Protein Expression in Triple-negative Breast Cancer Treated With Neoadjuvant Chemotherapy: An Exploratory Study of Association With Tumor Response and Prognosis
Fineberg S, Tian X, Makower D, Harigopal M, Lo Y. EZH2 Protein Expression in Triple-negative Breast Cancer Treated With Neoadjuvant Chemotherapy: An Exploratory Study of Association With Tumor Response and Prognosis. Applied Immunohistochemistry & Molecular Morphology 2021, 30: 157-164. PMID: 35262520, DOI: 10.1097/pai.0000000000000998.Peer-Reviewed Original ResearchConceptsTriple-negative breast cancerResidual cancer burdenNeoadjuvant chemotherapyEZH2 protein expressionEZH2 expressionBreast cancerHigh-risk triple negative breast cancerLogistic regressionContinuous variablesStratification of outcomesDisease-free survivalProtein expressionTumor-infiltrating lymphocytesHigh EZH2 expressionMultivariable logistic regressionRisk of relapseDevelopment of metastasesLogistic regression analysisPretherapy biopsiesDisease recurrenceMetastatic recurrenceClinicopathologic featuresCancer burdenTumor responseCore biopsyApocrine Breast Cancer: Unique Features of a Predominantly Triple-Negative Breast Cancer
Saridakis A, Berger ER, Harigopal M, Park T, Horowitz N, Le Blanc J, Zanieski G, Chagpar A, Greenup R, Golshan M, Lannin DR. Apocrine Breast Cancer: Unique Features of a Predominantly Triple-Negative Breast Cancer. Annals Of Surgical Oncology 2021, 28: 5610-5616. PMID: 34426884, DOI: 10.1245/s10434-021-10518-9.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorBone NeoplasmsCarcinoma, Ductal, BreastFemaleHumansRetrospective StudiesTriple Negative Breast NeoplasmsConceptsBreast cancer-specific survivalCancer-specific survivalHigh-grade tumorsMolecular subtypesApocrine carcinomaBreast cancerBetter survivalHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Triple-negative breast cancerRare breast cancerEnd Results (SEER) databaseGrowth factor receptor 2Triple-negative patientsTriple-negative cancersLow-grade tumorsFactor receptor 2Life table methodApocrine tumorsLuminal patientsWorse survivalClinicopathologic featuresResults databaseAggressive featuresReceptor 2
2019
Interobserver variability in breast carcinoma grading results in prognostic stage differences
Rabe K, Snir OL, Bossuyt V, Harigopal M, Celli R, Reisenbichler ES. Interobserver variability in breast carcinoma grading results in prognostic stage differences. Human Pathology 2019, 94: 51-57. PMID: 31655171, DOI: 10.1016/j.humpath.2019.09.006.Peer-Reviewed Original ResearchConceptsPathologic prognostic stagePrognostic stageStage II carcinomaInterobserver variabilityIntra-observer variabilityGood intra-observer variabilityStage IABreast pathologistsConsecutive casesTumor gradeBreast carcinomaTumor gradingDiscordant gradesAJCC cancerDiscordant casesCarcinoma gradeInterobserver agreementGrading criteriaPathologistsCarcinomaComplete concordanceGradeOverall gradeGrading results
2016
Automated measurement of estrogen receptor in breast cancer: a comparison of fluorescent and chromogenic methods of measurement
Zarrella ER, Coulter M, Welsh AW, Carvajal DE, Schalper KA, Harigopal M, Rimm D, Neumeister V. Automated measurement of estrogen receptor in breast cancer: a comparison of fluorescent and chromogenic methods of measurement. Laboratory Investigation 2016, 96: 1016-1025. PMID: 27348626, PMCID: PMC5008858, DOI: 10.1038/labinvest.2016.73.Peer-Reviewed Original Research
2013
Quantitative Analysis of Estrogen Receptor Expression Shows SP1 Antibody Is More Sensitive Than 1D5
Welsh AW, Harigopal M, Wimberly H, Prasad M, Rimm DL. Quantitative Analysis of Estrogen Receptor Expression Shows SP1 Antibody Is More Sensitive Than 1D5. Applied Immunohistochemistry & Molecular Morphology 2013, 21: 139-147. PMID: 22820659, PMCID: PMC3482297, DOI: 10.1097/pai.0b013e31825d73b2.Peer-Reviewed Original Research
2003
Interpretative problems and preparative technique influence reliability of intraoperative parathyroid touch imprints.
Yao DX, Hoda SA, Yin DY, Kuhel WI, Harigopal M, Resetkova E, DeLellis RA. Interpretative problems and preparative technique influence reliability of intraoperative parathyroid touch imprints. Archives Of Pathology & Laboratory Medicine 2003, 127: 64-7. PMID: 12521369, DOI: 10.5858/2003-127-64-ipapti.Peer-Reviewed Original ResearchMeSH KeywordsCytodiagnosisFrozen SectionsHumansIntraoperative PeriodParathyroid DiseasesParathyroid GlandsReproducibility of ResultsRetrospective StudiesThyroid GlandConceptsFrozen section examinationParathyroid tissueIntraoperative consultationSection examinationUnanimous diagnosisLymph node casesSmall uniform cellsLymph nodesRetrospective studyThyroid surgeryHemorrhagic backgroundCytologic featuresPepper chromatinTissue 1Touch imprintsOval nucleiDiff-QuikNaked nucleiPT cellsThyroid casesFollicular arrangementConsultationDiagnosisExaminationPT cases