2024
Fibroepithelial Neoplasm with Hybrid Features of Benign Phyllodes Tumor, Juvenile Papillomatosis, and Juvenile Fibroadenoma: A Case Report.
Liu B, Mehrotra M, Kowtha L, Guan M, Houldsworth J, Baskovich B, Harigopal M. Fibroepithelial Neoplasm with Hybrid Features of Benign Phyllodes Tumor, Juvenile Papillomatosis, and Juvenile Fibroadenoma: A Case Report. International Journal Of Surgical Pathology 2024, 10668969241256112. PMID: 38839253, DOI: 10.1177/10668969241256112.Peer-Reviewed Original ResearchBenign phyllodes tumorPhyllodes tumorJuvenile fibroadenomaJuvenile papillomatosisFibroepithelial lesionsFibroepithelial neoplasmsFamily history of breast cancerHistory of breast cancerHyperplastic ductal epitheliumPapillary apocrine metaplasiaBreast cancer developmentMiddle-aged patientsProliferative breast tumorsHypoechoic solid massMicropapillary projectionsPreoperative biopsyBiphasic neoplasmPalpable massApocrine metaplasiaTumor featuresBreast tumorsCase reportDuctal epitheliumCellular fibroadenomaBreast cancer
2022
Increased Expression of LEF1 and β-Catenin in Invasive Micropapillary Carcinoma of the Breast is Associated With Lymphovascular Invasion and Lymph Node Metastasis
Dolezal D, Zhang X, Harigopal M. Increased Expression of LEF1 and β-Catenin in Invasive Micropapillary Carcinoma of the Breast is Associated With Lymphovascular Invasion and Lymph Node Metastasis. Applied Immunohistochemistry & Molecular Morphology 2022, 30: 557-565. PMID: 35960138, DOI: 10.1097/pai.0000000000001052.Peer-Reviewed Original ResearchConceptsInvasive micropapillary breast carcinomaLymph node metastasisLymphoid enhancer-binding factor 1Lymphovascular invasionNode metastasisNodal metastasisPrimary tumorΒ-cateninBreast tumorsRare breast cancer subtypeSmall tumor cell clustersLEF1 expressionMicropapillary breast carcinomaAggressive breast tumorsBasal-like carcinomasInvasive micropapillary carcinomaΒ-catenin expression levelsBreast cancer subtypesΒ-catenin expressionTumor cell clustersEnhancer-binding factor 1Disease relapseMicropapillary carcinomaBreast carcinomaHigh incidence
2018
Loss of c-KIT expression in breast cancer correlates with malignant transformation of breast epithelium and is mediated by KIT gene promoter DNA hypermethylation
Janostiak R, Vyas M, Cicek AF, Wajapeyee N, Harigopal M. Loss of c-KIT expression in breast cancer correlates with malignant transformation of breast epithelium and is mediated by KIT gene promoter DNA hypermethylation. Experimental And Molecular Pathology 2018, 105: 41-49. PMID: 29852185, DOI: 10.1016/j.yexmp.2018.05.011.Peer-Reviewed Original ResearchConceptsC-kit expressionNormal breast tissueC-kitMalignant transformationReceptor tyrosine kinasesBreast tissueBreast cancer correlatesKIT proto-oncogene receptor tyrosine kinaseBreast cancer cell linesC-kit protein expressionBreast tumor developmentProto-oncogene receptor tyrosine kinaseBreast tumor samplesCancer cell linesNormal breast epithelial tissuesTyrosine kinaseBreast epithelial tissueCancer correlatesBreast malignancyC-kit mRNABreast epitheliumBreast tumorsTransmembrane receptor tyrosine kinaseCopy number alterationsTumor samples