2023
A large-scale retrospective study enabled deep-learning based pathological assessment of frozen procurement kidney biopsies to predict graft loss and guide organ utilization
Yi Z, Xi C, Menon M, Cravedi P, Tedla F, Soto A, Sun Z, Liu K, Zhang J, Wei C, Chen M, Wang W, Veremis B, Garcia-Barros M, Kumar A, Haakinson D, Brody R, Azeloglu E, Gallon L, O'Connell P, Naesens M, Shapiro R, Colvin R, Ward S, Salem F, Zhang W. A large-scale retrospective study enabled deep-learning based pathological assessment of frozen procurement kidney biopsies to predict graft loss and guide organ utilization. Kidney International 2023, 105: 281-292. PMID: 37923131, PMCID: PMC10892475, DOI: 10.1016/j.kint.2023.09.031.Peer-Reviewed Original ResearchArterial intimal fibrosisGraft lossOrgan utilizationIntimal fibrosisSclerotic glomeruliLarge-scale retrospective studyGlomerular filtration rateDeceased donor kidneysPathologist scoresTransplant outcomesBiopsy findingsSurvival prediction modelWedge biopsyRisk stratificationRetrospective studyFiltration ratePathological assessmentDonor biopsiesNeedle biopsySimilar survivalHistological scoringUnnecessary organsDiscovery setKidneyLesion scores
2020
Genome-wide non-HLA donor-recipient genetic differences influence renal allograft survival via early allograft fibrosis
Zhang Z, Menon MC, Zhang W, Stahl E, Loza BL, Rosales IA, Yi Z, Banu K, Garzon F, Sun Z, Wei C, Huang W, Lin Q, Israni A, Keating BJ, Colvin RB, Hao K, Murphy B. Genome-wide non-HLA donor-recipient genetic differences influence renal allograft survival via early allograft fibrosis. Kidney International 2020, 98: 758-768. PMID: 32454123, PMCID: PMC7483801, DOI: 10.1016/j.kint.2020.04.039.Peer-Reviewed Original ResearchConceptsAllograft survivalIntimal fibrosisDeath-censored allograft survivalLong-term allograft failureAcute rejection episodesDonor-recipient differencesRenal allograft survivalHuman leukocyte antigen (HLA) lociNon-HLA SNPsLong-term survivalAllograft failureHLA mismatchesKidney recipientsRejection episodesSubclinical rejectionAllograft fibrosisMultivariable analysisHistologic damageR differencesOrgan SharingCox modelFibrosisHLA regionSurvivalGenome-wide single-nucleotide polymorphism array data