2022
Dematiaceous fungal infections in solid organ transplantation: Systematic review and Bayesian meta‐analysis
Radcliffe C, Radcliffe AJ, Azar MM, Grant M. Dematiaceous fungal infections in solid organ transplantation: Systematic review and Bayesian meta‐analysis. Transplant Infectious Disease 2022, 24: e13819. PMID: 35253959, DOI: 10.1111/tid.13819.Peer-Reviewed Original ResearchConceptsSolid organ transplant recipientsDematiaceous fungal infectionSoft tissue infectionsFungal infectionsInfectious syndromesSystematic reviewEarly post-transplant periodCentral nervous system infectionCommon infectious syndromesPost-transplant periodNervous system infectionOrgan transplant recipientsSolid organ transplantationEnglish-language reportsInfection typeKidney recipientsLiver recipientsPediatric reportsTransplant recipientsPulmonary infectionSystem infectionTissue infectionsWorse prognosisDisseminated infectionMean agePoor outcomes in both infection and colonization with carbapenem-resistant Enterobacterales
Howard-Anderson JR, Earley M, Komarow L, Abbo L, Anderson DJ, Gallagher JC, Grant M, Kim A, Bonomo RA, van Duin D, Muñoz-Price LS, Jacob JT. Poor outcomes in both infection and colonization with carbapenem-resistant Enterobacterales. Infection Control And Hospital Epidemiology 2022, 43: 1840-1846. PMID: 35105408, PMCID: PMC9343470, DOI: 10.1017/ice.2022.4.Peer-Reviewed Original ResearchConceptsCRE colonizationClinical outcomesCRE infectionsTract colonizationEpidemiology of patientsOutcomes of patientsProspective observational cohortCharacteristics of patientsOverall clinical outcomeShort-term acute care hospitalsUrinary tract colonizationCarbapenem-resistant EnterobacteralesRespiratory tract colonizationAcute care hospitalsDesirable clinical outcomesObservational cohortReadmission ratesSecondary outcomesPrimary outcomePoor outcomeUrinary tractRespiratory tractPatientsBetter outcomesClinical cultures
2021
Genetic and Epidemiologic Analyses of an Outbreak of Pneumocystis jirovecii Pneumonia Among Kidney Transplant Recipients in the United States
Azar MM, Cohen E, Ma L, Cissé OH, Gan G, Deng Y, Belfield K, Asch W, Grant M, Gleeson S, Koff A, Gaston DC, Topal J, Curran S, Kulkarni S, Kovacs JA, Malinis M. Genetic and Epidemiologic Analyses of an Outbreak of Pneumocystis jirovecii Pneumonia Among Kidney Transplant Recipients in the United States. Clinical Infectious Diseases 2021, 74: 639-647. PMID: 34017984, PMCID: PMC9012955, DOI: 10.1093/cid/ciab474.Peer-Reviewed Original ResearchConceptsKidney transplant recipientsCases of PCPPneumocystis pneumoniaClinic visitsRisk factorsClinic exposureLow absolute lymphocyte countRisk of PCPAbsolute lymphocyte countFrequent clinic visitsPneumocystis jirovecii pneumoniaStrong risk factorNon-white raceCase-control analysisBelatacept groupMonthly infusionsTransplant recipientsBaseline characteristicsJirovecii pneumoniaLymphocyte countMultilocus sequence typingInterhuman transmissionRespiratory specimensUnivariate analysisEpidemiologic data
2020
COVID-19 infections and outcomes in a live registry of heart failure patients across an integrated health care system
Caraballo C, McCullough M, Fuery MA, Chouairi F, Keating C, Ravindra NG, Miller PE, Malinis M, Kashyap N, Hsiao A, Wilson FP, Curtis JP, Grant M, Velazquez EJ, Desai NR, Ahmad T. COVID-19 infections and outcomes in a live registry of heart failure patients across an integrated health care system. PLOS ONE 2020, 15: e0238829. PMID: 32997657, PMCID: PMC7526909, DOI: 10.1371/journal.pone.0238829.Peer-Reviewed Original ResearchConceptsHeart failure patientsIntegrated health care systemHeart Failure RegistryHealth care systemFailure patientsCOVID-19 infectionCare systemCOVID-19SARS-CoV-2 infectionReal-time registryRenin-angiotensin blockersRetrospective chart reviewCoronary artery diseaseRisk of deathCOVID-19 testingAngiotensin blockersMultiple comorbiditiesRespiratory failureChart reviewSymptomatic patientsArtery diseaseHeart failureComorbid conditionsPatient mortalityClinical managementA rare case of lupoid leishmaniasis defying diagnosis for a decade
Gehlhausen J, Sibindi C, Ko CJ, Grant M, Zubek A. A rare case of lupoid leishmaniasis defying diagnosis for a decade. Journal Of Cutaneous Pathology 2020, 47: 1054-1057. PMID: 32623733, DOI: 10.1111/cup.13793.Peer-Reviewed Case Reports and Technical NotesConceptsCutaneous leishmaniasisGranulomatous rosaceaPolymerase chain reactionFacial plaquesLupoid leishmaniasisMultiple medical therapiesAcid-fast bacilliExtensive travel historyStandard histopathologic examinationMedical therapyNew lesionsMultiple biopsiesRare presentationHistopathologic examinationGranulomatous diseaseTuberculoid granulomasUltimate diagnosisRare caseSustained improvementEndemic areasSpecial stainsTravel historySarcoidosisCommon diseaseRosaceaEfficacy and safety of chronic antimicrobial suppression therapy for left ventricular assist device driveline infections: A single‐center descriptive experience
Radcliffe C, Doilicho N, Niu YS, Grant M. Efficacy and safety of chronic antimicrobial suppression therapy for left ventricular assist device driveline infections: A single‐center descriptive experience. Transplant Infectious Disease 2020, 22: e13379. PMID: 32574417, DOI: 10.1111/tid.13379.Peer-Reviewed Original ResearchConceptsCAS therapyDriveline infectionSuppression therapyTreatment failureVentricular assist device driveline infectionsShort-term antimicrobial therapyExperienced treatment failureTertiary transplant centerChronic kidney diseaseCornerstone of managementContinuous-flow LVADInfectious complicationsAdverse eventsLocal debridementRetrospective reviewTransplant centersKidney diseaseStable symptomsMean ageAntimicrobial therapyCommon causePatientsTherapySuccessful outcomeInfectionOver 870 days of successful antibiotic suppression therapy for VRE‐infected left ventricular assist device
Radcliffe C, Grant M. Over 870 days of successful antibiotic suppression therapy for VRE‐infected left ventricular assist device. Journal Of Cardiac Surgery 2020, 35: 1746-1748. PMID: 32557822, DOI: 10.1111/jocs.14690.Peer-Reviewed Case Reports and Technical NotesConceptsVancomycin-resistant Enterococcus faeciumSuppression therapyVentricular assist devicePocket infectionPump exchangeAssist deviceMethicillin-sensitive Staphylococcus aureusAntibiotic suppression therapyLeft ventricular assist deviceUse of daptomycinAdvanced heart failureSymptomatic adverse eventsHeartMate II LVADLong-term suppressionMultidrug-resistant pathogensSurgical drainageAdverse eventsCommon complicationHeart failureClinical challengeInfectionDevice placementTherapyEnterococcus faeciumStaphylococcus aureusTender subcubcutaneous plaques in a patient with acute myeloid leukemia
Olamiju B, Myung P, Grant M, Leventhal JS. Tender subcubcutaneous plaques in a patient with acute myeloid leukemia. International Journal Of Dermatology 2020, 60: 311-313. PMID: 32424815, DOI: 10.1111/ijd.14943.Peer-Reviewed Case Reports and Technical NotesHumansLeukemia, Myeloid, AcuteNontuberculous mycobacterial infections in left ventricular assist device patients
Radcliffe C, Doilicho N, Grant M. Nontuberculous mycobacterial infections in left ventricular assist device patients. Journal Of Cardiac Surgery 2020, 35: 1138-1141. PMID: 32253770, DOI: 10.1111/jocs.14530.Peer-Reviewed Case Reports and Technical NotesConceptsNontuberculous mycobacterial infectionNTM infectionMycobacterial infectionLeft ventricular assist device patientsVentricular assist device patientsRefractory heart failureContinuous-flow LVADVentricular assist deviceLVAD infectionGram-negative enteric bacteriaLVAD patientsDevice patientsHeart failureDriveline infectionDevice exchangeMost infectionsClinical challengeNegative culturesAssist deviceSystematic reviewInfectionDevice placementMycobacterium fortuitumStaphylococcal sppPatientsMolecular and clinical epidemiology of carbapenem-resistant Enterobacterales in the USA (CRACKLE-2): a prospective cohort study
van Duin D, Arias C, Komarow L, Chen L, Hanson B, Weston G, Cober E, Garner O, Jacob J, Satlin M, Fries B, Garcia-Diaz J, Doi Y, Dhar S, Kaye K, Earley M, Hujer A, Hujer K, Domitrovic T, Shropshire W, Dinh A, Manca C, Luterbach C, Wang M, Paterson D, Banerjee R, Patel R, Evans S, Hill C, Arias R, Chambers H, Fowler V, Kreiswirth B, Bonomo R, Investigators M. Molecular and clinical epidemiology of carbapenem-resistant Enterobacterales in the USA (CRACKLE-2): a prospective cohort study. The Lancet Infectious Diseases 2020, 20: 731-741. PMID: 32151332, PMCID: PMC7473597, DOI: 10.1016/s1473-3099(19)30755-8.Peer-Reviewed Original ResearchConceptsCarbapenem-resistant EnterobacteralesCarbapenemase-producing EnterobacteralesCohort studyProspective cohort studyCRE infectionsIndex culturePrimary outcomeK pneumoniaeCRE groupAdmission ratesClinical dataClinical epidemiologyClinical culturesPatientsUS hospitalsDay 107Similar outcomesDisease controlDesirability of outcomeEnterobacteralesUnique isolatesNational InstituteOutcomesWhole-genome sequencingInfectionUnder Our Very Eyes
Koff A, Malinis M, Delgado S, Grant M, Ahmad T. Under Our Very Eyes. New England Journal Of Medicine 2020, 382: 952-957. PMID: 32130818, DOI: 10.1056/nejmcps1902835.Peer-Reviewed Case Reports and Technical NotesInvasive pseudomembranous upper airway and tracheal Aspergillosis refractory to systemic antifungal therapy and serial surgical debridement in an Immunocompetent patient
Khan SN, Manur R, Brooks JS, Husson MA, Leahy K, Grant M. Invasive pseudomembranous upper airway and tracheal Aspergillosis refractory to systemic antifungal therapy and serial surgical debridement in an Immunocompetent patient. BMC Infectious Diseases 2020, 20: 13. PMID: 31906888, PMCID: PMC6945574, DOI: 10.1186/s12879-019-4744-2.Peer-Reviewed Case Reports and Technical NotesConceptsImmunocompetent patientsEndoscopic debridementLong-term antibiotic treatmentComplete disease resolutionSystemic antifungal therapySerial surgical debridementEfficacious treatment approachVoriconazole dosingRefractory symptomsSymptom controlAggressive treatmentBacterial sinusitisDisease resolutionRespiratory symptomsSurgical debridementRespiratory infectionsVoriconazole monotherapyTreatment regimensFungal infiltrationMechanical debridementUpper airwayAntibiotic treatmentAntifungal therapyDisease progressionSuch infections
2019
Between a Rock and a Hard Place: Balancing Physician Deception and Patient Self-Harm in the Management of Delusional Infestation
Grant M. Between a Rock and a Hard Place: Balancing Physician Deception and Patient Self-Harm in the Management of Delusional Infestation. American Journal Of Tropical Medicine And Hygiene 2019, 102: 3-4. PMID: 31701863, PMCID: PMC6947769, DOI: 10.4269/ajtmh.19-0755.Commentaries, Editorials and LettersRepeat exchange transfusion for treatment of severe babesiosis
Radcliffe C, Krause PJ, Grant M. Repeat exchange transfusion for treatment of severe babesiosis. Transfusion And Apheresis Science 2019, 58: 638-640. PMID: 31526674, DOI: 10.1016/j.transci.2019.07.010.Peer-Reviewed Case Reports and Technical NotesConceptsRepeat exchange transfusionExchange transfusionSevere babesiosisHospital day 5Second exchange transfusionBabesia microti infectionHigh feverRheumatoid arthritisMicroti infectionTransfusionDay 5Literature searchDearth of informationParasitemiaInfectionBabesiosisEtanerceptArthritisFeverClindamycinHypoxiaCasesWeeksWomenActinomyces neuii: a case report of a rare cause of acute infective endocarditis and literature review
Yang WT, Grant M. Actinomyces neuii: a case report of a rare cause of acute infective endocarditis and literature review. BMC Infectious Diseases 2019, 19: 511. PMID: 31182045, PMCID: PMC6558687, DOI: 10.1186/s12879-019-4149-2.Peer-Reviewed Case Reports and Technical NotesConceptsInfective endocarditisActinomyces sppEnd-stage renal diseaseBilateral cerebral infarctsOral antibiotic therapyAcute infective endocarditisStage renal diseaseVulnerable patient populationBackgroundInfective endocarditisSeptic emboliValvular surgeryAcute presentationCerebral infarctsCase presentationAFacial droopAntibiotic therapyRenal diseaseRare causePatient populationCase reportClassic presentationConclusionsThis caseEndovascular infectionBlood culturesMonoclonal gammopathySlowly progressive fatal PML-IRIS following antiretroviral initiation at CD4+ nadir of 350 cells/mm3 despite CD4+ cell count rise to 900 cells/mm3
Sandhu MR, Rutledge R, Grant M, Mahajan A, Spudich S. Slowly progressive fatal PML-IRIS following antiretroviral initiation at CD4+ nadir of 350 cells/mm3 despite CD4+ cell count rise to 900 cells/mm3. International Journal Of STD & AIDS 2019, 30: 810-813. PMID: 31046614, DOI: 10.1177/0956462419835966.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAdultAIDS-Related Opportunistic InfectionsAntiretroviral Therapy, Highly ActiveBrainCD4 Lymphocyte CountDisease ProgressionDystonic DisordersFatal OutcomeHIV InfectionsHumansImmune Reconstitution Inflammatory SyndromeJC VirusLeukoencephalopathy, Progressive MultifocalMagnetic Resonance ImagingMaleTreatment OutcomeConceptsImmune reconstitution inflammatory syndromePML-IRISAntiretroviral therapyCell countInflammatory syndromeInitiation of ARTHIV/AIDS patientsReconstitution inflammatory syndromeRobust immune reconstitutionCells/mm3Progressive multifocal leukoencephalopathyRole of CD4Blood-brain barrierCells/Antiretroviral initiationInflammatory picturePersistent positivityImmune reconstitutionMultifocal leukoencephalopathyNeurological symptomsOpportunistic infectionsAIDS patientsVirus antigenImmune responseJC virus
2017
Fatal case of cutaneous‐sparing orolaryngeal zoster in a renal transplant recipient
Helou E, Grant M, Landry M, Wu X, Morrow JS, Malinis MF. Fatal case of cutaneous‐sparing orolaryngeal zoster in a renal transplant recipient. Transplant Infectious Disease 2017, 19 PMID: 28401625, DOI: 10.1111/tid.12704.Peer-Reviewed Case Reports and Technical NotesConceptsTransplant recipientsHerpes zosterSolid organ transplant recipientsCTLA-4 inhibitorsKidney transplant recipientsRenal transplant recipientsOrgan transplant recipientsAcute rejectionSOT recipientsMucosal lesionsMeningo-encephalitisPoor outcomeFatal casesHerpesvirus infectionSignificant causeRecipientsZosterPneumonitisMorbidityPatientsLesionsInfectionMortalityCasesMycobacterium goodii endocarditis following mitral valve ring annuloplasty
Parikh RB, Grant M. Mycobacterium goodii endocarditis following mitral valve ring annuloplasty. Annals Of Clinical Microbiology And Antimicrobials 2017, 16: 14. PMID: 28327156, PMCID: PMC5361780, DOI: 10.1186/s12941-017-0190-4.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAgedAnti-Bacterial AgentsCluster AnalysisDNA, BacterialDNA, RibosomalEchocardiography, TransesophagealEndocarditis, BacterialHeartHumansMaleMitral Valve AnnuloplastyMycobacteriumMycobacterium Infections, NontuberculousPhylogenyRadiography, ThoracicReplantationRNA, Ribosomal, 16SSequence Analysis, DNATomography, X-Ray ComputedTreatment OutcomeConceptsMitral valve ring annuloplastyInfrequent human pathogenMitral valve replacementCombination of ciprofloxacinTrimethoprim/sulfamethoxazoleDrug susceptibility testingValve replacementCase presentationWeProsthetic infectionSuccessful treatmentDifferential diagnosisRing annuloplastyMicrobiologic laboratorySusceptibility testingEndocarditisPositive rodsInfectionDiagnosisHuman pathogensGene sequencingRDNA gene sequencingAnnuloplastyPatientsMolecular techniquesInjury