2017
Longitudinal analysis of quality‐of‐life outcomes in children during treatment for acute lymphoblastic leukemia: A report from the Children's Oncology Group AALL0932 trial
Zheng DJ, Lu X, Schore RJ, Balsamo L, Devidas M, Winick NJ, Raetz EA, Loh ML, Carroll WL, Sung L, Hunger SP, Angiolillo AL, Kadan‐Lottick N. Longitudinal analysis of quality‐of‐life outcomes in children during treatment for acute lymphoblastic leukemia: A report from the Children's Oncology Group AALL0932 trial. Cancer 2017, 124: 571-579. PMID: 29112230, PMCID: PMC5808870, DOI: 10.1002/cncr.31085.Peer-Reviewed Original ResearchConceptsAverage-risk acute lymphoblastic leukemiaQuality of lifeEmotional impairmentsLife Inventory (PedsQL) Generic CoreHigh-risk patientsProspective cohort studyTime of diagnosisEnd of therapyAcute lymphoblastic leukemiaFamily-based interventionsCohort studyQoL impairmentMean ageLymphoblastic leukemiaQOL outcomesPediatric QualityProportion of individualsEarly screeningPopulation normsImpaired rangeImpairmentMonthsTime pointsFunctioning impairmentImpairment patterns
2016
Prevalence and predictors of anxiety and depression after completion of chemotherapy for childhood acute lymphoblastic leukemia: A prospective longitudinal study
Kunin-Batson AS, Lu X, Balsamo L, Graber K, Devidas M, Hunger SP, Carroll WL, Winick NJ, Mattano LA, Maloney KW, Kadan-Lottick NS. Prevalence and predictors of anxiety and depression after completion of chemotherapy for childhood acute lymphoblastic leukemia: A prospective longitudinal study. Cancer 2016, 122: 1608-1617. PMID: 27028090, PMCID: PMC4860039, DOI: 10.1002/cncr.29946.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaCompletion of treatmentGreater riskEmotional-behavioral functioningChildren's Oncology Group protocolsChildhood acute lymphoblastic leukemiaAdjusted longitudinal analysesCompletion of chemotherapyDepressive symptoms 6 monthsSymptoms 6 monthsEmotional distressElevated anxiety scoresAnxiety 1 monthStandardized rating scalesElevated depression scoresChildren's emotional-behavioral functioningLymphoblastic leukemiaPredictors of anxietySocial support copingMeasures of copingDepressive symptomsGeneral populationDepression scoresPsychosocial interventionsEarly screening
2015
Prospective, longitudinal assessment of quality of life in children from diagnosis to 3 months off treatment for standard risk acute lymphoblastic leukemia: Results of Children's Oncology Group study AALL0331
Mitchell H, Lu X, Myers RM, Sung L, Balsamo LM, Carroll WL, Raetz E, Loh ML, Mattano LA, Winick NJ, Devidas M, Hunger SP, Maloney K, Kadan-Lottick N. Prospective, longitudinal assessment of quality of life in children from diagnosis to 3 months off treatment for standard risk acute lymphoblastic leukemia: Results of Children's Oncology Group study AALL0331. International Journal Of Cancer 2015, 138: 332-339. PMID: 26235006, PMCID: PMC5138856, DOI: 10.1002/ijc.29708.Peer-Reviewed Original ResearchConceptsStandard-risk acute lymphoblastic leukemiaAcute lymphoblastic leukemiaLymphoblastic leukemiaLife Inventory 4.0 Generic Core ScalesChildren's Oncology Group studyHRQoL 1 monthMean PedsQL scoresYears of therapyHealth-related qualityEnd of inductionHigh cure ratesGeneric Core ScalesSocial functioningRepeated-measures analysisTherapy completionTherapeutic trialsCure ratePediatric QualityPedsQL scoresConsiderable impairmentLongitudinal assessmentDiagnosisTherapyMonthsGroup study
2014
Family life events in the first year of acute lymphoblastic leukemia therapy: A children's oncology group report
Lau S, Lu X, Balsamo L, Devidas M, Winick N, Hunger SP, Carroll W, Stork L, Maloney K, Kadan‐Lottick N. Family life events in the first year of acute lymphoblastic leukemia therapy: A children's oncology group report. Pediatric Blood & Cancer 2014, 61: 2277-2284. PMID: 25175168, PMCID: PMC4282930, DOI: 10.1002/pbc.25195.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaChildren's Oncology Group reportChildhood acute lymphoblastic leukemiaAcute lymphoblastic leukemia therapyMonths of therapyProspective cohort studyAppropriate anticipatory guidanceHigh cure ratesLong-term outcomesMore childrenHealth care providersLess maternal educationFirst yearCohort studyPatient factorsCure rateLymphoblastic leukemiaCOG protocolsCare providersAnticipatory guidanceEligibility criteriaHigh incidenceLeukemia therapyMaternal educationAverage riskA prospective study of anxiety, depression, and behavioral changes in the first year after a diagnosis of childhood acute lymphoblastic leukemia
Myers RM, Balsamo L, Lu X, Devidas M, Hunger SP, Carroll WL, Winick NJ, Maloney KW, Kadan‐Lottick N. A prospective study of anxiety, depression, and behavioral changes in the first year after a diagnosis of childhood acute lymphoblastic leukemia. Cancer 2014, 120: 1417-1425. PMID: 24473774, PMCID: PMC4319360, DOI: 10.1002/cncr.28578.Peer-Reviewed Original ResearchMeSH KeywordsAggressionAntineoplastic Combined Chemotherapy ProtocolsAnxietyAsparaginaseBehaviorChildChild, PreschoolCohort StudiesCyclophosphamideDepressionDexamethasoneEmotionsFemaleHumansLongitudinal StudiesMalePolyethylene GlycolsPrecursor Cell Lymphoblastic Leukemia-LymphomaProspective StudiesPsychomotor AgitationVincristineConceptsStandard-risk acute lymphoblastic leukemiaAcute lymphoblastic leukemiaLymphoblastic leukemiaUnhealthy family functioningHispanic ethnicityChildren's Oncology Group protocolsChildhood acute lymphoblastic leukemiaClinical rangeSubpopulation of patientsWorse physical functioningMore childrenFirst yearCoping Health InventoryCohort studyProspective studyRisk factorsPhysical functioningFamily functioningHealth InventoryFamily Assessment DevicePopulation normsMonthsFunctioning ScaleDepressionGroup protocol