2023
Common and rare variants associated with cardiometabolic traits across 98,622 whole-genome sequences in the All of Us research program
Wang X, Ryu J, Kim J, Ramirez A, Mayo K, Condon H, Vaitinadin N, Ohno-Machado L, Talavera G, Ellinor P, Lubitz S, Choi S. Common and rare variants associated with cardiometabolic traits across 98,622 whole-genome sequences in the All of Us research program. Journal Of Human Genetics 2023, 68: 565-570. PMID: 37072623, PMCID: PMC10524735, DOI: 10.1038/s10038-023-01147-z.Peer-Reviewed Original ResearchMeSH KeywordsCarrier ProteinsCoronary Artery DiseaseDiabetes Mellitus, Type 2Genetic Predisposition to DiseaseGenome-Wide Association StudyHumansPopulation HealthProprotein Convertase 9ConceptsDiverse human populationsGenomic dataGene-based burden testsWhole genome sequencesRare variant analysisHuman populationQuantitative traitsBurden testsRare lossLociComplex diseasesGenetic associationVariant analysisFunction variantsCardiometabolic traitsRare variantsTraitsBiomedical researchGIGYF1VariantsNPR2ACANSequencePopulationLDLR
2022
Investigation of hypertension and type 2 diabetes as risk factors for dementia in the All of Us cohort
Nagar S, Pemu P, Qian J, Boerwinkle E, Cicek M, Clark C, Cohn E, Gebo K, Loperena R, Mayo K, Mockrin S, Ohno-Machado L, Ramirez A, Schully S, Able A, Green A, Zuchner S, Jordan I, Meller R. Investigation of hypertension and type 2 diabetes as risk factors for dementia in the All of Us cohort. Scientific Reports 2022, 12: 19797. PMID: 36396674, PMCID: PMC9672061, DOI: 10.1038/s41598-022-23353-z.Peer-Reviewed Original ResearchMeSH KeywordsChild, PreschoolCohort StudiesCross-Sectional StudiesDiabetes Mellitus, Type 2HumansHypertensionPopulation HealthRisk FactorsUnited StatesConceptsAssociation of hypertensionPrevalence of dementiaType 2 diabetesRisk factorsUS populationRace/ethnicityHigh prevalenceLarge observational cohort studyMultivariable logistic regression modelRisk factor modificationObservational cohort studyT2D risk factorsInvestigation of hypertensionAssociation of T2DOdds of dementiaRace/ethnicity groupsAssociation of sexCross-sectional analysisLogistic regression modelsWorld Health OrganizationElectronic health recordsConcurrent hypertensionModifiable comorbiditiesCohort studyFinal cohort
2015
The differential associations of preexisting conditions with trauma-related outcomes in the presence of competing risks
Calvo R, Lindsay S, Edland S, Macera C, Wingard D, Ohno-Machado L, Sise M. The differential associations of preexisting conditions with trauma-related outcomes in the presence of competing risks. Injury 2015, 47: 677-684. PMID: 26684173, DOI: 10.1016/j.injury.2015.10.055.Peer-Reviewed Original ResearchConceptsPre-existing chronic conditionsOlder trauma patientsHospital mortalityTrauma patientsMortality riskHigh-risk groupLow-risk subgroupsLower mortality riskLonger HLOSHospital lengthMost patientsRisk patientsClinical outcomesLiver diseaseRetrospective studyTrauma populationTrauma-related outcomesRisk regressionChronic conditionsExcess mortalityParkinson's diseaseLevel ICare facilitiesPatientsClinical decision