2024
A primer for quantum computing and its applications to healthcare and biomedical research
Durant T, Knight E, Nelson B, Dudgeon S, Lee S, Walliman D, Young H, Ohno-Machado L, Schulz W. A primer for quantum computing and its applications to healthcare and biomedical research. Journal Of The American Medical Informatics Association 2024, 31: 1774-1784. PMID: 38934288, PMCID: PMC11258415, DOI: 10.1093/jamia/ocae149.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2019
Protecting patient privacy in survival analyses
Bonomi L, Jiang X, Ohno-Machado L. Protecting patient privacy in survival analyses. Journal Of The American Medical Informatics Association 2019, 27: 366-375. PMID: 31750926, PMCID: PMC7025359, DOI: 10.1093/jamia/ocz195.Peer-Reviewed Original ResearchConceptsPrivacy protectionPrivacy risksHealthcare applicationsPatient privacyPrivacy protection methodProvable privacy protectionStrong privacy protectionPerson of interestKnowledgeable adversaryDifferential privacySynthetic datasetsFormal modelEpidemiology datasetPrivacyNonparametric survival modelFuture research directionsAdversaryResearch directionsDatasetBiomedical research applicationsFrameworkFrequent sharingResearch applicationsApplicationsSharingComparison of blockchain platforms: a systematic review and healthcare examples
Kuo T, Rojas H, Ohno-Machado L. Comparison of blockchain platforms: a systematic review and healthcare examples. Journal Of The American Medical Informatics Association 2019, 26: 462-478. PMID: 30907419, PMCID: PMC7787359, DOI: 10.1093/jamia/ocy185.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsBlockchain platformPopular blockchain platformsBlockchain applicationsSuitable blockchain platformDifferent blockchain platformsClinical informatics researchersTechnical featuresSoftware engineersHealth informatics applicationsHealthcare applicationsInformatics applicationsHealthcare exampleInformatics researchersPlatformBiomedical research applicationsHealthcareBlockchainImportant technical featuresKey featuresApplicationsResearch applicationsFeaturesBrief introductionTechnologyRequirements
2018
Clinical informatics applications of medication reconciliation, decision support systems, and online portal patient-provider communications
Ohno-Machado L. Clinical informatics applications of medication reconciliation, decision support systems, and online portal patient-provider communications. Journal Of The American Medical Informatics Association 2018, 25: 1431-1431. PMID: 30380084, PMCID: PMC7646928, DOI: 10.1093/jamia/ocy150.Commentaries, Editorials and Letters
2017
Blockchain distributed ledger technologies for biomedical and health care applications
Kuo T, Kim H, Ohno-Machado L. Blockchain distributed ledger technologies for biomedical and health care applications. Journal Of The American Medical Informatics Association 2017, 24: 1211-1220. PMID: 29016974, PMCID: PMC6080687, DOI: 10.1093/jamia/ocx068.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHealth care domainHealth care applicationsBlockchain technologyLedger technologyCare domainFeatures of blockchainBenefits of blockchainCare applicationsFamous BitcoinInformatics researchersBlockchainTechnologyApplicationsCovered topicsBitcoinDomainLatest applicationsPotential challengesDatabase
2012
Predicting accurate probabilities with a ranking loss.
Menon A, Jiang X, Vembu S, Elkan C, Ohno-Machado L. Predicting accurate probabilities with a ranking loss. Proceedings Of The ... International Conference On Machine Learning. 2012, 2012: 703-710. PMID: 25285328, PMCID: PMC4180410.Peer-Reviewed Original ResearchReal-world applicationsProbability distributionStatistical workhorseIsotonic regressionAccurate probabilityParticular classProbability predictionRegression performanceSemi-parametric techniquesRanking lossRich setBest rankingProbabilityExperimental resultsClassifierApplicationsMachineTechniqueClassSimple technique
2010
DSGeo: Software tools for cross-platform analysis of gene expression data in GEO
Lacson R, Pitzer E, Kim J, Galante P, Hinske C, Ohno-Machado L. DSGeo: Software tools for cross-platform analysis of gene expression data in GEO. Journal Of Biomedical Informatics 2010, 43: 709-715. PMID: 20435161, PMCID: PMC2934864, DOI: 10.1016/j.jbi.2010.04.007.Peer-Reviewed Original ResearchConceptsAggregation of dataData loaderRelational databaseGene expression dataUser preferencesData browserData browsingCross-platform dataSoftware toolsSeamless integrationCross-platform analysisGroups of dataQueriesExpression dataPublic gene expression dataSpecific sample characteristicsLarge resourcesBrowserToolBrowsingAnnotatingUsersRetrievalApplicationsPlatform
2007
Effects of SVM parameter optimization on discrimination and calibration for post-procedural PCI mortality
Matheny M, Resnic F, Arora N, Ohno-Machado L. Effects of SVM parameter optimization on discrimination and calibration for post-procedural PCI mortality. Journal Of Biomedical Informatics 2007, 40: 688-697. PMID: 17600771, PMCID: PMC2170520, DOI: 10.1016/j.jbi.2007.05.008.Peer-Reviewed Original ResearchConceptsSupport vector machineRadial Basis Kernel Support Vector MachineKernel support vector machineCross-entropy errorSVM parameter optimizationUnseen test dataSVM kernel typesTraining dataVector machineEvolutionary algorithmGrid searchMean squared errorKernel typeMachineOptimization methodPrediction modelNumber of methodsParameter optimizationTest dataMedical applicationsOptimization parametersMortality prediction modelAlgorithmBest modelApplications
2004
The Goodman-Kruskal coefficient and its applications in genetic diagnosis of cancer
Jaroszewicz S, Simovici D, Kuo W, Ohno-Machado L. The Goodman-Kruskal coefficient and its applications in genetic diagnosis of cancer. IEEE Transactions On Biomedical Engineering 2004, 51: 1095-1102. PMID: 15248526, DOI: 10.1109/tbme.2004.827267.Peer-Reviewed Original Research
1999
NEURAL NETWORK APPLICATIONS IN PHYSICAL MEDICINE AND REHABILITATION1
Ohno-Machado L, Rowland T. NEURAL NETWORK APPLICATIONS IN PHYSICAL MEDICINE AND REHABILITATION1. American Journal Of Physical Medicine & Rehabilitation 1999, 78: 392-398. PMID: 10418849, DOI: 10.1097/00002060-199907000-00022.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsThe decision systems group: creating a framework for decision making.
Greenes R, Boxwala A, Ohno-Machado L. The decision systems group: creating a framework for decision making. M.D. Computing 1999, 16: 23-7. PMID: 10507232.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements