MNGI-12. PLEIOTROPIC MLLT10 VARIATION CONFERS RISK OF MENINGIOMA, BREAST, AND OVARIAN CANCERS
Walsh K, Zhang C, Calvocoressi L, Hansen H, Berchuck A, Schildkraut J, Bondy M, Wiemels J, Claus E. MNGI-12. PLEIOTROPIC MLLT10 VARIATION CONFERS RISK OF MENINGIOMA, BREAST, AND OVARIAN CANCERS. Neuro-Oncology 2019, 21: vi142-vi142. PMCID: PMC6847155, DOI: 10.1093/neuonc/noz175.594.Peer-Reviewed Original ResearchBody mass indexER- breast cancerRisk of meningiomaOvarian cancerBreast cancerMeningioma riskCancer riskElevated body mass indexHigher body fat percentageRisk allelesExogenous hormone useEstrogen receptor statusFemale breast cancerBreast cancer riskOvarian cancer riskBody fat percentageEndogenous hormonal factorsRecent genome-wide association studiesReceptor statusWaist circumferenceHormone useMass indexEpidemiologic studiesEstrogenic mechanismsHigh riskMendelian randomization provides support for obesity as a risk factor for meningioma
Takahashi H, Cornish AJ, Sud A, Law PJ, Disney-Hogg L, Calvocoressi L, Lu L, Hansen HM, Smirnov I, Walsh KM, Schramm J, Hoffmann P, Nöthen MM, Jöckel KH, Schildkraut JM, Simon M, Bondy M, Wrensch M, Wiemels JL, Claus EB, Turnbull C, Houlston RS. Mendelian randomization provides support for obesity as a risk factor for meningioma. Scientific Reports 2019, 9: 309. PMID: 30670737, PMCID: PMC6343031, DOI: 10.1038/s41598-018-36186-6.Peer-Reviewed Original ResearchConceptsRisk of meningiomaMeningioma riskObesity-related traitsLipoprotein cholesterolBlood pressureRisk factorsOdds ratioLow-density lipoprotein cholesterolHigh-density lipoprotein cholesterolMendelian randomizationCause of meningiomaGenetic instrumentsDiastolic blood pressureEpidemiological observational studiesSystolic blood pressureBody mass indexBody fat percentageWaist circumferenceTotal cholesterolMass indexObservational studyMeningioma patientsMeningiomasBasal metabolic rateObesity