Evidence for vesicle-mediated antigen export by the human pathogen Babesia microti
Thekkiniath J, Kilian N, Lawres L, Gewirtz MA, Graham MM, Liu X, Ledizet M, Mamoun C. Evidence for vesicle-mediated antigen export by the human pathogen Babesia microti. Life Science Alliance 2019, 2: e201900382. PMID: 31196872, PMCID: PMC6572159, DOI: 10.26508/lsa.201900382.Peer-Reviewed Original ResearchConceptsApicomplexan parasitesCell fractionation studiesImmunoelectron microscopy analysisMode of secretionInvasion of erythrocytesParasite effectorsTrafficking motifsPlasma membraneExport mechanismClose relativesParasitophorous vacuoleHost erythrocyteMorphogenic changesFractionation studiesNovel mechanismHuman malariaFatal tick-borne diseaseMalaria-like illnessMouse red blood cellsParasitesAntigen exportTick-borne diseaseRed blood cellsHuman babesiosisImmunodominant antigensParasite‐Derived Vesicular‐Mediated Protein Export by the Human Pathogen Babesia microti
Mamoun C, Thekkiniath J, Kilian N, Lawres L, Gewirtz M, Abraham A, Graham M, Liu X, Ledizet M. Parasite‐Derived Vesicular‐Mediated Protein Export by the Human Pathogen Babesia microti. The FASEB Journal 2019, 33: 649.2-649.2. DOI: 10.1096/fasebj.2019.33.1_supplement.649.2.Peer-Reviewed Original ResearchMajor morphogenetic changesImmunoelectron microscopy analysisB. microtiProtein exportPhylum ApicomplexaMorphogenetic changesSecreted proteinsCell fractionationIntraerythrocytic developmentCanonical motifsExport systemPlasma membraneErythrocyte cytoplasmMajor immunodominant antigenBabesia microtiParasitophorous vacuoleHost erythrocyteWorldwide geographic distributionMalaria-like illnessGeographic distributionMalaria parasitesCell environmentProteinFASEB JournalFull-text articles