Featured Publications
Amplitude and phase measurements from harmonic analysis may lead to new physiologic insights: lower body negative pressure photoplethysmographic waveforms as an example
Alian A, Shelley K, Wu HT. Amplitude and phase measurements from harmonic analysis may lead to new physiologic insights: lower body negative pressure photoplethysmographic waveforms as an example. Journal Of Clinical Monitoring And Computing 2022, 37: 127-137. PMID: 35896756, DOI: 10.1007/s10877-022-00866-6.Peer-Reviewed Original Research
2018
Using support vector machines on photoplethysmographic signals to discriminate between hypovolemia and euvolemia
Reljin N, Zimmer G, Malyuta Y, Shelley K, Mendelson Y, Blehar DJ, Darling CE, Chon KH. Using support vector machines on photoplethysmographic signals to discriminate between hypovolemia and euvolemia. PLOS ONE 2018, 13: e0195087. PMID: 29596477, PMCID: PMC5875841, DOI: 10.1371/journal.pone.0195087.Peer-Reviewed Original ResearchConceptsBlood lossTrauma patientsTraditional vital signsLast time pointBlood pressureHemorrhagic shockCombat casualty careBlood withdrawalHealthy volunteersPhotoplethysmographic recordingsHeart rateBlood volumeEuvolemiaVital signsHypovolemiaPercentage changeTime pointsAbsolute changeCasualty carePatientsBattlefield settingsEarly stagesHemorrhageRecordingsHospital
2016
Ventilation-Induced Modulation of Pulse Oximeter Waveforms
Alian AA, Atteya G, Gaal D, Golembeski T, Smith BG, Dai F, Silverman DG, Shelley K. Ventilation-Induced Modulation of Pulse Oximeter Waveforms. Anesthesia & Analgesia 2016, 123: 346-356. PMID: 27284998, DOI: 10.1213/ane.0000000000001377.Peer-Reviewed Original ResearchConceptsSystolic blood pressureArterial pressure waveformBlood volumeFluid resuscitationBlood pressureOnly systolic blood pressurePressure waveformAirway pressure waveformFinger pulse oximetrySubstantial blood lossDynamic preload indicesVenous blood volumeArterial pressure measurementsArterial waveform parametersP-valuePulse oximeter waveformWilcoxon signed-rank testArterial pressureBlood lossBlood transfusionEarly bleedingPediatric patientsPreload indexHemodynamic dataScoliosis surgery
2014
Photoplethysmography
Alian AA, Shelley KH. Photoplethysmography. Best Practice & Research Clinical Anaesthesiology 2014, 28: 395-406. PMID: 25480769, DOI: 10.1016/j.bpa.2014.08.006.Peer-Reviewed Original ResearchAnalysis of plethysmographic waveform changes induced by beach chair positioning under general anesthesia
Zhu R, Atteya G, Shelley KH, Silverman DG, Alian AA. Analysis of plethysmographic waveform changes induced by beach chair positioning under general anesthesia. Journal Of Clinical Monitoring And Computing 2014, 28: 591-596. PMID: 24420341, DOI: 10.1007/s10877-014-9555-9.Peer-Reviewed Original ResearchConceptsBeach chair positioningVasoactive drugsBlood pressureShoulder surgeryNoninvasive hemodynamic parametersPostoperative cerebral ischemiaMean arterial pressureTidal carbon dioxideBeach chair positionIntermittent blood pressureChair positionWilcoxon signed-rank testPosition surgeryArterial pressureCerebral ischemiaGeneral anesthesiaSigned-rank testHemodynamic parametersRare caseDevastating outcomesHeart rateRespiratory frequencyPatientsSurgeryAmplitude density
2012
Modulation of finger photoplethysmographic traces during forced respiration: Venous blood in motion?
Phillips J, Belhaj A, Shafqat K, Langford R, Shelley K, Kyriacou P. Modulation of finger photoplethysmographic traces during forced respiration: Venous blood in motion? Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2012, 2012: 3644-3647. PMID: 23366717, DOI: 10.1109/embc.2012.6346756.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood CirculationFemaleFingersFourier AnalysisHumansMaleOximetryOxygenPhotoplethysmographyPressureRespirationRespiratory SystemSpirometryVeinsConceptsVenous oxygen saturationOxygen saturationBlood volumeNegative airway pressureAirway pressureVenous bloodArterial saturationRespiratory modulationHealthy volunteersRespiratory frequencyTissue bedsPilot studyResultant modulationArteryModulationFingerBloodPhotoplethysmographic signalsVolunteersUsing Time-Frequency Analysis of the Photoplethysmographic Waveform to Detect the Withdrawal of 900 mL of Blood
Scully CG, Selvaraj N, Romberg FW, Wardhan R, Ryan J, Florian JP, Silverman DG, Shelley KH, Chon KH. Using Time-Frequency Analysis of the Photoplethysmographic Waveform to Detect the Withdrawal of 900 mL of Blood. Anesthesia & Analgesia 2012, 115: 74-81. PMID: 22543068, DOI: 10.1213/ane.0b013e318256486c.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood PressureBlood Pressure DeterminationBlood Transfusion, AutologousBlood VolumeBlood Volume DeterminationCluster AnalysisConnecticutElectrocardiographyHeart RateHumansHypovolemiaInfrared RaysMalePhotoplethysmographyPredictive Value of TestsRespiratory MechanicsSensitivity and SpecificitySignal Processing, Computer-AssistedTime FactorsConceptsML of bloodArterial blood pressureBlood lossBlood pressureHeart rateHeart rate frequencyBlood withdrawalML blood lossMean percent decreaseBlood volume lossHeart rate componentSignificant changesPhotoplethysmographic waveformSpontaneous breathingTrauma settingCuff measurementsPPG waveformBlood reinfusionHealthy volunteersStandard electrocardiogramBloodEarly detectionEar PPG signalsBaselineConfidence intervalsRespiratory Physiology and the Impact of Different Modes of Ventilation on the Photoplethysmographic Waveform
Alian AA, Shelley KH. Respiratory Physiology and the Impact of Different Modes of Ventilation on the Photoplethysmographic Waveform. Sensors 2012, 12: 2236-2254. PMID: 22438762, PMCID: PMC3304164, DOI: 10.3390/s120202236.Peer-Reviewed Original Research
2010
Measuring venous oxygenation using the photoplethysmograph waveform
Walton ZD, Kyriacou PA, Silverman DG, Shelley KH. Measuring venous oxygenation using the photoplethysmograph waveform. Journal Of Clinical Monitoring And Computing 2010, 24: 295-303. PMID: 20644985, DOI: 10.1007/s10877-010-9248-y.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsData Interpretation, StatisticalEsophagusHumansOxygenPhotoplethysmographyPulsatile FlowVeinsConceptsVenous saturationVenous systemRegional venous oxygen saturationPeripheral venous waveformCardiac surgery patientsVenous oxygen saturationPeripheral venous systemPhotoplethysmograph waveformsWilcoxon signed-rank testVenous waveformSurgery patientsAtrial contractionSigned-rank testVenous bloodVenous oxygenationOxygen saturationGold standardPPG characteristicsHigh complianceBonferroni correctionSignificant differencesPPG analysisBloodPPG waveformPatients
2009
Peripheral venous pressure waveform
Wardhan R, Shelley K. Peripheral venous pressure waveform. Current Opinion In Anaesthesiology 2009, 22: 814. PMID: 19844178, DOI: 10.1097/aco.0b013e328332a343.Peer-Reviewed Original ResearchConceptsPeripheral venous pressure waveformsPeripheral intravenous cathetersPeripheral venous pressurePeripheral venous systemCarotid artery puncturePressure waveformVenous waveformVenous pressureArtery punctureIntraoperative monitoringIntravenous cathetersVenous systemRespiratory variationCardiovascular homeostasisInvasive monitoringArterial waveformProcedure timeVenous componentPhysiologic challengesFurther studiesCirculatory systemInexpensive monitoring deviceNumerous studiesCritical rolePneumothorax
2007
Photoplethysmography: Beyond the Calculation of Arterial Oxygen Saturation and Heart Rate
Shelley KH. Photoplethysmography: Beyond the Calculation of Arterial Oxygen Saturation and Heart Rate. Anesthesia & Analgesia 2007, 105: s31-s36. PMID: 18048895, DOI: 10.1213/01.ane.0000269512.82836.c9.Peer-Reviewed Original Research