2024
Predictors of Participation in a Perinatal Text Message Screening Protocol for Maternal Depression and Anxiety: Prospective Cohort Study
Barnwell J, Robert C, Nguyen T, Davis K, Gratton C, Elgbeili G, Pham H, Meaney M, Montreuil T, O'Donnell K. Predictors of Participation in a Perinatal Text Message Screening Protocol for Maternal Depression and Anxiety: Prospective Cohort Study. JMIR Pediatrics And Parenting 2024, 7: e53786. PMID: 39361419, PMCID: PMC11487212, DOI: 10.2196/53786.Peer-Reviewed Original ResearchMaternal Adverse Childhood Experiences and Biological Aging During Pregnancy and in Newborns
Dye C, Alschuler D, Wu H, Duarte C, Monk C, Belsky D, Lee S, O’Donnell K, Baccarelli A, Scorza P. Maternal Adverse Childhood Experiences and Biological Aging During Pregnancy and in Newborns. JAMA Network Open 2024, 7: e2427063. PMID: 39120899, PMCID: PMC11316241, DOI: 10.1001/jamanetworkopen.2024.27063.Peer-Reviewed Original ResearchConceptsMaternal adverse childhood experiencesAdverse childhood experiencesEdinburgh Postnatal Depression ScaleAccessible Resource for Integrated Epigenomics StudiesEpigenetic age accelerationGestational age accelerationAssociated with epigenetic agingAvon Longitudinal Study of ParentsLongitudinal Study of ParentsPostnatal Depression ScalePrimary outcomeChildhood experiencesAvon Longitudinal StudyEpigenetic ageStudy of ParentsAge accelerationHigher ACE scoresCross-sectional studyEpigenetic clocksMother-offspring dyadsDepression ScaleHealth districtMother-child dyadsDNA methylation–based epigenetic clocksInvestigate depressionDifferential interactions between gene expressions and stressors across the lifespan in major depressive disorder
Wang R, Su Y, O'Donnell K, Caron J, Meaney M, Meng X, Li Y. Differential interactions between gene expressions and stressors across the lifespan in major depressive disorder. Journal Of Affective Disorders 2024, 362: 688-697. PMID: 39029669, DOI: 10.1016/j.jad.2024.07.069.Peer-Reviewed Original ResearchMDD riskDepressive disorderPatterns of stressorsVulnerability-stress theoriesSusceptibility to MDDTranscriptome-wide association studyDimensions of stressorsLatent profile modelsLongitudinal community-based cohortPrefrontal cortexLifetime stressorsMDDGene expressionBrain amygdalaBasal gangliaStress researchNominal p-values <Southwest MontrealStressorsBrainFine-mapping analysisBrain cortexStudy cohortGenetic predispositionCortexVariation in the mu-opioid receptor gene (OPRM1) moderates the influence of maternal sensitivity on child attachment
Tchalova K, Lydon J, Atkinson L, Fleming A, Kennedy J, Lecompte V, Meaney M, Moss E, O’Donnell K, O’Donnell K, Silveira P, Sokolowski M, Steiner M, Bartz J. Variation in the mu-opioid receptor gene (OPRM1) moderates the influence of maternal sensitivity on child attachment. Translational Psychiatry 2024, 14: 181. PMID: 38580654, PMCID: PMC10997775, DOI: 10.1038/s41398-024-02888-x.Peer-Reviewed Original ResearchConceptsMaternal sensitivityChild attachmentAttachment behaviorExpression of attachment behaviorLevels of maternal sensitivityOPRM1 A118G genotypeInfluence of maternal sensitivityNon-human animal researchAmbivalent attachment patternsStrange Situation paradigmMu-opioid receptor geneOPRM1 A118G polymorphismA118G genotypeChildren's attachment stylesMother-child interactionA118G polymorphismEndogenous opioid systemMinor G alleleSensitive maternal careMother-infant attachmentInfant rhesus macaquesG alleleC77G polymorphismReceptor geneSituation paradigmThe effects of pregnancy, its progression, and its cessation on human (maternal) biological aging
Pham H, Thompson-Felix T, Czamara D, Rasmussen J, Lombroso A, Entringer S, Binder E, Wadhwa P, Buss C, O'Donnell K. The effects of pregnancy, its progression, and its cessation on human (maternal) biological aging. Cell Metabolism 2024, 36: 877-878. PMID: 38521058, DOI: 10.1016/j.cmet.2024.02.016.Peer-Reviewed Original ResearchAssociations between Social Adversity and Biomarkers of Inflammation, Stress, and Aging in Children
Pantell M, Silveira P, de Mendonça Filho E, Wing H, Brown E, Keeton V, Pokhvisneva I, O’Donnell K, Neuhaus J, Hessler D, Meaney M, Adler N, Gottlieb L. Associations between Social Adversity and Biomarkers of Inflammation, Stress, and Aging in Children. Pediatric Research 2024, 95: 1553-1563. PMID: 38233512, PMCID: PMC11126389, DOI: 10.1038/s41390-023-02992-6.Peer-Reviewed Original ResearchSocial adversityChildhood social adversityBiomarkers of inflammationEpigenetic ageSocial risk factorsChildren aged 0ResultsOur final sampleCytokine clusterCumulative adversityFinal sampleSocial predictorsPediatric clinicAged 0Logistic regressionNeuroendocrine functionBiomarkers of stressRisk factorsImpactOur studySocial factorsU-shaped distributionAdversityAssociationBiomarker samplingChildhoodChildren
2023
Maternal social support during and after pregnancy and child cognitive ability: examining timing effects in two cohorts.
Lähdepuro A, Räikkönen K, Pham H, Thompson-Felix T, Eid R, O'Connor T, Glover V, Lahti J, Heinonen K, Wolford E, Lahti-Pulkkinen M, O'Donnell K. Maternal social support during and after pregnancy and child cognitive ability: examining timing effects in two cohorts. Psychological Medicine 2023, 54: 1661-1670. PMID: 38087866, DOI: 10.1017/s0033291723003550.Peer-Reviewed Original ResearchChildren's cognitive abilitiesChildren's cognitive developmentGeneral cognitive abilityMaternal social supportCognitive abilitiesCognitive developmentSocial supportChildren's general cognitive abilitiesWechsler Intelligence ScaleMaternal experienceIntelligence ScaleTiming effectsAvon Longitudinal StudyMaternal anxietySensitive periodLongitudinal studyMaternal symptomsProspective longitudinal cohortAnxietyChildrenLess attentionDepressionLongitudinal cohortSupportWISCIndependent Prediction of Child Psychiatric Symptoms by Maternal Mental Health and Child Polygenic Risk Scores
Chen L, Pokhvisneva I, Lahti-Pulkkinen M, Kvist T, Baldwin J, Parent C, Silveira P, Lahti J, Räikkönen K, Glover V, O'Connor T, Meaney M, O'Donnell K. Independent Prediction of Child Psychiatric Symptoms by Maternal Mental Health and Child Polygenic Risk Scores. Journal Of The American Academy Of Child & Adolescent Psychiatry 2023, 63: 640-651. PMID: 37977417, PMCID: PMC11105503, DOI: 10.1016/j.jaac.2023.08.018.Peer-Reviewed Original ResearchPrenatal maternal depressionMaternal mental healthMaternal depressionAttention-deficit/hyperactivity disorderChild psychiatric symptomsPolygenic risk scoresPsychiatric symptomsRisk scoreMental healthFetal originGenomic riskAvon Longitudinal StudySimilar independent effectsAdolescent psychiatric symptomsHealth hypothesisMaternal symptomsChild CohortIndependent cohortBehavioral symptomsALSPAC cohortMental disordersSymptom dataSymptomsCohortChildren's symptomsEpigenetic age acceleration as a biomarker for impaired cognitive abilities in adulthood following early life adversity and psychiatric disorders
Felt J, Yusupov N, Harrington K, Fietz J, Zhang Z, Sliwinski M, Ram N, O'Donnell K, Group B, Meaney M, Putnam F, Noll J, Binder E, Shenk C. Epigenetic age acceleration as a biomarker for impaired cognitive abilities in adulthood following early life adversity and psychiatric disorders. Neurobiology Of Stress 2023, 27: 100577. PMID: 37885906, PMCID: PMC10597797, DOI: 10.1016/j.ynstr.2023.100577.Peer-Reviewed Original ResearchEarly life adversityPsychiatric disordersEpigenetic age accelerationLife adversityAge accelerationProspective cohort studyBiological agingNon-abused controlsCohort studyNeurocognitive screeningPeripheral bloodCommunity cohortNeurocognitive declineIndependent cohortCognitive declineEarly screeningMental disordersCohortGrimAge clockDisordersBiomarkersLower general cognitive abilityEarly declineNeurocognitive abilitiesCognitive abilitiesPerinatal Trajectories of Maternal Depressive Symptoms in Prospective, Community-Based Cohorts Across 3 Continents
Kee M, Cremaschi A, De Iorio M, Chen H, Montreuil T, Nguyen T, Côté S, O’Donnell K, Giesbrecht G, Letourneau N, Chan S, Meaney M. Perinatal Trajectories of Maternal Depressive Symptoms in Prospective, Community-Based Cohorts Across 3 Continents. JAMA Network Open 2023, 6: e2339942. PMID: 37883082, PMCID: PMC10603499, DOI: 10.1001/jamanetworkopen.2023.39942.Peer-Reviewed Original ResearchConceptsSelf-reported depressive symptomsMaternal depressive symptomsDepressive symptomsPerinatal periodPostnatal periodEdinburgh Postnatal Depression ScalePostnatal Depression ScaleEpidemiological Studies DepressionHealth policy guidelinesPublic health initiativesGroups of mothersCohort studyObservational cohortProspective cohortPregnancy influencesReferral guidelinesMultiple time pointsDepression ScaleMAIN OUTCOMEPregnancyPostnatal onsetStudies DepressionHealth initiativesTimely interventionCohortEarly intervention to prevent adverse child emotional and behavioural development following maternal depression in pregnancy: study protocol for a randomised controlled trial
Milgrom J, Hirshler Y, Holt C, Skouteris H, Galbally M, East C, Glover V, Reece J, O’Donnell K, Walker S, Malloy S, Gemmill A. Early intervention to prevent adverse child emotional and behavioural development following maternal depression in pregnancy: study protocol for a randomised controlled trial. BMC Psychology 2023, 11: 222. PMID: 37542332, PMCID: PMC10401817, DOI: 10.1186/s40359-023-01244-w.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyChild Behavior ChecklistChild outcomesBehavioral developmentMaternal depressionAntenatal depression treatmentChild developmental outcomesRevised Infant Behavior QuestionnaireInfant Behavior QuestionnaireActive psychological treatmentsMother-infant interactionAntenatal depressionAdditional secondary outcome measuresMonths of ageAdverse child outcomesOutcome measuresPsychological treatmentCBT programMental health disordersBehavioral therapyAnxiety symptomsBehavior ChecklistBehavioral problemsExternalising problemsInternalising scalesA Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes
Arcego D, Buschdorf J, O'Toole N, Wang Z, Barth B, Pokhvisneva I, Rayan N, Patel S, de Mendonça Filho E, Lee P, Tan J, Koh M, Sim C, Parent C, de Lima R, Clappison A, O'Donnell K, Dalmaz C, Arloth J, Provençal N, Binder E, Diorio J, Silveira P, Meaney M. A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes. Biological Psychiatry 2023, 95: 48-61. PMID: 37406925, DOI: 10.1016/j.biopsych.2023.06.028.Peer-Reviewed Original ResearchConceptsHippocampal dentate gyrusDentate gyrusPsychiatric disordersHuman hippocampal cellsBrain gray matter densityEarly adversitySingle nucleotide polymorphismsMultiple psychiatric conditionsEarly life adversityGray matter densityAdult female macaquesMental health outcomesTranscriptional activityGlucocorticoid exposureNucleotide polymorphismsLater psychosisStress mediatorsHippocampal cellsPsychotic disordersAnimal modelsHealth outcomesPsychiatric conditionsSignificant associationFemale macaquesMental healthThe impact of genetic predisposition to depression on quality of life in patients with head and neck cancer immediately post-treatment: A longitudinal study.
Henry M, Chen L, Meaney M, Rosberger Z, Frenkiel S, Hier M, Zeitouni A, Kost K, Mlynarek A, Richardson K, Deamond H, Lang J, Silver J, Ducharme L, Mascarella M, Sadeghi N, Sultanem K, Shenouda G, Cury F, O'Donnell K. The impact of genetic predisposition to depression on quality of life in patients with head and neck cancer immediately post-treatment: A longitudinal study. Journal Of Clinical Oncology 2023, 41: 6063-6063. DOI: 10.1200/jco.2023.41.16_suppl.6063.Peer-Reviewed Original ResearchNeck cancerPolygenic risk scoresGenetic predispositionRisk scoreSuicidal ideationConsecutive adult patientsMedical chart reviewTreatment of patientsLongitudinal studyProspective longitudinal studyQuality of lifePost-treatment periodAdult patientsChart reviewPrimary HNCPrevious historyMedical variablesPatientsSaliva samplesLife compromiseCancerPast historyPsychosocial vulnerabilityMaternal prenatal depression is associated with dysregulation over the first five years of life moderated by child polygenic risk for comorbid psychiatric problems
Babineau V, Jolicoeur‐Martineau A, Szekely E, Green C, Sassi R, Gaudreau H, Levitan R, Lydon J, Steiner M, O'Donnell K, Kennedy J, Burack J, Wazana A. Maternal prenatal depression is associated with dysregulation over the first five years of life moderated by child polygenic risk for comorbid psychiatric problems. Developmental Psychobiology 2023, 65: e22395. PMID: 37338256, DOI: 10.1002/dev.22395.Peer-Reviewed Original ResearchConceptsMaternal prenatal depressionPolygenic risk scoresPrenatal depressionPsychiatric problemsChild psychiatric problemsComorbid psychiatric problemsChildhood psychiatric problemsMajor depressive disorderHigher dysregulationYears of lifeAttention deficit hyperactivity disorderDeficit hyperactivity disorderWeeks' gestationPsychiatric comorbidityPrenatal cohortDepressive disorderPostnatal depressionRisk scorePrenatal stressDepression symptomsMaternal educationGreater riskHyperactivity disorderDysregulationPolygenic riskGenetic predisposition to depression and inflammation impacts symptom burden and survival in patients with head and neck cancer: A longitudinal study
Henry M, Harvey R, Chen L, Meaney M, Nguyen T, Kao H, Rosberger Z, Frenkiel S, Hier M, Zeitouni A, Kost K, Mlynarek A, Richardson K, Greenwood C, Melnychuk D, Gold P, Chartier G, Black M, Mascarella M, MacDonald C, Sadeghi N, Sultanem K, Shenouda G, Cury F, O'Donnell K. Genetic predisposition to depression and inflammation impacts symptom burden and survival in patients with head and neck cancer: A longitudinal study. Journal Of Affective Disorders 2023, 331: 149-157. PMID: 36948466, DOI: 10.1016/j.jad.2023.03.007.Peer-Reviewed Original ResearchConceptsSymptom burdenNeck cancerGenetic predispositionPolygenic risk scoresRisk scoreAnxiety disordersImmediate post-treatment periodMedical chart reviewDose of radiotherapyStructured Clinical InterviewHigher polygenic risk scoreLongitudinal studyProspective longitudinal studyLife-threatening diseaseDose-related responsePost-treatment periodChart reviewHADS anxietyCancer survivalHigh prevalencePrimary headHigh riskDSM disordersPatientsClinical InterviewMaternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation?
Creasey N, Beijers R, O'Donnell K, de Weerth C, Tollenaar M. Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation? Development And Psychopathology 2023, 36: 967-978. PMID: 36896668, DOI: 10.1017/s0954579423000226.Peer-Reviewed Original ResearchAge 5 weeksChild mental healthMaternal sensitivityMental healthGlucocorticoid receptor gene methylationAge 6 yearsChildren's internalizingMethylation levelsMother-infant interactionDNA methylation levelsAnimal modelsEarly infancyStress regulatory systemsExternalizing behaviorsEarly caregiving environmentGene DNA methylationAge 6Longitudinal studyLower DNA methylation levelsResponsive caregivingSame childrenCommunity sampleCaregiving environmentGene methylationDNA methylationA sparse additive model for high-dimensional interactions with an exposure variable
Bhatnagar S, Lu T, Lovato A, Olds D, Kobor M, Meaney M, O'Donnell K, Yang A, Greenwood C. A sparse additive model for high-dimensional interactions with an exposure variable. Computational Statistics & Data Analysis 2023, 179: 107624. DOI: 10.1016/j.csda.2022.107624.Peer-Reviewed Original ResearchInvestigating the effects of maltreatment and acute stress on the concordance of blood and DNA methylation methods of estimating immune cell proportions
Apsley A, Etzel L, Hastings W, Heim C, Noll J, O’Donnell K, Schreier H, Shenk C, Ye Q, Shalev I. Investigating the effects of maltreatment and acute stress on the concordance of blood and DNA methylation methods of estimating immune cell proportions. Clinical Epigenetics 2023, 15: 33. PMID: 36855187, PMCID: PMC9976543, DOI: 10.1186/s13148-023-01437-5.Peer-Reviewed Original ResearchConceptsComplete blood countImmune cell proportionsAcute psychosocial stressCell proportionPsychosocial stressPsychosocial stress altersImmune cell subtypesAcute laboratory stressorEarly life adversityStress-exposed individualsChild maltreatmentPediatric cohortBlood countCell subtypesAcute stressStress-induced changesPathophysiological statesLife adversityCritical covariatesLaboratory stressorYoung adultsEffects of maltreatmentDNAm alterationsClinical populationsDNA methylationTemperature variability and birthweight: Epidemiological evidence from Africa
Wang P, O'Donnell K, Warren J, Dubrow R, Chen K. Temperature variability and birthweight: Epidemiological evidence from Africa. Environment International 2023, 173: 107792. PMID: 36841185, DOI: 10.1016/j.envint.2023.107792.Peer-Reviewed Original ResearchAssociations between epigenetic aging and childhood peer victimization, depression, and suicidal ideation in adolescence and adulthood: A study of two population-based samples
Perret L, Geoffroy M, Barr E, Parnet F, Provencal N, Boivin M, O'Donnell K, Suderman M, Power C, Turecki G, Ouellet-Morin I. Associations between epigenetic aging and childhood peer victimization, depression, and suicidal ideation in adolescence and adulthood: A study of two population-based samples. Frontiers In Cell And Developmental Biology 2023, 10: 1051556. PMID: 36712964, PMCID: PMC9879289, DOI: 10.3389/fcell.2022.1051556.Peer-Reviewed Original ResearchDepressive symptomsSuicidal ideationEpigenome-wide DNA methylationHigh riskHigher depressive symptom scoresSelf-reported depressive symptomsDepressive symptom scoresTwo-cohort studyEpigenetic agingPopulation-based sampleEpigenetic indexBritish birth cohortChildhood peer victimizationQuebec Longitudinal StudySymptom scoresCohort 1Birth cohortSymptomsDNA methylation markersCohortPace of agingCandidate gene studiesLongitudinal studyIdeationMethylation markers